What you ACTUALLY need to know about B6 & Toxicity
Summary
TLDRDieses Video skizziert die Toxizität von Vitamin B6 und erklärt, warum ein für das menschliche Überleben essentieller Nährstoff zu Problemen führen kann. Der Experte Dr. Paul Anderson erläutert, wie Vitamin B6 in verschiedenen Formen (Vitamers) im Körper metabolisiert wird und wie Inflammationen und genetische Faktoren die Bildung von schädlichen Formen fördern können. Er betont die Notwendigkeit, sowohl die zugrunde liegenden Entzündungsprozesse als auch die genetische Disposition zu berücksichtigen, um Vitamin B6-Intoxikation zu vermeiden und behandeln.
Takeaways
- 🧬 Vitamin B6 ist in mehreren Formen vorliegend, die als Vitamer bezeichnet werden und unterschiedliche Metabolisierungspfade verfolgen.
- 🚫 Vitamin B6-Intoxikation ist meist eine neurotoxische Reaktion, die peripheren Nerven beeinträchtigt und kann durch hohe Dosen über längere Zeit verursacht werden.
- 🔄 Vitamin B6 kann durch verschiedene Wege metabolisiert werden, einschließlich zur Aktivform Pyridoxyl 5-Phosphate (P5P) und Pyridoxin.
- 🔍 Die Intoxikation tritt oft auf, wenn Vitamin B6 aufgrund von Entzündungsreaktionen in Formen umgewandelt wird, die für das Nervensystem schädlich sind.
- 🚭 Raucher haben aufgrund von Entzündungen und epigenetischen Veränderungen ein erhöhtes Risiko für Vitamin B6-Intoxikation.
- 🧬 Genomische Probleme, wie Single Nucleotide Polymorphismen, können die Metabolisierung von Vitamin B6 beeinträchtigen und zu Intoxikation führen.
- ❌ Eine Vitamin B6-Bluttest kann irreführend sein, da er mehrere Vitamer misst und nicht zwischen den schädlichen und nützlichen Formen unterscheidet.
- ⚠️ Eine erhöhte Vitamin B6-Konzentration im Blut ist nur ein Teil des Puzzles und kann aufgrund von Testfehlern unreliabel sein.
- 🛑 Bei Verdacht auf Vitamin B6-Intoxikation sollte die Aufnahme von zusätzlichem Vitamin B6 eingestellt werden, bis die Ursache des Problems geklärt ist.
- 🔄 Langfristig sollte man auf die zugrunde liegenden entzündlichen Bedingungen und genetischen Faktoren eingehen, um eine erneute Intoxikation zu vermeiden.
- 👨⚕️ Die Entscheidungen zur Gesundheitsversorgung sollten in Zusammenarbeit mit medizinischen Fachleuten getroffen werden, und die hier gegebenen Informationen dienen der Information und nicht der medizinischen Entscheidungsfindung.
Q & A
Was ist die Hauptursache für Vitamin B6-Intoxikation?
-Die Hauptursache für Vitamin B6-Intoxikation ist eine neurotoxische Wirkung, die oft durch eine Inflammationsreaktion ausgelöst wird, anstatt direkt durch das Vitamin selbst.
Welche Formen von Vitamin B6 gibt es und was sind Vitamers?
-Vitamin B6 hat verschiedene Formen, die als Vitamers bezeichnet werden. Vitamers sind verschiedene chemische Formen eines Vitamins, die unterschiedliche Metabolisierungswege einschlagen können.
Welche Form von Vitamin B6 wird oft als aktivierte Form angesehen?
-Pyridoxyl 5-Phosphat (P5P) wird als eine der aktivierten Formen von Vitamin B6 angesehen, die man als Nahrungsergänzung einnehmen kann.
Was sind die Konsequenzen, wenn der Vitamin B6-Stoffwechsel durch Inflammation beeinflusst wird?
-Ein beeinflusster Vitamin B6-Stoffwechsel durch Inflammation kann dazu führen, dass es in weniger nützliche Vitamers umgewandelt wird, die für das Nervensystem schädlich sein können.
Welche Rolle spielen genetische Faktoren wie Single Nucleotide Polymorphisms (SNPs) bei der Vitamin B6-Intoxikation?
-Genetische Faktoren wie SNPs können die Enzyme beeinflussen, die an der Metabolisierung von Vitamin B6 beteiligt sind, was zu einer ungleichen Verteilung der Vitamers führen kann und somit zu Intoxikation neigt.
Was passiert, wenn jemand Vitamin B6 übermäßig konsumiert?
-Übermäßiger Vitamin B6-Konsum kann über lange Zeit zu neurotoxischen Effekten führen, insbesondere wenn die Dosis 500 Milligramm oder mehr pro Tag beträgt.
Wie können Vitamin B6-Mangelsymptome vermieden werden?
-Vitamin B6-Mangelsymptome können vermieden werden, indem man die empfohlenen täglichen Mengen einnimmt und auf eine ausgewogene Ernährung achtet.
Was sind die Anzeichen von Vitamin B6-Intoxikation?
-Anzeichen von Vitamin B6-Intoxikation können neurologische Symptome wie Peripherne Neuropathie oder Schäden am Zentralnervensystem sein.
Welche Rolle spielen Wasserstoffperoxide und freie Radikale bei der Vitamin B6-Intoxikation?
-Wasserstoffperoxide und freie Radikale können die Metabolisierung von Vitamin B6 beeinflussen und dazu führen, dass es in schädliche Vitamers umgewandelt wird, die für das Nervensystem problematisch sein können.
Wie wird Vitamin B6 im Körper metabolisiert?
-Vitamin B6 wird im Körper durch verschiedene Metabolismuswege in verschiedene Vitamers umgewandelt, wobei einige von ihnen für das Nervensystem schädlich sein können.
Was ist der Unterschied zwischen kurzfristigem und langfristigem Vitamin B6-Konsum?
-Kurzfristiger Vitamin B6-Konsum kann therapeutisch sein, langfristiger Konsum jedoch in hohen Dosen kann zu Intoxikation führen, insbesondere wenn der Stoffwechsel durch Inflammation beeinflusst wird.
Outlines
🧬 Vitamin B6 und Toxizität
Dieses Absatz beschäftigt sich mit der Metabolisierung von Vitamin B6 im menschlichen Körper und der Möglichkeit, dass es zu einer Toxizität kommt. Es wird erklärt, dass Vitamin B6 verschiedene Metaboliten bildet, die durch bestimmte Biochemiekreise in der Körper aktiv sind. Die Toxizität von Vitamin B6 wird oft durch Neurotoxizität hervorgerufen, die durch die Einnahme von hohen Dosen über einen längeren Zeitraum ausgelöst wird. Es wird betont, dass Vitamin B6 eine Gruppe von Metaboliten namens Vitamers umfasst, die unterschiedliche Auswirkungen auf das Nervensystem haben können. Eine der Hauptursachen für Vitamin B6 Toxizität ist die Inflammation im Körper, die bestimmte Metabolitenreaktionen auslöst. Des Weiteren wird die Rolle von Genomproblemen und Enzymimbalancen bei der Entstehung von Vitamin B6 Toxizität diskutiert.
🚫 Umgang mit Vitamin B6 Toxizität
In diesem Absatz wird auf die Herausforderungen eingegangen, die mit der Diagnose und Behandlung von Vitamin B6 Toxizität verbunden sind. Es wird erläutert, dass die Vermeidung von zusätzlichen Vitamin B6 Einnahmen eine kurzfristige Maßnahme ist, während langfristig die zugrunde liegenden entzündlichen Bedingungen und Genomprobleme angegangen werden müssen. Es wird betont, dass die Bluttests für Vitamin B6 nicht spezifisch genug sind, um die Art der Metaboliten zu bestimmen, die in der Toxizität involviert sind. Die Bedeutung der Behandlung der zugrunde liegenden entzündlichen Zustände und der Genomfaktoren wird hervorgehoben, um die Vitamin B6 Toxizität zu bekämpfen.
🤔 Empfehlungen und Ressourcen
Schließlich bietet dieser Absatz einige Empfehlungen und Ressourcen für diejenigen, die sich mit Vitamin B6 Toxizität auseinandersetzen. Es wird auf die Notwendigkeit hingewiesen, mit einem Gesundheitsversorger zusammenzuarbeiten, um eine fundierte Entscheidungsfindung bezüglich der Gesundheitsversorgung zu treffen. Es werden auch Links zu Gesundheitsanbieterverbänden und Informationen über den Podcast und YouTube Kanal des Sprechers aufgeführt, um den Zuhörern mehr Informationen und Ressourcen zur Verfügung zu stellen.
Mindmap
Keywords
💡Vitamin B6
💡Toxizität
💡Neurotoxizität
💡Vitamer
💡Pyridoxyl 5-Phosphat (P5P)
💡Inflammation
💡Genomprobleme
💡Enzyme
💡Antioxidantien
💡Epigenetik
💡Diagnostik
Highlights
Vitamin B6 can metabolize into different forms through various pathways in humans.
Vitamin B6 toxicity is primarily neurotoxicity affecting peripheral and central nerves.
High doses of Vitamin B6 over long periods can lead to toxicity.
Vitamin B6 is unique among water-soluble vitamins due to its potential for toxicity.
Vitamin B6 exists as a pool of vitamers, which are different forms of the vitamin.
Pyridoxyl 5-phosphate (P5P) is an active form of Vitamin B6 that can be taken as a supplement.
Inflammation and peroxide radicals can trigger pathways leading to the buildup of harmful B6 vitamers.
Smoking can cause improper metabolism of Vitamin B6 due to inflammation and epigenetic changes.
Genomic problems and single nucleotide polymorphisms can affect Vitamin B6 metabolism.
People with B6 toxicity syndromes tend to accumulate unfriendly B6 vitamers due to inflammation.
Avoiding additional B6 intake is the first step in managing B6 toxicity.
Addressing underlying inflammatory conditions is crucial for long-term management of B6 toxicity.
Blood tests for Vitamin B6 measure multiple vitamers and may not accurately reflect metabolism.
Diagnostic tests for Vitamin B6 can be prone to false positives and negatives due to technical challenges.
Working on genomics and rebalancing the inflammatory cascade is important for managing B6 toxicity.
Chronic deficiencies in antioxidants like Vitamin C, E, and glutathione can contribute to B6 toxicity.
The speaker emphasizes the importance of working with healthcare providers for health care decision-making.
The speaker provides resources for further information on health care and chronic illness care.
Transcripts
and so if you look at vitamin B6 once it
goes inside of a mammal especially a
human it can metabolize through all
these different Pathways and become
different vitamins vitamin B6
it's Dr am answering your questions
today and this question was really a
good one we get this a lot and it's
about vitamin B6 toxicity why would that
happen what happens when you get vitamin
B6 toxic and why would a nutrient that
is critical for your life to keep going
on and like your brain to function
everything else create a problem so we
get comments especially when certain you
know I think we're talking about maybe
long covet or mast cells or something
like that go check those uh playlists
out over on YouTube if you want but I
got a lot of comments around B6 and
people saying well I'd stop taking b6
because I I got a toxicity Syndrome from
it so first thing uh every nutrient has
a potential deficit problem and a
potential toxicity or access problem we
humans are sort of set up to work in the
Middle where we don't want too little
and you know get some deficiency disease
we don't want too much
Now water-soluble Vitamins usually leave
your body roughly the same day they come
in so we have to you know eat them or
get them every day
but vitamin B6 is a little bit unique
now there's other vitamins similar B6 is
a little unique and this is where the
toxicity usually comes from so I just
want to talk about that in an effort to
answer this particular question how do
people get B6 toxic well the first thing
is most well recognized vitamin B6
toxicity is more of a neurotoxicity
peripheral nerves maybe Central nerves
Etc and in the literature when they're
first describing it it tended to be in
people taking very large doses of
vitamin B6 so they were taking you know
500 or more milligrams a day for long
periods of time which short term you
might need a lot of B6 long term that's
way too much okay but here's the problem
because you might say well you know a
lot of people take vitamin B6 every day
and they don't get toxic if human
biochemistry were really simple then
every B vitamin for example would
metabolize exactly the same way the
problem with vitamin B6 is it's a pool
of what we call Vitamin B6 vitamers okay
so vitamer is an unusual name unless
you're into nutrient biochemistry but
you might have heard of something like
called an isomer right so there might be
two forms of a chemical well a vitamer
is multiple forms of a of a vitamin
hence the name so vitamin B6 has a lot
of different forms and I almost did one
of my little graphs I was going to show
you but it's it's a little bit busy but
here's the problem there are Pathways
for vitamin B6 to metabolize inside of a
human the first one generally is being
activated one of the active forms which
you can take as a supplement is
pyridoxyl 5-phosphate or p5p and then
there's pyridoxine and that is the
normal B6 vitamin that's given and it's
a little step above so it has more
metabolism options but even p5p being
quote unquote more active has a bunch of
places it can go and so if you look at
vitamin B6 once it goes inside of a
mammal especially a human it can
metabolize through all these different
Pathways and become different vitamins
vitamin B6 and one of the pathways that
tends to pool the vitamers that are not
friendly to your nervous system is
triggered by
inflammation it's triggered by peroxide
radicals and other inflammatory things
so the evil in the system and the actual
trigger is not the vitamin B6 it is the
inflammatory reaction that the vitamin
B6 undergo and it's a different type of
reaction it's related that happens if
someone is a smoker and their vitamin B6
will metabolize you know inappropriately
because of the inflammatory and some of
the epigenetic changes from smoking but
you don't have to be a smoker to have
this happen and this is the reason why
you can have a thousand people taking
vitamin B6 they don't have a problem the
thousand and first person gets vitamin
B6 toxic now it has an overlay in many
people not everybody of genomic Problems
single nucleotide polymorphisms
imbalances in the enzymes that
metabolize all these different Pathways
of vitamins Etc but the bottom line is
is that we tend to pool and uh increase
the vitamers that are more unfriendly
the nervous system in people who have B6
toxicity syndromes
so then you might say to yourself well
should everyone not take B6 anymore no
it's not how it works this is just for
particular people at B6 stocks if you
are V6 toxic obviously one of the things
is not to take any extra until you get
this sorted out but if you think about
it if I take away B6 and you're not
taking that anymore that's great because
you're not getting extra P6 but then if
you have this underlying inflammatory
problem and that is never dealt with or
the genomic problems never dealt with
you are always going to have this
nutrient that is used to run your body
when it gets over a certain level
trigger this uh unfortunate buildup of
the vitamers of B6 that are you know
nasty to your nervous system so
decreasing B6 intake is the acute thing
that you do long term if you are to work
with somebody who's working on all these
other things in your inflammatory State
Etc and they look at your Sage genomics
and you you see maybe we've got
metabolism issues that need some help
here or I need to avoid certain things
long-term a person with B6 toxicity who
works on the underlying problems can
have it in their food and maybe a little
bit in supplements they are not affected
by it but what tends to happen is outs
remember I said the initial reports were
all people taking you know stupid high
amounts of vitamin B6 long term all
right stupid High short term is used
therapeutically for particular things we
do that all the time but long term you
don't leave people on super high doses
but they were taking a long term at high
dosage we take that group out then you
get people who are maybe taking a
moderate dose or a medium dose of B6 or
p5p and they get toxic with it that is
because they're metabolizing it and it's
having this inflammatory Cascade problem
now if the person was or is a smoker
there's different things to do there but
if a person's not a smoker and has no
history of smoking then what we really
have to look at is what is the real
cause of the problem the real cause of
the problem is not actually the B6
that's the trigger but the real cause of
the problem is the inflammatory buildup
of the B6 vitamers that are not friendly
to the to the nervous system particular
so in that case then we have to take
away the exogenous the extra vitamin B6
and then we have to work on the
inflammatory conditions underlying
what's going on with you and like we
talked about along covid and other stuff
that can be different things for
different people if we subtract smoking
away from it it could be any number of
things you can have genetics that make
you more inflammatory in the in the
first trigger you notice is is B6 can be
a bunch of other stuff you can have a
genetic polymorphisms you know that that
are giving you a problem like
rebalancing your inflammatory Cascade
you can have chronic deficiencies in
some of your primary antioxidants like
vitamin C and vitamin E and glutathione
and some of their support molecules you
can have it imbalance where you have
good amounts of two of those
antioxidants and not good amounts of
others and that can be sort of dynamite
for you so the big thing is if you had
B6 toxicity the first thing is you don't
take any more until you sort all this
stuff out but the next thing is you have
to get down and you have to work on the
underlying inflammatory problems maybe
look at the genomics all of this stuff
that needs to be done and so when we're
thinking about that the next thing that
happens is people say well I had a blood
test for B6 and it was really high well
it may be but what you need to remember
is that blood test for B6 is not
measuring just one kind of vitamin B6
it's measuring at least six vitamers
maybe more in a pool so the problem with
that is a diagnostic tool is not that
maybe it's elevated but also it's not
telling you am I metabolizing it to the
good ones or the bad ones totally
different very important critical thing
to know the other thing about the test
for vitamin B6 is
um even with a little bit more updated
technology it's very hard to do that
test correctly meaning if they they draw
your blood the wrong way the test will
be in inaccurate if they don't stabilize
the tube and the blood they don't
process the blood exactly correctly it's
going to be inaccurate and even if they
do all that correct you can have
variation in the chemistry reading that
they actually do at the lab where you
can have variation there and so having a
B6 test that is elevated is a piece of
the puzzle but it is a very shaky piece
of the puzzle because number one it
doesn't tell you what vitamers you have
that are in excess and number two it's a
test that is very fraught with uh you
know false positive readings and false
negative readings so the test is a
little slower of the pie mostly what you
have to do is look at your underlying
inflammation you take away the offending
substance the B6 and then you figure out
what the inflammatory Cascade is messed
up wherever it's messed up and what it's
doing
well to ever asked this question it was
three or four of you I hope this helps
at least give you a start for the
intellectual understanding of what's
going on uh we do it in the show notes
or the description box on YouTube we
usually have links to healthcare
provider associations people that do
more chronic illness care that sort of
thing so sometimes that's helpful what I
always say is I'm just telling you my
experience as a clinician for a few
decades doing this and this is for your
information and your edification is not
for your health care decision making
that's done with your health care
provider or providers but check us out
on draynow.com
d-r-a-n-ow.com that's my Hub website
where you can get to the YouTube page or
pod burner so you can see the newsletter
that comes out all that stuff and check
us out there if you're listening on one
of the Pod burners please like share
subscribe I'd love you to check out the
YouTube channel if you're not on that
listening to this and again like share
subscribe notifications are important
and also comment on the video that helps
us with the algorithm and we're getting
back in the good graces of the algorithm
so we're happy about that all right it's
been Dr Paul Anderson for medicine and
health with Dr Paul Anderson and it's
been my pleasure answering this question
I'm going to answer some more in a
little bit thank you
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