Supplements Shown to Extend Lifespan - Top Longevity Program Results
Summary
TLDRThis video explores the National Institute of Aging's Intervention Testing Program (ITP), which rigorously tests compounds for their potential to extend the lifespan of mice. Over 20 years, ITP identified nine molecules—including acarbose, canagliflozin, aspirin, and rapamycin—that have shown life-extension effects in mice. The video discusses the mechanisms and potential side effects of these compounds, highlighting the promise of rapamycin as a leading candidate for human longevity. It also touches on the importance of considering sex differences in the effects of these molecules and the need for further clinical trials to confirm their impact on human lifespan.
Takeaways
- 🧪 The National Institute of Aging's Intervention Testing Program (ITP) is the world's most rigorous program for investigating the effects of longevity molecules on mice.
- 🐁 Over 20 years, ITP has identified nine molecules that extend lifespan in mice, including acarbose, aspirin, canagliflozin, captopril, glycine, nordihydroguaiaretic acid (NDGA), protandim, rapamycin, and 17 alpha-estradiol.
- 💊 Acarbose, a diabetes drug, has shown to extend median lifespan in male mice by 22%, but its effects on muscle mass and strength might be negative for older adults.
- 💊 Canagliflozin, another diabetes drug, extended median survival in male mice by 14%, but had no effect in female mice, suggesting sex differences in response.
- 💊 Aspirin, an anti-inflammatory drug, extended median survival in male mice by 8%, yet daily intake in humans, especially the elderly, has been linked to a higher risk of mortality.
- 💊 Glycine, an amino acid, increased maximum lifespan in mice by 4 to 6%, and its high intake might mimic methionine restriction, a known life extension strategy.
- 💊 Captopril, an ACE inhibitor for high blood pressure, extended median lifespan in female mice by 4 to 5%, but its side effects make it less appealing for recreational use.
- 🌿 NDGA, found in creosote bush, increased lifespan in mice by 10%, and is being investigated for its anti-inflammatory properties.
- 🌿 Protandim, a herbal supplement, increased median survival in male mice by 7%, but its proprietary blend and high cost make it less attractive.
- 💊 Rapamycin, known for its life extension effects, increased median survival by 14% in females and 9% in males, and is considered the most promising longevity molecule.
- 💊 17 Alpha-estradiol, a non-feminizing estrogen, increased median male lifespan by 19%, and might counteract the shortening effects of androgens like testosterone.
Q & A
What is the Intervention Testing Program (ITP) and what does it do?
-The Intervention Testing Program (ITP) is considered the world's most rigorous peer-reviewed program for investigating longevity molecules and their effects on mice. It started in 2002 and has been running for over 20 years, testing dozens of different compounds for their potential to extend lifespan.
How many molecules has the ITP identified that can extend lifespan in mice?
-Over the 20 years, the ITP has identified nine molecules that have extended lifespan in mice: acarbose, aspirin, canagliflozin, captopril, glycine, nordihydroguaiaretic acid (NDGA), protandim, rapamycin, and 17 Alpha estradiol.
What is acarbose and how does it affect lifespan in mice?
-Acarbose is a diabetes drug that blocks glucose absorption. ITP studies found that it extended median lifespan in male mice by 22% and by only 5% in female mice, with maximum lifespan increasing by 11% in males and 9% in females.
What are the potential negative side effects of acarbose on muscle mass and strength?
-Acarbose may lead to a decrease in muscle mass, hand grip strength, and walking speed, particularly in type two diabetics. It might also blunt the muscle growth signal in response to resistance training in older adults.
How does glycine supplementation impact lifespan according to the ITP study?
-The 2019 ITP study found that glycine supplementation increased maximum lifespan in both male and female mice by 4 to 6%. It is thought to mimic methionine restriction, which is known to extend lifespan in animals.
What is the potential issue with the high methionine and low glycine intake in the average human diet?
-The average human diet is high in methionine, primarily from animal proteins, and low in glycine. This imbalance could theoretically reduce longevity, as glycine is thought to counterbalance methionine toxicity and extend lifespan.
What is rapamycin and how does it show potential for life extension?
-Rapamycin is a known life extension molecule in animals and has shown to increase median survival by 14% in females and 9% in males in ITP studies. It also extends life expectancy by 60% when given to middle-aged mice for only three months.
What are the current clinical trials investigating regarding rapamycin and human longevity?
-There are several clinical trials investigating rapamycin's potential to enhance immune system function when used transiently in elderly people, and its effects on health, brain function, and general well-being when taken off-label by longevity enthusiasts.
What is 17 Alpha estradiol and how does it affect male mice lifespan according to the ITP?
-17 Alpha estradiol, also called non-feminizing estrogen, increased median male lifespan by 19% in the ITP study. It is thought to counteract the shortening effects of androgens and testosterone on lifespan.
Why might 17 Alpha estradiol not extend lifespan in female mice?
-17 Alpha estradiol might not extend female lifespan because it works in the presence of elevated male hormones, androgens, which are not present in the same levels in female mice.
What is the practical takeaway from the ITP studies for individuals interested in longevity?
-The practical takeaway is that while certain compounds like acarbose, glycine, and rapamycin have shown potential in extending lifespan in mice, it's important to consider the specific effects and potential side effects for each compound. For example, the speaker personally takes glycine and is considering rapamycin in the future, but recommends against taking pharmaceuticals like acarbose recreationally without medical need.
Outlines
🧪 The Quest for Longevity: A Deep Dive into ITP's Findings
The paragraph delves into the historical and contemporary pursuit of longevity, highlighting the National Institute of Aging's Intervention Testing Program (ITP). Since its inception in 2002, ITP has been at the forefront of peer-reviewed research on longevity molecules. Over two decades, ITP has tested numerous compounds, identifying nine that significantly extend the lifespan of mice by up to 60%. These findings underscore the complexity and rarity of discovering substances with life-extension properties. The paragraph also introduces the first of these molecules, Acarbose, a diabetes drug that intriguingly extends median lifespan in male mice but with less pronounced effects in females. The discussion points to the potential link between reduced glucose absorption and life extension, contrasting Acarbose with Metformin, another diabetes drug without similar benefits unless combined with Rapamycin. The paragraph concludes with a nuanced view on the implications of these findings for human longevity, suggesting that while Acarbose may have benefits, it also presents potential muscle mass and strength reduction, which could counteract its life-extending effects.
💊 Exploring the Impact of Canagliflozin and Aspirin on Longevity
Paragraph 2 continues the exploration of substances that may impact longevity, focusing on Canagliflozin and Aspirin. Canagliflozin, an FDA-approved diabetes drug, is shown to extend median survival in male mice, with no significant effect on females, despite improving glucose tolerance. The discussion suggests that Canagliflozin's mechanism might be similar to Acarbose, yet it raises questions about its impact on muscle growth and stem cells, which are crucial for longevity. Aspirin, a widely available nonsteroidal anti-inflammatory drug, is also examined. While it extends median survival in male mice, its effects in humans are more complex, with some studies linking daily aspirin use to higher all-cause mortality, particularly due to cancer-related deaths. The paragraph highlights the importance of considering age-related factors when evaluating the benefits of such substances, as aspirin's effects differ significantly between younger and older populations.
🌿 Herbal Compounds and Pharmaceuticals in Longevity Research
Paragraph 3 introduces a variety of compounds, including herbal ingredients and pharmaceuticals, that have been tested for their potential to extend lifespan. Captopril, an ACE inhibitor for hypertension, is noted for its modest life extension in female mice. Nordihydroguaiaretic acid (NDGA), derived from natural sources, is highlighted for its anti-inflammatory properties and potential to activate Nrf2, a key factor in reducing inflammation. The paragraph also discusses Protandim, a proprietary blend of herbal ingredients, which showed a modest increase in median survival in male mice but faced regulatory challenges due to misleading marketing. Rapamycin emerges as a standout compound, with significant life extension effects in both sexes and potential to improve healthspan. The discussion concludes with 17 Alpha estradiol, a non-feminizing estrogen, which intriguingly extends male lifespan but not female, suggesting a complex interplay with androgens and testosterone.
🔬 The ITP's Comprehensive Longevity Study and Practical Takeaways
The final paragraph summarizes the ITP's comprehensive study on longevity, noting that while many popular molecules like resveratrol and curcumin did not extend lifespan, others like Glycine and Rapamycin show promise. The speaker shares a personal decision to consider using Glycine and Rapamycin in the future, reflecting on the need for more clinical trials to confirm these substances' effects on human longevity. The paragraph concludes with a call to action for viewers to explore evidence-based methods to slow aging and improve health, referencing a book titled 'The Longevity Leap' for further insights.
Mindmap
Keywords
💡Life Extension
💡Intervention Testing Program (ITP)
💡Acarbose
💡Metformin
💡Calorie Restriction
💡Rapamycin
💡Glycine
💡Captopril
💡Protandim
💡17 Alpha Estradiol
Highlights
Humans have been searching for longevity solutions for thousands of years, from the Water of Life to modern supplements and pharmaceuticals.
It's virtually impossible to definitively test the longevity effects of supplements in humans.
Animal studies on rodents, worms, and flies have shown life extension effects with various compounds.
The National Institute of Aging's Intervention Testing Program (ITP) is the world's most rigorous program for investigating longevity molecules.
ITP has tested dozens of compounds over 20 years and identified nine molecules that extend lifespan in mice.
Acarbose, a diabetes drug, extended median lifespan in male mice by 22% and maximum lifespan by 11%.
Metformin, another diabetes drug, does not extend lifespan unless paired with rapamycin.
Calorie restriction is the most proven non-genetic method of life extension in animals.
Acarbose may have negative side effects on muscle mass and strength.
Canagliflozin, an FDA-approved diabetes drug, extended median survival in male mice by 14%.
Aspirin, an anti-inflammatory drug, extended median survival in male mice by 8%.
Glycine, an amino acid, increased maximum lifespan in both male and female mice by 4 to 6%.
Captopril, an ACE inhibitor for high blood pressure, extended median lifespan of female mice by 4 to 5%.
NDGA, a herbal compound, resulted in a 10% increase in lifespan in both sexes.
Protandim, a herbal supplement, increased median survival of male mice by 7%.
Rapamycin, a known life extension molecule, increased median survival by 14% in females and 9% in males.
17 Alpha estradiol, a non-feminizing estrogen, increased median male lifespan by 19%.
Most compounds extend lifespan more in male mice than in female mice, possibly due to sex differences.
Transcripts
humans have been searching for the magic
pill for Aging for eons thousands of
years ago it was the Water of Life that
supposedly made you young again but
today is various supplements and
pharmaceuticals that are touted as
having longevity benefits how do you
know if a supplement is going to make
you live longer well you can't because
it's virtually impossible to do that
kind of an experiment in humans however
we do have a bunch of animal studies on
rodents worms and flies that have found
life extension effects with different
compounds in this video I'm going to go
through through the findings of the
National Institute of aging's
intervention testing program and see
what supplements and molecules they've
found to work in extending the lifespan
of mice by 20 30 and up to 60% so what
is the interventions testing program or
ITP for short it's considered the
world's most rigorous peer-reviewed
program for investigating longevity
molecules and their effects on mice they
started in 2002 so the program has ran
for over 20 years and have tested dozens
of different compounds you can read all
their supported into ditions and
Publications at the National Institute
of aging's website over the 20 years the
ITP has identified nine molecules that
have extended lifespan in mice they are
acaros aspirin canag flosin captopril
glycine nordi Hydro gutic acid ndga
protm rapamycin and 17 Alpha estrad
that's not a very large amount of
compounds from the dozens of compounds
that have been tested which kind of
shows that most supplements don't have
life extension effects even in animals
this doesn't mean that the list is
conclusive either because the ITP is
continuously testing new molecules so
let's take a look at these molecules
more closely the first one is a carbos a
carbos is a diabetes drug that blocks
glucose absorption the ITP studies on a
carbos found that it extended median
lifespan in male mice by 22% and by only
5% in female mice maximum lifespan
increased by 11% in males and 9% in
females this is quite interesting and
you would predict that these life
extension effects were because of lower
ing blood sugar levels however the ITP
studies done on Metformin which is
another diabetes drug and also lowers
blood sugar levels have found that
metformin doesn't extend Lipan unless
it's paired with rapamycin so it's
rapamycin that does the extension
effects not meformin metformin does
reduce the risk of heart disease
mortality in people with diabetes but it
hasn't been found to have any longevity
effects in otherwise healthy humans
either so in my opinion the life
extension effects of a carbos might have
to do more with the reduction in glucose
absorption rather than lowering of the
blood sugar levels if you absorb less
glucose you also absorb fewer calories
and we know that calorie restriction is
the most proven non- gentic method of
Life Extension in animals does this mean
that taking a carbos is going to be
beneficial for human longevity a carbos
does reduce the risk of heart disease
and hypertension in people with impaired
glucose tolerance a carbos also induces
weight loss through reduced glucose
absorption as well as by increasing the
expression of glp1 which is the
mechanism by which OIC works the problem
is that a carbos also appears to to have
some negative side effects type two
diabetics who take a carbos see a
decrease in muscle mass hand grip
strength and walking speed metformin has
also been seen to blunt the muscle
growth signal in response to resistance
training in older adults muscle mass and
muscle strength are both very important
for longevity and in appears that acaros
and Metformin could be harmful for older
people who have low muscle mass and low
strength it might be that with acaros
you can mitigate the negative effects on
muscle mass by just lifting weights
because in these studies the patients
didn't do any form of resistance strange
however in the metformin study the
people did lift weights and they still
saw the reduction in the hypertrophy
response from the training so I would
predict that it might happen the same
with a carbos metformin has been seen to
decrease V to Max an aerobic capacity as
well which is a bad thing for
cardiovascular function a higher V to
Max is linked to longevity when it comes
to acaros then acaros hasn't been seen
to reduce V to Max and in one 2006 study
they found that exercise combined with a
carbos treatment actually increased V to
Max whereas exercise alone didn't that
is very interesting but obviously we
would need more studies to confirm that
so overall acaros as well as metformin
can be life-saving for diabetics if
you're otherwise healthy you don't have
impaired glucose tolerance then taking
these medications might have negative
effects on your Fitness taking these
Pharmaceuticals recreationally for ler
purposes is also somewhat of a mixed bag
on one hand we have the ITP results
showing that a carbos works but on the
other hand the human evidence suggests
that a carbos can result in loss of
muscle and strength but honestly I think
you can mitigate it with resistance
training and a higher protein intake
it's the same with OIC you lose muscle
because of not lifting weights and
you're undereating protein personally
I'm not taking at carbos I don't have
any plans to take it in the future right
now but I do think that it's quite
interesting the next one is canag gloin
canlin is another FDA approved diabetes
drug that supports skinny function and
cardiovascular function it also inhibits
the sodium glucose Transporter 2 by
blocking renal uptake and intestinal
absorption of glucose in the ITP study
can flow in extended median survival of
male mice by 14% Kaa also increased the
age for 90th percental Survival by 9%
however they found no effects in female
mice although their glucose tolerance
still improved this drug appears to be
very similar to a carbos it works
through reduced glucose absorption and
it improves glucose tolerance but does
it have the same negative side effects
on muscle growth there's no studies in
humans but in mice canic Flows In does
downregulate certain proteins and muscle
stem cells next up we have aspirin which
is a non idal anti-inflammatory drug or
Nate you can get it over the counter
which makes it very easily found in the
ITP study aspirin treatment extended
median survival in male mice by 8% but
it wasn't very significant there are
other animal studies as well that find
how aspirin extends their lifespan the
effects are probably because of
aspirin's anti-inflammatory effects
however in humans daily intake of
aspirin has been actually seen to be
linked to a higher risk of Alla morality
primarily because of increased cancer
related deaths this applies to elderly
people who see an increased risk of
cancer metastasis from aspirin treatment
and accelerated cancer progression as
shown by several randomized control
trials there have been previous studies
that found that aspirin treatment
reduces the risk of cancer but those
studies were mostly done on younger
populations whereas the recent clinical
trials were done on the elderly people
and in those people aspirin treatment
appears to increase the risk of cancer
the reason why there's a discrepancy
between younger and older people might
be because of the age related decrease
in the immune system older people have
weaker immune systems and aspirin might
modulate the immune system in a negative
way that enables the proliferation of
cancer more easily so it looks like
aspirin isn't a good idea later in life
historically aspirin has been used for
primary prevention of cardiovascular
disease which means preventing a heart
attack or preventing the onset of
atherosclerosis taking baby aspirin or
small amounts of 50 to 100 milligrams of
aspirin per day has been very common for
decades for this reason so the question
is does Micro doing baby aspirin every
day reduce the risk of heart disease the
American Heart Association says low do
aspirin could be considered for primary
prevention of AOS scerotic
cardiovascular disease in adults aged 40
to 70 who are at a high risk of
atherosclerosis but with no increased
risk of bleeding because aspirin
increases the risk of bleeding they
don't recommend it for people over the
age of 70 or for anyone who's at
increased risk of bleeding what about
secondary prevention which means
preventing getting a second heart attack
here daily lowd dose aspirin has more
benefits and is generally recommended by
the American Heart Association for
people who aren't at increased risk of
bleeding next supplement is glycine
which is an amino acid that supports
collagen turnover gathan production
creatin synthesis and heem synthesis the
2019 ITP study found that glycine
supplementation increased maximum
lifespan in both male and female mice by
4 to 6% the mice consumed a diet
comprising of 8% glycine which is quite
a large amount and another 2011 study
found that a diet comprising of 8 to 12%
glycine extended the median lifespan of
rats by 28% the rats lived on 113 weeks
instead of 88 maximum lifespan also
increased by 30% from 91 to 119 weeks
the reason why glycine extends Lipan is
thought to be because of mimicking
methine restriction methine is another
amino acid you get primarily from animal
protein and methan in restriction has
been often seen to extend lifespan in
animals glycine counterbalances methan
in toxicity and has been seen to have
the same life extension effects as
methine restriction without restricting
methine that's why in these studies you
see that a very large intake of glycine
8 to 12% of their diet extends lifespan
in humans the evidence is obviously more
limited but the average person's diet is
very high in methine and it doesn't
contain that much glycine muscle meat
eggs dairy chicken fish Etc they're all
very high in methine and very low in
glycine glycine you can get from tendon
Meats collagen fish skin chicken skin
and gelatin powder this creates a
scenario where most people could
theoretically improve their longevity by
balancing their methan in ratio with
more glycine they would either need to
reduce their methan intake or increase
their glycine intake but most people
would benefit from both there are no
hard outcomes observed from high methan
and low glycin intake but there are a
few benefits that have been seen in
clinical trials in older adults they
have found that low plasma glycine
levels are a marker of visceral
adiposity independent of sex age body
composition or chronic diseases serum
glycine is also negatively associated
with intramuscular atos tissue which is
the fat inside the muscles methan in
restriction on the other hand appears to
reduce visceral fat in both animals and
humans and glycine is also useful for
other things such as collagen production
for the skin and Joints glut thean
production for antioxidant fence and
inflammation sleep blood sugar and
creatine synthesis so although we can't
say whether or not glycine
supplementation is going to extend
lifespan in humans we can be pretty sure
that most people are eating too much
methine and not enough glycine that's
why I'm also taking 10 grams of glycine
as a supplement every day and I'm eating
plenty of glycine rich foods next on the
list is captopril captopril is an
Angiotensin converting enzyme ace
inhibitor used to treat high blood
pressure in the ITP study captopril
extended median lifespan of female mice
by 4 to 5% hypertension is one of the
most common co-morbidities in the world
and it's called the silent killer that
increases the risk of heart disease
kidney disease and neurod degeneration
if you have elevated blood pressure then
you should try to normalize it as fast
as possible because the longer your
blood pressure stays elevated the more
damage it can cause to your body ACE
inhibitors have some nasty side effects
which is why I think the recreational
use of captopril is probably not worth
it furthermore the life extension
benefits in the ITP study weren't that
big it was only 4 to 5% and it was only
absorbed in the female mice so if you
were ever going to take any
pharmaceutical for recreational purposes
to support your longevity then you would
be probably better off by taking
something like a carbos or rapamycin
instead of CapTel the next compound is
nordi hydro WTIC acid ndga it's a ligant
found in croso Bush or grease wood in
the TP study it resulted in 10% increase
in Lipan in both sexes ndga is basically
a herbal compound that's been seen to
increase Nrf2 activation and thus reduce
inflammation it's not a very common
compound although it's being
investigated for clinical purposes at
the moment and I haven't found any
supplements that have ndga in it so
that's pretty much all I have to say
about this compound prandom is another
herbal supplement that contains a patent
and mix of five herbal ingredients that
support nf2 activation it has termic
root green tea milk thisle bopa moneri
and ashwagandha in the ITP study
Protandim resulted in 7% increase in
median survival of male mice but there
was no significant difference in
survival at the age at 90% mortality the
company selling pandum Life Vantage has
gotten into some trouble with the FDA
because of their misleading and illegal
marketing claims that claim pandum can
help with different conditions like
cancer and diabetes there's no evidence
that pendum or the specific ingredients
in the supplement could help with those
conditions the ITP study did find that
pendum resulted in 7% increase in median
lifespan but there was no difference at
the end of life so in my opinion taking
this supplement isn't worth it the
problem is also that it's a patented
proprietary blend which means that you
don't know exactly how much of each
ingredient is in the blend and it's also
$66 for 30 capsules which is over $2 per
day next up we have the most successful
life extension molecule and the one with
the greatest potential rapy it's been
known to have life extension effects in
animals for decades and in the it PP
studies it has done so by 14% in females
and 9% in males even if Romy was given
late in life Romy increases median
Survival by 10% in males and 18% in
females and it attenuates age related
decline in spontaneous activity in males
but not in females in another 2016 study
treating middle-aged mice with rap ayin
for only 3 months extended their life
expectancy by 60% and improved Health
span that's very interesting because
they treated the mice with rap ayine for
only 3 months a mouse usually lives 12
to 18 months so they got repy in only
about a quarter of their life and they
still saw a large life extension effect
for humans the equivalent duration would
be something like 20 years which is a
very long time but it's still not your
entire lifespan but are there any
longevity studies about rapamycin in
humans if you don't know then rapamycin
is used for organ transplantation
rejection as it suppresses the immune
system if taken chronically however
there are now several clinical trials
showing that rapamycin actually enhances
immune system function when used
transiently it appears that rather than
using rapy daily you would have to pulse
it something like once a week or once
every two weeks to avoid the
immunosuppressive effects and by doing
that the elderly people actually see an
improvement in their immune system
function many longevity enthusiasts are
taking Ramy off label in hopes of
extending the lifespan a 2023 study by
Matt caban and colleagues looked that
333 such people they found that at an
average dose of 3 to 6 Mig per week rap
a didn't have any adverse side effectss
on health with the most common side
effects being abdominal cramps and mouth
Alters most people also didn't know if
the drug was working but they did
self-report improvements in their health
brain function youthfulness coldness and
general aches and pains the problem is
that the placebo effect can be very big
in these people who are taking rapamycin
thinking that it's going to extend their
Lipan you can't just buy rapamycin from
the pharmacy you need to go out of your
way to get it and if you are doing that
then you probably have some expect that
is going to improve your health so it
wasn't a placebo controlled study
overall I do think that out of all these
compounds rapy is the most promising one
I think it has the greatest potential of
being the first geroprotective drug we
obviously need a lot more clinical
trials on humans to see what the effects
are but many of the leading longevity
experts do think that rapamycin does
work in extending lifespan I'm
personally not taking Romy at the moment
I don't have any plans in the near
future either I'm waiting for more of
these clinical trials to come out in the
next next few years the last compound is
17 Alpha estradi which is also called
non-feminizing estrogen in the ITP study
in increased media male lifespan by 19%
and by 11% when fed late in life this is
quite interesting and estrogens are
known to have cardioprotective and
neuroprotective effects it's even
thought that estrogen might be one of
the reasons why women live on average 5
to 10 years longer than men as you've
seen repeatedly throughout this video
most of the compounds extend lifespan in
male mice more so than they do in female
fale mice that's very interesting and it
might be partly because of the six
differences between male and female
animals and in the ITP study 17 Alpha
estrad didn't extend female lifespan
what other Studies have also found is
that the life extension effects of 17
Alpha estrad go away in castrated male
mice which suggests that it works in the
presence of elevated male hormones and
androgens androgens and testosterone
tend to shorten Lipan and they're
associated with increased risk of heart
disease which is why it looks like 17
Alpha estral counteracts those effects
in males who have testicles it doesn't
do so in females who don't have
testicles and it doesn't do so in
castrated males interestingly castrated
males having also seen to live longer
than regular males in different human
cohort studies I'm pretty sure most men
would like to keep their testicles and
they would much rather take something
like 17 Alpha estr rather than castrate
themselves 17 Alpha estr is called
non-feminizing estrogen because it
doesn't have any of the feminizing
effects of estrogen such as breast
tissue growth or other feminizing
effects it's obviously very early to say
if 17 Alpha estral is going to extend
lifespan or longevity in humans
especially in male humans but I'll be
interested to see the future clinical
trials there you go these are the
compounds that have been shown to extend
Lipan in the ITP program they've tested
many other popular molecules like
reservatrol methylin blue nicotinum at
riboside corcumin and MCT oil and those
compounds didn't increase Lipan what's
the Practical takeaway from this well
personally me I'm going to macro do
Glycine and I might think about using
rapamycine in a few years but not right
now if if you want to know about the
non- phological evidence-based methods
to slow down aging and add healthy years
to your life then check out my new book
the longevity leap in the description
thanks for watching this video make sure
to click a like And subscribe to future
videos about living longer and staying
healthier my name is seam stay optimized
stay empowered
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