Sysmex Inostics' Plasma-Safe-SeqS NGS Technology

Summary

This video explains the process of liquid biopsy for detecting circulating tumor DNA (ctDNA) in a patient's blood. Sysmex Inostics' plasma-safe C-Seg Liquid Biopsy uses an ultra-sensitive library preparation method to capture even the smallest DNA fragments shed by cancer cells. Through unique PCR primer tags, the targeted DNA is amplified and sequenced using next-generation sequencing (NGS). The data is then analyzed to minimize errors, providing oncologists and researchers with an easy-to-understand report. The company also offers high-level customer service throughout the process, ensuring comprehensive support before, during, and after report delivery.

Takeaways

• 😀 Circulating tumor DNA (ctDNA) is shed by cancer cells into the bloodstream as they go through their life cycle.
• 😀 Liquid biopsies enable the detection of ctDNA fragments from a patient's blood sample.
• 😀 Not all liquid biopsies are the same; the Sysmex Inostics plasma safe cgas liquid biopsy stands out.
• 😀 The process begins with the arrival of the blood sample at a CLIA-certified laboratory for analysis.
• 😀 The library preparation process is optimized to detect ctDNA with ultra-sensitivity, ensuring no molecule is left behind.
• 😀 PCR primers with unique identifiers are used to tag the DNA targets specific to the cancer type being analyzed.
• 😀 These tagged DNA molecules are amplified and undergo massively parallel Next Generation Sequencing (NGS).
• 😀 The sequencing data is processed through a proprietary analysis engine to minimize NGS error rates.
• 😀 After analysis, a clear, easy-to-understand report is generated for oncologists or researchers.
• 😀 The laboratory offers high-level customer service throughout the process, including before, during, and after report delivery.
• 😀 Sysmex Inostics looks forward to collaborating with healthcare professionals to advance cancer detection and research.

Q & A

What is circulating tumor DNA (ctDNA)?

Circulating tumor DNA (ctDNA) consists of DNA fragments shed by cancer cells into the bloodstream as they progress through their life cycle.

How does liquid biopsy help in detecting cancer?

Liquid biopsy allows for the detection of ctDNA fragments in a patient's blood, providing a non-invasive method for cancer detection and monitoring.

What makes Sysmex Inostics' liquid biopsy different from others?

Sysmex Inostics' liquid biopsy stands out due to its ultra-sensitive detection process, which ensures that no ctDNA molecules are left behind during sample analysis.

What is the role of library preparation in the liquid biopsy process?

Library preparation is crucial as it optimizes the process for ctDNA detection, ensuring that all relevant DNA fragments are captured and processed for further analysis.

Why are PCR primers with unique identifiers used during the library preparation process?

PCR primers with unique identifiers are used to tag specific DNA targets related to certain cancer types, ensuring accurate detection and analysis of the ctDNA.

What happens after the PCR amplification of tagged DNA molecules?

After PCR amplification, the tagged DNA molecules undergo massively parallel next-generation sequencing (NGS) for deep analysis and accurate detection of mutations.

How does Sysmex Inostics' proprietary analysis engine enhance the liquid biopsy process?

The proprietary analysis engine reduces NGS error rates, improving the accuracy and reliability of the sequencing results for better diagnostic insights.

What is included in the final report generated after sequencing?

The final report includes an easy-to-understand analysis of the sequencing results, which is then provided to the oncologist or researcher who requested the liquid biopsy analysis.

What kind of customer service does Sysmex Inostics offer?

Sysmex Inostics provides a white-glove level of customer service, offering support before, during, and after the report delivery to ensure a seamless experience for healthcare professionals.

What benefits does Sysmex Inostics’ liquid biopsy offer to researchers and oncologists?

Sysmex Inostics’ liquid biopsy offers researchers and oncologists highly accurate, ultra-sensitive ctDNA detection, alongside exceptional customer service and detailed, easy-to-interpret results that aid in cancer diagnosis and treatment planning.