Is Rancid Fish Oil Killing You?
Summary
TLDRThis video addresses concerns about the potential harm of oxidized fish oil supplements. Despite the known health benefits of fish oil, there's worry that rancid or oxidized forms could be detrimental. The video reviews a study that found no increase in body oxidation from consuming oxidized fish oil, suggesting it's not harmful. However, it acknowledges the possibility of other unknown negative effects and emphasizes the importance of sourcing fish oil from reputable suppliers for quality assurance.
Takeaways
- 🤔 There are concerns about the potential health risks of consuming oxidized fish oil, which could negate the health benefits it's known for.
- 🔬 A study was referenced that examined the effects of oxidized fish oil on bodily oxidation, aiming to determine if it leads to increased cellular damage.
- 🧪 The study involved three groups consuming different types of oils: sunflower oil, non-oxidized fish oil, and oxidized fish oil, with the focus on measures of body oxidation.
- 📊 The study found no significant increase in oxidation across three measures in the group that consumed oxidized fish oil, suggesting it does not contribute to an increased oxidative state of the body.
- 📈 Other researchers acknowledge the study's findings but suggest that oxidized fish oil might have other negative health effects not measured in the study.
- 🐟 Studies exposing animals to high concentrations of oxidized fats have shown potential heart problems and inflammation, but these are not directly comparable to the consumption of oxidized fish oil by humans.
- 💊 Some research indicates that oxidized fish oil might hinder the reduction in blood cholesterol seen with non-oxidized fish oil, but the evidence is not conclusive.
- 🛒 It's important to purchase fish oil supplements from reputable suppliers, as they are more likely to have lower levels of oxidation.
- 🔎 The evidence currently available does not strongly support the claim that oxidized fish oil causes significant health harm, and some studies suggest it may be neutral or even beneficial for certain health markers like triglycerides.
- ⚖️ The fear around oxidized fish oil may be overstated, and more research is needed to fully understand its impact on health.
Q & A
What is the main concern regarding fish oil supplements mentioned in the script?
-The main concern is that fish oils can become rancid, oxidized, and potentially harmful to health if they are not in good condition.
What happens when cells become overly oxidized?
-When cells become overly oxidized, they are damaged, which means they don't function correctly and are more prone to dying.
How do omega-3 fats affect cell membranes?
-Omega-3 fats are incorporated into the cell membrane, improving the cell's ability to function by changing its fluidity and engaging with various molecules, including hormones.
What are lipid peroxides and how do they affect cell membranes?
-Lipid peroxides are oxidized forms of omega-3 fats. They can increase the oxidation of nearby fats, which could lead to a high risk of oxidation in cell membranes, potentially causing damage.
What was the purpose of the study mentioned in the script?
-The study aimed to assess the impact of oxidized fish oil on the body's oxidation levels and to determine if it contributes to an increased oxidative state.
What were the three groups in the study, and what were they given?
-The three groups were given sunflower oil, nonoxidized fish oil, and oxidized fish oil to compare their effects on body oxidation.
What were the three measures of body oxidation used in the study?
-The three measures of body oxidation used were 4-hydroxy-2-hexenal (4-HHE), nonanal, and an assessment of lipid peroxidation and inflammation called 8-isoprostane PGF2α.
What were the results of the study regarding the effect of oxidized fish oil on body oxidation?
-The study found no significant increase in body oxidation across the three measures in the oxidized fish oil group, suggesting it does not contribute to an increased oxidative state of the body.
What are some other potential negative effects of oxidized fish oil mentioned in the script?
-Other potential negative effects mentioned include causing heart problems, inflammation, and possibly impeding the reduction in blood cholesterol seen with nonoxidized fish oil.
What is the conclusion drawn from the study regarding the health impact of oxidized fish oil?
-The conclusion from the study is that oxidized fish oil does not have a negative effect on health based on the measures taken, and there is no evidence to suggest it causes harm.
What is the recommendation for consumers of fish oil supplements based on the script?
-The recommendation is to purchase fish oil supplements from reputable suppliers that have their products independently tested to ensure they are not oxidized.
Outlines
🔬 Impact of Oxidized Fish Oil on Health
The paragraph discusses concerns regarding the potential health risks of consuming rancid or oxidized fish oil supplements. It highlights the importance of understanding the science behind oxidized fish oil and its effects on the body. The speaker references a study that evaluated the impact of oxidized fish oil on bodily oxidation levels. The study involved three groups consuming different types of oils and measured various biomarkers of oxidation and inflammation. The results indicated that oxidized fish oil did not significantly increase the oxidative state of the body, contradicting common fears. However, the speaker acknowledges that there might be other, unmeasured health consequences of consuming oxidized fish oil.
🐟 The Effects of Oxidized Fish Oil: A Closer Look
This paragraph delves deeper into the debate surrounding oxidized fish oil, presenting contrasting research findings. It mentions studies that have shown high concentrations of oxidized fats can lead to health issues in animals, such as heart problems and inflammation. However, it also points out that certain biomarkers, like 4-hydroxy-2-hexenal (HHE), did not change with oxidized fish oil consumption, suggesting it might not be a significant concern. The speaker critiques other studies that claim oxidized fish oil impedes the reduction of blood cholesterol, arguing that the evidence presented is contradictory. The paragraph concludes by suggesting that while oxidized fish oil may not be harmful, it might have some beneficial effects, such as reducing triglycerides. The speaker emphasizes the importance of purchasing fish oil from reputable suppliers and considering independently tested brands.
Mindmap
Keywords
💡Fish Oil Supplements
💡Rancid
💡Oxidized
💡Oxidative Stress
💡Omega-3 Fatty Acids
💡Cell Membrane
💡Lipid Peroxides
💡Inflammation
💡C-reactive Protein
💡Triglycerides
Highlights
Concerns about rancid and oxidized fish oils potentially causing health harm.
The impact of oxidized fish oil on bodily oxidation is a subject of scientific study.
Omega-3 fats are integral to cell membrane health, affecting cell function and fluidity.
Oxidized Omega-3s, or lipid peroxides, can increase oxidation of nearby fats.
A study compared the effects of sunflower oil, non-oxidized fish oil, and oxidized fish oil on body oxidation.
The study found no significant increase in body oxidation from oxidized fish oil consumption.
Researchers measured oxidation through three biomarkers: 4-hydroxy-2-hexenal, 4-hydroxynonenal, and 8-isoprostane PGF2α.
The study's results indicated no change in oxidation levels with oxidized fish oil intake.
Other researchers suggest oxidized fish oil may have unmeasured negative health effects.
Studies on animals show high concentrations of oxidized fats can lead to heart problems and inflammation.
A separate human study found oxidized fish oil did not increase liver damage, contrary to some claims.
Some research suggests oxidized fish oil may hinder the reduction of blood cholesterol.
The presenter disagrees with certain conclusions drawn from studies on oxidized fish oil's effects on cholesterol.
Oxidized fish oil appears to have no negative effects except possibly reducing triglycerides.
The level of oxidation required to cause harm in the study was extreme and unlikely to occur in typical fish oil supplements.
Reputable suppliers and independent testing can ensure the quality and safety of fish oil supplements.
The evidence does not strongly support the fear that oxidized fish oil is harmful to health.
Fish oil continues to offer profound health benefits as outlined in further research.
Transcripts
one of the chief complaints I see
popping up against fish oil supplements
is that fish oils are often rancid
oxidized and harmful to our health in
that form considering the many health
benefits linked to fish oil it's pretty
concerning to think that the fish oil
supplement that you've been using to
help your health is a double-edged sword
and causing you harm if it's gone bad so
let's discuss the science of oxidized
fish oil and how bad it really is for
you I actually looked into this a long
time ago and ran across a single study
in humans that assessed the impact
oxidized fish oil has on the body's
oxidation so means uh do you experience
greater oxidation of your cellular
components when fish oil is oxidized
this is of some concern because when our
cells become overly oxidized which means
that they become damaged at least in
this context the cells don't function
correctly and are more prone to Dying
For example omega-3 fats are known to be
incorporated into the membrane of your
cells that make up your body and once
Incorporated they can change the
fluidity of the cell improving the
cell's ability to function through the
scattered receptors that engage with
many molecules including hormones that
affect cell function However if those
Omega-3s are oxidized known as lipid
peroxides they can increase the
oxidation of nearby fats so say since
the cell membrane is primarily made up
of lipids fats it is a high risk of
oxidation if it's encountering these
lipid peroxides it makes sense then that
reducing oxidized Omega-3s would help
avoid the incorporation of damaging
oxidized Omega-3s lipid peroxides into
the cell membrane in that study the
researchers had three groups one was
given sunflower oil the other had a
confirmed nonoxidized fish oil and
another an oxidized fish oil then they
measured blood values of oxidation
across three measures of body oxidation
two were different forms of four hydroxy
2 hexanol and nonanol and the other
assessed lipid peroxidation and
inflammation called 8 isop pgf2 Alpha
the marketing department for these
molecules was on vacation during the
naming process clearly here's the data
and I'll walk you through it first let
me acknowledge two things uh one the
Baseline values between the two groups
were the same and two I'm cutting the
table in half to focus your attention on
the oxidation measures however in full
disclosure the researchers also looked
at some red blood cell measures of
oxidation as well as overall
inflammation marker called C-reactive
protein I'll spoil the plot by telling
you that well nothing changed in those
measures now disclosures out of the way
how do we read this we have the three
conditions up top fish oil oxidized fish
oil and sunflower oil and we have the
Baseline values including the median
value which is the main result that
we're focused on the medians we have the
results at the end of the study which
lasted just shy of two months also we
have our highly marketable oxidation
measures on the left that we discussed
and we have two P values are two
statistical comparisons on the very side
the first is the comparison of all three
baselines and the second is the
comparison of the change between
Baseline and the end of the study across
all three groups so if the oxidized fish
oil group had an increase in body lipid
peroxides of 60 and the sunflower
condition had a reduction of 20 it would
detect that difference finally if any of
the P values are below 0.05 it was
considered statistically significant so
all that explanation out of the way when
we look at the body oxidation across all
three metrics in our oxidized fish oil
group we're looking at the median
measures of before and after we see that
all three measures
show a reduction in
oxidation okay not quite to be fair the
True Result is no change statistically
speaking then we can then compare across
the groups and the results is are again
no difference so this data indicates
oxidized fish oil does not contribute to
increased oxidative state of the body
across these three measures however
other researchers while they acknowledge
the results of this study they also
point out that rancid or oxidized fish
oil may have other dous effects that we
aren't measuring here and honestly I
have to agree this study that we just
went over is pretty well conducted and
it clearly shows no negative effects but
we're also limited to the measures that
we have so it's possible that oxidized
Omega-3s May provide negative Health
consequences in ways that we haven't
measured yet is there any proof of that
though continuing with these researchers
they point out that there have been
studies injecting or exposing high
concentrations of oxidized fats in
animals to the effect of heart problems
inflammation and honestly much more
however interestingly they also referen
studies where hhe which is the uh four
hydroxy 2 hexanol that we discussed
earlier but the marketing department
came back from vacation anyway the
researchers injected hhe and showed
increased liver damage but considering
that we saw hhe didn't change with
oxidized fish oil consumption I don't
see this as much of a concern one more
study I found again in humans looked at
biomedical markers like triglycerides
cholesterol and blood sugar levels the
researchers argue that oxidized fish oil
does impede the reduction in blood
cholesterol seen in nonoxidized fish oil
but if I'm Frank with you although my
name's Nick I was incredulous as to how
they came to that conclusion when they
even show evidence to the contrary and
ignore other evidence in their own study
that also contradicts that verbiage here
look for yourself I won't go through it
all exhaustively but group two is the
group consuming more oxidized fish oil
none of the metrics worsened except
triglycerides was dramatically reduced I
don't know about you but that doesn't
scream problematic there's more to that
story but I'll just say that I disagree
with how they presented the conclusions
I would argue that oxidized fish oil has
no effect for the most part except
triglycerides where it seems to show a
benefit I'd also like to point out one
more thing which I think is really
important in this first study the
researchers had to expose omega-3 fats
to
100% pure oxygen for 20 minutes twice a
day for 21 days and then
encapsulated how many fish oil
manufacturers are going to be exposing
your encapsulated fish oil to that level
of oxidation that doesn't mean that
oxidation can't happen but analyses
quantifying the amount indicate it tends
to be a large minority so to be clear it
does happen but if you get ears directly
from a reputable supplier and there are
several it just doesn't seem to me that
we have anything near enough evidence to
claim grantd or oxidized fish oil is
actually causing Health harm in fact we
have evidence to the contrary of net
neutral I don't think that this is a
shut case and it's still possible
there's something there but the evidence
so far does not substantiate the level
of certain fear that some people are
exhibiting especially if you buy from
independently tested Brands speaking of
all this fish oil there are also
profound benefits like those outlined in
this next video right here I'll speak
with you over there bye
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