Prof. Glen Jeffrey | Red Light Revolution: Charge Your Cells, Reduce Ageing & Decrease Inflammation

Degrees of Health Podcast
10 Sept 202459:31

Summary

TLDR本视频脚本探讨了红光和近红外光对人体健康的影响,特别是它们对线粒体功能的积极作用。嘉宾格伦·杰弗瑞博士分享了他从研究果蝇到临床试验的科研之旅,解释了不同光谱的光如何影响人体代谢和衰老。他讨论了现代生活中红光缺失的问题,并提出了通过红光照射改善视力、促进伤口愈合和调节血糖水平的潜力。杰弗瑞博士还强调了自然光的重要性,并对未来光疗法在医疗和日常生活中的应用表示乐观。

Takeaways

  • 🧬 研究眼睛和光线对健康的影响,特别是红光和近红外光对线粒体功能的积极作用。
  • 👨‍🔬 线粒体对光非常敏感,光线可以调节线粒体的活动,影响代谢和衰老过程。
  • 🌞 阳光包含了广泛的光谱,人类只能看到其中的一小部分,而现代生活中我们常常缺乏某些光谱,尤其是红外光。
  • 🚨 现代建筑阻挡了阳光中的红外光,这可能导致了所谓的“红光饥饿”现象。
  • 👓 红光和近红外光可以深入身体内部,刺激线粒体,对健康有积极影响。
  • 🦟 实验显示,红光能够改善蜜蜂和果蝇的代谢健康,类似效应在人类中也得到了验证。
  • 🩸 红光疗法被发现可以降低血糖水平,可能对糖尿病管理有积极作用。
  • 🌡️ 红光疗法的效果似乎是开关式的,而不是剂量依赖性的,短时间的照射就能产生效果。
  • 🌅 早晨是使用红光疗法的最佳时机,因为线粒体在早晨最为活跃。
  • 📚 市面上的红光设备效果参差不齐,消费者在购买时应考虑具体的波长和能量输出。

Q & A

  • 红光对线粒体有什么影响?

    -红光能够调节线粒体的功能,线粒体对长波长的光有响应,可以通过充电来改善线粒体的状态,从而有助于减缓衰老过程和改善新陈代谢。

  • 线粒体与衰老有什么关系?

    -线粒体在调节人的新陈代谢和衰老速度方面起着关键作用。如果线粒体功能下降,可能会导致衰老加速以及与衰老相关的疾病的发生。

  • 红光疗法在临床试验中的应用是什么?

    -红光疗法正在从学术研究走向临床试验,研究者正在探索它在改善视力、治疗代谢疾病、帕金森病以及黄斑变性等疾病方面的潜在效果。

  • 为什么说我们可能处于“红光饥饿”状态?

    -现代建筑通常使用阻挡红外线的玻璃,同时室内使用的LED照明缺乏红光光谱,导致我们接收不到足够的红光,这可能会影响我们的健康。

  • 红光对糖尿病人的血糖水平有何影响?

    -研究表明,通过红光照射可以激发线粒体更高效地工作,从而消耗更多的血糖,有助于降低血糖水平。

  • 为什么红光疗法在早晨最有效?

    -线粒体有自己的生物钟,通常在早晨激活。因此,在早晨使用红光疗法可以更好地刺激线粒体,提高其功能。

  • 如何选择合适的红光疗法设备?

    -应选择波长在660至850纳米之间的设备,避免使用低于670纳米的设备,因为其效果可能不佳。同时,应确保设备使用的是LED而非激光,以确保安全性。

  • 红光疗法是否对所有人都安全?

    -目前的研究显示红光疗法对大多数人是安全的,但使用任何医疗设备之前,最好先咨询医疗专业人员。

  • 红光疗法对于视力有哪些潜在的好处?

    -红光疗法可以改善视网膜功能,对于视力有积极影响,尤其对于黄斑变性等眼疾患者可能有改善视力的潜力。

  • 如何将红光疗法融入日常生活?

    -可以在早晨起床后使用红光设备进行短时间的照射,或者在户外活动时,确保有足够时间暴露在阳光下,以获得红光的益处。

  • 红光疗法对于宇航员在国际空间站的健康问题有何帮助?

    -研究表明,红光可能有助于改善宇航员在国际空间站上经历的线粒体功能下降问题,从而减缓衰老迹象和改善健康状况。

Outlines

00:00

🔬 研究兴趣的起源

本段落介绍了研究者如何开始对红光和不同波长的光产生兴趣。最初是因为被邀请评审一篇关于红光的论文,尽管最初难以理解且持怀疑态度,但研究者最终通过自己的简单实验确认了红光对生物体有实际影响。这项研究在过去12年中从学术兴趣发展到临床试验,特别是研究光对线粒体的影响,线粒体是细胞的能量工厂,与代谢和衰老有关。

05:00

🌞 光与生物学的关系

这段落讨论了线粒体对光的敏感性,尤其是长波长的光如何为老化或病态的线粒体充电,而短波长的光,如蓝光,则会放电。这种光敏性与生物体的代谢和炎症反应有关。此外,提到了人们对于光和生物学之间联系的普遍认识,以及阳光与人造光源(如LED灯)之间的光谱差异。

10:01

👵 红光对衰老的影响

本段落探讨了随着寿命延长,人们在疾病中生存的时间更长,导致线粒体功能下降,从而引起衰老和各种与衰老相关的疾病。现代建筑阻挡了有益的红外光,加剧了所谓的“红光饥饿”。研究者通过实验发现,红光可以改善视力和提高能量,对抗衰老的影响。

15:01

🐝 红光对蜜蜂血糖的影响

研究者通过在蜜蜂身上的实验发现,红光能够通过加速线粒体工作来降低血糖水平。这一发现后来在人类志愿者身上得到了验证,表明红光有潜力用于治疗2型糖尿病。红光通过刺激线粒体在全身范围内产生影响,即使只照射身体的一小部分。

20:03

🚫 对蓝光的警告

这段落讨论了蓝光对生物体可能产生的负面影响,尤其是对线粒体的损害。研究者提倡减少在日常生活中对LED照明的使用,因为它们发出的光缺乏红光,可能对健康产生不利影响。同时,提出了红光疗法作为一种潜在的改善公共健康的方法。

25:03

🌅 红光与皮肤和胶原蛋白

本段落讨论了红光对于皮肤健康和胶原蛋白生成的潜在益处,尽管市场上的一些红光设备可能价格昂贵且效果未经验证。研究者指出,红光疗法应该在早晨进行,因为这是线粒体活动的高峰期。

30:08

🌱 红光对儿童近视的影响

研究者提到了红光可能有助于预防儿童近视的发展,这与中国孩子在室内长时间学习和缺乏户外活动有关。红光的照射可能有助于减缓近视的发展。

35:11

🧠 红光对大脑和帕金森病的潜在影响

这段落探讨了通过鼻腔照射红光可能对治疗帕金森病有益的理论。虽然这种方法听起来不寻常,但研究者认为它可能有助于快速将光线传递到大脑中的深部结构。

40:13

🔍 红光研究的未来方向

研究者表达了对红光研究未来方向的兴奋,包括其对罕见线粒体疾病的潜在影响,以及可能如何改善公共健康。他强调了将研究成果转化为实际应用的重要性,并分享了自己的个人红光使用习惯。

45:18

📚 推荐阅读和个人健康实践

在这段落中,研究者推荐了Nick Lane的《Power, Sex, Suicide》一书,并分享了自己如何通过每天早晨做瑜伽来改善健康。他还表达了对火光与人类进化之间可能联系的研究兴趣。

Mindmap

Keywords

💡线粒体

线粒体是细胞内的一种重要细胞器,负责细胞的能量代谢,被称为细胞的‘能量工厂’。在视频中,线粒体与光的关系被广泛讨论,特别是在红光和近红外光如何影响线粒体功能,进而影响人的代谢和衰老过程。例如,视频提到线粒体对光非常敏感,光可以调节线粒体的功能,而线粒体的功能又与人体的代谢和衰老速率密切相关。

💡红光

红光是视频讨论的重点之一,特别是在670纳米以上波长的光如何对人体产生积极影响。红光能够深入人体组织,刺激线粒体,从而有助于提高细胞的能量产生和减少炎症。视频中提到,红光疗法可以改善视力、促进伤口愈合以及可能对抗与衰老相关的疾病。

💡近红外光

近红外光是波长在700纳米以上的光,它与红光类似,能够深入人体组织并刺激线粒体。在视频中,近红外光被认为在健康方面可能具有更大的潜力,因为它的穿透力比可见红光更强。讨论了近红外光对于改善视力和线粒体功能的潜在效果。

💡代谢

代谢是指生物体内进行的一系列化学反应,用于维持生命过程。在视频中,代谢与线粒体的功能紧密相关,因为线粒体负责调节代谢过程。红光和近红外光能够通过影响线粒体来改善代谢,例如通过提高能量产生或减少有害的代谢副产品。

💡衰老

衰老是生物体随时间功能逐渐下降的过程。视频中提到,线粒体的效能下降与衰老有关,而通过红光和近红外光照射可以提高线粒体的功能,从而可能减缓衰老过程。这表明适当的光照可能有助于维持细胞和器官的健康状态,对抗老化。

💡光敏感性

光敏感性是指生物体对光的反应能力。视频强调线粒体对光特别敏感,这种敏感性是光如何影响细胞功能的关键。光敏感性的研究有助于我们理解如何利用特定波长的光照来改善健康和治疗疾病。

💡LED灯

LED灯是一种半导体发光器件,因其节能和长寿命而广泛使用。然而,视频中提到,LED灯的光谱可能缺乏红光,这可能导致所谓的'红光饥饿',影响人体的健康和功能。讨论了如何通过改变照明类型来改善公共健康问题。

💡光生物调节作用

光生物调节作用是指光对生物组织产生的影响,包括光如何影响细胞功能和生理过程。视频讨论了红光和近红外光如何通过光生物调节作用改善线粒体功能,进而影响健康和疾病治疗。

💡褪黑激素

褪黑激素是一种在黑暗中分泌增加的激素,有助于调节睡眠-觉醒周期。虽然视频中没有直接提到褪黑激素,但讨论了红光和近红外光对睡眠和昼夜节律的潜在影响,因为这些光类型可能影响人体的内部时钟。

💡光疗

光疗是一种使用光线治疗疾病的疗法。视频讨论了红光和近红外光在光疗中的应用,包括改善视力、促进伤口愈合和可能对抗某些疾病如帕金森病。光疗的潜力在于其非侵入性和低风险,使其成为一种有吸引力的治疗手段。

Highlights

研究者最初因为评审一篇论文而对红光和不同波长的光产生兴趣。

经过12年的发展,研究从学术兴趣发展到临床试验。

红光和近红外光被认为对健康有益,但具体原因尚不清楚。

线粒体对光非常敏感,光可以调节线粒体的功能,而线粒体又调节新陈代谢和衰老过程。

长波长的光可以为状态不佳的线粒体充电,而短波长的光,如蓝光,会放电。

红光可以改善视力,因为它能重新为眼睛中的线粒体充电。

阳光是生命进化的主要能源,包含了从紫外线到红外线的广泛光谱。

现代建筑阻挡了对我们有益的红外线,可能导致了所谓的“红光饥饿”。

红光可以穿透身体,刺激任何细胞中的线粒体。

红光对提高老年人视觉功能有积极影响。

线粒体理论认为,随着年龄的增长,线粒体功能衰退,可能导致衰老和炎症。

红光可能对治疗帕金森病等与线粒体功能障碍相关的疾病有益。

红光对改善蜜蜂的血糖水平显示出积极效果,可能对人类也有类似效果。

红光照射可以作为改善胰岛素抵抗和血糖水平的潜在干预手段。

红光照射的效果不依赖于照射面积的大小,而是像开关一样,存在一个阈值。

红光对伤口愈合有积极影响,可能促进炎症减少。

在国际空间站上,宇航员显示出线粒体功能衰退的迹象,可能与长期暴露在LED光源下有关。

红光可能有助于减少近视的发展,特别是在儿童中。

市场上的红光设备价格昂贵,但实际效果与低成本的LED灯相似。

红光设备应在早晨使用,因为线粒体在下午不响应红光。

研究者提倡回归使用白炽灯,以提供更广泛的光谱光,改善公共健康。

研究者个人实践包括早晨进行瑜伽和使用红光照射。

研究者对未来红光研究的期待包括其在人类进化中的作用,特别是与火光的关系。

Transcripts

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okay awesome wonderful well where are

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you Ben I'm in Oxfordshire where are you

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uh I'm at The Institute of Opthalmology

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at University College London brilliant

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but that that that's where you spend

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most of your time these days am I

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correctly saying sadly

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yes so did your did your research into

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the eye uh I guess Spike uh the interest

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in red light I mean how did the interes

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in red and sort of different wave

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lengths of light come about um it came

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about originally because I was asked to

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review a paper and I looked at this

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paper and I thought I don't understand a

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word of this and it was one of the first

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papers on red light and the next

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reaction was I didn't believe it um but

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then when I read it I thought these

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people that did this research are really

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solid they're really solid the

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inadequacy is in me um and that's where

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it start started to roll and I did a few

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simple experiments myself and it

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confirmed that something was happening

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you know that there was something here

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and and really over the last 12 years

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this has grown and it's grown from being

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um what should we say an academic

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interest to us running it all the way

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through into clinical trials um so it's

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been a it's been an interesting

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organic development of of a subject from

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me working on flies to now working on uh

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working on people and kids yeah it's a

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really interesting um field because I

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think you have all these uh all these

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Health nerds who buy the massive red

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lights and near Fred lights but yet

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don't quite know why I mean I bought one

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back in 2021 and if anyone asked me why

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have you bought this I wouldn't be able

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to give them an answer um but saying

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that when uh my friends come around and

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see my red light they think why the red

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light why they new infared can we to

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start with can we understand the

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relationship or could you help us

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understand the relationship between

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mitochondria and light yeah sure now the

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area of mitochondria mitochondria

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research is very much the area of kind

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of people who are quite Technical

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biochemists and so um they they go into

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mitochondria they rip them apart they

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look at what's inside the

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Machinery um I come from it from a

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different perspective because I don't

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know any

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biochemistry um that's not my area so we

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tend to treat them as black

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boxes um so we do something to them and

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something happens and we don't worry too

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much about the middle ground I think

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that when it comes to biology in general

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if you take if you if you take plants

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out of the equation and you take eyes

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out of the equation people are very

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unhappy looking at light and biology

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right so if we look about skin cell or

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we look at something like that people

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are not very very comfortable but one of

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the issues at stake here is that

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mitochondria are very very light

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sensitive and that was known a long time

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ago but seems to have got a little bit

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lost um and what is critical for us is

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that light can regulate what

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mitochondria do and mitochondria

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regulate your metabolism and they also

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regulate your pace of Aging so you know

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they do do rather a lot of things and if

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we've got a if we've got a spanner that

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can actually be used to crack

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mitochondria that actually is very very

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important so that's how I came in I came

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in I am an outsider as far as a lot of

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the mitochondrial people are concerned

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but know very very few people look at

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mitochondria as black

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boxes I guess I mean I get the

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mitochondri sort of Heavy Hitters unique

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lanes and those uh those types I imagine

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um the looking at the Black Box I think

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is a lovely way to frame the discussion

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because you don't need to know the

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intricacies of what goes on inside the

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mitochondria right as you said something

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happens light black box something

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happens come out so what is the effect

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um of different spectrums of light to

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mitochondria okay so I always use the

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analogy that let's view mitochondria as

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a battery with a charge and it is a

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battery and it does have a charge um but

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with aging and with disease the battery

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runs down you know they the mitochondria

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regulate aging so it happens that long

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wavelengths of light are mitochondria

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respond to them by charging a battery

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that is actually in a poor state so it

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can be a poor State through aging it can

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be in a poor State because of metabolic

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disease that's one end of the spectrum

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the other end of the

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spectrum look at the sort of the short

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wavelengths

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blue the blue discharges the battery it

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reduces the charge on the battery and as

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you reduce the charge on the battery you

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can imagine like an old car battery as

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it runs down it starts to it starts to

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leak acid in this case it produces

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something called reactive oxygen species

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and what that does is it drives

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inflammation right so our battery runs

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down we get old we don't have the energy

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to kick our legs out of bed in the way

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that used to and at the same time we

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start to get inflammation because the

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batter's leaking acid so that's the kind

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of the simple basics of it I mean we can

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talk a lot about what is it in the

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mitochondria that are absorbing the

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light um and I think we pretty much

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identified that now giving us a sort of

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good grounding for me I for me the most

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important thing is driving that forward

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to an application you know what can we

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do do what can we do with people with

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mitochondria that don't work very well

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what can we do with people who who are

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old I mean at the end of the day we all

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get old um and many diseases are

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embedded in mitochondrial function and

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uh so macular degeneration Parkinson's

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disease is fundamentally a mitochondrial

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disease um so we've got lots of

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applications we can move

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towards um if we feel secure about them

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definitely I I I'm I'm looking at my

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script right now and I want to stay on

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topic but part of me wants to deviate

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and ask let tangents

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and sort of the the different imbalances

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of mitochondri and what that has

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implications for specifically I've read

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the book last week called the metabolic

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theory of cancer by Thomas sa I don't

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know if you've come across it no I

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haven't come across that essentially

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it's a theory where cancer is a uh is

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coming about as a result of the defect

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mitochondria um which Downstream of that

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um creates all sorts of cancer but we

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won't go there yet to frame the

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discussion I'd love to understand and

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just sort of set the parameters up of um

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what different light waves do we get

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from the sun because I think when you

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say light everyone is used to sort of

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the incandescent bulbs that get in the

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home the different spectrum of light

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they get in the Sun and then from there

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maybe we can sort of zoom in on an

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infrared and red light yes so sunlight

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and I really going to sell the point to

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kick off with you've evolved life has

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evolved for billions of years under

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sunlight light is the energy that that

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drives

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Evolution um so sunlight you could very

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crudely say runs from the ultraviolet

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that we can't see you know 350 320

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nanometers and then it runs all the way

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out to you around 2,000 nanometers so

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it's a really wide wide spectrum but we

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only see a really small window of that

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Spectrum

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so we only see from about 400 nanometers

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to about 700 nanometers so sunlight out

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here we see this bit and because we only

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see a small part of it that's the bit we

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tend to pay attention to and we don't

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pay attention to a lot of the other

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stuff now um we've evolved under

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sunlight and when we when we and and

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Fire Light is very similar to sunlight

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in its Spectrum so you could think well

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as we've evolved we've got fires uh and

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then when we started to um when we

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developed light in the built environment

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we developed incandescent light bulbs

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which are the ones that get hot which

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are very Eco unfriendly at the moment um

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but they give off a very wide spectrum

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of light as well so um even though we've

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moved in houses and into and into into

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buildings for a period of time we did

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have light that was rather like sunlight

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and of course that changed when we moved

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over to LEDs because they have got an

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extremely restricted wavelength of

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spectrum that we're exposed to so okay

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so that that is a it's really helpful to

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know so just to get on the same page for

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The Listener who's not familiar with um

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all the different implications of light

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the sun is almost this sort of cocktail

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of different light spectrums we can only

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see a a select few spectrums but there

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many many many and uh we're born to be

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exposed to these different light

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spectrums but we spend 92% of our time

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indoors bulbs can mess with how we've

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meant to be evolved and that can cause

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all sorts of issues to my understanding

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why so much attention on specifically

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the red and near infrared spectrums of

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light at the moment um it's because of

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you know it's about recharging that

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battery we know they recharg the battery

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um let's put it into a wider context

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which is we're living much longer right

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so first of all we're coming under

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threat um in terms of Lifestyle because

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we're living too long you know if we

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were knocking about in the savannah in

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Africa we'd probably be you know

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probably been making 35 or 40 years

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we're not now the average life

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expectancy in the UK is about 82 years

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so the battery is already in very very

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poor condition because of lifespan

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extension and then also we're surviving

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in disease because medicine is helping

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us survive disease so that's putting us

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all in a very very difficult situation

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so and another thing that most people

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don't take into account is that in

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modern buildings our glass blocks

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infrared light so we're blocking the

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sunlight element that is very very

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helpful to us which is infrared and we

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do that because you want to control the

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internal temperature of the building and

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if we let infrared light in buildings

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get hot so we're inside we're not

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getting any infrared from our lighting

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anymore we're blocking the infrared

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lighting um in our glass in modern

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buildings um so we have an an infrared

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crisis now Bob Fosbury my colleague

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draws the analogy with scurvy uh scurvy

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is a disease that you get because you

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don't get enough vitamin C you get a

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disease because something is absent so

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he draws the analogy I think very very

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correctly with red light starvation we

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are in a situation of red light

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starvation so hence this interest in red

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light we're all kind of scurrying around

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saying red light yeah maybe we should be

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getting some red light but at the same

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time you're correct we need a rationale

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what is the rationale for this what is

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our Target what what are our devices

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what do we want to do with it um so we

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are in a situation of red light

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starvation it's a it's a really bizarre

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I mean I don't know how you feel about

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this because you're so close to it but

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this year specifically I've gone from

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knowing nothing about light to suddenly

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I know I still know nothing but I

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understand this crisis and you know feel

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I got to do something about it so

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spending consciously and and uh you know

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reading your papers and speaking to you

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if we start with some um uh

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understanding of the way wavelengths

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between red light so how far can W red

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light specifically penetrate the body

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well okay so this is this the longer the

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wavelength the deeper the

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penetration um and this isn't published

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yet but it will be published shortly so

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um again and my colleague Bob Fosbury

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who's fundamentally an astronomer said

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Glenn I I I think this red light some of

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this red light can go through your body

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so we lined up a whole group of

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individuals on a sunny day outside the

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back of the Institute of Opthalmology

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and we got them to take their shirts off

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and we put some instrumentation on their

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back and we can measure sunlight coming

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through your quad now the bit that comes

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out of the other end is pretty small

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very small but that does demonstrate

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that that those deep red wavelengths

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which are beyond the range that you can

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see about 850 um they're penetrating

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your body when you're walking down the

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street they're penetrating your body and

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clothes don't stop them unless you're

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wearing rubber or metal um so those

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wavelengths of light penetrating

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straight through the body so if you

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think about deep organs of your body um

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they're being exposed to they're being

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exposed to Long wavelengths of light if

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you're

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outside well it's it's quite hard to get

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your head around so yeah it is as a

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result it can penetrate the body and

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stimulate the mitochondria in any sort

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of cell skin you name it right well no

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you don't have to pale skins um you know

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some of the people we measured it in are

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people who you know Africa cariban um so

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what what we do with this is you know we

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we we work out which wavelengths they

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are and they tend to be the longer ones

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but we then take people into into

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laboratory settings where with those

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wavelengths we expose them to those

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wavelengths and then we test their

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vision and we find that in and vision is

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highly dependent on mitochondria and we

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find if we expose them to those

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wavelengths we recharge the batteries in

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their eyes and we can get their visual

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function to

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improve um so so sunlight is important

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for lots of metabolic processes um it's

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important

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for uh high energy demanding processes

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like your visual system uh we know if we

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expose um insects to Long wavelength red

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light they their Mobility improves so

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older flies and older bees become have a

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greater degree of Mobility if we pump

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their mitochondria up so it has a very

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wide effect now if we look at things

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like flies flies are very cheap it's

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very easy to do experiments with flies

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and you can ask them to do things like

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can you remember this can you do this we

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find that older Flies who have got

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memory deficits and have got problems

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with uh how they walk around and

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understand their world we get an

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improvement with long wavelength life so

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all of this is seated in the in in the

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situation of Aging we get these

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improvements in aging flies we get these

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improvements primarily in aging

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individuals you can get them in younger

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ones as well and if you remember some of

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the things that some of the unfortunate

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things that are happening in public

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health now is we have aging populations

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but we have an explosion in diseases of

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Aging populations such as diabetes

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Parkinson's disease and macular

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degeneration so so much on tap there so

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um would would that be all under the I

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guess the bracket of the mitochondrial

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Theory of Aging yeah a lot of it would

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and then that Theory of Aging which oh

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God it's really old now it's terribly

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old I don't think the Harmon the I don't

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know if Harmon is still alive or not I'd

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love to take him out for a drink um yeah

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you know there are many theories of

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Aging the mitochondrial Theory of Aging

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um sticks to the wall really well you

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know the basic process that that he

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talked about about mitochondria failing

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and failing to produce enough energy and

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then starting to produce

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pro-inflammatory things like reactive

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oxygen spe he was spot on absolutely

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spot on well there seems to be some

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parallels with the ketogenic diet of a

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lot of the benefits of the ketogenic

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diet for things like cardiovascular

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disease Alzheimer's and Dementia um and

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epilepsy and things apparently is the

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mechanism is down to it makes you more

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mitochondrially healthy a quick question

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on the eye um when you said that when

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they're exposed to red light in the eye

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is is the retina really mitochondrial

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dense is is there a lots of mitochondria

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there or is it just so your photo

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receptors in your retina have got more

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mitochondria than any other cell in your

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body now your your retina burns more

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energy than any other part of your body

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it burns more energy than your muscles

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it burns more energy than your heart it

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burns more energy than your liver it is

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in

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a we talk about it as being on a

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metabolic Cliff it is in a very

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dangerous situation because if you burn

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lots of energy you generate lots of

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rubbish

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right so that dust bin is filling up

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because you're burning lots of energy um

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the retina is unique in that respect um

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and yeah retina is incredibly energy

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dependent and that made life very easy

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for me because when I came into this

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field I came in as a retinal person and

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so my my home territory was completely

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fertile for trying to attack this

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problem wow okay that makes sense so so

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you came to this through the retina

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which is one of the most mitochondrial

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packed places and then that gives you

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this sort of mechanism of red light in

play18:34

blackbox mitochondria recharged energy

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out yeah yeah to be honest with you any

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anyone that makes that story more

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complicated is pulling wool over your

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eyes really well this that that this

play18:46

music to my ears because I can roughly

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understand that at least um so okay so

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that's with the retina looking at sort

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of other interventions I really enjoyed

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your paper on um the effects on insulin

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could you walk us through how that paper

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came about um and then maybe we just

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talk about sort of how how does red

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light affect insul okay so um this was

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this was down to one of my colleagues

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Mike poer and we're beginning to realize

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that mitochondria rule lots of other

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things and there's lots of things we

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don't know about but we know that

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mitochondria they themselves demand

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energy and that energy is glucose and

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oxygen

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so Mike and I were on a long drive to go

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and do a piece of research somewhere

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else and Mike said to me if we make

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mitochondria work harder then in theory

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um they're going to need more sugar and

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the only place I can get it from is your

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serum and you know this was a bit of a

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revelation it's you you only come you

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only have these conversations up when

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you you're sitting there and you got a

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long period of you know just mind

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rolling so I said well I'm not taking a

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risk on that um so Mike then said

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because we'd always been working on and

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off on bees he said well why don't we do

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it on

play20:06

bees sampling blood in bees and but we

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had a bit of experience there so what

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Mike and I did was we took some bees we

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um we gave we gave them a blood glucose

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tolerance test which is lots of people

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have had them but what we do is we just

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starve the be overnight so then you give

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the bee a big drop of glucose and of

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course the be

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goes and it blood glucose level or the

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equivalent of blood hemolymph went woof

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right and really really high so we did

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two horrible things to the bee some bees

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we gave them a big burst of red light

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and the other bees we gave them a big

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burst of blue light so one in one with

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the red light we're making their

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mitochondria work hard and with the with

play20:56

with the red light with the blue light

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we're slowing their mitochondria down

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and it had an a direct effect on their

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blood glucose levels so we knew from

play21:06

that model and everything with

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mitochondria if it works in a fly tends

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to work in a human so we knew proof of

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principle right proof of principle it

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worked so then uh we got ethical

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permission we got a whole group of

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people in and it was a horrible

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experiment you know you stick a oxygen

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you stick a tube up people's noses to

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measure this CO2 because if you're

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burning more oxygen you'll kick out more

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CO2 we're pricking their fingers every

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few minutes and then we're asking them

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to drink the most disgusting pile of

play21:37

glucose you really know who your friends

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are when you when you need subjects like

play21:42

this and lo it came out came out so well

play21:47

I said to Mike I want the whole lot

play21:49

replicated let's just put all the data

play21:51

aside let's start again with a different

play21:54

group of people let's replicate the

play21:55

whole thing and we did and was one of

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those perfect experiments the

play22:00

replication came out exactly the same as

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in the first the first experiment

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so red light can reduce blood glucose by

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making your

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mitochondria drink more glucose that

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they take from your serum now these were

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ordinary healthy

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people um including some of my relatives

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um but Mike has now gone on to do it

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with type two diabetics and I have seen

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early signs of that data and it looks

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great right so and with that we were

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shining red light on a region of

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people's backs uh for about 15 minutes I

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think we could do better I think we can

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I think we can give less light um

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shorter time periods and get and get the

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same effect now a natural question from

play22:57

this is

play22:59

Shining Light on a little bit of

play23:00

someone's back small proportions of body

play23:04

area why a mitochondria all over the

play23:07

place consuming more

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sugar and the thing is that if you

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manipulate mitochondria in one part of

play23:14

the body the story gets out mitochondria

play23:19

talking to one another right across the

play23:21

body we know that from a number of

play23:23

experiments that been done ages ago

play23:25

where people would manipulate

play23:27

mitochondria one bit of an animal and

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then they'd see them change the

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following day over here no one really

play23:33

had a great idea what what was going on

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but of course you know you you can't

play23:39

have metabolism changing in one place

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not the other so um we did find in in

play23:45

animal experiments the moment we hit

play23:47

them with a burst of red

play23:49

light a signal changes in the blood and

play23:53

that signal is something called cyto

play23:54

kindes and they're very often associated

play23:57

with inflammation but they're also

play23:59

signaling molecules so mitochondria are

play24:04

affected by the red light they change

play24:07

their

play24:08

metabolism and they leave a message that

play24:10

goes out and that message goes out to

play24:13

mitochondria in other parts of the body

play24:16

that do not receive the red light and

play24:18

those mitochondria change and come into

play24:21

line with the ones that were exposed wow

play24:28

so you wouldn't have to um there

play24:31

wouldn't be any argument for say the

play24:33

stomach over the back because it's not

play24:35

centralized it it spans out for the

play24:37

whole body body yeah so I had a dream to

play24:41

I had a dream which we talked about with

play24:42

the team I said wouldn't it be this was

play24:45

before all this came out I said wouldn't

play24:46

it be fantastic if you went to the hole

play24:49

in the wall to take your money out when

play24:53

you did that you used your hand as an

play24:56

ident as an identifier so you put your

play24:58

hand down as a unique identifier and

play25:01

then while you were doing that you were

play25:02

getting a burst of red light while

play25:04

you're waiting for your money to come

play25:05

out now that was a dream ticket um

play25:09

that's not a dream ticket anymore that's

play25:11

doable that is doable there are other

play25:14

people in other Lads exposing different

play25:17

parts of the body and getting effects in

play25:20

completely different regions right so I

play25:23

don't have to shine stuff in your eye I

play25:25

don't have to do something which you're

play25:26

going to find uncomfortable

play25:29

awkward we just need to expose one part

play25:32

of your body and if we wait 24 hours

play25:35

we'll get it to kick in wow I wonder

play25:37

what the minimum effective dose is

play25:39

because the back's quite a big area

play25:41

right like how I guess my question is

play25:43

how how much could you shrink that down

play25:46

what's the threshold where you could

play25:48

shrink it down to actually get the same

play25:50

effect really good question um now I

play25:54

can't answer you in terms of area but I

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can answer you in terms of time so if we

play26:00

go to if we go back to our bees remember

play26:03

what we find in a bee we very often find

play26:05

in a uh we find normally finding a human

play26:09

if I take the time

play26:11

down um to you know I take the time down

play26:15

to three minutes fine everything works

play26:18

as well as if it was 15 minutes if I

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take the time down to under one minute

play26:23

nothing happens now what is interesting

play26:26

here is this is not a dose respon curve

play26:29

it's not like I've got a hangover I'll

play26:31

take 15 Aspirin because it's better than

play26:33

one this is a switch everything that

play26:37

people have found in this area indicates

play26:40

it is a switch so that we are doing

play26:43

something maybe an enzymes being

play26:45

released proteins being released and

play26:48

that is the key thing now when it comes

play26:51

to um energy the amount of energy you

play26:55

might need in that red light again that

play26:57

is coming down so a study that was done

play27:00

in morefields Eye Hospital on improving

play27:03

retinal function showed that well they

play27:06

did an experiment and we gave them the

play27:08

devices to do it and the devices ran on

play27:10

batteries and when the batteries came

play27:12

back I said to them you've not changed

play27:14

the batteries the batteries are

play27:17

underperforming um and then when we

play27:19

looked at the data we found that um they

play27:23

were getting a result they were getting

play27:24

a good result

play27:26

so there we been using let's let's let's

play27:30

say 8 to 10 millatt per per centimeter

play27:33

Square just just remember 8 to 10 well

play27:36

these people who are you know generally

play27:38

really good were getting a result with

play27:40

one now the reason they were getting a

play27:43

result with one was that when they were

play27:46

administrating administrating the light

play27:48

there was no blue anywhere it was red

play27:51

only okay so if you if you start to mix

play27:54

blue in with it from other sources it

play27:56

doesn't work as well so all of this now

play27:59

I can't answer your question about how

play28:01

many square meters of skin we need but

play28:04

everything is telling us that what we've

play28:06

been doing so far has been over the top

play28:10

we can reduce it

play28:13

um hopefully hopefully we know the time

play28:16

we know it's going to be a minute we

play28:18

know the dose is really quite low when

play28:20

I'm saying one um uh millatt per cm

play28:24

squared that really is a relatively thin

play28:26

bike light you know that is that is not

play28:29

that great area we'll find out but I

play28:33

don't know at the moment if you had to

play28:35

Hazard a guess which would be the most

play28:36

effective area or would that

play28:39

be well well when you think about retina

play28:43

when I'm doing the eye I mean that's an

play28:45

area like that that's pretty small but

play28:47

it shouts it shouts at the rest of the

play28:49

body I think we're probably talking

play28:54

about maybe 10 square cm

play28:58

you know it may be the case that if we

play29:00

if we cut it down further we get an

play29:01

effect but maybe the effect takes a

play29:03

little bit longer to kick off that's

play29:05

quite possible there's so many things

play29:08

here I I we know it works we know we get

play29:11

a result we know that the result can

play29:13

have clinical impact we haven't hunged

play29:17

down yet the real bottom end where's the

play29:20

bottom end of all this I don't know that

play29:23

from a pragmatic point of view if I was

play29:25

sitting here I'd be saying pragmatic

play29:27

point of view I don't care

play29:28

because I'm already giving you something

play29:30

that's not disturbing your life it's not

play29:34

inconvenient and I'm getting effect you

play29:37

know so switch worry as you said it's

play29:41

the switch it's not the sort of dose

play29:42

dependent an hour is better than half

play29:44

hour it's just turning that switch on

play29:46

yeah just just as you thinking as you're

play29:48

talking

play29:50

the most studies ever done in the lab

play29:53

have been under blue light is that

play29:55

correct um well when people have been

play29:57

doing studies with light there have been

play29:59

a lot of studies on animals done on Blue

play30:01

Light um hunting out for damage um very

play30:08

rarely have they defined the exact

play30:11

wavelength of the light they've used and

play30:13

the exact energy of the light they have

play30:16

used people go Blue well blue is a

play30:18

meaningless term it just happens to be

play30:20

something that we Define because we see

play30:23

this and we call it blue in natur fact

play30:25

you've got to give the wavelength what

play30:27

is the wavelength length you know if

play30:29

I've got if I've got an eagle sitting

play30:30

next to me and I show it one type of

play30:33

blue it's going to look very different

play30:35

to that eagle than it will do for me you

play30:37

know it's it's just that our photo

play30:39

receptors are tuned in a certain way so

play30:42

yeah there's been a lot of work done on

play30:44

Blue Light because there is this this

play30:47

notion that is correct although poorly

play30:49

defined that blue light is damaging and

play30:53

blue light on its own does you very few

play30:55

favors because it discharges your

play30:58

mitochondrial

play30:59

battery so but is there an argument for

play31:04

surgeries to be done under red light as

play31:07

a result

play31:08

is sorry carry on no I was just sorry I

play31:11

mean I was just more just making these

play31:13

questions up because I'm F on this

play31:14

tangent but

play31:15

the okay go as long as you okay with

play31:18

that because it just if the history of

play31:21

the last 100 years most clinical things

play31:24

be surgeries or scientific studies on

play31:26

anything have been under one wavelength

play31:29

of

play31:30

light I shouldn't say color but I wonder

play31:33

if there's a um if there's any reason to

play31:36

actually change the spectrum of light

play31:38

you might change the outcome in

play31:39

surgeries or things that could help I

play31:41

don't know key one here is one of the

play31:43

early experiments that was done under

play31:46

red light was a NASA study where they

play31:50

were doing something under red light

play31:53

that involved them nicking their

play31:55

fingers and they found that wound healed

play31:59

faster under red light now all of the

play32:02

data that we are currently looking at

play32:05

indicate

play32:06

that wounds will heal better under long

play32:10

wavelength L now if that's a pile of

play32:14

rubbish worst case scenario is you

play32:17

bought a red light you

play32:20

know the belief amongst us is very firm

play32:25

that um the red light is going to be is

play32:29

going to help wounds heal and the

play32:31

mechanism for that is there we can

play32:33

understand that because it will reduce

play32:36

inflammation now most of the most of the

play32:40

lighting in hospitals is now LED

play32:43

lighting it's very very strong in blue

play32:45

and it has almost no red in it and that

play32:48

is a point that needs to be

play32:51

addressed um and again it's it's minimum

play32:54

cost absolute minimum cost if we can get

play32:57

people out of

play32:59

beds if we can reduce bed blocking by

play33:03

changing a light bulb if we can reduce

play33:06

it by

play33:08

5% the NHS is onto a winner right now

play33:13

particularly in older people where their

play33:15

battery the mitochondria are

play33:16

underperforming if we can get those

play33:18

older people out of beds in hospitals by

play33:23

changing a light bulb that's got to be a

play33:26

winner wow it just seems like such a

play33:29

such loow hanging fruit for yeah see you

play33:34

know this El this aging population with

play33:36

all these diseases and if you can as you

play33:38

say flip this switch in them and how

play33:39

they live um it seems like quite a

play33:42

lowcost solution that has a load of B

play33:45

your bu yeah so let's get rid of the

play33:47

blue light here's another great story um

play33:51

it's a very important story and again it

play33:54

bounces back to NASA so NASA published

play33:56

this big paper

play33:59

um with Lo loads of authors loads of

play34:01

really big names on it and they said we

play34:03

have a problem with astronauts on the

play34:05

International Space Station they are all

play34:08

suffering they are suffering from

play34:12

mitochondrial Decline and that is being

play34:15

presented in two forms one is they're

play34:18

showing signs of premature aging

play34:20

remember these people are up there for

play34:21

for long periods and everything they do

play34:25

all the day is being monitored so there

play34:27

suffering from premature aging and

play34:29

they're suffering from pre-diabetes all

play34:33

these really fit people look at the

play34:35

environment they're all under super

play34:38

harsh white

play34:40

LEDs now the great thing about the NASA

play34:44

study was they excluded the obvious

play34:46

which is no gravity it wasn't something

play34:49

to do with that and they put it out

play34:51

there as they put it out really as a

play34:53

question what is going on but it was a

play34:55

great experiment because it's an

play34:57

experiment where you know I can't get

play34:59

hold of a group of people and put them

play35:00

under LED lighting 24 hours a day for

play35:03

months on end but they did it for us and

play35:07

that was great wow yeah the extremes

play35:10

teach the best good or bad right in that

play35:12

extreme environment you

play35:13

suddenly uh this environment you can

play35:15

pull those a lessons from so now in NASA

play35:18

uh in the International Space Station do

play35:20

they have red lights everywhere or no no

play35:24

I think that perhaps we should also see

play35:26

NASA in it wider context

play35:28

so

play35:29

NASA is partly run by the military um

play35:33

you don't get all the stories out that

play35:34

you want but NASA want to unload

play35:38

long-term space flight to private

play35:40

companies so private companies they

play35:43

would like private companies to be

play35:44

involved in um sending people to Mars

play35:48

are they really going to go and tell

play35:49

everybody that these people they're

play35:51

sending out to Mars could get

play35:53

mitochondrial disease because they're

play35:55

going to be they're going to be out to

play35:56

Mars for a of a lot longer than the

play35:59

people on the International Space

play36:01

Station so we've announced it we've told

play36:05

the European Space Agency um about it

play36:09

and they certainly listened um I don't

play36:11

know if they're doing anything about it

play36:14

but uh Bob Fosbury who was the person

play36:17

who uh coined the term about red light

play36:21

starvation he was a leading scientist at

play36:25

the European uh space

play36:28

Association and he is the guy who built

play36:31

the spectrometers on the James web

play36:34

telescope so he has a lot of profile

play36:36

with them um and I'm sure they're

play36:39

listening but they're not saying a lot

play36:41

wow okay maybe some first incentives

play36:43

there that's uh you've got the um as

play36:46

with health often you've got the the

play36:49

research and the anecdotal data all sort

play36:52

of screaming and then you've got public

play36:54

policy just taking a little bit longer

play36:56

to to catch up so what you think the uh

play37:00

the the the Catalyst to to force some

play37:03

change the catalyst is someone listening

play37:06

and that is why I'm really happy to talk

play37:08

to you and I will take off any amount of

play37:10

time to talk to yourselves and other

play37:14

people I need a senior civil servant in

play37:17

the department of health or a

play37:20

minister in a health department to pay

play37:23

attention and I would say you know I

play37:26

would emphasize yet again

play37:28

we have got ethical approval from

play37:29

morfield Eye Hospital from University

play37:31

College there is we've had some people

play37:34

taking red light on their own bat for

play37:37

years there is no health problem okay

play37:41

there is no

play37:42

downside the only downside to all this

play37:46

is you got to go and buy a red light now

play37:50

the red lights that you're seeing you

play37:52

know that are on the market 100 quid you

play37:54

know those lights that you're paying 100

play37:57

for can be can be landed UK at

play38:01

$12 right because it's Health they're

play38:04

charging a fortune in fact I had to

play38:08

exclude and story much told a lovely old

play38:12

lady from a clinical trial she was great

play38:15

and I had to say look because of a b c

play38:17

and d i can't include you and she was

play38:21

she was bit fed up with me um and she

play38:23

turned up back on the door about a month

play38:26

later and she had a battery in her hand

play38:28

and she had an LED an infrared LED and

play38:32

she joined it with her fingers and she

play38:34

held it up in front of her eye and she

play38:37

said Glenn will it work I was I was

play38:40

really taking a back and I said well

play38:41

come and have a cup of

play38:43

tea and I asked a member of the team to

play38:46

measure the energy and measure the

play38:48

wavelength and they came back and they

play38:50

said that'll work so there is nothing

play38:53

mystical here there is nothing that

play38:55

requires high tech there is nothing that

play38:57

requires a vast amount of money okay as

play39:00

I say worst case scenario you bought a

play39:03

battery you bought an LED and I look

play39:05

like a fool but I don't think that's

play39:07

going to happen yeah there's this old uh

play39:11

this old phrase where there's mystery

play39:12

there's margin

play39:14

and yeah yeah so you know we're just not

play39:18

talking about that little old lady in

play39:19

her vision we're not just talking about

play39:21

people with Maul degeneration we're

play39:23

talking about people um we're talking

play39:25

about diabetic crisis

play39:28

country has a has a diabet that is

play39:30

costing us a fortune yeah why don't we

play39:32

just think

play39:33

laterally well the market for so my

play39:36

background's um Health startups and the

play39:38

market for uh um I guess things to

play39:42

manage insulin um better and reduce that

play39:44

glucose Spike or insulin Spike um it's

play39:47

vast and you more people have continuous

play39:50

glucose sponsors and um you know I I got

play39:53

I got pitched a a supplement that

play39:55

reduces your insulin Spike you take it

play39:57

with when you take it with food actually

play40:00

well red light seems to be way more

play40:02

cost- effective solution than that I

play40:04

mean just it's just interesting uh an

play40:06

interesting tool that no one is really

play40:08

talking about in that Spectrum in that

play40:10

in that space which is very very

play40:12

fascinating you know ABS we've got um

play40:15

we've got a we do talk to we are now

play40:19

talking very very seriously to

play40:21

Architects I spend most of my time now

play40:24

not in the medical school but actually

play40:26

in the Bartlet School of AR architecture

play40:28

at UCL they they are firmly they know

play40:32

what's happening firmly on board there's

play40:34

also a number of small lighting

play40:35

companies that are at The Cutting Edge

play40:39

specialist lighting companies and one of

play40:41

the people that run one of those

play40:43

companies um put a patch on his arm

play40:46

walked around and took red light and he

play40:48

came back and said Glen this works I

play40:50

said yeah I know it

play40:51

works how do we get belief how you know

play40:55

how many papers have I got to publish

play40:58

before someone says you know okay

play41:01

there's something in this there was a

play41:03

good colleague of mine once said you

play41:05

know is there much point in publishing

play41:06

because a lot of people just don't

play41:08

bother to read it anyway you've got to

play41:10

make a splash you've got to go in the

play41:11

media you've got to talk and and and

play41:14

pick people up that

play41:15

way well I don't know I mean I've never

play41:18

published a paper but I imagine it's the

play41:19

you know you got have the right products

play41:21

and the right distribution and uh you

play41:22

know things like this is the

play41:23

distribution right you got you got got

play41:24

to talk about it um yeah I mean that's

play41:27

the wonderful thing about these podcasts

play41:29

um not necessarily this one or this guy

play41:31

hosting it at all but it's just reduces

play41:34

all friction to to to get a message out

play41:37

um I'd be remiss if I didn't ask about

play41:39

skin complexion and collagen um a lot of

play41:41

questions coming in about you know you

play41:43

see all the red light masks specifically

play41:45

for way more than 100 100 pounds um is

play41:49

there any efficacy behind that and sort

play41:52

of it can upregulate collagen and what

play41:54

all these companies claim or is that

play41:56

well

play41:57

I don't think they know what they're

play41:59

doing right very few of these companies

play42:02

actually know what they're doing very

play42:04

few of these companies will give you any

play42:06

specific data about their devices and

play42:09

what their devices are doing I would say

play42:11

that the evidence in favor of wound

play42:14

healing and reduction in wrinkles the

play42:18

evidence is there that something is

play42:20

going on but when you go and buy your

play42:23

device and you pay some outrageous

play42:25

figure like $400 quit they don't know

play42:28

how much that energy they've got to give

play42:30

you you know they've got absolute they

play42:32

don't know the exact wavelengths that

play42:34

they should be using it's all out there

play42:35

you can read it even more importantly

play42:39

one of the one of the key things about

play42:41

red light devices is your mitochondria

play42:43

you can only sort of recharge your

play42:45

mitochondria in the mornings doesn't

play42:48

work in the afternoon doesn't work in

play42:50

the afternoon because mitochondria do so

play42:52

many different things that you know I

play42:54

say to people look in the afternoon the

play42:56

mitochondri doing the ironing doing the

play42:58

dishes doing the other things they need

play43:00

to do in life so everyone's selling you

play43:03

these devices and they're not telling

play43:05

you they don't work in the afternoon wow

play43:08

so you have to fall in line with the

play43:09

Master Clock which is you say Kum Rhythm

play43:13

the the the mitochondria have got their

play43:16

own clocks the mitochondria kick

play43:20

themselves into action I think it's

play43:22

related to perceived Dawn and they kick

play43:25

themselves into action about half an

play43:28

hour before perceived Dawn and then when

play43:31

they're working really hard you can give

play43:33

them a red light and they'll work even

play43:35

harder if you catch them at 3 o00 in the

play43:38

afternoon you can give buckets of red

play43:39

light and nothing happens and that's

play43:41

true in a fly and it's true in a human

play43:44

being wow funny I don't know if there

play43:46

anything to do with things but it seems

play43:48

to follow the same dial rhythm of

play43:50

hormones you know testosterone is very

play43:52

high and and cortisol very high in the

play43:54

morning and fluctuates down wonder if

play43:56

there's a link between I I I think the

play43:59

link is very much um in your

play44:01

evolutionary history when you were

play44:03

waking up or you know in in Africa um

play44:07

you know um when you wake up you're

play44:10

extremely vulnerable very vulnerable

play44:12

you've been vulnerable for a while

play44:14

you've been you've been asleep you've

play44:15

probably been snoring announcing your

play44:17

presence to absolutely everybody the

play44:19

Tigers the sabertooth tigers have come

play44:21

along they know where you are your

play44:24

testosterone has to be high your glucose

play44:27

levels has to be high and your

play44:28

mitochondria have to be pumping out ATP

play44:32

because you need to be in a super fit

play44:34

State when you wake up in the morning I

play44:36

think it's all tied into that that makes

play44:39

yeah that that that makes a lot makes a

play44:41

lot of sense it's so fascinating where

play44:43

this field goes and um sorry the wind

play44:46

was blowing my door open um where this

play44:48

field goes and uh I don't know what the

play44:50

next five years look like I mean from a

play44:52

policy point of view and sort of the

play44:53

entrepreneurial potential there is here

play44:55

and you know which one sort of Push It

play44:57

Forward I don't know um what are you

play44:59

most excited about in this field

play45:04

um there are so many things that excite

play45:07

me so I'll let I'll let you know I'll

play45:09

let you know about One um and it's

play45:12

personal okay um we've got children with

play45:17

a very rare

play45:19

disease um that is mitochondrial based

play45:24

and um

play45:27

one of the parents asked me whether they

play45:29

whether there was any Theory whether red

play45:31

light could be used and I said I don't

play45:34

have ethics to do this I don't know

play45:37

enough about it I suspect that at this

play45:40

stage I said I suspect that you're not

play45:43

going to do any

play45:45

harm they used red light and there was a

play45:48

very dramatic effect within two weeks um

play45:53

when I saw the pictures I you know

play45:56

people know I I went to the toilet and

play45:57

burst of Tears um now we now have a

play46:00

small clinical trial for that it's a

play46:02

rare disease that excites me and it you

play46:04

know I roll over in bed and I think I

play46:06

did something worthwhile today you know

play46:08

that something really worthwh where else

play46:11

does it excitement it excites me because

play46:13

I go into talk to groups of people and I

play46:16

say you've just not paid attention to

play46:18

light generally what light is doing we

play46:22

have to and part of the mission that a

play46:24

small group of us have got now is let's

play46:27

remove LED lighting there is something

play46:30

in L well we know what it is it's an

play46:32

absence of red light let's go back and

play46:35

find another way of delivering broad

play46:38

spectrum light so I am going into

play46:41

environments where people are

play46:44

sitting um in rooms without daylight um

play46:49

and they're sitting there with LED

play46:51

lighting and we're carrying out quite

play46:53

sophisticated experiments to test their

play46:56

their visual function and then I'm

play46:58

taking the light bulbs out and I'm

play47:00

giving them old incandescent light bulbs

play47:03

and I'm going back a week later and

play47:04

we're reasuring their visual function

play47:06

and it's better now I'm not measuring

play47:08

their blood sugars I'm not measuring

play47:10

anything else but you know it seems to

play47:14

me that someone W won the Nobel Prize

play47:18

for LED lighting because we're saving

play47:20

energy and that was a great bit of

play47:23

science but we didn't realize the

play47:25

consequences just didn't realize if we

play47:28

can get people to go back to a different

play47:32

form of lighting we're going to improve

play47:35

it's a public health issue you know it's

play47:37

it's public health if we condent blood

play47:41

sugars um if we cond Dent these problems

play47:45

that are

play47:46

mitochondrial that are all to do with an

play47:48

aging population um like Parkinson's

play47:52

disease like macul

play47:54

degeneration that's great I mean I I I

play47:56

will put a I will put a punctuation

play47:59

point at my career if if we can get

play48:02

policy makers to pick that one up

play48:04

because the science is

play48:06

there I love uh I love your optimism for

play48:10

that and I hope I hope becomes a becomes

play48:13

a becomes a thing um the Matt Ridley

play48:17

wrote a great book of how Innovation

play48:19

Works and he makes a good argument for

play48:21

uh entrepreneurship pushes policy faster

play48:24

than policy can push entrepreneurship

play48:27

and uh maybe that's the the way way to

play48:29

do it who knows um what is your personal

play48:33

practi because obviously you're so in in

play48:35

in in the literature and you're

play48:37

publishing literature yourself what is

play48:38

your personal practice with a red light

play48:41

look like uh my personal practice and

play48:43

that of most of my colleagues is well I

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mean if you could come in my office

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you'd realize that all my lighting is

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incandescent lighting um my outer lab

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space is all incandescent lighting my

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home is incandescent lighting

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um I when I get up in the mornings I

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will very often turn on a a red light

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and Just Bounce It Off the Wall while

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I'm getting breakfast or if I miss that

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one what I do is I I cycle into work and

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I get into the office close the door and

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start stripping off the kind of horrible

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sweaty cycling gear and then I've got a

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red light that again I'll bounce off the

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bounce off the wall

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and all of us are doing it you know all

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of us are doing and the big mistake is

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is to suddenly think because I'm

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bouncing this red light off the wall I'm

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going to I've going to have better

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memory I'm going to have better muscle

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control I'm going to better this better

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that it doesn't work like that it just

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it just means that in the long run

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things are going to improve things are

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not going to go downhill at the same

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Pace that they would do otherwise and

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there's this I've struggled I've

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struggled like crazy to find a downside

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I need I need I need some that is a

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downside and we haven't found it we

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haven't found it at all and the other

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thing is you know I um I cycled down the

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Holloway road which is a pretty

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miserable Road in London but I as I'm

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cycling down it I'm facing

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south and on a sunny day I'm getting

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half an hour of burst of

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sunlight and would you say that's

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enough I'd say it's a bare minimum bare

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minimum you said I have I can I can I

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can wield this technology into a

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situation and say Here's a light at 850

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nmet I've got the I think I've got a

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very very good sticking plaster on a

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problem the resolution of the problem is

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really going outside just going outside

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I mean another really interesting angle

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on this is that there is a strong

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relationship between the development of

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myopia in

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children and the absence of red light

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the Chinese have and I'm I'm unsure of

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the mechanism but I do believe the

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result and it's clear that if you bring

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kids inside spend a lot of time in in in

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classrooms if they're doing lots of

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close work um you're going to develop a

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myopic problem and that's that's

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enormous in the Far East Malaysia China

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Japan um and the answer there is

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sunlight the uh my my stepdad he had a

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um retina because he was very very

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myopic and classic classic yeah in we we

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came across some of the the papers in

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prepping for this and actually sort

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of would have that would that have

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helped um pre-retina detach um by all

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accounts yes so it would have helped him

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when he was a child and he was

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developing the myopia see once you're an

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adult my opio is when the eye grows too

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long once it's out here

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you can't do anything to bring it back

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here but you can slow its growth by

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making children spend more time outside

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in sunlight great study well initially a

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great study done by the Chinese showing

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that red

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light reduces the rate of myopia

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published relatively recently the

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downside was they used a

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laser and you should really never use a

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laser on the retina unless you really

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have to and the consequence was some of

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these children developed retinal lesions

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and that's held that is going to hold

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the field back there is no reason for

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using a laser for all of the things that

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we do go and get an LED it's safe it's

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cheap um all this technology should be

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led based and not laser based yeah if

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there's a if there's a downside like

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like that why why would you use it and

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just a question on near infrared light

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um what uh how does it different from

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red light and are there other benefits

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that that can unlock is that a whole

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different field or just so so the

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wavelengths that people are using

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predominantly um are 670 and above if

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you go below 670 the efficacy is reduced

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now 670 is defined as near infrared

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infrared starts sort of 700 plus okay

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but this is just it's nomenclature it's

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it's about where we're where we're

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drawing borders so um a device at 630

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which is red it's not near infrared it's

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not going to do you any good bicycle

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light probably won't do you any good at

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all so you know people want a cheap

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version um it is the wavelengths are

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tend to be 660 670 up to about 800 850

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nanometers you'll stop seeing the red

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light at 700 to

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750 um because your retina is not

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sensitive to it okay so my one I've got

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one red light and I can see that and the

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near I can't visibly see yeah yeah

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that's that's that's pretty and it's

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probably the infrared one that you can't

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see that's doing it's got the bigger

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kick in it in terms of health right I

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see okay because it's penetrating your

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body

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further okay right so we can get deeper

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do you have any opinion on um the uh I

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guess I don't know what you call the

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nodes you can sort of stick up your nose

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and they shine a light and yeah I do I

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do because I had a colleague doing it

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and I thought it was the most bizarre

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thing on the planet but he had a longer

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track record in in in this area of

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research than I did um and he has been

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one of the leaders in using red light

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Parkinson's disease and he did all the

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work on primate models of Parkinson's

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disease and his rationale was well if

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you stick it up your nose it's going to

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get into your brain really quickly and

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of course dealing with Parkinson's

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disease he's actually dealing with a

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deep brain structure that was his

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rationale um I can only say that I hope

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he washes it when he takes it

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out yeah I'm sure don't we all um

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interesting uh Dr Jeffy can I just end

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with some quick fire questions for you

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if you don't mind sure um okay so one of

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my favorites what's the most notable

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change you've made to your health in the

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past five

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years um the most noticeable change I've

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made uh

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doing 5 to 10 minutes yoga first thing

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in the

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morning oh I needed to hear that okay

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you know that's because I'm getting old

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I'm really aware that my back is getting

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stiff

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yeah I think the world needs to hear

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that it's uh it's easy to neglect um

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yeah and flexibility and it's so boring

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but yeah 10 minutes is it's boring it is

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terribly boring I find it so dull um

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okay and are there any books you can

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recommend that don't have to be necess

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on lights or mitochondria but that maybe

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shape your world

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VI oh there's a big big big thick book

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called um Power sex and suicide by Nick

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Lane um that but that's that's a bit of

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a that's a bit of an academic that's a

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bit of an academic book but for anyone

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who wants to dig there get their feet

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into it then I'd do that and to be

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honest with you when I go home I don't

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read academic

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books you know so I can probably give

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you a list of novels I'm finding pretty

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good but um you know when I look at when

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I look around me I say Nick Lan's books

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are very good they're extremely good but

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um I'm just reading a John lary book at

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the moment and thoroughly enjoying it

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lovely you need a bit of both right you

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need a bit of both do yeah yeah I've uh

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yeah I've got Nick Lane's book on my um

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my bookshelf and I don't want to start

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it until I'm convinced I'm going to

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finish it but it is daunting um yes it

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really is and you most of his books are

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but he heard him speak he seems very um

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he comes across really well um and last

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question from me if you could know one

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thing in your field that you don't know

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yet what would it

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be okay this is where I'm going tomorrow

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okay so when

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I when we shine light sun when we shine

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long wavelength light on people's bodies

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we get all these changes in the in the

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cyto kindes all these things are

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happening and a physical Anthropologist

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from America Nate came in and said tell

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me about fire light and I went well

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what' you want to know about fire light

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and I said and I said oh yeah fire light

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fire light's got lot of long wavelength

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light in it and he said and I think this

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is really great what has fire light got

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to do with human evolution is there a

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link between Fire Light particularly as

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we move north is there a link between

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Fire Light improving mitochondrial

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function and something to do with human

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evolution I find that absolutely

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gripping you know Absolut when when

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humans came out of East Africa and they

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moved North okay fine they went to the

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Lebanon and still nice and sunny they

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went to Turkey still nice and sunny when

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they finally ended up in tooting it

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wasn't nice and sunny right it was great

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it was miserable and they had to wear

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lots of clothing is there a link between

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how we advance in human evolution and

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our brains Advance with Fire

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Light that's that's I I really want to

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know that one before I die God I would

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love to read that

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book I'll give you

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yeah um well Dr Glenn Jeffrey that was

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unbelievable thank you so much for

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wasting your time with with this yo-yo

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here there no way I told everybody in

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the lab we got to stop doing science and

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we got to start talking Because unless

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we talk we're not going to get

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traction well wonderful well I'm I'm no

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doubt The Listener will have a a great

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time listening to this conversation so

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can't thank you once again for coming on

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great thank you very much for your time

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