Video Formulasi Tablet Paracetamol dengan Metode Granulasi Basah

Summary

This video tutorial focuses on the formulation of tablets using the wet granulation method. The process begins with creating mucilage using starch, which is then mixed with other ingredients like paracetamol (active ingredient), manihot starch (binder), and lactose (filler). The mixture is made into a compact mass, sieved to form granules, and dried. The final granules are tested for quality. The video provides detailed steps on preparing the granules, highlighting the importance of each ingredient and technique in ensuring the tablet's desired characteristics.

Takeaways

• 😀 The introduction welcomes viewers and sets the stage for the practical session on tablet formulation using wet granulation.
• 😀 Wet granulation is the most common method used for producing tablets as it results in granules with the necessary properties for tablet compression.
• 😀 The script introduces the materials required for the practical: Paracetamol (active ingredient), Manihot starch (binder and filler), and aquades for preparing the mucilage.
• 😀 The mucilage preparation process involves mixing starch with aquades, heating, and stirring until a thick, clear solution forms.
• 😀 In the first step of granulation, Paracetamol is weighed and ground to a homogeneous powder.
• 😀 The next step adds lactose as a filler, which is ground again to ensure uniformity.
• 😀 Manihot starch is then added as a disintegrating agent and mixed until the powder is homogenous.
• 😀 The mucilage is gradually added to the powder mixture, and it is stirred until a compact mass forms.
• 😀 The resulting mass is sieved through a mesh to form granules, which are spread evenly and left to dry.
• 😀 After drying, the granules are sieved again and weighed to ensure proper consistency before testing the final product in preformulation studies.

Q & A

What is the main topic of the practical session in the script?

The main topic of the practical session is the formulation of tablets using the wet granulation method.

Why is the wet granulation method commonly used?

The wet granulation method is widely used because it produces granules that have the required properties for tablet compression and results in more compact tablets.

What is the purpose of adding a binding agent in the wet granulation process?

The binding agent helps to bind the powder mixture together and transform it into granules that flow freely into the mold.

Which binding agents are mentioned in the script?

The binding agents mentioned in the script include mucilage amyli, gelatin solution, and CMC (Carboxymethylcellulose).

What are the ingredients used in the practical session for tablet formulation?

The ingredients used are paracetamol as the active ingredient, amilum manihot as the disintegrating agent, amilum manihot as the binder, lactose as the filler, and aquades for preparing mucilage amyli.

How is mucilage amyli prepared in the practical session?

Mucilage amyli is prepared by weighing 40 grams of amilum manihot and mixing it with aquades, then heating the mixture on a hotplate while stirring until it turns clear and thick.

What is the purpose of grinding the ingredients in the mortar and pestle?

The ingredients are ground in a mortar and pestle to achieve a homogeneous mixture before adding the binding solution.

How is the granulation process carried out after mixing the ingredients?

After mixing, the mucilage amyli is gradually added to the mixture using a spatula until a compact mass forms.

What happens to the granules after they are formed in the practical session?

After the granules are formed, they are sieved using a mesh sieve (MS14), then spread evenly on the tray and left to dry in a drying oven at 40-60°C for about 24 hours.

What is the next step after drying the granules in the practical session?

Once the granules are dry, they are sieved again using a finer mesh sieve (MS12), then weighed, and tested for preformulation characteristics.