Ostarine Only Cycle? | Doctor's Analysis
Summary
TLDRIn this video, Dr. [__] explores Ostarine, a selective androgen receptor modulator (SARM), discussing its pharmacokinetics, mild anabolic effects, and potential use in cutting cycles. The script reviews studies on rats and humans, noting Ostarine's selectivity, minimal suppression of LH and FSH, and liver toxicity concerns. It suggests a daily dosage not exceeding six milligrams and a cycle duration of eight weeks to avoid side effects, emphasizing the importance of liver support and the limited benefits of higher doses.
Takeaways
- 🚫 Dr. [__] does not condone the use of illegal substances or PEDs but provides an opinion based on research.
- 🔬 Ostarine, also known as S22 or a nobo song, is a well-researched SARM with mild effects, suitable for cutting cycles.
- 💊 Ostarine is highly bioavailable, meaning it is well absorbed when taken orally and peaks within an hour of intake.
- 📊 Pharmacokinetic studies suggest daily dosing, with 3-30 mg daily for 8 weeks being common, though the highest studied dosage is 3 mg for 12 weeks.
- 🐁 In rat studies, Ostarine was found to be highly selective, increasing muscle mass without affecting the prostate or suppressing LH and FSH levels.
- 🔄 Ostarine is a weak antagonist of the progesterone receptor, which may lead to elevated prolactin levels and potential issues with gyno.
- 👵👴 A phase one trial in postmenopausal women showed lean mass gain without significant changes in strength.
- 👴👵 A phase two trial in elderly individuals found a significant increase in lean mass with a dosage as low as 3 mg, along with improved insulin sensitivity and decreased triglycerides.
- ⚠️ Ostarine can cause liver enzyme elevations at low dosages, indicating liver toxicity that is more potent than traditional oral steroids.
- 🏥 Another phase 2 trial in cancer patients with cachexia showed similar lean mass gains with 1 mg being as effective as 3 mg, with common side effects being nausea and diarrhea.
- 💪 Ostarine is not reported to be great for gaining size but is anecdotally known to help maintain size during cutting cycles.
- ⚠️ Dr. [__] suggests that going over 6 mg daily may be pointless due to a lack of additional anabolic benefits and increased risk of side effects and toxicity.
Q & A
What is the main topic of the video?
-The main topic of the video is discussing Osterine and an Osterine-only cycle, including its effects, dosages, and research findings.
What is Osterine also known as?
-Osterine is also known by names such as S22 and Anobosong.
Why is Osterine considered mild among anabolic agents?
-Osterine is considered mild because it is highly selective, attaching to muscles to increase size without affecting other tissues like the prostate, and it doesn't cause significant suppression of LH and FSH in rats.
What is the bioavailability of Osterine when taken as a tablet?
-Osterine is very bioavailable, meaning it is highly absorbed in the stomach when taken as a tablet.
What is the recommended dosing frequency for Osterine based on pharmacokinetics?
-Daily dosing is recommended for Osterine due to its presence in the system for around 14 to 21 hours after intake.
What dosages were used in the studies mentioned in the video?
-The highest dosage used in the studies was 3 milligrams for 12 weeks, but forum reports suggest dosages of 5 to 30 milligrams daily for eight weeks.
What was the outcome of the phase one trial involving healthy menopausal women?
-The phase one trial showed a lean mass gain without a significant change in strength.
What were the findings from the phase two trial involving healthy elderly women and men?
-The phase two trial found that individuals taking 3 milligrams of Osterine gained about 1.3 kilograms in lean mass, improved insulin sensitivity, and decreased triglycerides, but also experienced a decrease in HDL.
Why might Osterine cause an elevation in prolactin levels?
-Osterine is a weak antagonist of the progesterone receptor, and antagonists to progesterone can sometimes cause an elevation in prolactin levels.
What liver-related side effect was observed in some patients during the trials?
-Elevations in liver enzymes were observed in a few patients, with one having to discontinue therapy due to drug-induced liver toxicity.
What is the speaker's hypothesis regarding the optimal dosage of Osterine for anabolic effects?
-The speaker hypothesizes that the optimal dosage of Osterine for anabolic effects is around 0.1 milligrams per day in rats, which converts to approximately 6 milligrams daily for an average 70 kg human, suggesting that going over this dosage may not provide additional benefits.
Why is the speaker concerned about the use of Osterine in higher dosages?
-The speaker is concerned because higher dosages of Osterine may not provide additional anabolic benefits but could increase the risk of side effects and toxicity, especially liver-related issues.
What is the speaker's recommendation regarding the duration of an Osterine cycle?
-The speaker recommends limiting the duration of an Osterine cycle to eight weeks to minimize the risk of suppression and toxicity.
What precautions does the speaker suggest for liver health when using Osterine?
-The speaker suggests taking extra precautions for liver health, such as using liver support supplements, due to the liver toxicity associated with Osterine.
What is the speaker's view on the use of Osterine for muscle mass gain?
-The speaker believes that while Osterine can help maintain lean mass during cutting, using it at higher dosages for muscle mass gain is not beneficial and may lead to unnecessary side effects.
Outlines
💊 Introduction to Ostarine and Cycle Discussion
The speaker, Dr. [Name], introduces the topic of an Ostarine-only cycle, a follow-up to a previous video comparing Ostarine to Anavar. They clarify that they do not endorse the use of illegal substances but will share their insights based on research. Ostarine, also known as S22 or Anobosyn, is a well-researched SARM known for its mild effects and suitability for cutting cycles. It's bioavailable, meaning it can be taken orally and doesn't require injection. The pharmacokinetics show it peaks within an hour and stays in the system for 14 to 21 hours, recommending daily dosing. Studies range from 3mg for 12 weeks, with anecdotal evidence suggesting 5 to 30mg daily for 8 weeks. The speaker plans to discuss the background and their opinion on an Ostarine-only cycle.
🧪 Ostarine's Pharmacokinetics and Selectivity
The speaker delves into the pharmacokinetics of Ostarine, highlighting its high bioavailability and absorption when taken orally. They discuss the drug's peak time and duration in the system, emphasizing the recommended daily dosing. Turning to studies, the speaker references rat studies showing Ostarine's selectivity for muscle growth without affecting tissues like the prostate. They also mention the lack of suppression on LH and FSH levels, contrasting it with other SARMs like RAD 140 or LGD 4033. The speaker notes Ostarine's weak antagonist effect on the progesterone receptor, which could potentially elevate prolactin levels. Human studies are then summarized, with a focus on a phase one trial involving postmenopausal women and a phase two trial on elderly individuals, both showing significant lean mass gains and improved insulin sensitivity, albeit with some concerning liver enzyme elevations.
🚫 Warnings on Ostarine's Liver Toxicity and Dosage Considerations
The speaker addresses the liver toxicity associated with Ostarine, warning that it can be more potent than traditional oral steroids. They advise taking liver support seriously when using SARMs. Moving on to dosage, the speaker suggests that going beyond 6mg daily may be pointless due to diminishing returns on muscle mass gain, as indicated by a graph from a previous video. They argue that the optimal dosage may be around 0.1mg per day in rats, translating to approximately 6mg daily for a 70kg human. The speaker also discusses the potential for Ostarine to maintain lean mass during a cut but cautions against higher dosages due to increased toxicity and suppression. They recommend an 8-week cycle duration to minimize these risks.
Mindmap
Keywords
💡Osterine
💡Anavar
💡Pharmacokinetics
💡Selective
💡LH and FSH
💡Progesterone Receptor
💡Lean Mass
💡Insulin Sensitivity
💡Triglycerides
💡SHBG
💡Liver Toxicity
💡Cachexia
💡HCG
💡Estrogen
💡Aromatase Inhibitor (AI)
Highlights
Introduction to the discussion of Ostarine (MK-2866) and its effects in an Ostarine-only cycle.
Ostarine is also known as S22, ANO, or MK-2866 and is one of the most researched SARMs.
Anecdotal evidence suggests Ostarine is mild and effective for cutting due to its minimal anabolic effects.
Pharmacokinetics of Ostarine show high bioavailability and a peak within an hour of intake.
Studies suggest dosages of 3-30 mg daily for 8 weeks, with a recommended daily dosing.
Rat studies show Ostarine to be highly selective, affecting muscles without impacting the prostate.
Ostarine does not affect LH and FSH levels, indicating minimal suppression in rats.
Ostarine is a weak antagonist of the progesterone receptor, potentially causing elevated prolactin levels.
Phase one trial in postmenopausal women showed lean mass gain without significant strength changes.
Phase two trial in elderly subjects found a significant increase in lean mass with 3 mg dosage.
Ostarine improved insulin sensitivity and decreased triglycerides in elderly subjects.
A decrease in HDL levels at low dosages indicates Ostarine's potency and potential cardiovascular risks.
Liver enzyme elevations were observed in some patients, indicating liver toxicity concerns.
Phase 2 trial in cachectic cancer patients showed similar lean mass gains with lower dosages.
Common side effects include nausea, diarrhea, and transient liver enzyme elevations.
Hypothesis on why Ostarine may not be effective for size gain at dosages higher than 6 mg.
The optimal dosage for anabolic effects in humans is suggested to be around 6 mg daily based on rat studies.
Duration of Ostarine cycles should be limited to 8 weeks to minimize suppression and toxicity.
The importance of liver support when using SARMs due to their liver toxicity.
Ostarine's effectiveness in maintaining lean mass during cutting but not for significant size gain.
Transcripts
hi guys welcome back to the channel i'm
dr [ __ ] and today we are going to
discuss osterine and an osterine only
cycle
so this is a follow-up video to the
video i released yesterday comparing
osterine to anavar
so some individuals wanted me
to make another video on an osterine
only cycle and what i what i think of it
personally
obviously i don't condone the use of
illegal substances or peds
but i will give my opinion on the
research remember this is not medical
advice
so austrian is also known by many other
names such as s22 and a nobo song or
something like that and it's one of the
most researched psalms and anecdotal
evidence on the internet would suggest
that it's one of the mildest arms and
best to use when doing a cut since it
isn't particularly anabolic in
the fact that it won't gain you a lot of
muscle mass but it'll help maintain your
size while cutting so first i'll just go
over some background information and
then i will say what i think about an
osterine only cycle
so first of all let's look at the
pharmacokinetics so it is very
bioavailable meaning it's highly
absorbed in the stomach when taken via
you know it as a tablet
which means that you don't have to
inject it um it peaks within an hour or
so of intake and it lost it'll be in
your system for around 14 to 21 hours
so daily dosing is recommended
um
in terms of studies three gr milligrams
for 12 weeks is the highest these
studies ever went to however um reports
on forums usually suggest five to thirty
milligrams daily for eight weeks but
let's look at the studies and see what
the studies suggest
so first we'll look at the rat studies
and
see how it reacts in rats
so in rat studies ostering was shown to
be highly selective meaning it
attached to the muscles and made muscles
bigger without affecting other tissues
such as the prostate
furthermore which was surprising to me
because
other studies haven't demonstrated this
effect as well before but lh and fsh was
not affected meaning there was minimal
suppression in these rats
and um if we look at rad 140 or lgd 4033
these are actually have been shown to be
suppressive in rats and so is anavar and
obviously s23 is highly po
potent at suppressing lh and fsh
what is also interesting is it was found
to be a weak antagonist of the
progesterone receptor and what this
means in terms of clinical application
is that um it's well known that
antagonists to progesterone do sometimes
cause an elevation in prolactin so
prolactin may be an issue for some i did
not know about this effect until
yesterday where someone pointed it out
to me and i thought it was very
interesting
now let's see how it fares in human
studies so the first or phase one trial
was done on healthy menopausal women
three milligrams for 12 weeks they just
noticed the typical thing lean mass gain
however they didn't know change in
strength now or the change in strength
was not significant
um this study was a bit of a boring one
so we'll move on to the next which i
referenced yesterday and this phase two
trial was done in elderly women and men
healthy elderly women and men and they
looked at varying dosages
three milligrams was the highest used
and they did it for 12 weeks they found
that the individuals taking three
milligrams gained about 1.3 kilograms in
mass lean mass that is
which is a very significant amount
especially for the dosage they use
that's a quite a low dosage and you
wouldn't really find that with your
typical oral steroids such as an
increase in lean mass at such a low
dosage
furthermore it actually improved their
insulin sensitivity and decreased
triglycerides triglycerides being a
some like to use it as a marker of
cardiovascular risk
interestingly though at such a low dose
it decreased hdl quite substantially
which is
not a good sign which means it's more
potent at such a low dose
because things like anova typically do
not cause such drastic changes at a low
dose but remember slimes are stronger at
lower dosages and you can expect more
side effect
effects at lower dosages
in terms of estrogen free and total
testosterone those were not altered
which was interesting fsh and lh in men
was also not altered however in women it
did decrease slightly
which suggests that it might not be very
suppressive especially to men
shbg decreased meaning oh well
significantly meaning that if you were
to stack it with another steroid it
would make that other steroid more
available to attach to the receptors so
it could be useful in stacking
what was problematic however is that
there were elevations in the patient's
liver enzymes
um in a few of the patients and one had
to discontinue therapy because they had
evidence of disease
drug induced liver toxicity
so at these low dosages they are quite
potent and quite toxic
so in another phase 2 trial done in
cancer patients suffering from cachexia
dosages of one milligram and three
milligrams were compared to placebo
and what was interesting is that the one
milligram group actually had the same if
not more lean mass gain than the three
milligram group
again a common side effect was nausea
and diarrhea and a few individuals had
transient elevations in their liver
enzymes all of these
disappeared on discontinuation
the reason i think that the one
milligram group had more lean mass gain
than the three milligram group is that
the three milligram group had more
evidence of nausea and diarrhea meaning
they probably did not consume as much
food as a one milligram group so this
would suggest that three milligrams is
quite potent and could might not be
beneficial to gaining size if you cannot
eat
currently there are phase 3 trials going
on demonstrating similar effects for
lean
lean tissue gain
so let's look at an osterine only cycle
and see what you should expect if you
are currently using one i do not suggest
you do one
at all um but let's see hypothetically
if someone were to do an ostrin only
cycle as i mentioned it is possibly one
of the least suppressive compounds i
have come across in the research however
anecdotal reports of bodybuilders using
higher dosages on forums does suggest it
is suppressive however not to the extent
of traditional oral steroids
it doesn't appear to be estrogenic so it
doesn't convert to estrogen however
might possibly decrease testosterone
which could decrease estrogen
however this wasn't shown in the studies
but at higher dosages this may change
especially if there is suppression
the only issue is that with the decrease
of testosterone the testosterone to
estrogen ratio is changed meaning you
could possibly have gynecomastia as a
result of that and therefore a serum
would be most applicable for this case
to prevent gyno you do not want an a.i
because your estrogen levels will always
be already be low however they'll be
high in comparison to testosterone but
you don't want to lower your estrogen
lower than it already is because then
you come in then you have more side
effects than you already do
i also suggest that if you do want to
try combat these um suppression side
effects combining
hcg or human chorionic gonadotropin
along with the psalm
might help with the symptoms of
suppression if you do experience them
now
what i want to mention is the liver this
is a massive issue which i don't think
is spoken about in the bodybuilding
community especially in the science
community and that's that psalms are
much more liver toxic
than
traditional oral steroids
even more potent than compounds like
anadrol i've well milligram per
milligram that is
but
in studies with anadrol at 50 milligrams
they have not demonstrated this level of
liver toxicity as three milligrams of
austrian has or perhaps they have but it
would be a similar
similar degree
this means that it's really important to
take care of your liver when on psarms
and not just ignore the fact that your
liver could be affected when on psalms
just er people assume that swarms are
safe and that they don't cause these
side effects however it appears in the
literature that at low dosages those
lower than
what most people take these side effects
do occur and so i think it's important
just to take the extra precaution and
use a liver support
now for the part that everyone wants to
know about what about muscle mass what
could you expect in terms of muscle mass
so remember lean mass gains were
noticeable even at one milligram was
equivalent to three milligrams in the
one study
anecdotally most people don't report
that it's great for size however they do
report that it does help keeping on to
size when cutting but i have an
interesting hypothesis about about why
austrian is not good for size and why
austrine should not be used at a dose
higher than six milligrams
so if we look at this graph which i
displayed in the previous video the top
curve is levita annie muscle so
levita annie muscle is what is used to
test the anabolic ability of a drug in a
rat they look at the size of that
so one would traditionally expect that
as the doses increase the
effect or anabolic ability of the drug
also decreases however we look here at
plateaus almost completely which means
that over a certain point there is
literally no point of taking this drug
because you will just accumulate side
effects and actually have no additional
muscle mass gain
and what point would this be and at what
point would this be
well if we look at this graph it's about
at point one milligrams per day in the
rat
the effects seem to decrease ever so
slightly and 0.1 seems to be the most
optimal so you'll get the most optimal
anabolic effect so 0.1 milligram per day
in a rat if we use various conversion
factors this converts to about
0.083 milligrams per kg
or milligram per kg per day in humans
therefore the average 70 kg interven
individual
would need
or would take something like six
milligrams daily
and going over six milligrams daily is
almost pointless because as you see
in the graph i just displayed
there seems to be no anabolic benefit
therefore i would argue that there is
not much point of going over six
milligrams is that three milligrams
there only there's already evidence of
toxicity and going over six milligrams
may accumulate this to a point where
osterine isn't safe at all to run it
still isn't safe to use but it's even
less safe when used over these drug
dosages
so again it does seem like austrian can
hold on to lean mass as demonstrated in
the studies they lost fat mass while
building one to two kgs of lean mass but
as i said higher dosages seem kind of
pointless
the duration should be limited to eight
weeks however these studies were done
for 12 weeks but as you extend the
duration of your cycle
suppression will become more of an issue
and so will toxicity
as that will accumulate
eventually
so i hope you enjoyed this video if you
did leave a comment below like subscribe
and i'll see you in the next one
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