David Sinclair’s 2024 REVISED Supplement Protocol | Critical Changes!!

Summary

In this video, viewers are updated on Dr. David Sinclair's latest supplement routine changes, focusing on anti-aging and health. Sinclair has dropped quercetin and possibly trimethylglycine (TMG), while continuing with resveratrol, NMN, spermidine, and metformin. He's added new supplements like Elysium's torine and experimented with rapamycin. The video also discusses the importance of magnesium, provides a free report on quercetin, and suggests resources for further research on supplements like torine.

Takeaways

• 🔬 Dr. David Sinclair, a prominent figure in the field of aging and longevity, frequently updates his supplement routine based on the latest research and personal experimentation.
• 📉 In recent updates, Dr. Sinclair appears to have discontinued the use of quercetin, a supplement he previously took for its potential to combat senescent cells.
• 🍇 Resveratrol, found in grapes, and pterostilbene, found in other plants, are still part of his regimen, typically taken in the morning, with Sinclair suggesting a range of half a gram to 1 gram.
• 🧪 Sinclair's early research focused on alpha-lipoic acid, a supplement he's likely been taking for over 20 years, and he continues to include it in his routine, often in a dose of about 300 mg.
• 🍄 Spermidine, a molecule that has shown potential in extending lifespan, is currently part of Sinclair's protocol, with a daily intake of 1 to 2 milligrams.
• 💊 NAD+ boosters like NMN are a staple in his routine, with Sinclair taking 1 gram daily to support cellular energy and health.
• 🐁 He has recently added Elysium Health's Basis supplement to his regimen, which includes two grams of the amino acid taurine per day, based on promising longevity research.
• 🧗‍♂️ Sinclair also takes metformin, a drug used to manage blood sugar levels, and has recently started taking rapamycin, an experimental longevity drug, despite previous reservations.
• 🍏 While not explicitly mentioned, it's suggested that Sinclair may still be taking vitamin D and K2, as well as fish oil, for general health and longevity benefits.
• 📚 For those interested in following Sinclair's lead, the video provides a detailed summary of his current supplement routine and offers additional resources for further research and supplementation guidance.

Q & A

What are the two major changes Dr. David Sinclair made to his supplement routine in the recent year?

Dr. David Sinclair dropped one of the supplements he used to take, possibly quercetin, and he added a new supplement, Elysium's torin, to his routine.

Why did Dr. Sinclair decide to take Fisetin and Quercetin?

Dr. Sinclair took Fisetin and Quercetin to target senescent cells, which are cells that have stopped dividing and can contribute to aging. He ran an experiment on himself based on the idea that these compounds could help kill off these cells, at least in mice and potentially in humans.

What is the recommended daily intake of Resveratrol and Physan according to Dr. Sinclair?

Dr. Sinclair takes between half a gram and 1 gram of Resveratrol and Physan in the morning.

Why did Dr. Sinclair drop Quercetin from his supplement routine?

It is suggested that Dr. Sinclair dropped Quercetin due to its potential side effects when taken in excess, such as inhibiting ceramides which promote longevity, inhibiting Nrf2, a potent longevity mechanism, and reducing glutathione.

What is the significance of alpha-lipoic acid in Dr. Sinclair's supplement routine?

Alpha-lipoic acid is significant because it was the subject of Dr. Sinclair's PhD research and is known for its benefits to cellular energy. He has likely been taking it for over 20 years.

How much spermidine does Dr. Sinclair take daily, and what is the source of his intake?

Dr. Sinclair takes 1 to 2 milligrams of spermidine daily. He takes it as a supplement, but it's also found in foods like mushrooms, broccoli, and green peas.

What is the current daily dose of NMN that Dr. Sinclair takes?

Dr. Sinclair takes 1 gram of NMN every day with water in the morning.

Why did Dr. Sinclair start taking spermidine?

Dr. Sinclair started taking spermidine because it has been shown to extend the lifespan of various animals, likely by stabilizing the epigenome.

What is the current status of Dr. Sinclair's supplement routine regarding Torin (Elysium Health's product)?

Dr. Sinclair added Elysium Health's torin to his routine in 2023, taking 2 grams a day to see how it works with him.

What are the two longevity drugs that Dr. Sinclair is currently taking?

Dr. Sinclair is currently taking Metformin and Rapamycin for longevity. He takes Metformin for its potential benefits in preventing diabetes and its mimicry of fasting benefits, and Rapamycin for its potential to allow more protein intake without overstimulating mTOR.

What is Dr. Sinclair's stance on taking TMG (Trimethylglycine)?

Dr. Sinclair used to take TMG to counteract the potential depletion of methyl groups caused by NAD boosters, but it is uncertain if he still takes it as he did not mention it in his latest interviews.