NAD, NAC, NMN, NR, Glutathione... What are the differences?
Summary
TLDRDr. Payam Hakimi, a functional medicine doctor, discusses the differences and roles of NAD, NAC, NMN, and NR in the body. NAC, a precursor to glutathione, is used for detoxification and lung health, while NAD, crucial for cellular metabolism and energy, decreases with age. NMN and NR are precursors that help increase NAD levels, supporting anti-aging and cellular health. The video also touches on liver detoxification and the importance of a clean digestive system for overall health.
Takeaways
- 🧬 NAC (N-acetylcysteine) and NAD (Nicotinamide adenine dinucleotide) are distinct molecules with different functions in the body.
- 💊 NAC is used in medical settings for various purposes, including treatment for acetaminophen poisoning, lung conditions, and liver detoxification.
- 🌿 NAC serves as a precursor to glutathione, a powerful antioxidant, and plays a crucial role in liver detoxification processes.
- 🔋 NAD is a cofactor in cellular metabolism, involved in energy production, DNA repair, and immune regulation, and its levels decrease with age.
- 🏋️♂️ NAD is also linked to the nervous system and has been studied for its potential benefits in Alzheimer's, Parkinson's, and addiction recovery.
- 💊 NAD can be increased in the body through supplementation with its precursors like NR (Nicotinamide riboside) and NMN (Nicotinamide mononucleotide), or through IV therapy.
- 🥗 Natural ways to boost NAD include reducing inflammation, maintaining a clean digestive system, regular exercise, and a diet rich in leafy greens and whole foods.
- 💊 Detoxy liver is a supplement mentioned that contains NAC, along with other ingredients beneficial for liver detoxification and hormone balance.
- 🧘♂️ The combination of NAC and NAD can enhance detoxification, antioxidant levels, and potentially slow down the aging process in cells.
- 👨⚕️ The video emphasizes the importance of medical supervision when using NAD for various health conditions, including detoxification from medications.
Q & A
What is NAC and what are its primary uses?
-NAC stands for N-acetylcysteine. It is used for various medical purposes including treating acetaminophen poisoning, helping with lung issues like chronic bronchitis to clear phlegm, and preventing kidney damage during imaging studies with contrast dyes. It is also used in liver detoxification and for cough and lung clearance.
How does NAC work in the body?
-NAC functions as a precursor to glutathione, which is a potent antioxidant and plays a crucial role in liver detoxification. By increasing glutathione levels, NAC aids in detoxifying the liver and the body, thereby supporting overall health and potentially slowing down cellular aging and death.
What is the role of glutathione in the body?
-Glutathione is one of the body's most powerful antioxidants, helping to neutralize free radicals and prevent oxidative stress. It is also essential for liver detoxification processes and plays a role in balancing steroid hormones like testosterone, estrogen, progesterone, DHEA, and cortisol.
How is NAC used in supplements and treatments?
-NAC is available in supplement form, IV form, and inhaled form. It is often included in liver detoxification supplements and can be administered intravenously to support cleansing the body, especially during times of illness such as flu or cold.
What is the difference between NAC and NAD?
-NAC and NAD are distinct molecules. NAC is an antioxidant and detoxifying agent, while NAD (Nicotinamide adenine dinucleotide) is a cofactor in cellular metabolism, involved in energy production, DNA repair, and immune regulation. NAD levels decrease with age, affecting cellular functions.
What are the health benefits associated with NAD?
-NAD benefits include increased cellular energy, improved DNA repair, support for the anti-aging pathway, and immune regulation. It has been used to address conditions like Alzheimer's, Parkinson's, addiction, depression, anxiety, and insomnia. It also aids in metabolism and can positively affect inflammatory conditions.
How can one naturally increase NAD levels in the body?
-Natural ways to increase NAD levels include reducing inflammation, ensuring a clean digestive system, performing liver detoxification, exercising properly, getting good sleep, and consuming a diet rich in leafy green vegetables, whole foods, and whole grains. Fasting and a keto diet may also help increase NAD levels.
What are NMN and NR, and how are they related to NAD?
-NMN (Nicotinamide mononucleotide) and NR (Nicotinamide riboside) are precursors to NAD. The biosynthesis pathway of NAD starts with NR, which becomes NMN, and then NMN is converted into NAD. Both NMN and NR can be used to raise NAD levels in the body.
What supplements are recommended to support NAD levels and why?
-Supplements like Mitochondria Boost, D-ribose, B complex vitamins, Coenzyme Q10, and Resveratrol are recommended to support NAD levels and mitochondrial function. These supplements help in the production of ATP through the citric acid cycle and support overall cellular energy and health.
How do NAC and NAD work together in the body?
-NAC and NAD, when used together, can enhance detoxification and antioxidant processes in the body. NAC helps detoxify the liver and lungs, while NAD supports cellular energy production and waste removal, contributing to anti-oxidation, detoxification, and anti-aging effects.
Outlines
🧬 Understanding NAC and Its Medical Applications
Dr. Payam Hakimi introduces the video by discussing the differences between NAD, NAC, NMN, and NR. He explains that NAC, or N-acetylcysteine, is a molecule used in various medical settings, including poisoning treatment, ICU for lung issues, and kidney protection during imaging studies. NAC is also used in liver detoxification and is a precursor to glutathione, a potent antioxidant involved in liver detoxification processes. The liver's detoxification function is crucial for overall body detoxification, hormone balance, and cellular health. NAC is available in various forms, including supplements and IV treatments, and is beneficial for conditions like non-alcoholic fatty liver disease and lung issues. The video also mentions supplements containing NAC and glutathione, such as Detoxy Liver and a buffered form of Vitamin C.
🔬 The Role of NAD in Cellular Metabolism and Anti-Aging
Dr. Hakimi contrasts NAC with NAD, explaining that NAD is a cofactor essential for cellular metabolism, synthesized from vitamin B3 or through amino acids like tryptophan and aspartate. As people age, NAD levels decrease, leading to reduced cellular energy and functions, such as waste removal and DNA repair. NAD is vital for cellular energy production, immune regulation, and plays a role in anti-aging pathways. It's been studied for its potential in treating Alzheimer's, Parkinson's, addiction, depression, anxiety, and insomnia. NAD also aids in detoxification from certain medications and substances. The video suggests natural ways to increase NAD levels, such as reducing inflammation, maintaining a clean digestive system, exercising, sleeping well, and consuming leafy greens and whole foods. Fasting and a keto diet are also mentioned as potential methods to boost NAD levels.
🌿 Exploring NMN and NR as NAD Precursors
The video concludes with a discussion on NMN (nicotinamide mononucleotide) and NR (nicotinamide ribose), which are precursors to NAD. Dr. Hakimi explains the biosynthesis pathway of NAD, which starts with NR, becomes NMN, and ultimately forms NAD. Both NMN and NR can be used to raise NAD levels in the body, with IV treatments providing high doses of NAD. The video also mentions the importance of supporting mitochondrial function and the citric acid cycle with supplements like Mitochondria Boost, D-ribose, Coenzyme Q10, and resveratrol. The key takeaway is that combining NAD and NAC can enhance detoxification, antioxidant production, and anti-aging effects in the body. The video encourages viewers to share their experiences with NAD, NMN, NR, or other biohacking techniques.
Mindmap
Keywords
💡NAC (N-Acetylcysteine)
💡Glutathione
💡Liver Detoxification
💡NAD (Nicotinamide adenine dinucleotide)
💡NMN (Nicotinamide mononucleotide)
💡NR (Nicotinamide riboside)
💡Mitochondria
💡Detoxification
💡Antioxidants
💡Hormone Balance
💡Supplements
Highlights
NAC is used for various medical purposes, including poisoning by acetaminophen and lung issues.
NAC, known as Mucomist, is used in ICU settings for patients with chronic bronchitis to help clear phlegm.
NAC is administered before IV contrast imaging to prevent kidney damage in patients with kidney conditions.
NAC is a precursor to glutathione, a potent antioxidant, and aids in liver detoxification.
Glutathione plays a crucial role in liver detoxification and maintaining steroid hormone balance.
Detoxification of the liver with NAC can help retard cellular aging and death.
Glutathione is administered intravenously due to its instability when taken orally.
Supplements containing NAC and glutathione are available, such as Detoxy Liver and Buffered Vitamin C.
NAD is a cofactor in cellular metabolism and is synthesized from vitamin B3, niacin, or NMN.
NAD levels decrease with age, leading to less cellular energy and increased oxidative stress.
NAD is essential for DNA repair, immune regulation, and has anti-aging properties.
NAD has been used to treat conditions like Alzheimer's, Parkinson's, and addiction, and to lessen withdrawal symptoms.
Natural ways to increase NAD include reducing inflammation, proper digestion, liver detoxification, and a healthy diet.
NMN and NR are precursors to NAD and can be used to raise NAD levels in the body.
NAD, NR, and NMN are different molecules, but NR and NMN are related to NAD and help increase cellular energy.
Combining NAC and NAD can enhance detoxification, antioxidation, and anti-aging effects in the body.
Transcripts
nad and nac are they the same molecule
are they related what's nmn what's nr
hello i'm dr payam hakimi i'm a
functional medicine doctor and today i'm
going to talk about the difference
between nad nac nmn and nr and along
with that we're going to talk about
other molecules like glutathione and
liver detoxification
[Music]
i'm going to talk about nac first
when i first came across this molecule i
was a medical student i noticed that we
used this molecule for different reasons
one of the reasons was poisoning by
tylenol or people who wanted to commit
suicide taking a bottle of tidal knoll
this was a medication to use
also notice that in icu we use this
molecule for people who have
lung issues chronic bronchitis people
who could not clear
the phlegm from their lungs that's when
we used it as well this molecule is
called mucomist when we use it in icu
settings we also use it before
a contrasted an iv contrasted
imaging study in hospital for people who
do have kidney conditions so we
basically use mucomist or an
acetylcysteine to make sure that there
is no kidney damage for these people
it's been used for people who want to
help out with their liver detoxification
in a lot of the supplements that are
to detoxify liver
non-alcoholic fatty liver disease is
another condition that we use this for
and that is when the liver cells have
been engorged with fat
we also know that an acetylcysteine has
been used for
people who have cough or lung issues or
just want to clear their lungs
let's talk about how nac works in the
body nac is a precursor to another
molecule called glutathione and
glutathione
is one of the strongest antioxidants in
the body its other function is to help
with liver detoxification it's one of
the major molecules in the phases of
detoxification in liver
so
if we help liver detoxify itself
we're actually helping you to detoxify
your body as well because the function
of liver is basically to detoxify the
blood
other functions of liver one of them is
to help with steroid hormone
balance in the body or recycling steroid
hormones are testosterone estrogen
progesterone dhea pregnenolone
and cortisol and these are major
molecules in the body major hormones in
the body
and how does this help us
it helps by balancing out the hormones
for example in conditions like pms
acne that's related to pms
infertility decreased libido menopausal
issues
weight gain or if you want to create
weight loss and the most important thing
when we detoxify the body
in essence we're detoxifying the cells
which basically means that we're
retarding cellular aging and cellular
death it's a supplement that you can
take especially during the times that
you're suffering with
flu or cold or
lung issues
we use glutathione a lot glutathione is
not a stable molecule by mouth so you're
not going to find a lot of supplements
that will give you glutathione properly
and that's why we use it as an iv so
after a lot of our ivs in the office we
use iv glutathione push or as a drip so
that it can help out with cleansing the
body
we offer a couple of supplements that
have glutathione and nac in them one of
them is detoxy liver the toxic liver has
alpha lipoic acid
artichoke extract
calcium diglucrate which is very
important in balancing the
hormones that we talked about in the
body folate green tea
extract msm milk thistle which is very
important to help detoxify the liver and
acetylcysteine as well as other vitamins
that help out the other supplement that
we have is called vitamin c it's a
buffered form of vitamin c
which has
buffered vitamin c obviously calcium
copper magnesium and manganese potassium
quercetin and reduced l-glutathione and
zinc
these are important supplements most of
my patients use this at a certain point
in their
journey towards health with me just to
make sure that we are cleansing their
liver we're getting their body ready
for the next step
so i'm going to summarize this nac
is a molecule that's been used in
medicine as well as integrative and
functional medicine there's supplements
form there's iv form there's inhaled
form and its function is to increase
glutathione and as it increases
glutathione it creates the effects that
we talk about
so this molecule different than nad
[Laughter]
[Music]
now obviously nac is different than nad
i'll share a link below
to one of my videos talking about nad
nad is a cofactor in the cellular
metabolism pathway krebs cycle or citric
acid cycle
it's synthesized from vitamin b3 which
is nicotinic acid or nicotinamide
or from niacin or from nmn
and it can be formed from amino acids
tryptophan and aspartate
we know nad decreases as we age
and as that happens there's less energy
for the cell to be able to
do all of its function
some of these functions are
removing the waste from the cell itself
so
that is what becomes oxidative stress
and eventually cellular aging and
cellular death
nad is the master regulator of cellular
metabolism it helps with production of
cellular energy
it's important in dna repair
and it's the raw material for certains
and sertoins are in the anti-aging
pathway and it helps with immune
regulation
if we're talking about the nervous
system we know that nad has been used
for alzheimer's and parkinson's
it's also been used for
drug and alcohol addiction and to help
with lessening the withdrawal symptoms
we also know it helps with depression it
helps with anxiety it helps with
insomnia as well patients who get nad
actually tell us that for the next two
three days they have more energy but
they also sleep much better at night
there's recent data that shows that
there is also a place for nad in
detoxification from antidepressants and
from anxiolytics and as you know
we've had an issue with opiates recently
and we're seeing that issue with
antidepressants and anxiolytics as well
where people are now addicted to
antidepressants and anxiolytic and it's
very hard for them to stop them not only
that we're also seeing that people go
from one antidepressant and then after
four or five years another
antidepressant gets added to it and
those antidepressants never come off so
it's a good way of helping with
decreasing the symptomatology that goes
with
detoxification of antidepressant
obviously all of this needs to be done
under medical supervision
nad also helps with metabolism and it
helps with changing the markers of
metabolic issues like diabetes and
insulin resistant weight gain
it helps with athletic
conditioning and performance
nad also causes positive effect in
inflammatory conditions like chronic
fatigue syndrome and it actually helps
to stimulate immune system as well
in essence when we use nad we're helping
all of the cells in the body
to restore themselves what are the
natural ways that we can help increasing
nad in our body number one make sure
that there is no inflammation in your
body or decrease inflammation do a food
sensitivity test to make sure you know
what are the food groups that your body
does not like and are inflammatory in
nature
make sure you have a cleanse
digestive system
make sure you do liver detoxification
exercise properly
sleep good
make sure you have leafy and green
vegetables in your diet
whole foods and whole grains
as well as there is recent data that
shows that fasting
and being on a keto diet helps out with
helping increase nad as well
now i'm going to switch gears and talk
about nmn and another related molecule
called nr nmn stands for nicotinamide
mononucleotide and nr stands for
nicotinamide ribose
and obviously these molecules are used
to increase nad in the
body the biosynthesis pathway of nad
starts with nr and r becomes nmn and nmn
becomes nad so in essence we can use
both molecules in order to raise nad in
our body obviously the easiest way is to
do an iv where we can give you high
doses of nad
but we also ask our patients to
supplement the precursors of nad so that
during their
treatment time when they're not here
they're actually raising their nad on a
daily basis as well
those precursors are vitamin b3 or
niacin
nr and nmn you can tell that the goal
now is becoming to increase our nad
and to do that we need to help the
mitochondria
so to increase nad we're going to use
the substrates which are nr or nmn or
nad itself
we also need b complex but you also need
other things other supplements and
ingredients that come into effect with
helping the mitochondria and the citric
acid cycle or the krebs cycle which
produces atp
one of those supplements is mitochondria
boost
the other important molecule is d
ribose
and obviously there needs to be higher
amount of coenzyme q10 and resveratrol
which have shown to help out with the
functions of mitochondria itself
takeaway points from this video
obviously nad nac nmn and nr are all
different molecules however an r and n
are related to nad and the precursors of
nad helping raise the cellular energy
nac is a detoxifying molecule
it helps with detoxifying the lungs the
liver the kidneys nad and nac used
together will help the body do wonders
on one hand we're detoxifying the liver
we're adding antioxidants to the body
as the liver detoxifies itself it's
basically helping all cells to get
detoxified
as we increase nad in our body we help
the cells to do their function properly
one of these functions is to dump the
extra toxins and waste products that's
in the cell
so using both of these molecules
together we can actually help out with
anti-oxidation and help with detoxifying
the body faster as well as producing
anti-aging effects in the body
i hope you've enjoyed this video if you
have any questions please leave it in
the comments
and also
share your experience with
nadnmr
or any other biohacking techniques that
you're doing we'd love to hear it
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