Prof. Glen Jeffrey | Red Light Revolution: Charge Your Cells, Reduce Ageing & Decrease Inflammation
Summary
TLDR本视频脚本探讨了红光和近红外光对人体健康的影响,特别是它们对线粒体功能的积极作用。嘉宾格伦·杰弗瑞博士分享了他从研究果蝇到临床试验的科研之旅,解释了不同光谱的光如何影响人体代谢和衰老。他讨论了现代生活中红光缺失的问题,并提出了通过红光照射改善视力、促进伤口愈合和调节血糖水平的潜力。杰弗瑞博士还强调了自然光的重要性,并对未来光疗法在医疗和日常生活中的应用表示乐观。
Takeaways
- 🧬 研究眼睛和光线对健康的影响,特别是红光和近红外光对线粒体功能的积极作用。
- 👨🔬 线粒体对光非常敏感,光线可以调节线粒体的活动,影响代谢和衰老过程。
- 🌞 阳光包含了广泛的光谱,人类只能看到其中的一小部分,而现代生活中我们常常缺乏某些光谱,尤其是红外光。
- 🚨 现代建筑阻挡了阳光中的红外光,这可能导致了所谓的“红光饥饿”现象。
- 👓 红光和近红外光可以深入身体内部,刺激线粒体,对健康有积极影响。
- 🦟 实验显示,红光能够改善蜜蜂和果蝇的代谢健康,类似效应在人类中也得到了验证。
- 🩸 红光疗法被发现可以降低血糖水平,可能对糖尿病管理有积极作用。
- 🌡️ 红光疗法的效果似乎是开关式的,而不是剂量依赖性的,短时间的照射就能产生效果。
- 🌅 早晨是使用红光疗法的最佳时机,因为线粒体在早晨最为活跃。
- 📚 市面上的红光设备效果参差不齐,消费者在购买时应考虑具体的波长和能量输出。
Q & A
红光对线粒体有什么影响?
-红光能够调节线粒体的功能,线粒体对长波长的光有响应,可以通过充电来改善线粒体的状态,从而有助于减缓衰老过程和改善新陈代谢。
线粒体与衰老有什么关系?
-线粒体在调节人的新陈代谢和衰老速度方面起着关键作用。如果线粒体功能下降,可能会导致衰老加速以及与衰老相关的疾病的发生。
红光疗法在临床试验中的应用是什么?
-红光疗法正在从学术研究走向临床试验,研究者正在探索它在改善视力、治疗代谢疾病、帕金森病以及黄斑变性等疾病方面的潜在效果。
为什么说我们可能处于“红光饥饿”状态?
-现代建筑通常使用阻挡红外线的玻璃,同时室内使用的LED照明缺乏红光光谱,导致我们接收不到足够的红光,这可能会影响我们的健康。
红光对糖尿病人的血糖水平有何影响?
-研究表明,通过红光照射可以激发线粒体更高效地工作,从而消耗更多的血糖,有助于降低血糖水平。
为什么红光疗法在早晨最有效?
-线粒体有自己的生物钟,通常在早晨激活。因此,在早晨使用红光疗法可以更好地刺激线粒体,提高其功能。
如何选择合适的红光疗法设备?
-应选择波长在660至850纳米之间的设备,避免使用低于670纳米的设备,因为其效果可能不佳。同时,应确保设备使用的是LED而非激光,以确保安全性。
红光疗法是否对所有人都安全?
-目前的研究显示红光疗法对大多数人是安全的,但使用任何医疗设备之前,最好先咨询医疗专业人员。
红光疗法对于视力有哪些潜在的好处?
-红光疗法可以改善视网膜功能,对于视力有积极影响,尤其对于黄斑变性等眼疾患者可能有改善视力的潜力。
如何将红光疗法融入日常生活?
-可以在早晨起床后使用红光设备进行短时间的照射,或者在户外活动时,确保有足够时间暴露在阳光下,以获得红光的益处。
红光疗法对于宇航员在国际空间站的健康问题有何帮助?
-研究表明,红光可能有助于改善宇航员在国际空间站上经历的线粒体功能下降问题,从而减缓衰老迹象和改善健康状况。
Outlines
🔬 研究兴趣的起源
本段落介绍了研究者如何开始对红光和不同波长的光产生兴趣。最初是因为被邀请评审一篇关于红光的论文,尽管最初难以理解且持怀疑态度,但研究者最终通过自己的简单实验确认了红光对生物体有实际影响。这项研究在过去12年中从学术兴趣发展到临床试验,特别是研究光对线粒体的影响,线粒体是细胞的能量工厂,与代谢和衰老有关。
🌞 光与生物学的关系
这段落讨论了线粒体对光的敏感性,尤其是长波长的光如何为老化或病态的线粒体充电,而短波长的光,如蓝光,则会放电。这种光敏性与生物体的代谢和炎症反应有关。此外,提到了人们对于光和生物学之间联系的普遍认识,以及阳光与人造光源(如LED灯)之间的光谱差异。
👵 红光对衰老的影响
本段落探讨了随着寿命延长,人们在疾病中生存的时间更长,导致线粒体功能下降,从而引起衰老和各种与衰老相关的疾病。现代建筑阻挡了有益的红外光,加剧了所谓的“红光饥饿”。研究者通过实验发现,红光可以改善视力和提高能量,对抗衰老的影响。
🐝 红光对蜜蜂血糖的影响
研究者通过在蜜蜂身上的实验发现,红光能够通过加速线粒体工作来降低血糖水平。这一发现后来在人类志愿者身上得到了验证,表明红光有潜力用于治疗2型糖尿病。红光通过刺激线粒体在全身范围内产生影响,即使只照射身体的一小部分。
🚫 对蓝光的警告
这段落讨论了蓝光对生物体可能产生的负面影响,尤其是对线粒体的损害。研究者提倡减少在日常生活中对LED照明的使用,因为它们发出的光缺乏红光,可能对健康产生不利影响。同时,提出了红光疗法作为一种潜在的改善公共健康的方法。
🌅 红光与皮肤和胶原蛋白
本段落讨论了红光对于皮肤健康和胶原蛋白生成的潜在益处,尽管市场上的一些红光设备可能价格昂贵且效果未经验证。研究者指出,红光疗法应该在早晨进行,因为这是线粒体活动的高峰期。
🌱 红光对儿童近视的影响
研究者提到了红光可能有助于预防儿童近视的发展,这与中国孩子在室内长时间学习和缺乏户外活动有关。红光的照射可能有助于减缓近视的发展。
🧠 红光对大脑和帕金森病的潜在影响
这段落探讨了通过鼻腔照射红光可能对治疗帕金森病有益的理论。虽然这种方法听起来不寻常,但研究者认为它可能有助于快速将光线传递到大脑中的深部结构。
🔍 红光研究的未来方向
研究者表达了对红光研究未来方向的兴奋,包括其对罕见线粒体疾病的潜在影响,以及可能如何改善公共健康。他强调了将研究成果转化为实际应用的重要性,并分享了自己的个人红光使用习惯。
📚 推荐阅读和个人健康实践
在这段落中,研究者推荐了Nick Lane的《Power, Sex, Suicide》一书,并分享了自己如何通过每天早晨做瑜伽来改善健康。他还表达了对火光与人类进化之间可能联系的研究兴趣。
Mindmap
Keywords
💡线粒体
💡红光
💡近红外光
💡代谢
💡衰老
💡光敏感性
💡LED灯
💡光生物调节作用
💡褪黑激素
💡光疗
Highlights
研究者最初因为评审一篇论文而对红光和不同波长的光产生兴趣。
经过12年的发展,研究从学术兴趣发展到临床试验。
红光和近红外光被认为对健康有益,但具体原因尚不清楚。
线粒体对光非常敏感,光可以调节线粒体的功能,而线粒体又调节新陈代谢和衰老过程。
长波长的光可以为状态不佳的线粒体充电,而短波长的光,如蓝光,会放电。
红光可以改善视力,因为它能重新为眼睛中的线粒体充电。
阳光是生命进化的主要能源,包含了从紫外线到红外线的广泛光谱。
现代建筑阻挡了对我们有益的红外线,可能导致了所谓的“红光饥饿”。
红光可以穿透身体,刺激任何细胞中的线粒体。
红光对提高老年人视觉功能有积极影响。
线粒体理论认为,随着年龄的增长,线粒体功能衰退,可能导致衰老和炎症。
红光可能对治疗帕金森病等与线粒体功能障碍相关的疾病有益。
红光对改善蜜蜂的血糖水平显示出积极效果,可能对人类也有类似效果。
红光照射可以作为改善胰岛素抵抗和血糖水平的潜在干预手段。
红光照射的效果不依赖于照射面积的大小,而是像开关一样,存在一个阈值。
红光对伤口愈合有积极影响,可能促进炎症减少。
在国际空间站上,宇航员显示出线粒体功能衰退的迹象,可能与长期暴露在LED光源下有关。
红光可能有助于减少近视的发展,特别是在儿童中。
市场上的红光设备价格昂贵,但实际效果与低成本的LED灯相似。
红光设备应在早晨使用,因为线粒体在下午不响应红光。
研究者提倡回归使用白炽灯,以提供更广泛的光谱光,改善公共健康。
研究者个人实践包括早晨进行瑜伽和使用红光照射。
研究者对未来红光研究的期待包括其在人类进化中的作用,特别是与火光的关系。
Transcripts
[Music]
okay awesome wonderful well where are
you Ben I'm in Oxfordshire where are you
uh I'm at The Institute of Opthalmology
at University College London brilliant
but that that that's where you spend
most of your time these days am I
correctly saying sadly
yes so did your did your research into
the eye uh I guess Spike uh the interest
in red light I mean how did the interes
in red and sort of different wave
lengths of light come about um it came
about originally because I was asked to
review a paper and I looked at this
paper and I thought I don't understand a
word of this and it was one of the first
papers on red light and the next
reaction was I didn't believe it um but
then when I read it I thought these
people that did this research are really
solid they're really solid the
inadequacy is in me um and that's where
it start started to roll and I did a few
simple experiments myself and it
confirmed that something was happening
you know that there was something here
and and really over the last 12 years
this has grown and it's grown from being
um what should we say an academic
interest to us running it all the way
through into clinical trials um so it's
been a it's been an interesting
organic development of of a subject from
me working on flies to now working on uh
working on people and kids yeah it's a
really interesting um field because I
think you have all these uh all these
Health nerds who buy the massive red
lights and near Fred lights but yet
don't quite know why I mean I bought one
back in 2021 and if anyone asked me why
have you bought this I wouldn't be able
to give them an answer um but saying
that when uh my friends come around and
see my red light they think why the red
light why they new infared can we to
start with can we understand the
relationship or could you help us
understand the relationship between
mitochondria and light yeah sure now the
area of mitochondria mitochondria
research is very much the area of kind
of people who are quite Technical
biochemists and so um they they go into
mitochondria they rip them apart they
look at what's inside the
Machinery um I come from it from a
different perspective because I don't
know any
biochemistry um that's not my area so we
tend to treat them as black
boxes um so we do something to them and
something happens and we don't worry too
much about the middle ground I think
that when it comes to biology in general
if you take if you if you take plants
out of the equation and you take eyes
out of the equation people are very
unhappy looking at light and biology
right so if we look about skin cell or
we look at something like that people
are not very very comfortable but one of
the issues at stake here is that
mitochondria are very very light
sensitive and that was known a long time
ago but seems to have got a little bit
lost um and what is critical for us is
that light can regulate what
mitochondria do and mitochondria
regulate your metabolism and they also
regulate your pace of Aging so you know
they do do rather a lot of things and if
we've got a if we've got a spanner that
can actually be used to crack
mitochondria that actually is very very
important so that's how I came in I came
in I am an outsider as far as a lot of
the mitochondrial people are concerned
but know very very few people look at
mitochondria as black
boxes I guess I mean I get the
mitochondri sort of Heavy Hitters unique
lanes and those uh those types I imagine
um the looking at the Black Box I think
is a lovely way to frame the discussion
because you don't need to know the
intricacies of what goes on inside the
mitochondria right as you said something
happens light black box something
happens come out so what is the effect
um of different spectrums of light to
mitochondria okay so I always use the
analogy that let's view mitochondria as
a battery with a charge and it is a
battery and it does have a charge um but
with aging and with disease the battery
runs down you know they the mitochondria
regulate aging so it happens that long
wavelengths of light are mitochondria
respond to them by charging a battery
that is actually in a poor state so it
can be a poor State through aging it can
be in a poor State because of metabolic
disease that's one end of the spectrum
the other end of the
spectrum look at the sort of the short
wavelengths
blue the blue discharges the battery it
reduces the charge on the battery and as
you reduce the charge on the battery you
can imagine like an old car battery as
it runs down it starts to it starts to
leak acid in this case it produces
something called reactive oxygen species
and what that does is it drives
inflammation right so our battery runs
down we get old we don't have the energy
to kick our legs out of bed in the way
that used to and at the same time we
start to get inflammation because the
batter's leaking acid so that's the kind
of the simple basics of it I mean we can
talk a lot about what is it in the
mitochondria that are absorbing the
light um and I think we pretty much
identified that now giving us a sort of
good grounding for me I for me the most
important thing is driving that forward
to an application you know what can we
do do what can we do with people with
mitochondria that don't work very well
what can we do with people who who are
old I mean at the end of the day we all
get old um and many diseases are
embedded in mitochondrial function and
uh so macular degeneration Parkinson's
disease is fundamentally a mitochondrial
disease um so we've got lots of
applications we can move
towards um if we feel secure about them
definitely I I I'm I'm looking at my
script right now and I want to stay on
topic but part of me wants to deviate
and ask let tangents
and sort of the the different imbalances
of mitochondri and what that has
implications for specifically I've read
the book last week called the metabolic
theory of cancer by Thomas sa I don't
know if you've come across it no I
haven't come across that essentially
it's a theory where cancer is a uh is
coming about as a result of the defect
mitochondria um which Downstream of that
um creates all sorts of cancer but we
won't go there yet to frame the
discussion I'd love to understand and
just sort of set the parameters up of um
what different light waves do we get
from the sun because I think when you
say light everyone is used to sort of
the incandescent bulbs that get in the
home the different spectrum of light
they get in the Sun and then from there
maybe we can sort of zoom in on an
infrared and red light yes so sunlight
and I really going to sell the point to
kick off with you've evolved life has
evolved for billions of years under
sunlight light is the energy that that
drives
Evolution um so sunlight you could very
crudely say runs from the ultraviolet
that we can't see you know 350 320
nanometers and then it runs all the way
out to you around 2,000 nanometers so
it's a really wide wide spectrum but we
only see a really small window of that
Spectrum
so we only see from about 400 nanometers
to about 700 nanometers so sunlight out
here we see this bit and because we only
see a small part of it that's the bit we
tend to pay attention to and we don't
pay attention to a lot of the other
stuff now um we've evolved under
sunlight and when we when we and and
Fire Light is very similar to sunlight
in its Spectrum so you could think well
as we've evolved we've got fires uh and
then when we started to um when we
developed light in the built environment
we developed incandescent light bulbs
which are the ones that get hot which
are very Eco unfriendly at the moment um
but they give off a very wide spectrum
of light as well so um even though we've
moved in houses and into and into into
buildings for a period of time we did
have light that was rather like sunlight
and of course that changed when we moved
over to LEDs because they have got an
extremely restricted wavelength of
spectrum that we're exposed to so okay
so that that is a it's really helpful to
know so just to get on the same page for
The Listener who's not familiar with um
all the different implications of light
the sun is almost this sort of cocktail
of different light spectrums we can only
see a a select few spectrums but there
many many many and uh we're born to be
exposed to these different light
spectrums but we spend 92% of our time
indoors bulbs can mess with how we've
meant to be evolved and that can cause
all sorts of issues to my understanding
why so much attention on specifically
the red and near infrared spectrums of
light at the moment um it's because of
you know it's about recharging that
battery we know they recharg the battery
um let's put it into a wider context
which is we're living much longer right
so first of all we're coming under
threat um in terms of Lifestyle because
we're living too long you know if we
were knocking about in the savannah in
Africa we'd probably be you know
probably been making 35 or 40 years
we're not now the average life
expectancy in the UK is about 82 years
so the battery is already in very very
poor condition because of lifespan
extension and then also we're surviving
in disease because medicine is helping
us survive disease so that's putting us
all in a very very difficult situation
so and another thing that most people
don't take into account is that in
modern buildings our glass blocks
infrared light so we're blocking the
sunlight element that is very very
helpful to us which is infrared and we
do that because you want to control the
internal temperature of the building and
if we let infrared light in buildings
get hot so we're inside we're not
getting any infrared from our lighting
anymore we're blocking the infrared
lighting um in our glass in modern
buildings um so we have an an infrared
crisis now Bob Fosbury my colleague
draws the analogy with scurvy uh scurvy
is a disease that you get because you
don't get enough vitamin C you get a
disease because something is absent so
he draws the analogy I think very very
correctly with red light starvation we
are in a situation of red light
starvation so hence this interest in red
light we're all kind of scurrying around
saying red light yeah maybe we should be
getting some red light but at the same
time you're correct we need a rationale
what is the rationale for this what is
our Target what what are our devices
what do we want to do with it um so we
are in a situation of red light
starvation it's a it's a really bizarre
I mean I don't know how you feel about
this because you're so close to it but
this year specifically I've gone from
knowing nothing about light to suddenly
I know I still know nothing but I
understand this crisis and you know feel
I got to do something about it so
spending consciously and and uh you know
reading your papers and speaking to you
if we start with some um uh
understanding of the way wavelengths
between red light so how far can W red
light specifically penetrate the body
well okay so this is this the longer the
wavelength the deeper the
penetration um and this isn't published
yet but it will be published shortly so
um again and my colleague Bob Fosbury
who's fundamentally an astronomer said
Glenn I I I think this red light some of
this red light can go through your body
so we lined up a whole group of
individuals on a sunny day outside the
back of the Institute of Opthalmology
and we got them to take their shirts off
and we put some instrumentation on their
back and we can measure sunlight coming
through your quad now the bit that comes
out of the other end is pretty small
very small but that does demonstrate
that that those deep red wavelengths
which are beyond the range that you can
see about 850 um they're penetrating
your body when you're walking down the
street they're penetrating your body and
clothes don't stop them unless you're
wearing rubber or metal um so those
wavelengths of light penetrating
straight through the body so if you
think about deep organs of your body um
they're being exposed to they're being
exposed to Long wavelengths of light if
you're
outside well it's it's quite hard to get
your head around so yeah it is as a
result it can penetrate the body and
stimulate the mitochondria in any sort
of cell skin you name it right well no
you don't have to pale skins um you know
some of the people we measured it in are
people who you know Africa cariban um so
what what we do with this is you know we
we we work out which wavelengths they
are and they tend to be the longer ones
but we then take people into into
laboratory settings where with those
wavelengths we expose them to those
wavelengths and then we test their
vision and we find that in and vision is
highly dependent on mitochondria and we
find if we expose them to those
wavelengths we recharge the batteries in
their eyes and we can get their visual
function to
improve um so so sunlight is important
for lots of metabolic processes um it's
important
for uh high energy demanding processes
like your visual system uh we know if we
expose um insects to Long wavelength red
light they their Mobility improves so
older flies and older bees become have a
greater degree of Mobility if we pump
their mitochondria up so it has a very
wide effect now if we look at things
like flies flies are very cheap it's
very easy to do experiments with flies
and you can ask them to do things like
can you remember this can you do this we
find that older Flies who have got
memory deficits and have got problems
with uh how they walk around and
understand their world we get an
improvement with long wavelength life so
all of this is seated in the in in the
situation of Aging we get these
improvements in aging flies we get these
improvements primarily in aging
individuals you can get them in younger
ones as well and if you remember some of
the things that some of the unfortunate
things that are happening in public
health now is we have aging populations
but we have an explosion in diseases of
Aging populations such as diabetes
Parkinson's disease and macular
degeneration so so much on tap there so
um would would that be all under the I
guess the bracket of the mitochondrial
Theory of Aging yeah a lot of it would
and then that Theory of Aging which oh
God it's really old now it's terribly
old I don't think the Harmon the I don't
know if Harmon is still alive or not I'd
love to take him out for a drink um yeah
you know there are many theories of
Aging the mitochondrial Theory of Aging
um sticks to the wall really well you
know the basic process that that he
talked about about mitochondria failing
and failing to produce enough energy and
then starting to produce
pro-inflammatory things like reactive
oxygen spe he was spot on absolutely
spot on well there seems to be some
parallels with the ketogenic diet of a
lot of the benefits of the ketogenic
diet for things like cardiovascular
disease Alzheimer's and Dementia um and
epilepsy and things apparently is the
mechanism is down to it makes you more
mitochondrially healthy a quick question
on the eye um when you said that when
they're exposed to red light in the eye
is is the retina really mitochondrial
dense is is there a lots of mitochondria
there or is it just so your photo
receptors in your retina have got more
mitochondria than any other cell in your
body now your your retina burns more
energy than any other part of your body
it burns more energy than your muscles
it burns more energy than your heart it
burns more energy than your liver it is
in
a we talk about it as being on a
metabolic Cliff it is in a very
dangerous situation because if you burn
lots of energy you generate lots of
rubbish
right so that dust bin is filling up
because you're burning lots of energy um
the retina is unique in that respect um
and yeah retina is incredibly energy
dependent and that made life very easy
for me because when I came into this
field I came in as a retinal person and
so my my home territory was completely
fertile for trying to attack this
problem wow okay that makes sense so so
you came to this through the retina
which is one of the most mitochondrial
packed places and then that gives you
this sort of mechanism of red light in
blackbox mitochondria recharged energy
out yeah yeah to be honest with you any
anyone that makes that story more
complicated is pulling wool over your
eyes really well this that that this
music to my ears because I can roughly
understand that at least um so okay so
that's with the retina looking at sort
of other interventions I really enjoyed
your paper on um the effects on insulin
could you walk us through how that paper
came about um and then maybe we just
talk about sort of how how does red
light affect insul okay so um this was
this was down to one of my colleagues
Mike poer and we're beginning to realize
that mitochondria rule lots of other
things and there's lots of things we
don't know about but we know that
mitochondria they themselves demand
energy and that energy is glucose and
oxygen
so Mike and I were on a long drive to go
and do a piece of research somewhere
else and Mike said to me if we make
mitochondria work harder then in theory
um they're going to need more sugar and
the only place I can get it from is your
serum and you know this was a bit of a
revelation it's you you only come you
only have these conversations up when
you you're sitting there and you got a
long period of you know just mind
rolling so I said well I'm not taking a
risk on that um so Mike then said
because we'd always been working on and
off on bees he said well why don't we do
it on
bees sampling blood in bees and but we
had a bit of experience there so what
Mike and I did was we took some bees we
um we gave we gave them a blood glucose
tolerance test which is lots of people
have had them but what we do is we just
starve the be overnight so then you give
the bee a big drop of glucose and of
course the be
goes and it blood glucose level or the
equivalent of blood hemolymph went woof
right and really really high so we did
two horrible things to the bee some bees
we gave them a big burst of red light
and the other bees we gave them a big
burst of blue light so one in one with
the red light we're making their
mitochondria work hard and with the with
with the red light with the blue light
we're slowing their mitochondria down
and it had an a direct effect on their
blood glucose levels so we knew from
that model and everything with
mitochondria if it works in a fly tends
to work in a human so we knew proof of
principle right proof of principle it
worked so then uh we got ethical
permission we got a whole group of
people in and it was a horrible
experiment you know you stick a oxygen
you stick a tube up people's noses to
measure this CO2 because if you're
burning more oxygen you'll kick out more
CO2 we're pricking their fingers every
few minutes and then we're asking them
to drink the most disgusting pile of
glucose you really know who your friends
are when you when you need subjects like
this and lo it came out came out so well
I said to Mike I want the whole lot
replicated let's just put all the data
aside let's start again with a different
group of people let's replicate the
whole thing and we did and was one of
those perfect experiments the
replication came out exactly the same as
in the first the first experiment
so red light can reduce blood glucose by
making your
mitochondria drink more glucose that
they take from your serum now these were
ordinary healthy
people um including some of my relatives
um but Mike has now gone on to do it
with type two diabetics and I have seen
early signs of that data and it looks
great right so and with that we were
shining red light on a region of
people's backs uh for about 15 minutes I
think we could do better I think we can
I think we can give less light um
shorter time periods and get and get the
same effect now a natural question from
this is
Shining Light on a little bit of
someone's back small proportions of body
area why a mitochondria all over the
place consuming more
sugar and the thing is that if you
manipulate mitochondria in one part of
the body the story gets out mitochondria
talking to one another right across the
body we know that from a number of
experiments that been done ages ago
where people would manipulate
mitochondria one bit of an animal and
then they'd see them change the
following day over here no one really
had a great idea what what was going on
but of course you know you you can't
have metabolism changing in one place
not the other so um we did find in in
animal experiments the moment we hit
them with a burst of red
light a signal changes in the blood and
that signal is something called cyto
kindes and they're very often associated
with inflammation but they're also
signaling molecules so mitochondria are
affected by the red light they change
their
metabolism and they leave a message that
goes out and that message goes out to
mitochondria in other parts of the body
that do not receive the red light and
those mitochondria change and come into
line with the ones that were exposed wow
so you wouldn't have to um there
wouldn't be any argument for say the
stomach over the back because it's not
centralized it it spans out for the
whole body body yeah so I had a dream to
I had a dream which we talked about with
the team I said wouldn't it be this was
before all this came out I said wouldn't
it be fantastic if you went to the hole
in the wall to take your money out when
you did that you used your hand as an
ident as an identifier so you put your
hand down as a unique identifier and
then while you were doing that you were
getting a burst of red light while
you're waiting for your money to come
out now that was a dream ticket um
that's not a dream ticket anymore that's
doable that is doable there are other
people in other Lads exposing different
parts of the body and getting effects in
completely different regions right so I
don't have to shine stuff in your eye I
don't have to do something which you're
going to find uncomfortable
awkward we just need to expose one part
of your body and if we wait 24 hours
we'll get it to kick in wow I wonder
what the minimum effective dose is
because the back's quite a big area
right like how I guess my question is
how how much could you shrink that down
what's the threshold where you could
shrink it down to actually get the same
effect really good question um now I
can't answer you in terms of area but I
can answer you in terms of time so if we
go to if we go back to our bees remember
what we find in a bee we very often find
in a uh we find normally finding a human
if I take the time
down um to you know I take the time down
to three minutes fine everything works
as well as if it was 15 minutes if I
take the time down to under one minute
nothing happens now what is interesting
here is this is not a dose respon curve
it's not like I've got a hangover I'll
take 15 Aspirin because it's better than
one this is a switch everything that
people have found in this area indicates
it is a switch so that we are doing
something maybe an enzymes being
released proteins being released and
that is the key thing now when it comes
to um energy the amount of energy you
might need in that red light again that
is coming down so a study that was done
in morefields Eye Hospital on improving
retinal function showed that well they
did an experiment and we gave them the
devices to do it and the devices ran on
batteries and when the batteries came
back I said to them you've not changed
the batteries the batteries are
underperforming um and then when we
looked at the data we found that um they
were getting a result they were getting
a good result
so there we been using let's let's let's
say 8 to 10 millatt per per centimeter
Square just just remember 8 to 10 well
these people who are you know generally
really good were getting a result with
one now the reason they were getting a
result with one was that when they were
administrating administrating the light
there was no blue anywhere it was red
only okay so if you if you start to mix
blue in with it from other sources it
doesn't work as well so all of this now
I can't answer your question about how
many square meters of skin we need but
everything is telling us that what we've
been doing so far has been over the top
we can reduce it
um hopefully hopefully we know the time
we know it's going to be a minute we
know the dose is really quite low when
I'm saying one um uh millatt per cm
squared that really is a relatively thin
bike light you know that is that is not
that great area we'll find out but I
don't know at the moment if you had to
Hazard a guess which would be the most
effective area or would that
be well well when you think about retina
when I'm doing the eye I mean that's an
area like that that's pretty small but
it shouts it shouts at the rest of the
body I think we're probably talking
about maybe 10 square cm
you know it may be the case that if we
if we cut it down further we get an
effect but maybe the effect takes a
little bit longer to kick off that's
quite possible there's so many things
here I I we know it works we know we get
a result we know that the result can
have clinical impact we haven't hunged
down yet the real bottom end where's the
bottom end of all this I don't know that
from a pragmatic point of view if I was
sitting here I'd be saying pragmatic
point of view I don't care
because I'm already giving you something
that's not disturbing your life it's not
inconvenient and I'm getting effect you
know so switch worry as you said it's
the switch it's not the sort of dose
dependent an hour is better than half
hour it's just turning that switch on
yeah just just as you thinking as you're
talking
the most studies ever done in the lab
have been under blue light is that
correct um well when people have been
doing studies with light there have been
a lot of studies on animals done on Blue
Light um hunting out for damage um very
rarely have they defined the exact
wavelength of the light they've used and
the exact energy of the light they have
used people go Blue well blue is a
meaningless term it just happens to be
something that we Define because we see
this and we call it blue in natur fact
you've got to give the wavelength what
is the wavelength length you know if
I've got if I've got an eagle sitting
next to me and I show it one type of
blue it's going to look very different
to that eagle than it will do for me you
know it's it's just that our photo
receptors are tuned in a certain way so
yeah there's been a lot of work done on
Blue Light because there is this this
notion that is correct although poorly
defined that blue light is damaging and
blue light on its own does you very few
favors because it discharges your
mitochondrial
battery so but is there an argument for
surgeries to be done under red light as
a result
is sorry carry on no I was just sorry I
mean I was just more just making these
questions up because I'm F on this
tangent but
the okay go as long as you okay with
that because it just if the history of
the last 100 years most clinical things
be surgeries or scientific studies on
anything have been under one wavelength
of
light I shouldn't say color but I wonder
if there's a um if there's any reason to
actually change the spectrum of light
you might change the outcome in
surgeries or things that could help I
don't know key one here is one of the
early experiments that was done under
red light was a NASA study where they
were doing something under red light
that involved them nicking their
fingers and they found that wound healed
faster under red light now all of the
data that we are currently looking at
indicate
that wounds will heal better under long
wavelength L now if that's a pile of
rubbish worst case scenario is you
bought a red light you
know the belief amongst us is very firm
that um the red light is going to be is
going to help wounds heal and the
mechanism for that is there we can
understand that because it will reduce
inflammation now most of the most of the
lighting in hospitals is now LED
lighting it's very very strong in blue
and it has almost no red in it and that
is a point that needs to be
addressed um and again it's it's minimum
cost absolute minimum cost if we can get
people out of
beds if we can reduce bed blocking by
changing a light bulb if we can reduce
it by
5% the NHS is onto a winner right now
particularly in older people where their
battery the mitochondria are
underperforming if we can get those
older people out of beds in hospitals by
changing a light bulb that's got to be a
winner wow it just seems like such a
such loow hanging fruit for yeah see you
know this El this aging population with
all these diseases and if you can as you
say flip this switch in them and how
they live um it seems like quite a
lowcost solution that has a load of B
your bu yeah so let's get rid of the
blue light here's another great story um
it's a very important story and again it
bounces back to NASA so NASA published
this big paper
um with Lo loads of authors loads of
really big names on it and they said we
have a problem with astronauts on the
International Space Station they are all
suffering they are suffering from
mitochondrial Decline and that is being
presented in two forms one is they're
showing signs of premature aging
remember these people are up there for
for long periods and everything they do
all the day is being monitored so there
suffering from premature aging and
they're suffering from pre-diabetes all
these really fit people look at the
environment they're all under super
harsh white
LEDs now the great thing about the NASA
study was they excluded the obvious
which is no gravity it wasn't something
to do with that and they put it out
there as they put it out really as a
question what is going on but it was a
great experiment because it's an
experiment where you know I can't get
hold of a group of people and put them
under LED lighting 24 hours a day for
months on end but they did it for us and
that was great wow yeah the extremes
teach the best good or bad right in that
extreme environment you
suddenly uh this environment you can
pull those a lessons from so now in NASA
uh in the International Space Station do
they have red lights everywhere or no no
I think that perhaps we should also see
NASA in it wider context
so
NASA is partly run by the military um
you don't get all the stories out that
you want but NASA want to unload
long-term space flight to private
companies so private companies they
would like private companies to be
involved in um sending people to Mars
are they really going to go and tell
everybody that these people they're
sending out to Mars could get
mitochondrial disease because they're
going to be they're going to be out to
Mars for a of a lot longer than the
people on the International Space
Station so we've announced it we've told
the European Space Agency um about it
and they certainly listened um I don't
know if they're doing anything about it
but uh Bob Fosbury who was the person
who uh coined the term about red light
starvation he was a leading scientist at
the European uh space
Association and he is the guy who built
the spectrometers on the James web
telescope so he has a lot of profile
with them um and I'm sure they're
listening but they're not saying a lot
wow okay maybe some first incentives
there that's uh you've got the um as
with health often you've got the the
research and the anecdotal data all sort
of screaming and then you've got public
policy just taking a little bit longer
to to catch up so what you think the uh
the the the Catalyst to to force some
change the catalyst is someone listening
and that is why I'm really happy to talk
to you and I will take off any amount of
time to talk to yourselves and other
people I need a senior civil servant in
the department of health or a
minister in a health department to pay
attention and I would say you know I
would emphasize yet again
we have got ethical approval from
morfield Eye Hospital from University
College there is we've had some people
taking red light on their own bat for
years there is no health problem okay
there is no
downside the only downside to all this
is you got to go and buy a red light now
the red lights that you're seeing you
know that are on the market 100 quid you
know those lights that you're paying 100
for can be can be landed UK at
$12 right because it's Health they're
charging a fortune in fact I had to
exclude and story much told a lovely old
lady from a clinical trial she was great
and I had to say look because of a b c
and d i can't include you and she was
she was bit fed up with me um and she
turned up back on the door about a month
later and she had a battery in her hand
and she had an LED an infrared LED and
she joined it with her fingers and she
held it up in front of her eye and she
said Glenn will it work I was I was
really taking a back and I said well
come and have a cup of
tea and I asked a member of the team to
measure the energy and measure the
wavelength and they came back and they
said that'll work so there is nothing
mystical here there is nothing that
requires high tech there is nothing that
requires a vast amount of money okay as
I say worst case scenario you bought a
battery you bought an LED and I look
like a fool but I don't think that's
going to happen yeah there's this old uh
this old phrase where there's mystery
there's margin
and yeah yeah so you know we're just not
talking about that little old lady in
her vision we're not just talking about
people with Maul degeneration we're
talking about people um we're talking
about diabetic crisis
country has a has a diabet that is
costing us a fortune yeah why don't we
just think
laterally well the market for so my
background's um Health startups and the
market for uh um I guess things to
manage insulin um better and reduce that
glucose Spike or insulin Spike um it's
vast and you more people have continuous
glucose sponsors and um you know I I got
I got pitched a a supplement that
reduces your insulin Spike you take it
with when you take it with food actually
well red light seems to be way more
cost- effective solution than that I
mean just it's just interesting uh an
interesting tool that no one is really
talking about in that Spectrum in that
in that space which is very very
fascinating you know ABS we've got um
we've got a we do talk to we are now
talking very very seriously to
Architects I spend most of my time now
not in the medical school but actually
in the Bartlet School of AR architecture
at UCL they they are firmly they know
what's happening firmly on board there's
also a number of small lighting
companies that are at The Cutting Edge
specialist lighting companies and one of
the people that run one of those
companies um put a patch on his arm
walked around and took red light and he
came back and said Glen this works I
said yeah I know it
works how do we get belief how you know
how many papers have I got to publish
before someone says you know okay
there's something in this there was a
good colleague of mine once said you
know is there much point in publishing
because a lot of people just don't
bother to read it anyway you've got to
make a splash you've got to go in the
media you've got to talk and and and
pick people up that
way well I don't know I mean I've never
published a paper but I imagine it's the
you know you got have the right products
and the right distribution and uh you
know things like this is the
distribution right you got you got got
to talk about it um yeah I mean that's
the wonderful thing about these podcasts
um not necessarily this one or this guy
hosting it at all but it's just reduces
all friction to to to get a message out
um I'd be remiss if I didn't ask about
skin complexion and collagen um a lot of
questions coming in about you know you
see all the red light masks specifically
for way more than 100 100 pounds um is
there any efficacy behind that and sort
of it can upregulate collagen and what
all these companies claim or is that
well
I don't think they know what they're
doing right very few of these companies
actually know what they're doing very
few of these companies will give you any
specific data about their devices and
what their devices are doing I would say
that the evidence in favor of wound
healing and reduction in wrinkles the
evidence is there that something is
going on but when you go and buy your
device and you pay some outrageous
figure like $400 quit they don't know
how much that energy they've got to give
you you know they've got absolute they
don't know the exact wavelengths that
they should be using it's all out there
you can read it even more importantly
one of the one of the key things about
red light devices is your mitochondria
you can only sort of recharge your
mitochondria in the mornings doesn't
work in the afternoon doesn't work in
the afternoon because mitochondria do so
many different things that you know I
say to people look in the afternoon the
mitochondri doing the ironing doing the
dishes doing the other things they need
to do in life so everyone's selling you
these devices and they're not telling
you they don't work in the afternoon wow
so you have to fall in line with the
Master Clock which is you say Kum Rhythm
the the the mitochondria have got their
own clocks the mitochondria kick
themselves into action I think it's
related to perceived Dawn and they kick
themselves into action about half an
hour before perceived Dawn and then when
they're working really hard you can give
them a red light and they'll work even
harder if you catch them at 3 o00 in the
afternoon you can give buckets of red
light and nothing happens and that's
true in a fly and it's true in a human
being wow funny I don't know if there
anything to do with things but it seems
to follow the same dial rhythm of
hormones you know testosterone is very
high and and cortisol very high in the
morning and fluctuates down wonder if
there's a link between I I I think the
link is very much um in your
evolutionary history when you were
waking up or you know in in Africa um
you know um when you wake up you're
extremely vulnerable very vulnerable
you've been vulnerable for a while
you've been you've been asleep you've
probably been snoring announcing your
presence to absolutely everybody the
Tigers the sabertooth tigers have come
along they know where you are your
testosterone has to be high your glucose
levels has to be high and your
mitochondria have to be pumping out ATP
because you need to be in a super fit
State when you wake up in the morning I
think it's all tied into that that makes
yeah that that that makes a lot makes a
lot of sense it's so fascinating where
this field goes and um sorry the wind
was blowing my door open um where this
field goes and uh I don't know what the
next five years look like I mean from a
policy point of view and sort of the
entrepreneurial potential there is here
and you know which one sort of Push It
Forward I don't know um what are you
most excited about in this field
um there are so many things that excite
me so I'll let I'll let you know I'll
let you know about One um and it's
personal okay um we've got children with
a very rare
disease um that is mitochondrial based
and um
one of the parents asked me whether they
whether there was any Theory whether red
light could be used and I said I don't
have ethics to do this I don't know
enough about it I suspect that at this
stage I said I suspect that you're not
going to do any
harm they used red light and there was a
very dramatic effect within two weeks um
when I saw the pictures I you know
people know I I went to the toilet and
burst of Tears um now we now have a
small clinical trial for that it's a
rare disease that excites me and it you
know I roll over in bed and I think I
did something worthwhile today you know
that something really worthwh where else
does it excitement it excites me because
I go into talk to groups of people and I
say you've just not paid attention to
light generally what light is doing we
have to and part of the mission that a
small group of us have got now is let's
remove LED lighting there is something
in L well we know what it is it's an
absence of red light let's go back and
find another way of delivering broad
spectrum light so I am going into
environments where people are
sitting um in rooms without daylight um
and they're sitting there with LED
lighting and we're carrying out quite
sophisticated experiments to test their
their visual function and then I'm
taking the light bulbs out and I'm
giving them old incandescent light bulbs
and I'm going back a week later and
we're reasuring their visual function
and it's better now I'm not measuring
their blood sugars I'm not measuring
anything else but you know it seems to
me that someone W won the Nobel Prize
for LED lighting because we're saving
energy and that was a great bit of
science but we didn't realize the
consequences just didn't realize if we
can get people to go back to a different
form of lighting we're going to improve
it's a public health issue you know it's
it's public health if we condent blood
sugars um if we cond Dent these problems
that are
mitochondrial that are all to do with an
aging population um like Parkinson's
disease like macul
degeneration that's great I mean I I I
will put a I will put a punctuation
point at my career if if we can get
policy makers to pick that one up
because the science is
there I love uh I love your optimism for
that and I hope I hope becomes a becomes
a becomes a thing um the Matt Ridley
wrote a great book of how Innovation
Works and he makes a good argument for
uh entrepreneurship pushes policy faster
than policy can push entrepreneurship
and uh maybe that's the the way way to
do it who knows um what is your personal
practi because obviously you're so in in
in in the literature and you're
publishing literature yourself what is
your personal practice with a red light
look like uh my personal practice and
that of most of my colleagues is well I
mean if you could come in my office
you'd realize that all my lighting is
incandescent lighting um my outer lab
space is all incandescent lighting my
home is incandescent lighting
um I when I get up in the mornings I
will very often turn on a a red light
and Just Bounce It Off the Wall while
I'm getting breakfast or if I miss that
one what I do is I I cycle into work and
I get into the office close the door and
start stripping off the kind of horrible
sweaty cycling gear and then I've got a
red light that again I'll bounce off the
bounce off the wall
and all of us are doing it you know all
of us are doing and the big mistake is
is to suddenly think because I'm
bouncing this red light off the wall I'm
going to I've going to have better
memory I'm going to have better muscle
control I'm going to better this better
that it doesn't work like that it just
it just means that in the long run
things are going to improve things are
not going to go downhill at the same
Pace that they would do otherwise and
there's this I've struggled I've
struggled like crazy to find a downside
I need I need I need some that is a
downside and we haven't found it we
haven't found it at all and the other
thing is you know I um I cycled down the
Holloway road which is a pretty
miserable Road in London but I as I'm
cycling down it I'm facing
south and on a sunny day I'm getting
half an hour of burst of
sunlight and would you say that's
enough I'd say it's a bare minimum bare
minimum you said I have I can I can I
can wield this technology into a
situation and say Here's a light at 850
nmet I've got the I think I've got a
very very good sticking plaster on a
problem the resolution of the problem is
really going outside just going outside
I mean another really interesting angle
on this is that there is a strong
relationship between the development of
myopia in
children and the absence of red light
the Chinese have and I'm I'm unsure of
the mechanism but I do believe the
result and it's clear that if you bring
kids inside spend a lot of time in in in
classrooms if they're doing lots of
close work um you're going to develop a
myopic problem and that's that's
enormous in the Far East Malaysia China
Japan um and the answer there is
sunlight the uh my my stepdad he had a
um retina because he was very very
myopic and classic classic yeah in we we
came across some of the the papers in
prepping for this and actually sort
of would have that would that have
helped um pre-retina detach um by all
accounts yes so it would have helped him
when he was a child and he was
developing the myopia see once you're an
adult my opio is when the eye grows too
long once it's out here
you can't do anything to bring it back
here but you can slow its growth by
making children spend more time outside
in sunlight great study well initially a
great study done by the Chinese showing
that red
light reduces the rate of myopia
published relatively recently the
downside was they used a
laser and you should really never use a
laser on the retina unless you really
have to and the consequence was some of
these children developed retinal lesions
and that's held that is going to hold
the field back there is no reason for
using a laser for all of the things that
we do go and get an LED it's safe it's
cheap um all this technology should be
led based and not laser based yeah if
there's a if there's a downside like
like that why why would you use it and
just a question on near infrared light
um what uh how does it different from
red light and are there other benefits
that that can unlock is that a whole
different field or just so so the
wavelengths that people are using
predominantly um are 670 and above if
you go below 670 the efficacy is reduced
now 670 is defined as near infrared
infrared starts sort of 700 plus okay
but this is just it's nomenclature it's
it's about where we're where we're
drawing borders so um a device at 630
which is red it's not near infrared it's
not going to do you any good bicycle
light probably won't do you any good at
all so you know people want a cheap
version um it is the wavelengths are
tend to be 660 670 up to about 800 850
nanometers you'll stop seeing the red
light at 700 to
750 um because your retina is not
sensitive to it okay so my one I've got
one red light and I can see that and the
near I can't visibly see yeah yeah
that's that's that's pretty and it's
probably the infrared one that you can't
see that's doing it's got the bigger
kick in it in terms of health right I
see okay because it's penetrating your
body
further okay right so we can get deeper
do you have any opinion on um the uh I
guess I don't know what you call the
nodes you can sort of stick up your nose
and they shine a light and yeah I do I
do because I had a colleague doing it
and I thought it was the most bizarre
thing on the planet but he had a longer
track record in in in this area of
research than I did um and he has been
one of the leaders in using red light
Parkinson's disease and he did all the
work on primate models of Parkinson's
disease and his rationale was well if
you stick it up your nose it's going to
get into your brain really quickly and
of course dealing with Parkinson's
disease he's actually dealing with a
deep brain structure that was his
rationale um I can only say that I hope
he washes it when he takes it
out yeah I'm sure don't we all um
interesting uh Dr Jeffy can I just end
with some quick fire questions for you
if you don't mind sure um okay so one of
my favorites what's the most notable
change you've made to your health in the
past five
years um the most noticeable change I've
made uh
doing 5 to 10 minutes yoga first thing
in the
morning oh I needed to hear that okay
you know that's because I'm getting old
I'm really aware that my back is getting
stiff
yeah I think the world needs to hear
that it's uh it's easy to neglect um
yeah and flexibility and it's so boring
but yeah 10 minutes is it's boring it is
terribly boring I find it so dull um
okay and are there any books you can
recommend that don't have to be necess
on lights or mitochondria but that maybe
shape your world
VI oh there's a big big big thick book
called um Power sex and suicide by Nick
Lane um that but that's that's a bit of
a that's a bit of an academic that's a
bit of an academic book but for anyone
who wants to dig there get their feet
into it then I'd do that and to be
honest with you when I go home I don't
read academic
books you know so I can probably give
you a list of novels I'm finding pretty
good but um you know when I look at when
I look around me I say Nick Lan's books
are very good they're extremely good but
um I'm just reading a John lary book at
the moment and thoroughly enjoying it
lovely you need a bit of both right you
need a bit of both do yeah yeah I've uh
yeah I've got Nick Lane's book on my um
my bookshelf and I don't want to start
it until I'm convinced I'm going to
finish it but it is daunting um yes it
really is and you most of his books are
but he heard him speak he seems very um
he comes across really well um and last
question from me if you could know one
thing in your field that you don't know
yet what would it
be okay this is where I'm going tomorrow
okay so when
I when we shine light sun when we shine
long wavelength light on people's bodies
we get all these changes in the in the
cyto kindes all these things are
happening and a physical Anthropologist
from America Nate came in and said tell
me about fire light and I went well
what' you want to know about fire light
and I said and I said oh yeah fire light
fire light's got lot of long wavelength
light in it and he said and I think this
is really great what has fire light got
to do with human evolution is there a
link between Fire Light particularly as
we move north is there a link between
Fire Light improving mitochondrial
function and something to do with human
evolution I find that absolutely
gripping you know Absolut when when
humans came out of East Africa and they
moved North okay fine they went to the
Lebanon and still nice and sunny they
went to Turkey still nice and sunny when
they finally ended up in tooting it
wasn't nice and sunny right it was great
it was miserable and they had to wear
lots of clothing is there a link between
how we advance in human evolution and
our brains Advance with Fire
Light that's that's I I really want to
know that one before I die God I would
love to read that
book I'll give you
yeah um well Dr Glenn Jeffrey that was
unbelievable thank you so much for
wasting your time with with this yo-yo
here there no way I told everybody in
the lab we got to stop doing science and
we got to start talking Because unless
we talk we're not going to get
traction well wonderful well I'm I'm no
doubt The Listener will have a a great
time listening to this conversation so
can't thank you once again for coming on
great thank you very much for your time
تصفح المزيد من مقاطع الفيديو ذات الصلة
Photobiomodulation Devices and Research (including Long COVID)
How to Choose the Best Aperture
fais ATTENTION à ÇA avant d'acheter une LUMIÈRE !
ZHIYUN MOLUS G60 & X100 🔥
カメラ初心者こそ「光」にこだわれ!ZHIYUN CINEPEER CX100 ビデオライトがおすすめ。100Wの高出力、710gの軽量設計で3万円台ってマジ?
The Critical Role of Supply Chains in Business and Society
5.0 / 5 (0 votes)