Considerations in Geriatric Pharmacology: Episode 157 | Straight A Nursing

Straight A Nursing Podcast
8 May 202327:41

Summary

TLDRIn this episode of the Straight A Nursing Podcast, Nurse Moe delves into geriatric pharmacology, focusing on how aging affects medication absorption, distribution, metabolism, and excretion. She emphasizes that drug dosages often need to be lower in the elderly due to these changes. The episode also covers the challenges of polypharmacy, the Beers list for potentially inappropriate medications in older adults, and the importance of deprescribing. Nurse-driven interventions for improving medication adherence in the elderly are also discussed, with practical tips for nurses to enhance patient care.

Takeaways

  • πŸ“š Aging affects pharmacokinetics, requiring lower drug dosages; start low and go slow.
  • πŸ’Š Geriatric patients face changes in drug absorption due to factors like decreased gastric emptying and increased gastric pH.
  • 🩺 Transdermal medications are often preferred for the elderly due to consistent drug concentrations and ease of use.
  • 🧠 Aging alters drug distribution, especially for lipophilic drugs, leading to prolonged effects and potential toxicity.
  • 🍎 Decreased serum albumin in the elderly can lead to higher levels of unbound drugs, increasing the risk of adverse effects.
  • πŸ›‘οΈ Reduced liver function in elderly patients affects drug metabolism, often requiring lower doses to prevent toxicity.
  • 🚰 Renal function decline in older adults reduces drug excretion, necessitating careful dosage adjustments for certain medications.
  • ❗ The Beers list identifies drugs potentially inappropriate for older adults, emphasizing the importance of medication safety.
  • πŸ“‰ Deprescribing aims to reduce polypharmacy risks in the elderly, improving cognitive function, fall risk, and overall safety.
  • πŸ“ Nurses can improve medication adherence in elderly patients through education, written instructions, and the use of medication management tools.

Q & A

  • What is the main topic of episode 157 of the Straight A Nursing Podcast?

    -The main topic of episode 157 is considerations with geriatric pharmacology and medication administration.

  • What does the acronym 'ADME' stand for in pharmacokinetics?

    -ADME stands for Absorption, Distribution, Metabolism, and Excretion, which are the four pillars of pharmacokinetics.

  • Why is the principle of 'start low and go slow' important when administering medication to the elderly?

    -The principle of 'start low and go slow' is important because many times drug dosages need to be lower in the elderly due to age-related changes in pharmacokinetics.

  • What are some factors that can affect drug absorption in the elderly?

    -Factors affecting drug absorption in the elderly include changes in gastric emptying, active transport, intestinal surface area, and gastric pH.

  • Why might transdermal medication delivery be beneficial for the elderly?

    -Transdermal medication delivery is beneficial for the elderly because it provides a steady rate of administration, is easy to use, and circumvents hepatic first-pass metabolism.

  • How does aging affect the distribution of highly lipophilic drugs?

    -Aging increases body fat and decreases total body water, which can lead to an increased distribution and half-life of highly lipophilic drugs, potentially causing increased levels and prolonged effects.

  • What is the significance of the 'Beers List' in geriatric pharmacology?

    -The Beers List identifies medications that are potentially inappropriate for use in older adults due to risks of adverse effects and aims to increase medication safety in this population.

  • What is the process of 'deprescribing' and why is it important for elderly patients?

    -Deprescribing is the process of evaluating and removing unnecessary or inappropriate medications from a patient's regimen to enhance medication safety, improve adherence, and reduce risks of adverse effects.

  • How can nurses improve medication adherence and safety among elderly patients?

    -Nurses can improve medication adherence and safety by providing patient education, using the teach-back method, providing written instructions and schedules, utilizing medication management tools, and assessing all medications during home visits.

  • What are some examples of nurse-led interventions to enhance medication adherence in the elderly?

    -Examples of nurse-led interventions include teaching the appropriate person, using the teach-back method, providing written instructions, using medication management tools like pill organizers or electronic dispensers, and setting reminders via telephone or electronic devices.

Outlines

00:00

πŸŽ™οΈ Introduction to Geriatric Pharmacology

In this episode of the Straight A Nursing Podcast, Nurse Moe introduces the topic of geriatric pharmacology, discussing the unique considerations needed when administering medication to the elderly. She acknowledges a listener's success in passing the NCLEX and emphasizes the importance of understanding how aging affects drug absorption, distribution, metabolism, and excretion. The episode promises to delve into pharmacokinetics, the concept of 'start low and go slow,' and the complexities introduced by multiple diseases and polypharmacy in the elderly.

05:01

πŸ‘΅ Age-Related Changes in Drug Absorption

This paragraph explores how the aging process impacts the absorption of drugs. It discusses conflicting research findings on the reliability of intramuscular administration due to variable absorption in the elderly. The general consensus is that while there are some changes, absorption may not be the most significant factor. The paragraph also covers gastrointestinal changes in the elderly, such as altered gastric emptying, decreased intestinal surface area, and increased gastric pH, and how these can affect the absorption of specific medications like levodopa, digoxin, and calcium carbonate. The benefits of transdermal drug administration for the elderly are highlighted, including steady drug release and ease of use.

10:05

πŸ’Š Distribution and Metabolism in Elderly Patients

The discussion moves on to the distribution of drugs within the body, noting that as body water decreases and body fat increases with age, the distribution of lipophilic drugs is affected. Examples of such drugs are provided, and the potential for increased half-life and prolonged effects are explained. The paragraph also addresses the impact of decreased serum albumin on drug binding, which can lead to higher levels of unbound drugs and increased risk of adverse effects. Metabolism is then covered, focusing on the liver's role in drug metabolism and the first-pass effect, which is reduced in the elderly, often necessitating lower doses of medication.

15:07

🚰 The Impact of Aging on Drug Excretion

This section delves into the excretion or elimination of drugs, with a focus on the renal system's role. It explains how creatinine clearance and glomerular filtration rate decline with age, affecting the kidneys' ability to eliminate drugs. Medications that rely heavily on renal clearance, such as morphine, metformin, and certain diuretics, require careful dosing considerations in the elderly. The importance of starting with lower doses and the concept of deprescribing to enhance medication safety are emphasized.

20:09

🧠 Pharmacodynamics and the Elderly

The paragraph discusses pharmacodynamics, particularly the increased sensitivity of elderly individuals to the central nervous system effects of medications, especially those with cognitive impairments. It uses diphenhydramine as an example, highlighting the potential for acute confusion and other adverse effects in the elderly. The BEERS list is introduced, noting drugs that are potentially inappropriate for older adults due to heightened risks, such as anticholinergics, ACE inhibitors, Warfarin, and benzodiazepines.

25:11

πŸ“‹ Improving Medication Adherence in the Elderly

This paragraph focuses on strategies to improve medication adherence and safety among the elderly. It discusses the challenges faced by the elderly in adhering to medication regimens, including cognitive decline and swallowing difficulties. Nurse-led interventions are suggested, such as patient education, the use of medication management tools, and regular assessment of medications. The importance of deprescribing to reduce polypharmacy and its associated risks is reiterated.

πŸ“ Conclusion and Study Resources

The final paragraph wraps up the episode with a quick summary of key points, emphasizing the importance of adjusting medication dosages for the elderly and the role of deprescribing. It introduces a new members-only podcast, 'Straight A Nursing Study Sesh,' which offers in-depth study materials, including pod quizzes, drills, case studies, and power hour sessions. Interested listeners are directed to a website for more information and to access these study resources.

Mindmap

Keywords

πŸ’‘Geriatric Pharmacology

Geriatric pharmacology is the study of how aging affects drug action and the unique considerations needed for medication administration in the elderly. It is a key theme in the video, as it discusses the impact of age-related physiological changes on drug absorption, distribution, metabolism, and excretion. The script emphasizes the importance of understanding these changes to ensure safe and effective medication use in older adults.

πŸ’‘Pharmacokinetics

Pharmacokinetics refers to the process of how a drug moves through the body, including absorption, distribution, metabolism, and excretion. In the video, it is highlighted as a crucial concept for understanding the differences in medication administration in the elderly, where age-related changes can affect each of these stages, often necessitating lower dosages and a 'start low and go slow' approach.

πŸ’‘Polypharmacy

Polypharmacy is the use of multiple medications by a single patient, which is common in the elderly population due to multiple health conditions. The script discusses how polypharmacy can lead to increased risk of adverse drug interactions and effects, emphasizing the need for careful medication management in older adults.

πŸ’‘Deprescribing

Deprescribing is the process of reducing or eliminating unnecessary medications in a patient's regimen, particularly important in geriatric care to enhance medication safety and adherence. The script mentions deprescribing as a strategy to combat the high pharmacological risks associated with polypharmacy in the elderly.

πŸ’‘Pharmacodynamics

Pharmacodynamics is the study of the effects of drugs on the body, including their mechanism of action and the relationship between drug concentration and effect. The video points out that elderly individuals are often more sensitive to the central nervous system effects of medications, which is a key aspect of pharmacodynamics.

πŸ’‘Beers List

The Beers List, or Beers Criteria, is a set of guidelines that identifies potentially inappropriate medications for use in older adults due to their risk of adverse effects. The script uses the Beers List as an example of how certain medications, such as diphenhydramine and benzodiazepines, are flagged for their risks in the elderly population.

πŸ’‘Absorption

Absorption in pharmacology is the process by which a drug moves from the site of administration into the bloodstream. The video script discusses how age-related changes in the gastrointestinal tract can affect drug absorption, with examples such as altered gastric emptying and increased gastric pH affecting certain medications.

πŸ’‘Distribution

Distribution refers to the transfer of a drug from the bloodstream to the tissues where it can exert its effect. The script explains that as people age, changes in body composition, such as decreased total body water and increased body fat, can affect the distribution of drugs, particularly lipophilic ones, leading to increased half-life and potential toxicity.

πŸ’‘Metabolism

Metabolism in the context of pharmacology is the process by which the body chemically transforms drugs into more or less active compounds, typically preparing them for excretion. The video mentions that metabolic activity and the first-pass effect are reduced in the elderly, which can affect the efficacy of medications that rely on hepatic metabolism.

πŸ’‘Excretion

Excretion, or elimination, is the process by which drugs are removed from the body, primarily through the kidneys. The script notes that renal function declines with age, affecting the excretion of many drugs, and highlights the need to adjust dosages for medications that rely heavily on renal clearance.

πŸ’‘Medication Adherence

Medication adherence refers to the extent to which patients take their medications as prescribed. The video discusses challenges in medication adherence among the elderly, such as difficulty swallowing pills, cognitive decline, and complicated regimens, and suggests nurse-led interventions to improve adherence and safety.

Highlights

Introduction to the topic of geriatric pharmacology and medication administration considerations.

Congratulation to Rebecca for passing the NCLEX, emphasizing the podcast's role in her success.

The concept that pharmacology is not 'one size fits all', especially in the elderly.

Explanation of pharmacokinetics and its four pillars: absorption, distribution, metabolism, and excretion.

The importance of starting medication dosages low and increasing slowly in elderly patients.

Discussion on the complexities of pharmacology in the elderly, including polypharmacy.

Impact of aging on drug absorption, including changes in the gastrointestinal tract.

Examples of drugs affected by decreased gastric emptying and active transport in the elderly.

The benefits of transdermal drug administration for the elderly.

How age-related changes in the body affect drug distribution and the impact on lipophilic drugs.

The role of plasma proteins in drug binding and the risks associated with decreased serum albumin in the elderly.

An overview of how the liver's metabolic activity and first-pass effect change with age.

The significance of renal function decline with age and its effect on drug excretion.

Introduction to pharmacodynamics and increased sensitivity to CNS effects in the elderly.

The Beers List and its purpose in identifying potentially inappropriate medications for older adults.

The practice of deprescribing to enhance medication safety in the elderly.

Challenges in medication adherence among the elderly and factors affecting it.

Nurse-led interventions to improve medication adherence and safety in geriatric patients.

Announcement of a new members-only podcast for nursing students focusing on study sessions.

Upcoming podcast episode on newborn assessment and the Apgar score.

Transcripts

play00:00

[Music]

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well hello there again everyone this is

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Nurse Moe and welcome back to the

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straight a nursing podcast this is

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episode 157 and today we are talking

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about some considerations with geriatric

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pharmacology and medication

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administration so before we dive into

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this really interesting topic I do want

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to take a moment for our listener shout

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out and this one goes out to Rebecca so

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Rebecca says I wanted to thank you just

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past my NCLEX in 75 questions you were

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integral in that success Rebecca I mean

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I'm sorry nurse Rebecca congratulations

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that is amazing I cannot wait to hear

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about all the amazing things that you do

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so please reach out touch base send us

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an email let us know where you land and

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how you're loving your new job

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so I have a big news flash for you guys

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pharmacology is not one size fits all

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okay if you have already listened to the

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episode on pediatric pharmacology you

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definitely understand this concept so

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now we're going to look at the other end

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of the spectrum

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to discuss how aging affects medication

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administration pharmacological

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considerations in the elderly and then

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at the end we'll be doing some of those

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pod quiz questions that you love so much

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and I have an exciting announcement

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about that as well

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so recall that pharmacokinetics is

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essentially what the body does to a drug

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after it's administered so the four

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pillars of pharmacokinetics are

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absorption

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distribution

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metabolism and excretion you may also

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hear elimination so adme absorption

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distribution metabolism excretion

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today we'll be talking about the

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age-related changes that occur in each

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of these pillars so the short version is

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that many times drug dosages will need

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to be lower in the elderly so the name

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of the game is start low and go slow and

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after we get through this episode you'll

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understand why so complexities of

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pharmacology and the elderly it's often

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compounded you guys by the presence of

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multiple disease conditions leading to

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polypharmacy and we're going to talk

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about that some more as well so let's

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dive down into the details

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absorption what is absorption it is the

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process of the drug basically moving

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from the site where it was administered

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into the bloodstream so it can you know

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get to where it needs to go and do what

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it needs to do

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so as I was researching this for you

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guys I was really surprised to see there

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is a lot of conflicting information out

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there about how aging affects drug

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absorption some of the materials

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suggested that intramuscular route is

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really unreliable because the absorption

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can be so variable and then other

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studies said not so much so the general

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consensus is that yes there are some

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changes in absorption but may not be the

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biggest factor for the elderly patient

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but I do want to look at po medications

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because there are some things that we

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need to talk about with that the general

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differences in the GI tract of the

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elderly is changes to gastric MTM time

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decreased small bowel surface area and

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increases in gastric pH but again most

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cases the absorption of drugs is not

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significantly different that's what the

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studies are saying right now but there

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are definitely differences in how long

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it takes for the drugs to have an effect

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but let's talk a little bit about some

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prime examples of how the GI tract is

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different in the elderly and how it

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could be affected as far as

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pharmacokinetics go

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so decreased gastric emptying

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can lead to altered absorption of some

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drugs such as levodopa and digoxin so

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that would be two prime examples of

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drugs where decreased gastric emptying

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does affect the absorption

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and then decreased active transport can

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lead to a decrease in the transport of

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vitamins and electrolytes

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and then that decreased intestinal

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surface area that I mentioned a moment

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ago leads to a general decrease in drug

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absorption for some medications again

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digoxin is another really great example

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of this

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and then that increased gastric pH can

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affect medications that do rely on a

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specific pH level so one example is

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calcium carbonate which does need a more

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acidic environment for optimal

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absorption so for this reason elderly

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patients are sometimes prescribed

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calcium citrate instead because it

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dissolves more easily in higher gastric

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pH levels

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another very key thing about the pH is

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with enteric coated tablets so this

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enteric coating is utilized for the

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purpose of extended release you remember

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that you never Crush an enteric coated

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tablet right the coding is designed to

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remain intact in that low PH environment

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of the stomach in that very acidic

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environment of the stomach and then

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begin to dissolve in the higher pH

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environment of the small intestines so

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in the elderly where gastric pH can be

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higher these medications could have an

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early release causing adverse GI effects

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or alterations in absorption

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one other route that I think we should

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talk about very briefly is the

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transdermal route

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transdermally delivered medications are

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actually typically considered really

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beneficial for the elderly because of

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that steady rate of administration and

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ease of use so some examples include

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fentanyl

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nitroglycerin estradiol

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mean I had to pause there for a minute

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and see if I could say that one and

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Scopolamine so some of the advantages of

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transdermal Administration are they

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circumvent hepatic first pass metabolism

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which we'll talk about in a moment there

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are decreased adverse GI effects and

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higher likelihood of compliance and more

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consistent drug concentrations

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though the skin absolutely changes with

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age Studies have shown that these

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changes in lipid structure and hydration

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really only affect medications with

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strongly

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hydrophilic properties so in general if

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dose alterations are needed in the

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elderly it's not typically due to

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alterations in absorption it's typically

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due to age-related cardiovascular renal

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and hepatic changes which will all make

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so much more sense as we get into the

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other pillars of pharmacokinetics

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so the next pillar that we need to talk

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about is distribution

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so distribution is that process of

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transferring a drug from the bloodstream

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to the tissues where it can exert its

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effect

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so as we age total body water decreases

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while body fat increases the

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distribution of Highly lipophilic drugs

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is therefore increased so some great

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examples of this are risperidone

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atorvastatin

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ciprofloxacin

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azithromycin and Propofol

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so what does this mean for your patient

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lipophilic drugs may have an increased

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Half-Life when body fat is higher

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leading to increased levels and

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prolonged effects of these types of

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medications

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and then distribution is also affected

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by the presence or the absence of plasma

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proteins as we age or even as we're

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malnourished serum albumin decreases and

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you guys know a lot of times aging and

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malnourishment can go hand in hand

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so this decrease in serum albumin leads

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to changes in the bindings of some

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medications so if you're elderly patient

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also has malnutrition then they are very

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high risk for alterations and the

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bindings of some medications and this

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can lead to higher levels of Unbound

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drugs like Warfarin and phenytoin and

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this in turn can lead to Serious adverse

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effects and toxicity

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and then metabolism is that third pillar

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so in general metabolism is the process

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that drugs go through that makes them

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either more or less active though

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generally metabolism makes drugs less

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active because that's how they're

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designed there are some that actually

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need to be metabolized to become active

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but that's pretty rare the process of

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metabolism converts the compound from

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its original state which is that active

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state in general and converts it into

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something else which is less active and

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then excreted from the body so a key

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player in metabolism is the liver not

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only does the liver metabolize many many

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medications it is also responsible for

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something called the first pass effect

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so when you take a medication by mouth

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it is absorbed through the intestinal

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mucosa and then enters hepatic

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circulation and taken straight to the

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liver for metabolism even before it gets

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to the heart for circulation

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in some cases the first pass effect can

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reduce the medication's efficacy by up

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to 90 percent when you compare it to IV

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Administration so this explains why IV

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doses are sometimes so so much smaller

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than po doses so a fantastic example of

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this is midazolam

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looking at the pediatric dose for

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midazolam IV it's

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.025 to .05 milligrams per kilogram and

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we're you know if we're using it for

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something like procedural sedation

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versus

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po 0.25 to 0.5 milligrams per kilogram

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so if that child weighs 30 kilograms

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that low end dose for an IV midazolam

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would be 0.75 milligrams versus

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7.5 milligrams po so you can see how po

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doses can sometimes be so much larger

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and that's because of first pass

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metabolism

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so in early patients metabolic activity

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is reduced and so is that first pass

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effect so for these reasons decreased

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doses are often needed in your elderly

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patients some examples of medications

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that rely on hepatic metabolism and will

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require scrutiny or Ibuprofen

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diltiazem

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Warfarin and levodopa remember the name

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of the game start low and go slow

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and then that final pillar of

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pharmacokinetics is excretion you may

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also hear it called elimination and this

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part involves how the drug is

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essentially removed from the body the

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key player here is the renal system and

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aging definitely has a significant

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impact here

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so after about age 40 which it does not

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seem that old to me creatinine clearance

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starts to decline along with GFR and

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tubular function the result is that many

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drugs have reduced elimination by the

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kidneys so any medication that relies

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heavily on renal clearance will need to

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be scrutinized for proper dosing so some

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great examples of these drugs are

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morphine metformin

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Gentamicin Gabapentin there's digoxin

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again and diuretics like furosemide and

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spironolactone again what's the name of

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the game start low and go slow

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Okay so we've talked about

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pharmacokinetics let's talk now a little

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bit about pharmacodynamics

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the key takeaway here is that elderly

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individuals will be more sensitive to

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the central nervous system effects of

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medications

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especially if they have underlying

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cognitive impairment

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so take diphenhydramine for example

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elderly patients are more sensitive to

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the CNS effects of diphenhydramine which

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is an anticholinergic so one of the main

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adverse effects the elderly can have

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with diphenhydramine is acute confusion

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and it can be very very pronounced they

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are also likely to be more strongly

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experiencing the adverse effects such as

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dizziness urinary retention blurred

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vision and tachycardia

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so be very careful or even wary of

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giving diphenhydramine to your elderly

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patient and you might want to talk with

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the MD about Alternatives when they are

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available

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So speaking of diphenhydramine brings us

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to the next thing we need to talk about

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and that is the beers list so you may

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hear

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something called a Beer's drug and

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that's a pretty common term you'll hear

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when you're learning about elderly and

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the pharmacology and no it does not mean

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that the drug comes with an ice cold

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bottle and a wedge of lime okay beers

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drugs are those that are marked as

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potentially inappropriate for use in

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older adults

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the goal with the beers list and that's

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b-e-e-r-s the goal with the beers list

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is to increase medication safety with

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this special population that is

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absolutely prone to polypharmacy

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diphenhydramine and other

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anticholinergics are on this list due to

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that high risk for cognitive decline in

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the elderly

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other medications include ACE inhibitors

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because of the risk for hyperkalemia

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Warfarin due to the increased risk of

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bleeding and benzodiazepines for the

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increased risk of Falls now it doesn't

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mean we don't use these medications in

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the elderly because I'm sure you've seen

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a lot of elderly patients on Warfarin or

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an Ace inhibitor but they have to be

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scrutinized very carefully there are

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quite a few medications on the beers

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list and I will include a link to some

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additions and updates in the episode

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notes they're also in your Davis drug

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guide if you happen to use that

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reference

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one of the highest pharmacologic risks

play16:52

for the elderly is polypharmacy like

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I've mentioned before and with that

play16:57

heightened risk for adverse interactions

play17:00

and effects so we have something called

play17:05

deprescribing and the practice of

play17:08

deprescribing involves that practitioner

play17:12

evaluating the patient's medical

play17:14

condition and current pharmacologic

play17:17

regimen to remove as many medications as

play17:22

possible

play17:23

the process of removing medications it's

play17:27

not as cut and dried as just stopping

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them all together the practitioner and

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the patient must work together in a lot

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of cases to taper or withdraw as

play17:37

appropriate with ongoing monitoring

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conducted as it is needed so some

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studies show that deprescribing leads to

play17:47

a fewer medications overall which tends

play17:50

to improve medication adherence

play17:53

B improving or preserving cognitive

play17:57

function

play17:59

C reducing fall risk and D reducing risk

play18:04

for hospitalization and even death

play18:07

so deprescribing is something you may

play18:09

hear about and it is basically the

play18:11

opposite of prescribing

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okay some special considerations with

play18:16

your geriatric patients so things to

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think about

play18:20

adherence can be challenging in the

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elderly population for a variety of

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factors so a 1998 study showed that

play18:30

adherence to pharmacologic regimens

play18:33

varies based on the drug dosage itself

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the form that the drug comes in its cost

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physician patient communication and

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insurance coverage

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complicated regimens and cognitive

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decline also play a very key role here

play18:54

and then we have to look at swallowing

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difficulty many elderly patients have

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difficulty swallowing so may even avoid

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taking pills or avoid taking them in

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their original form so let's say you

play19:09

have a patient who can't swallow pills

play19:11

so they Crush everything and then they

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add it to you know you have to add it to

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applesauce or some pudding have you guys

play19:18

ever tasted a pill that's been crushed

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and you try to disguise it in Pudding it

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doesn't taste like pudding okay it's

play19:26

very very bitter tasting and could cause

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a decreased medication adherence

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patients may not also understand that

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they should not Crush extended release

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or enteric coated tablets leading to

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Serious adverse effects and even

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toxicity

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and then medications that require very

play19:48

close monitoring such as Warfarin may be

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utilized in appropriately in patients

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who maybe don't have the resources for

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regular visits to the lab or visits to

play19:59

the doctor's office

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so what can the nurse do to help improve

play20:05

medication adherence and safety amongst

play20:09

this patient population so a 2017

play20:13

systematic review

play20:15

showed some basic General guidelines

play20:18

that are nurse-led interventions and

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these include lots of patient education

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right that's always a component as you

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are teaching make sure a that you're

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teaching the appropriate person if the

play20:32

individual you're teaching has severe

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dementia you're not teaching the

play20:36

appropriate person teach the caregiver

play20:39

the family members whoever it may be and

play20:41

utilize the teach back method where you

play20:45

have them teach it back to you that's a

play20:47

great way to really know okay they got

play20:50

it

play20:51

also providing written easy to follow

play20:55

instructions and written easy to follow

play20:58

schedules it's not enough just to have

play21:01

it on the pill bottle have it written

play21:03

out large print easy to see put it right

play21:07

there next to the location where they

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keep their medications

play21:11

also the utilization of medication

play21:13

management tools such as electronic pill

play21:16

dispensers is really great or simply

play21:20

those pill organizers that separated out

play21:22

by day of the week or AM and PM

play21:25

you can even have reminders via

play21:28

telephone or electronic devices there

play21:32

are several apps created specifically

play21:35

for this purpose

play21:37

and of course if you are a home health

play21:40

nurse a visiting nurse assessing all

play21:43

medications with each home visit and

play21:46

then when the patient comes into the

play21:48

inpatient setting or the outpatient

play21:50

setting like at a clinic or a doctor's

play21:52

office

play21:53

so there you have it you guys your basic

play21:57

guide to pharmacology and the elderly

play21:59

patient now if you're looking for just

play22:02

the very basic info let's do a quick too

play22:04

long didn't read I guess this would be a

play22:06

too long didn't listen and that is

play22:09

physiologic changes associated with

play22:12

aging lead to alterations and absorption

play22:16

distribution metabolism and excretion of

play22:19

medications though absorption not as

play22:22

much a factor as the others the name of

play22:25

the game is to start low and go slow

play22:29

the beers list Flags medications that

play22:32

may be inappropriate for the elderly and

play22:36

the goal of deprescribing is to enhance

play22:39

medication safety and adherence in the

play22:42

elderly and nurse driven interventions

play22:45

can improve medication adherence and

play22:48

safety okay you guys who is up for a few

play22:53

pod quiz questions

play22:56

if you've never done a pod quiz before I

play22:58

ask a question I pause for a little bit

play23:00

give you time to answer and then tell

play23:02

you the answer basically we are doing

play23:05

flash cards with our ears and if you

play23:07

enjoy this format then stay to the end

play23:10

because I'm going to tell you how you

play23:12

can get way more pod quizzes in your

play23:15

life okay so here we go

play23:17

what are the four pillars of

play23:20

pharmacokinetics

play23:27

absorption distribution

play23:30

metabolism and excretion very good

play23:35

what is the process of transferring a

play23:38

drug from the bloodstream into the

play23:41

tissues

play23:42

foreign

play23:47

what is the process drugs go through to

play23:51

make the drug more or less active and

play23:54

ready for excretion

play23:59

that is metabolism

play24:02

what is the process of the drug moving

play24:04

from the site of administration into the

play24:07

bloodstream

play24:12

that is absorption excellent work

play24:15

what is the process of removing the drug

play24:19

from the body

play24:23

that is excretion you may also hear it

play24:26

called elimination

play24:28

what is the key organ in medication

play24:31

excretion or elimination

play24:35

that's the kidneys what is the key organ

play24:38

in metabolism

play24:43

the liver great job and what is one of

play24:46

the highest pharmacologic risks for the

play24:49

elderly

play24:53

that is polypharmacy and to combat that

play24:56

we do

play24:58

deprescribing very very good okay so if

play25:01

you guys like doing pod quiz questions

play25:04

and you kind of got a feel for how

play25:06

beneficial that might be to review

play25:09

things that you've learned in class or

play25:11

from listening to this podcast then

play25:13

you're going to love my new members only

play25:16

podcast called straight a nursing study

play25:20

sesh so in this podcast we do a lot of

play25:25

pod quizzes and not just four or five an

play25:27

entire episode that dives into a topic

play25:30

and pod quizzes you on it and then in

play25:35

addition to that we have drills where we

play25:38

do recognize there are some things in

play25:40

nursing school that you need to memorize

play25:42

for instance if you memorize the blood

play25:45

flow pathway through the heart and you

play25:48

know that thing forwards and backwards

play25:51

then you can apply that to the much

play25:54

broader concepts of heart failure and

play25:57

Val of disorders so in drills we drill

play26:00

things into your head so that when you

play26:02

do need to memorize something we get it

play26:04

in there where it belongs and then we

play26:07

have case studies which is basically

play26:10

making clinical decisions evaluating

play26:12

scenario as we go through a patient

play26:15

situation and then the power hour

play26:18

sessions are those deep dives into more

play26:21

extensive Concepts so there's one in

play26:25

there right now on blood pressure

play26:27

regulation and it is just amazing and it

play26:31

comes with a study guide some of the

play26:33

episodes do come with study guides this

play26:36

study guide is awesome you guys so I

play26:38

want you to get your hands on all of

play26:40

that so you can learn more by going to

play26:43

straight a nursingstudent.com forward

play26:46

slash study Dash sesh forward slash

play26:50

study Dash Sash and all the information

play26:54

is there there's a bunch of FAQ at the

play26:56

bottom if you have a question setting it

play26:59

up is super easy so go check that out

play27:02

straightynursingstudent.com forward

play27:04

slash study Dash sesh okay next week you

play27:09

guys where are the nursing students that

play27:13

are heading into or in their OB or mom

play27:17

and baby or whatever they call it at

play27:18

your school clinical rotation because

play27:21

we're diving into newborn assessment

play27:23

specifically the apgar score so I'll see

play27:26

you back here next week to talk about

play27:28

that bye for now

play27:30

[Music]

play27:32

this podcast is brought to you by

play27:34

Straight a nursing

play27:40

foreign

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Related Tags
Geriatric PharmacologyMedication SafetyElderly CarePolypharmacyPharmacokineticsPharmacodynamicsNursing EducationDrug DosageDeprescribingPatient Adherence