Praktikum Teknologi Sediaan Farmasi Liquid dan Semisolid: Pembuatan Sediaan Suspensi

Summary

In this educational video, Fitria Nugrahainy discusses the preparation and evaluation of liquid suspensions and emulsions, as well as semi-solid creams. Viewers are guided through essential laboratory procedures, including safety measures, the use of a pH meter for calibration, and techniques for measuring viscosity and particle size. The video emphasizes the importance of evaluating the physical properties of formulations, such as sedimentation volume and dispersibility. Overall, this instructional content serves as a practical guide for students in pharmaceutical technology, enhancing their understanding of liquid dosage forms.

Takeaways

• 👩‍🔬 Always wear lab coats, masks, and gloves when entering the laboratory for safety.
• 💧 Prepare a liquid suspension by mixing water with HPMC as the suspending agent.
• 🔄 Use an ultra-turrax mixer at 3000 RPM for 5 minutes to achieve a homogeneous suspension.
• 🔍 Conduct evaluations for the suspension, including appearance, smell, taste, and color.
• 📏 Measure the pH using a calibrated pH meter to ensure it meets specifications.
• ⚖️ Use a pycnometer to evaluate the specific gravity of the suspension.
• ⏳ Perform a volume transfer test to confirm the volume of the suspension matches the label.
• 🧪 Use a Brookfield viscometer to measure the viscosity of emulsions and suspensions.
• 🔬 Evaluate particle size by observing a diluted suspension under a microscope.
• 📊 After sedimentation tests, assess the re-dispersibility of the suspension for quality control.

Q & A

What is the main focus of the practical course in pharmaceutical preparations?

The course focuses on the preparation and evaluation of liquid and semi-solid pharmaceutical formulations, including suspensions, emulsions, and creams.

What personal protective equipment should be worn when entering the laboratory?

Students should wear a lab coat, a mask, hand gloves, headphones, and closed footwear.

What is a suspension in pharmaceutical terms?

A suspension is a liquid preparation containing solid particles that are not dissolved in the liquid.

What is the role of HPMC in preparing suspensions?

HPMC (Hydroxypropyl Methylcellulose) acts as a suspending agent to help keep the solid particles evenly distributed in the liquid.

How is the pH of the suspension evaluated?

The pH is measured using a pH meter, which must be calibrated before use. The pH meter is dipped into the sample after calibration with buffer solutions.

What does the evaluation of specific gravity involve?

Specific gravity is evaluated using a pycnometer. The empty pycnometer is weighed, then filled with water and weighed again, followed by weighing it with the sample to calculate specific gravity.

What is the purpose of the volume transfer test?

The volume transfer test ensures that the volume of the suspension dispensed matches the labeled amount on the product.

What equipment is used to test the viscosity of emulsions, suspensions, or semi-solid preparations?

A Brookfield viscometer is used to measure the viscosity of these formulations.

How is the average particle diameter evaluated?

The average particle diameter is evaluated by diluting the suspension and observing the particles under a microscope.

What is the significance of sedimentation volume evaluation?

Sedimentation volume evaluation determines the stability of the suspension over time by measuring the volume of sediment formed after a certain period.