Is Your Diet Wrecking Your Gut Health & Weight Loss? | Ask Dr. Gundry
Summary
TLDRThe video script discusses the critical role of the human microbiome, which is home to trillions of bacteria essential for our health. It highlights how broad-spectrum antibiotics and agricultural practices have disrupted this delicate ecosystem, leading to unforeseen health consequences. The speaker also explores the connection between the microbiome and hormones, the influence of 'obesogenic' versus 'lean' bacteria on weight, and the role of postbiotics in controlling eating behavior. The script emphasizes the importance of understanding and preserving our microbiome for overall well-being.
Takeaways
- 🌿 The human microbiome, a diverse ecosystem of 100 trillion bacteria with 10,000 species, is crucial for our health but was only fully recognized after the Human Microbiome Project in 2017.
- 💊 The introduction of broad-spectrum antibiotics in the 1970s was revolutionary for treating infections but had the unintended consequence of disrupting the microbiome, which was unknown at the time.
- 🐷 The routine use of antibiotics in agriculture to promote faster growth in animals has led to the consumption of antibiotic residues, further impacting our microbiome.
- 🌱 Glyphosate, originally an antibiotic, is now a common herbicide that also negatively affects our gut microbiome when consumed through conventional crops.
- 🛡️ The microbiome plays a critical role in educating our immune system about potential threats and has evolved to protect us from harmful plant compounds.
- 🍽️ Certain bacteria in our microbiome help us digest and neutralize substances like gluten and oxalates, which can cause issues when the microbiome is disrupted.
- 🤰 Hormonal balance, including estrogen, progesterone, and testosterone, is influenced by and can be produced by the gut microbiome, affecting postmenopausal women and others.
- 🔄 There is a reciprocal relationship between hormones and the microbiome, with each influencing the other in complex ways.
- 🐹 The existence of both obesogenic and lean microbiomes influences weight gain and metabolism, with studies showing that gut bacteria can affect body weight in animals.
- 🍚 Bacteria can send 'text messages' or chemical signals to the brain indicating cravings for specific types of food, potentially leading to overconsumption.
- 🌾 Prebiotic fiber, a favorite food for beneficial gut bacteria, can satiate hunger by sending signals to the brain that the body's needs are met, reducing the desire to eat.
Q & A
What is the 'tropical rainforest' metaphor referring to in the context of the human body?
-The 'tropical rainforest' metaphor is used to describe the diverse ecosystem of the human microbiome, which is home to trillions of bacteria living in and on our bodies, particularly in the mouth and gut.
When was the human microbiome project completed, and what was its significance?
-The human microbiome project was completed in 2017. It was significant because it revealed the existence and roles of various bacteria within the human body that were previously unknown.
How do the bacteria in our microbiome affect our body systems?
-The bacteria in our microbiome produce messages that help regulate our body systems, including hormonal systems, ensuring they function properly.
What was the impact of broad-spectrum antibiotics on the human microbiome?
-Broad-spectrum antibiotics, introduced in the mid-1970s, had the unintended consequence of killing off the beneficial bacteria in our microbiome, disrupting the delicate balance of this 'tropical rainforest' within us.
How did the use of antibiotics in agriculture affect human health?
-The routine use of antibiotics in agriculture to promote faster growth in animals resulted in the presence of these antibiotics in their flesh. When humans consume these animals, it contributes to the destruction of our microbiome.
What is the connection between Roundup and the human microbiome?
-Roundup, originally patented as an antibiotic, is a weed killer that is also effective at killing off the gut microbiome. It is sprayed on both genetically modified and conventional crops, which we consume and can negatively impact our microbiome.
How do our gut bacteria influence our immune system?
-Gut bacteria have evolved over millions of years to educate our immune system about what to be concerned about and what to ignore, playing a crucial role in immune system regulation.
What is the role of gut bacteria in protecting us from harmful plant compounds?
-Some gut bacteria have evolved to consume and protect us from harmful plant compounds, such as gluten and oxalates, which can cause issues in individuals with a disrupted microbiome.
How do gut bacteria relate to hormone production and regulation?
-Gut bacteria are involved in the production and modulation of hormones, including estrogen, progesterone, and testosterone, which can have significant impacts on health and well-being.
What is the concept of an 'obesogenic microbiome' versus a 'lean microbiome'?
-An 'obesogenic microbiome' consists of bacteria that efficiently extract and absorb calories from food, contributing to weight gain. In contrast, a 'lean microbiome' contains bacteria that consume excess calories themselves, promoting a leaner body composition.
How do gut bacteria influence our eating behavior?
-Gut bacteria can send chemical signals, or 'text messages,' to the brain indicating their hunger for specific types of food, such as simple sugars, carbohydrates, or fats. This can influence our cravings and eating behaviors.
What is the 'gut-centric theory of hunger' and how does it relate to gut bacteria?
-The 'gut-centric theory of hunger' suggests that having a healthy, lean microbiome can send signals to the brain indicating satisfaction with the intake of prebiotic fiber, reducing hunger and the drive to seek out additional food.
Outlines
🌿 The Impact of Antibiotics and Herbicides on the Human Microbiome
This paragraph discusses the critical role of our microbiome, which is composed of trillions of bacteria that coexist with us, contributing to our overall health. The human microbiome project, completed in 2017, shed light on the diversity and importance of these bacteria, which were previously unknown. The speaker reflects on the introduction of broad-spectrum antibiotics in the 1970s, which, while life-saving, had the unintended consequence of disrupting this delicate ecosystem within our bodies. Additionally, the widespread use of antibiotics in agriculture has led to their presence in our food supply, further impacting our microbiome. The paragraph also touches on the use of glyphosate, originally an antibiotic, as a weed killer, which has been shown to negatively affect our gut bacteria. The speaker emphasizes the symbiotic relationship between our microbiome and our immune system, and how the loss of certain bacteria can lead to increased susceptibility to health issues.
🍽️ The Role of Microbiome in Hormone Regulation and Weight Management
The second paragraph delves into the influence of the gut microbiome on hormone production and weight regulation. It explains how the microbiome can produce hormones and even influence levels of estrogen, progesterone, and testosterone. The speaker discusses the concept of an 'obesogenic microbiome' versus a 'lean microbiome,' highlighting how certain bacteria can affect our body's ability to absorb and store calories. The paragraph also explores the idea of 'postbiotics,' chemical signals from gut bacteria that can influence our eating behavior by sending messages to the brain, indicating cravings for specific types of food. The speaker mentions a study in China that supports the idea that providing the gut bacteria with their preferred food, prebiotic fiber, can effectively suppress hunger, suggesting a gut-centric theory of hunger that could have implications for weight management and health.
Mindmap
Keywords
💡Seven Deadly Disruptors
💡Microbiome
💡Tropical Rainforest
💡Broad Spectrum Antibiotics
💡Antibiotic Resistance
💡Glyphosate
💡Desiccant
💡Hormonal Systems
💡Obesogenic Microbiome
💡Postbiotics
💡Prebiotic Fiber
Highlights
Human microbiome is a diverse ecosystem with 100 trillion bacteria and 10,000 different species.
The microbiome plays a crucial role in the proper functioning of our body systems, including hormonal systems.
Broad-spectrum antibiotics, introduced in the 1970s, were miraculous for treating infections but had unknown effects on the microbiome.
Antibiotics in agriculture have led to faster and fatter livestock growth, but also contribute to the destruction of the human microbiome.
70% of all antibiotics produced are fed to animals, which affects humans through the consumption of animal products.
Glyphosate, originally an antibiotic, is now a common weed killer that also negatively impacts the gut microbiome.
Glyphosate is sprayed on a wide range of crops, leading to its consumption through the food we eat.
The microbiome has evolved to educate our immune system and protect us from harmful plant compounds.
Certain bacteria in the microbiome can eat gluten and oxalates, which are often problematic in societies with disrupted microbiomes.
The microbiome can modulate hormones such as estrogen, progesterone, and testosterone.
Postmenopausal women may still experience hot flashes due to estrogen production by the gut microbiome, not ovaries.
There are obesogenic and lean microbiomes, which can influence body weight and fat distribution.
Bacterial transfer through feces can alter the body weight of animals, demonstrating the power of the microbiome.
Certain bacteria extract and absorb calories more efficiently, contributing to weight gain.
Lean bacteria consume extra calories, preventing weight gain and promoting a lean body type.
Postbiotics are chemical signals from bacteria that influence our eating behavior and food preferences.
The gut-centric theory of hunger suggests that a healthy microbiome can signal satiety, reducing the need for more food.
A study in China demonstrated that prebiotic fiber can significantly reduce hunger, supporting the gut-centric theory of hunger.
Transcripts
well you know I spent most of my time in
writing books talking about the the
seven deadly
disruptors of among other things our
microbiome we're supposed to have 100
trillion different bacteria living in us
living in our mouth living in our gut
and there are probably 10,000 different
species of these bacteria this is
supposed to be a tropical rainforest
it's supposed to be this diverse
ecosystem we didn't even know these guys
existed until the human microbiome
project was finished in 2017 we didn't
know they were there number one number
two we didn't know what these guys
actually did we now know that they make
all these messages that make all our
body systems including our hormonal
systems work properly the other thing we
had no idea I'm old enough to remember
when Broad Spectrum antibiotics were
introduced in the mid 1970s when I was
in medical school they were miraculous
because before then if somebody had an
infection let's say they had pneumonia
Well we'd have to culture a bacteria on
a petri dish hope it would grow and then
we'd have to test it against certain
antibiotics to find out which antibiotic
would kill that particular bacteria when
broad spectrum antibiotics came out we
didn't have to figure out what the bug
was we didn't have to figure out the
antibiotic was we basic Al got a shotgun
out and blasted every last living
bacteria to Smither and that was great
it was miraculous it saved a lot of
lives what we didn't know is that these
broads Spectrum antibiotics yeah solved
the Infectious problem but it killed off
this tropical rainforest within us we
had no idea number one that they were
there number two that we would kill them
too we should have realized and number
three at the same time researchers
figured out that if you gave animals
antibi iotics they would grow faster and
put on much more fat than if you didn't
give them antibiotics so it became a
routine part of Agriculture to give
antibiotics to chickens Beef Pork
whatever to make them grow faster and
fatter and we had no idea that those
antibiotics would be incorporated into
their flesh and we eating their flesh
would every day be eating antibiotics
that would kill off our microbiome
that's just actually one example that we
just didn't know 70% of all the
antibiotics produced in this country are
fed to animals right now and we eat
those animals we can say oh well we we
don't want to take broadspectrum
antibiotics and quite frankly we still
take much to many but more importantly
we're getting it in all the foods we eat
and add to the fact that simultaneous
with all this round up glyos s was
introduced as a weed killer 50 years ago
and most people don't know that Roundup
was actually patented as an antibiotic
it wasn't patented as a wheat killer
most people to this day still don't know
that Roundup is not primarily sprayed on
genetically modified crops it's sprayed
on conventional crops to desiccate the
plant to kill the plant because quite
frankly it's easier harvesting a crop
when the plant is dead because it
doesn't have any water and it's much
more efficient what we didn't know is
that glyphosate is really good at
killing off our gut microbiome and it's
sprayed on conventional wheat
conventional oats conventional rice
soybeans corn you choose the crop and
it's sprayed on it so we've just done an
incredible number on
destroying probably the most important
symbiotic organ within us that up until
a few years ago we didn't even know
existed and we're paying the price so so
getting back to the original question
these organisms number one evolved
through millions and millions of years
to educate our immune system about what
our immune system should be worried
about and not worried about these
organisms evolve to believe it or not
eat and protect us from plant compounds
that might wish us harm Believe It or
Not There are bacteria that eat gluten
there are bacteria that eat oxalates
they're gone most people killed them off
no wonder so many people have issues
with things that traditional societies
don't have issues with because they've
got an intact microbiome we now know
that there's a microbiome that makes
hormones that modulates hormones that
modulates estrogen that modulates
progesterone that even modulates
testosterone and those guys are gone or
they've been altered for instance many
women are shocked who are postmenopausal
they're still having hot flashes lo and
behold we can watch them make or not
make estrogen not from their ovaries but
from their gut microbiome they're
shocked that their 10 years
postmenopause and they make estrogen
think oh no no no that's impossible I
don't make estrogen well yes you do well
where's it coming from you know my ovar
has died a long time ago well it's
coming from you know your fat cells your
microbiome no wonder you've got into
this problem or at least that's
contributing to it interestingly enough
we know that hormones influence the
microbiome and the microbiome influences
hormones but what's fascinating is
there's an
obesogenic microbiome and there's a lean
microbiome this was actually discovered
a number of years ago in animal studies
where mice and rats are great because
mice and rats actually like to eat feet
feces that's their thing some dog owners
may have a dog that enjoys eating feces
so it's actually not unusual
interestingly enough you can take fat
rats who have been bred to be fat and
house them with skinny rats and the
skinny rats will become fat by eating
the feces of the fat rat you can take
human feces the humans are fat and feed
them to skinny rats and the skinny rats
will be become fat by eating the human
species how does that happen well in two
ways number one we know that there are
bacteria that are very efficient at
extracting calories from the food we eat
and then literally feeding it to us in
other words they make the calories more
absorbable on the contrary there are
lean bacteria that actually keep all
those extra calories for themselves
to make more of themselves and the
beauty of that is they're going gim me
givme giv me I'm going to eat it I'm
going to make more of myself and will
just poop out all those extra calories
now there's a third thing we've learned
and that is there's a control of our
eating Behavior by bacteria and these
are compounds these are chemical signals
we call them postbiotics I like people
to think of them them is text messages
that bacteria can make that go up to the
brain and say hey I'm hungry but I'm
hungry for specific things I'm hungry
for simple sugars for simple
carbohydrates and I'm hungry for fats
particularly saturated fats our brain
says hey we're getting the signal from
the gut that we should be looking for
these sorts of foods if we eat those
certain sorts of foods unfortunately the
gut bacteria say yeah that's exactly
what I'm looking for send some more on
the other hand there's a theory that I
like and I've written about called the
gut Centric theory of hunger that if you
got good bacteria if you've got lean
bacteria those bacteria send messages to
the brain that if you give them what
they want and quite simply that's
Prebiotic fiber soluble fiber that they
go yeah that's exactly what we wanted
eat we're full you don't have to go
looking for any more food and this has
actually been proven in humans in China
they took volunteers and put them on a
two we water fast one group all I got
was water the other group got 100
calories a day of Prebiotic fiber now
what that means is we don't digest
Prebiotic fiber we can't absorb it we
can't turn it into carbohydrates we
can't get to it but the gut bacteria
that's their favorite food the folks who
just had water were really hungry the
folks who got just a 100 calories of
Prebiotic fiber and again they couldn't
absorb it they had no hunger which
literally proves that yeah these text
messages were coming out of the gut from
the gut microbiome saying hey we're
great shape our needs are bet you're
fine you don't have to go find anything
else
[Music]
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