Newly Discovered Cause of Insulin Resistance is Not Sugar or Saturated Fat - Dr. Venn Watson

Summary

In this enlightening discussion, Dr. Stephanie Vin Watson reveals a groundbreaking study identifying a new nutritional deficiency syndrome, cellular fragility syndrome, linked to C15 fatty acid deficiency. The deficiency is associated with accelerated aging and increased risk of diseases like type 2 diabetes, heart disease, and fatty liver disease. Discovered through research on Navy dolphins, the syndrome is tied to ferroptosis, a form of cell death involving lipid peroxidation and iron. The conversation highlights the importance of C15 in cell membrane stability and the potential of supplementation and dietary changes in addressing this deficiency.

Takeaways

• 🧠 The script discusses a new study revealing a nutritional deficiency syndrome called 'cellular fragility syndrome' linked to C15 deficiencies.
• 🩸 The deficiency is connected to the weakening of cell membranes, accelerated aging, and a higher risk of diseases like type 2 diabetes, heart disease, and fatty liver disease at a younger age.
• 🧬 A decrease in C15 levels in cell membranes is associated with faster cell aging and the onset of aging-associated diseases.
• 🐬 The discovery was made through research on Navy dolphins, which showed signs of diseases typically seen in older age due to low C15 levels in their diet.
• 🔬 The study suggests that ferroptosis—a type of cell death involving iron and reactive oxygen species (ROS)—plays a role in the development of these diseases, especially when C15 is deficient.
• 🌐 The problem of C15 deficiency is widespread, particularly in developed countries, and is linked to modern dietary changes and agricultural practices.
• 🥛 Sardinia is highlighted as a region with unusually high life expectancy and lower rates of heart disease, possibly due to traditional diets rich in C15 from sheep and goat dairy products.
• 🧀 The script emphasizes the importance of C15 in dairy products, especially those from grass-fed animals, which have higher C15 content compared to grain-fed counterparts.
• 🌿 The potential solution includes supplementing with pure C15 to overcome dietary deficiencies and the challenges of modern food production.
• 👶 There is a call to action for the inclusion of C15 in infant formulas and a reconsideration of dietary guidelines regarding dairy fat for children.
• 🔗 The script concludes with the need for further research, awareness, and practical solutions to address the C15 deficiency and its global health implications.

Q & A

What is the primary issue discussed in the interview?

The primary issue discussed in the interview is the discovery of a new nutritional deficiency syndrome called cellular fragility syndrome, which is linked to a deficiency in C15 fatty acids and is associated with various health problems such as insulin resistance, metabolic syndrome, and increased risk of heart disease, stroke, and type 2 diabetes.

What is cellular fragility syndrome?

Cellular fragility syndrome is a newly discovered deficiency syndrome caused by a lack of C15 fatty acids in cell membranes. This deficiency leads to weak cell membranes, accelerated aging, and an increased risk of various diseases, including type 2 diabetes, fatty liver disease, and heart disease.

How does C15 deficiency impact the liver and pancreas?

C15 deficiency leads to lipid peroxidation and iron deposition in the liver, causing liver cells to become weak and not respond appropriately to glucose, leading to insulin resistance. In the pancreas, iron deposition affects beta cells, reducing insulin production, which further exacerbates metabolic issues.

What is the role of lipid peroxidation in cellular fragility syndrome?

Lipid peroxidation occurs when fragile fatty acids in the cell membrane are exposed to oxygen, leading to damage. This process, combined with iron deposition, results in the production of reactive oxygen species (ROS), which can damage cell components, including mitochondria, contributing to cell death and the onset of diseases.

What is the significance of the discovery of cellular fragility syndrome?

The discovery of cellular fragility syndrome is significant because it identifies a new nutritional deficiency that can be detected and corrected. Understanding and addressing this deficiency could help prevent or mitigate the development of various aging-associated diseases.

How does the study of Navy dolphins contribute to the understanding of cellular fragility syndrome?

The study of Navy dolphins, which showed signs of liver disease, insulin resistance, and fatty liver disease, led to the discovery of C15 deficiency as a key factor. This provided a clean model to understand the pathophysiology of the syndrome and the role of C15 in cellular health.

What is the connection between C15 deficiency and ferroptosis?

C15 deficiency is linked to the initiation of ferroptosis, a form of cell death characterized by lipid peroxidation and iron deposition. The deficiency leads to fragile cell membranes, which in turn triggers the ferroptosis process, contributing to various diseases.

What are the dietary sources of C15 fatty acids?

C15 fatty acids are primarily found in dairy fat, particularly in milk from grass-fed animals. The type of dairy, such as sheep and goat milk, and the diet of the animals (e.g., grass from high altitudes) can significantly influence the C15 content.

Why is Sardinia mentioned in the context of C15 and longevity?

Sardinia is noted for its high levels of longevity, and one factor contributing to this is the consumption of dairy products rich in C15, such as peino cheese. The high C15 content in their diet is thought to support cellular health and contribute to their longevity.

What are some potential solutions to address C15 deficiency?

Potential solutions include dietary changes to increase the intake of C15-rich foods, supplementation with pure C15, and possibly the fortification of foods with C15. Additionally, changes in agricultural practices to increase C15 content in dairy products could be beneficial.

Outlines

00:00

🧠 Cellular Fragility Syndrome and Metabolic Disorders

The paragraph discusses the onset of insulin resistance and metabolic syndrome due to iron deposition and lipid peroxidation in the liver and pancreas. Dr. Stephanie Vin Watson introduces a new study on a nutritional deficiency syndrome called cellular fragility syndrome, linked to C15 deficiencies. This syndrome is characterized by weak cell membranes due to the type of fatty acids present, leading to faster aging and increased risk of diseases like type 2 diabetes, heart disease, and fatty liver disease. The discovery is significant as it is the first nutritional deficiency syndrome identified in over 75 years, and it is both detectable and fixable.

05:02

🔬 The Discovery of Cellular Fragility Syndrome

This section delves into the discovery of cellular fragility syndrome, which is attributed to C15 deficiencies. The guest explains that cell membranes, made of lipids, can become weak based on the fatty acids present, and this weakness can lead to faster aging and various diseases. The conversation highlights the importance of C15 in maintaining cell membrane integrity and the connection between C15 deficiency and the acceleration of aging-associated diseases. The discussion also touches on the process of ferroptosis, a new way cells were found to die, which involves lipid peroxidation and iron, leading to reactive oxygen species that damage mitochondria.

10:03

🐬 C15 Deficiency and Its Impact on Health

The paragraph focuses on the research journey that led to the discovery of C15 deficiency's role in various health issues. It starts with the observation of health issues in Navy dolphins, which were found to have liver disease, insulin resistance, and fatty liver disease at a younger age. Metabolomics was used to analyze the dolphins' diet and bodies, leading to the identification of C15 as a key predictor of health. The lab studies showed that C15 helps mitigate the components of ferroptosis, including stabilizing cell membranes, reducing lipid peroxidation, and repairing mitochondria. The conversation also points out the global decrease in C15 intake due to changes in diet, particularly the reduction of dairy fat consumption.

15:05

🌐 The Global Implications of C15 Deficiency

This section discusses the widespread impact of C15 deficiency, drawing connections between the deficiency and the rise of diseases like type 2 diabetes, heart disease, and fatty liver disease at a younger age. The guest explains that the deficiency is not limited to any specific region but is a global issue, particularly in developed countries. The conversation emphasizes the need for increased awareness and action to address the deficiency, including the potential for supplementation and dietary changes to increase C15 intake.

20:06

🧴 The Role of Dairy Fat in C15 Intake

The paragraph explores the relationship between dairy fat consumption and C15 intake. It explains that dairy fat, particularly from grass-fed animals, contains higher levels of C15, which is essential for health. The guest discusses the findings from a panel of experts in dairy fat and nutrition who concluded that while whole dairy fat does not reliably improve health, individual nutrients within dairy fat, such as C15, can be beneficial when isolated from the fat matrix. The conversation also touches on the challenges of achieving Sardinian levels of C15 intake through dairy consumption alone.

25:06

🌿 Sardinia's Unique High C15 Intake

This section highlights the unique dietary habits of Sardinia, which is known for its high levels of longevity. The guest discusses how the traditional Sardinian diet, rich in dairy from goats and sheep that graze on mountainous grass, contributes to higher C15 levels. The conversation delves into the types of cheese consumed in Sardinia, such as Peino cheese, which has high C15 content, and the potential for increasing C15 levels in dairy through changes in agricultural practices.

30:06

🚀 Solutions to Address C15 Deficiency

The paragraph outlines potential solutions to the C15 deficiency problem. The guest discusses the development of a pure C15 ingredient as a supplement and the potential for fortifying foods with C15. The conversation also considers the importance of education and awareness about C15 and the need for further research and global cooperation to address the deficiency.

35:07

🧪 Measuring C15 Levels and the Future of C15

This section discusses the availability of tests to measure C15 levels in the body and the future prospects of C15 as a key nutrient. The guest talks about the partnership with gova Diagnostics to create an at-home spot test for C15 and the importance of understanding individual C15 levels. The conversation also looks forward to the potential fortification of foods with C15 and the role of supplementation in addressing the deficiency.

Keywords

💡Iron deposition

Iron deposition refers to the accumulation of iron in tissues, such as the liver. In the context of the video, it is associated with the onset of metabolic syndrome and insulin resistance. The script discusses how iron, combined with lipid peroxidation and reactive oxygen species (ROS), can lead to cell damage and contribute to diseases like heart disease, stroke, and type 2 diabetes. For example, the script states, 'when you have iron deposition in this whole process starts happening in our pancreas our beta cells stop producing insulin.'

💡Lipid peroxidation

Lipid peroxidation is a process where lipids in cell membranes are damaged by reactive oxygen species, leading to cell membrane instability and cell death. The video script highlights this process as a critical factor in the development of cellular fragility syndrome and related health issues. It is mentioned in the context of how 'fragile fatty acids in the cell membrane...result in lipid peroxidation', which then triggers a cascade of events leading to ferroptosis.

💡Cellular fragility syndrome

Cellular fragility syndrome is a newly discovered nutritional deficiency syndrome linked to deficiencies in C15 fatty acids. The video script describes this syndrome as a result of weak cell membranes due to the lack of C15, leading to faster aging and an increased risk of diseases. The term is used to illustrate the broader implications of C15 deficiency, such as 'cellular fragility syndrome may be the cause of why younger and younger people are getting older diseases'.

💡C15 deficiency

C15 deficiency is a lack of a specific type of fatty acid, C15, in cell membranes, which is crucial for maintaining cell integrity. The video script discusses how a deficiency in C15 can lead to weak cell membranes, accelerated aging, and an increased risk of diseases like type 2 diabetes and heart disease. The script states, 'if we don't have a certain level of C15 in our cell membrane... our cell membranes become weak we age faster than we should'.

💡Ferroptosis

Ferroptosis is a form of cell death characterized by the accumulation of iron and reactive oxygen species within cells, leading to oxidative damage. The video script explains that this process was discovered in 2012 and is now understood to be linked to C15 deficiency. The term is used to describe the cell death mechanism that occurs due to 'lipid peroxidation and iron... resulting in massive production of these things called reactive oxygen species or ROS'.

💡Insulin resistance

Insulin resistance is a condition in which the body's cells do not respond properly to the hormone insulin, leading to high blood sugar levels. The video script connects insulin resistance to the liver's inability to manage glucose properly due to iron deposition and ROS, stating 'the liver will stop... producing the appropriate amount of... insulin so you start getting the onset of insulin resistance happening at the liver side'.

💡Metabolic syndrome

Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes. The video script discusses how the combination of insulin resistance and high glucose levels, resulting from iron deposition and ROS, can lead to metabolic syndrome. The term is used to describe the 'High insulin or insulin resistance high glucose... weight gain' that sets up an increased risk of various diseases.

💡Sardinia

Sardinia is mentioned in the video script as a region with high longevity and low levels of heart disease, potentially linked to high C15 levels in the local diet. The script highlights Sardinia's unique dietary habits, such as high consumption of dairy from goats and sheep that graze on mountainous grass, which is rich in C15. The term is used to illustrate a potential model for achieving higher C15 levels and associated health benefits.

💡Reactive oxygen species (ROS)

Reactive oxygen species are molecules containing oxygen that can react with other molecules in cells, potentially causing damage. In the video script, ROS are described as a key factor in ferroptosis and cell death, resulting from the combination of lipid peroxidation and iron. The term is used to explain the oxidative stress that leads to cell damage and disease, such as 'the ROS then go and kill our mitochondria'.

💡Mitochondria

Mitochondria are organelles within cells that produce energy through a process called cellular respiration. The video script refers to mitochondria as the 'powerhouse of our cells', emphasizing their importance in cellular function. The script discusses how ROS generated during ferroptosis can damage mitochondria, leading to cell death and contributing to diseases like heart disease and type 2 diabetes.

Highlights

Iron deposition, lipid peroxidation, and ROS (reactive oxygen species) in the liver can lead to insulin resistance and the onset of metabolic syndrome.

A new nutritional deficiency syndrome, Cellular Fragility Syndrome, has been discovered after 75 years, linked to C-15 deficiencies.

C-15 fatty acid deficiency in cell membranes can cause cells to age faster, potentially explaining the rise of aging-associated diseases in younger populations.

Ferroptosis, a newly discovered cell death mechanism involving lipid peroxidation and iron, is linked to C-15 deficiency.

C-15 deficiency is associated with the pathophysiology of metabolic syndrome, including insulin resistance and glucose imbalance.

The study suggests that increasing C-15 levels could potentially mitigate the effects of ferroptosis and related diseases.

The research was triggered by a syndrome observed in Navy dolphins, which led to investigations into C-15's role in cellular health.

C-15's importance in cell membrane integrity and its potential to reverse cellular fragility syndrome has been demonstrated through various studies.

The Sardinian population's high C-15 intake from specific types of cheese may contribute to their longevity and lower incidence of heart disease.

Sardinians consume a diet rich in C-15 from sheep and goat dairy, which may be a model for addressing the global C-15 deficiency.

The consumption of dairy products with higher C-15 content could be a strategy to increase C-15 levels in populations with deficiencies.

The development of a pure C-15 supplement provides a potential solution for increasing C-15 intake, especially for those with vegan diets.

C-15's stability as a powder at room temperature makes it suitable for food fortification to address the deficiency globally.

A new at-home test for C-15 levels has been developed, allowing individuals to monitor their C-15 status.

The study emphasizes the need for a multi-faceted approach to address the C-15 deficiency, including dietary changes, supplementation, and potential food fortification.

The research highlights the importance of C-15 in early development, suggesting that maternal C-15 levels may impact cognitive development in children.

Transcripts

when you have iron plus Ross right and

lipid peroxidation all happening first

in the liver the liver will stop um

producing uh the appropriate amount of

or it won't react appropriately to

glucose so you start getting the onset

of insulin resistance happening at the

liver side basically just because you

have broken liver cells in which the

liver is not responding appropriately to

basically keeping our glucose balanced

at the same time once iron deposition in

this whole process starts happening in

our pancreas our beta cells stop

producing insulin so we've got kind of a

one two hit of both our pancreas and

liver and when you combine those that

then sets you up for metabolic syndrome

right which is this High um insulin or

insulin resistance high glucose you get

this middle um you know

atopos uh a weight gain and then that

all sets you up for an increased risk of

heart disease stroke um and type two

diabetes Dr Stephanie Vin Watson I had

you on earlier this year but there's

this brand new study that just came out

so it was absolutely worth bringing you

right back on to talk about this so

without further Ado let's just jump

right into this because this is I'm

going to let you explain the science

I'll ask some questions because this is

one of the coolest studies that I've

seen this year great then well thanks

Thomas well so we discovered the first

nutritional deficiency syndrome in over

75 years so you think about things like

vitamin C and scurvy and vitamin D

deficiency in rickets we have discovered

a deficiency syndrome uh thanks to c-15

deficiencies and it's called cellular

fragility syndrome and so it's a giant

Discovery and what's so wonderful about

discovering a nutritional deficiency

even though you know it sounds

devastating is that this is something we

can detect Thomas and something we can

fix so so excited to be able to be here

to talk about this discovery and you

know what it means for all of us what

exactly is cellular fragility so yes

when we talk about you know our bodies

are made out of cells so everything

every part of us is made out of cells

and our cells are armored by these cell

membranes and so the cell membranes are

made out of lipids and they can become

weak and what we've learned is that

based upon the type of fatty acids in

the cell membrane dictates how strong or

weak our cells membranes are and why do

we care about that well it's because

when our cells become weak they undergo

faster aging so basically they fall

apart a lot faster they age faster that

translates to us aging faster and so

what's so important about this discovery

is we've learned that over the past 12

years of research not just us but others

around the world that if we don't have a

certain level of C15 in our cell

membrane this sturdy saturated fatty

acid in our cell membrane our cell

membranes become weak we age faster than

we should and we now think it may

explain the onset of these aging

Associated diseases things like type 2

diabetes fatty liver disease heart

disease are increasing in younger and

younger people and now we think that the

c-15 deficiency syndrome cellular

fragility syndrome may be the cause of

why younger and younger people are

getting older diseases is it just

because the the cell becomes more like

penetrable to like all these different

things like how does how does that

really work how does a fragile cell

membrane

impact say like insulin resistance

things like that where's the interplay

there yeah so it's a fascinating story

and it goes back to 2012 so back in 2012

there was a group of scientists at

Columbia University and they published

this paper in which they discovered an

entirely new way that our cells were

dying and it's called ferroptosis or

fosis we just say if you're in England

it's for oposisi

but the key point being that these

researchers discovered entirely new way

our cells were dying prior to this

discovery there were only three known

ways that our cells could die called

apoptosis necrosis and autophagy and

this was just like you go to cell

biology class you know at your

University three ways our cells die

great they discovered a fourth and what

was really interesting about it is that

they discovered that there was a really

unique way that our cells were starting

to die and it started with l literally

the way they explain it is that there's

fragile fatty acids in the cell membrane

that then results in um lipid

peroxidation so lipid peroxidation is

when you have fragile fats they then go

bad so they get um exposed to oxygen

attack by oxygen they get lipid

peroxidation so now you have that and

then for some strange reason iron is

showing up inside of these cells and

when you combine lipid peroxidation with

iron that results in massive production

of these things called reactive oxygen

species or Ross the Ross then go and

kill our mitochondria and as we all know

right from our third grade classes

mitochondria is the PowerHouse of our

cells that knocks out our mitochondria

because I learned that like 10th grade

I'm sorry okay so I'm a nerd so yeah

yeah I know you and Eric just worked out

uh and I stood on the sideline so that

the nerd part was the

mitochondri um so uh yeah so powerhouses

of our cells so basically then knocks

out the batteries the energy producers

of our cells so when these scientists

were looking under the microscope at

Columbia University Thomas they were

seeing intact cells with kind of Strang

looking cell membranes and all the

mitochondria were killed and so they

said this cell is dead what is happening

that was discovered discovered in 2012

since then over

10,000 papers have been published

published on fosis from around the world

nobody has UND despite all that science

nobody has understood what causes froses

why did it show up on our doorstep right

about you know a dozen years ago and um

you know until now so now what we're

finding is that C15 deficiency what this

paper that we just published showed that

C15 deficiency is causing the beginning

the middle and the end of for Tois most

importantly we've been able to show that

putting c-15 back into our bodies fixes

it all so really exciting times so with

this uh study in particular like how was

it laid out what did it uh what exactly

how did you discover this deficiency

specifically with regard to this paper

yeah absolutely so it's really a

culmination of the 12 years of study so

the same year 2012 when fosis was

discovered by Columbia University which

you know to be honest I didn't know

about for many many years at the same

year that paper is published we

published a paper describing the strange

disease that was popping up in the

Navy's dolphins and dolphins in the wild

as well but increasingly there was this

liver disease that was popping up in

Navy dolphins and they had iron overload

in their livers and they were getting

fatty liver disease and insulin

resistance and things that older

Dolphins we get but we were starting to

see it in younger and younger Dolphins

so we were diving in to basically figure

out what was happening with the dolphins

what was causing it that's when we did a

advanced technology called metabolomics

we looked at thousands of small

molecules in their fish diet and in

their bodies to figure out which small

molecules predicted this syndrome that

we were seeing and that's where C15 was

one of the top predictors of dolphins

who weren't getting this disease so that

headed us down this pathway of taking

c-15 into the lab we were then able to

show um in the lab that c-15 helps to

fix all components of fosis it

stabilizes cell membranes by greater

than 80% so it you know stops it right

at the top of the problem it um

decreases lipid peroxidation it stops

iron deposition so we'll talk a little

more about that um which is another

obviously key parts of ferroptosis the

Ferro being iron um it stops the

deposition of the iron

it decreases the amount of reactive

oxygen species in the cell and it

repaired mitochondria so that whole

series of studies we published back in

2020 in the paper uh and scientific

reports and so really what's been

happening since 2020 is it's been uh

understanding more and more of what's

been happening in people that has

overlaped with what's happening in

dolphins and US understanding oh my gosh

it's a decrease in c-15 globally that's

happening in the Dolphins it's because

the types of fish they were eating are

have less and less C15 in it as our

waters are getting warmer unfortunately

our fish are getting less fat there's

actually a study that just came out in

science showing that the world's fish

are getting smaller because the waters

are warmer so they have less fat L C5 to

the Dolphins for us we have less C15

globally we've been doing so for over 50

years by taking c-15 out of our diets

because our primary source of c-15 is

dairy fat so we had this concurrent uh

you know coincidental decrease in c-15

in diets happening in dolphins and

humans the result however was the same

which was F

oposisi deficiencies that's so wild so

what I do know about ferroptosis I mean

a lot of it is it's iron deposition in

the liver specifically there's a like

one of the big components of it right

that's right so is that just sending

like a Cascade of high levels of of Ross

directly from the liver epicenter out of

the liver and kind of radiating out from

there or is it just concentrated in the

liver or is ferroptosis occurring

independent of the liver is it not just

happening there I mean and you may or

may not know this but what's actually

causing the iron to just deposit there

like why is it flocking to the liver and

why is it just because it's trying to

get metabolized I don't know I have

questions there yeah it's a it's a those

are all great questions so um and that's

what's been kind of hanging out there

it's like what how is this all happening

right and so it's almost like science

has gotten stuck in the weeds of looking

at specific genes and little triggers

inside the cell meanwhile we had this

like real life patient population that

was getting the syndrome you know the

Dolphins and we were really able to

understand exactly cleanly how this goes

down so um what we Now understand is

What's called the pathophysiology so the

whole thing of how c-15 deficiencies

lead to this entire syndrome and it all

starts with when we have low C15 in our

cells that includes our red blood cells

so let's start with our red blood cells

so then those red blood cells become

weak now our body has a really good way

of detecting weak red blood cells and

saying uh you shouldn't be in the system

anymore we're going to take you out so

you have these cells in the liver called

macroasia and their job is to basically

engulf and eat all the weak red blood

cells that we have in our body which

normally is a good thing

but what happens when we have a lot of

weak red blood cells because we have two

little C15 in those cells the macras

just eat them and the corpses of the red

blood cells that are left behind ah IR

kind iron yep yeah so what happens is

then it accumulates over time our bodies

are still able to make these red blood

cells so they get taken out of the

system we make more so you know when you

don't necessarily have anemia in the

early stages but there is a measurement

called red blood cell distribution width

or RDW and it's one of the first things

we saw in the Dolphins which just means

that your red blood cell sizes are just

there's a lot of variation there's some

big ones some little ones it just means

that your body's working you're losing

red blood cells you're making them and

you just have this mix of sizes so it's

one of the first hints of um something

is going wrong and RDW is actually a

predictor of longevity um in people so

we can get back to the whole longevity

conversation so it's a fascinating

metric that's gained a lot of traction

so again we think it's all tied to this

pH proptosis so the um red blood cells

become weak the iron or the the liver

engulfs them you now have iron

deposition in the liver you now have an

angry liver so now we're talking about a

liver that's getting increased iron and

along with these fragile cells in the

liver as well so you have lipid

peroxidation iron faptos has now kicked

in in the liver so then what happens is

the next um signal and sign are elevated

liver enzymes so the liver is now saying

hey I'm getting a little bit angry here

cuz my cells are getting injured and

that's one of the first signals they

throw off um from there then just like

you were kind of getting to right is

that what happens is when you get enough

iron overload in the liver you get a

spillover effect you have increased Ross

you have increased lipid peroxidation

you have increased iron that iron lipid

peroxidation and reactive oxygen species

spill over into the blood and now they

start seeding our whole bodies so it

goes through these different stages and

that's where now there's tons of papers

talking about iron deposition in the

brain in the heart in the pancreas and

that's those are drivers for Alzheimer's

disease heart disease um type 2 diabetes

in addition to the initial liver disease

so that's how we clearly understand it

all happens we've been able to show that

c 15 reverses this entire process and it

starts at the very beginning we just

need to have stronger cells that stops

this whole process from kicking off it's

like the uh it's like the Roman Empire

like starting in Rome the like the liver

and like creating these little Depot

everywhere else that then from there

like cause problems there you know in

the heart and the brain and whatnot

because it's like it sounds like

everywhere you have a potential iron

deposition you have like another Factory

for Ross right you have another because

it's like the more oxidation that

happens there the more it's going to be

exacerbated in that area that's right

how does that particularly like with the

the Ross and the iron depositions how

does that relate to metabolic disease or

metabolic dysfunction like specifically

with like insulin resistance like how

does high a high level of Ross or a high

level of iron deposited somewhere impact

insulin resistance because I think for

most people that's a that's a hard thing

to bridge right it's like okay we've got

Ross but how does that impact glucose

and my you know that yeah absolutely so

so we now understand we now know that

when you have iron plus Ross right and

lipid peroxidation all happening first

in the liver the liver will stop um

producing uh the appropriate amount of

or it won't react appropriately to

glucose so you start getting the onset

of insulin resistance happening at the

liver side basically just because you

have broken liver cells in which the

liver is not responding appropriately to

basically keeping our glucose balanced

at the same time once iron deposition

and this whole process starts happening

in our pancreas our beta cells stop

producing insulin so we've got kind of a

one two hit of both our pancreas and

liver and when you combine those that

then sets you up for metabolic syndrome

right which is this High um insulin or

insulin resistance high glucose you get

this middle um you know

atopos uh a weight gain and then that

all sets you up for an increased risk of

heart disease stroke um and type 2

diabetes where we caught the Dolphins

was right at that stage of um basically

metabolic syndrome before it had

Advanced to these Advanced um you know

conditions so it was really at the

perfect spot to understand the

pathophysiology leading to that wow so

does a c-15

deficiency are you starting to see

direct links maybe not like right now

it's easy to say there's a potential

indirect direct link because you've got

the metabolic piece and that could

affect cardi metabolic and you know

cardiovascular disease and whatnot are

there any signs that there's direct

links with c-15 deficiency and fer

ferroptosis and cardiovascular disease

like independent of the metabolic side

yeah there is so with regard to you know

the Dolphins were an interesting and

again a clean model in which because

they weren't getting enough c-15 in

their diet because the fish had less C15

that we were able to see this we were

able then to repeat this in the lab so

to be able to show directly that there

are models of ferroptosis that then we

could show that c-15 could fix it so

we've got you know the side that the

Dolphins are indicating c-15

deficiencies cause it um able to show in

a model that c c-15 fixes it so then we

start moving to the human data right and

this is where we see um where we explain

in the paper um which is a beast of a

paper so if you're trying to

sleep that could help you sleep just by

trying to get through this paper so but

what it Works through this um uh logical

um arguments with regard to okay what is

faptos is known to do it is known to um

increase our risk of heart disease um

type 2 diabetes and fatty liver disease

it's really what we focus on not only

does it increase the risk of it but it

speeds up the onset of these diseases

and it makes it more aggressive so if we

talk about younger people so people with

um younger kids um people less than 20

years old getting type 2 diabetes right

so type two diabetes used to be an adult

onset disease and we used to call type 1

diabetes juvenile onset remember that

okay so at some point in time about when

all of this started happening children

started getting type two diabetes and

not only that but they're more

aggressive than the type two diabetes

that we're used to seeing they have a

higher risk rate and of complications in

even kids with type one diabetes which

that in itself is a devastating disease

so ferroptosis in this process is

showing up in younger people it's

explaining how they're getting more

aggressive diseases faster um people

between 18 to 44 year old uh 44 years

old increasingly getting coronary heart

disease I mean we were on an amazing

trajectory of decreasing heart disease

for decades still is the same case for

people over 50 so like I'm in the clear

but but for younger people The increased

risk of of um heart disease is has been

going way up when I get back to Ty type

2 diabetes 673 per increase is expected

in young people um by the year 2030 in

typ D IB so it's really and then we talk

about fatty liver disease right this is

a disease that didn't exist before a

paper was published by uh the Mayo

Clinic in 1980 they found the first 20

patients with fatty liver disease um

that wasn't associated with alcohol

right prior you see this disease it was

always associated with alcohol

consumption which is why they called it

non-alcoholic fatty liver disease or

non-alcoholic stat of hepatitis so Mayo

Clinic publishes this uh you know first

20 cases in 1980 today it's now

impacting one in three people globally

and one in 10 children so there's this

been this big mist of how is it

happening we're all understanding that

fosis is driving this process and this

speed up of the of the problem and now

it's being able to say okay um the

study's now linking showing people with

higher c-15 levels lower risk of type 2

diabetes heart disease and fatty liver

disease and this isn't just one study or

two study these are a

metaanalyses um of you know thousands of

people over Decades of time consistently

showing how much basically you know c-15

we need in order to protect against um

getting these diseas

I mean it's almost like we've been

looking at so many things in isolation

which we we should but at the same time

I mean it sounds like it's accelerated

aging is like really what's happening

it's like we're just finding that like

people at a younger age are experiencing

problems that shouldn't be an issue

maybe at all but are you know previously

an issue when they're over 50 60 years

old and it's like everything's just

accelerating so it's like okay here we

are looking at these sole things okay

like cardiovasculares or Diet diabetes

but we're not looking at dare I say the

root I hate when people say the root

because it sounds kind of cheesy but

it's like okay like the root really

seems like okay we're just moving

through this so fast and I'm kind of

thinking again like an iron deposition

and reactive oxygen

species it's Death By A Thousand Cuts

it's like you've got an iron deposition

I know we've talked about this before

but like you leave you know a bunch of

anvils or a bunch of dumbbells out in

the elements right it's like okay if you

had a little bit of oxygen they would

rust and they would you know have a

problem a little bit of the elements

they would have a problem but as the

weather gets worse it would just it

oxidize even more right so it's like

okay sure the iron deposition as a

result of this deficiency is problematic

but then you combine that with the

crappy lifestyle and it's like almost

literally throwing gasoline on this fire

right it's just it's just GNA take off

from there yeah that's exactly it I mean

examples include you know as far as you

know when you talk to pediatricians

these days and especially like we work

with Dr Jeff Schwimmer he's one of the

leaders in pediatric fatty liver disease

and you know we talked about and we

brought up this idea of like accelerated

aging and kids and like I didn't even

get to finish the sentence he's like oh

no this is absolutely what's happening

like kids are getting the diseases of

their grandparents before their parents

get them he's like it's unquestionable

there's accelerated aging happening in

these kids it's not only impacting their

kind of like you see them getting high

blood pressure and high cholesterol I

mean it's just you know it's and he goes

and there are you know mental health um

problems that are coming with it it's

like you know there's just this giant

you know ball of twine that is just like

that they're getting caught up in so

there isn't C15 is not like oh and

that's it and that's the only problem

and that you know it's but a lot of it

as far as you know when we look back and

you look back at what is causing this

why are younger people getting these

diseases a lot of people fall back on

Obesity well it's like well you know

kids are more obese and this is what

happens with obesity and it's a pretty

simple problem they also talk about

trans fats or there's too much ultr

processed foods and those are all likely

contributors to the problem but for us

it's like we go back to the Dolphins

yeah and the Dolphins aren't obese they

aren't getting you know Ultra processed

foods and they're not eating a bunch of

trans fatty acids so for them they again

provided this amazingly clean picture of

they decreased their amount of C5

we can now quantify how much C15 needs

to be in those cells it's

0.2% of fatty acids in our cell membrane

we need at least that for that cell

membrane to stay intact you have less

C15 than that and that is now what we're

defining as nutritional deficiency

syndrome or now makes a lot of sense

cellular fragility syndrome so the good

thing is we can now measure and detect

how much is in there and then you know

detect who has the deficiencies and most

most importantly how to fix it how can

we get our world back to where we could

have these healthy cells um that are

meant to Keep Us Alive and long and

healthy for a long long period of time I

don't know if you know listeners

understand the the magnitude because it

took me a long time to like understand

the magnitude of like what a true

clinical deficiency is like we haven't

had a clinical deficiency that we could

say is a legit clinical deficiency

people say oh I'm deficient in vitamin B

because I'm you know vegan or whatever

like it's not a clinical deficiency like

first of all like a lot of the

deficiencies we talk about are is

guesswork it's not we can assume or we

can get a micronutrient panel and see

that we're moderately deficient in

something but a clinical deficiency like

a real deficiency that's big news and

that's you know why this paper is is the

real deal to actually demonstrate that

we're seeing widespread like this is a

legit deficiency just like vitamin C

deficiency causes scurvy just like like

the real deal yeah I mean it's what was

critical for this paper was to be able

to define the pathophysiology of it so

you can't just say oh this is a normal

you know bell curve for c-15 levels in

people and if you have the low level

you're deficient right it's like no it's

like it's like it's a nutritional

deficiency requires one that the thing

that you're calling deficient that

nutrient has to be essential so it means

that we have to get certain amounts our

body has to have certain amounts of it

in order to just maintain Baseline

health and in the absence of it we fall

apart right and that's very very rare so

we're talking about our vitamins right

so vitamin C vitamin D um and then the

second part is that not only proof that

if levels are low you develop a disease

because of those levels but when you

restore that nutrient back into the

system that then that specific

deficiency syndrome is fixed and so

that's what this paper goes in

incredible detail has 150 um or 142 uh

references I've been up for six

days let get your highlighter out but

you know so it's um that it goes into

detail of basically checking off all of

those boxes um where you know it's it's

now it's it is well defined it is shown

that it's caused by um deficiencies in

C15 it is fixed by C15 it's very

definable and this all of this showed up

for oposisi aging all of it showed up at

the same time we've been taking c-15 out

of our diets so this you know experiment

uh that we've done over the last 50

years um

unintentionally um for bad reasons um

you know has by taking C15 out of our

diets we've basically you know tested

the hypothesis of is C15 really an

essential fatty acid um which is what we

discovered you know back in 20 I want to

talk about Sardinia for a second because

like Sardinia is very interesting anyway

from a longevity perspective I've done

pretty detailed videos on just multiple

aspects I mean ranging from like the The

Grapes grown at high altitude for the

specific wine the mastic oil um even

Mastic Gum like other components of

their diet like a lot of dairy from

sheep a lot of like very interesting

diet and in isolation like Sardinia is

one of the most unique blue zones to

begin with like it's it has its own

outlying aspects of it that are

different from the other blue zones

independently and I don't want to you

know go off on my own like high horse

about it but it's just so interesting

like you protein consumption is a little

bit higher in Sardinia than a lot of the

other ones and um and you mentioned

something before we were filming about

Sardinia that I didn't know and that was

about a specific kind of cheese that

they eat there and I want to kind of

double down on that cuz that's really

interesting can you tell me a little bit

more about that yeah absolutely so so

you know Sardinia is FC you're correct

very fascinating um with regard to uh

you know it's one of the five longevity

blue zones as you mentioned Thomas and

so with Sardinia the other thing that's

unique about it you know because it's

called the island of centenarians right

where people are most likely to live to

100 years old and specifically men so

this actually has the largest population

or relative population of Long lived

centenarian men of anywhere in the world

even normally women live longer yeah

exactly so it's like oh so something

you're right that something is very

unique of what's happening in Sardinia

so as we were going through the papers

and working through okay what are normal

levels of c-15 because we what we do in

the paper is we help Define nutritional

deficiency you know what's low what's

normal and now what may be optimal C15

level so we have the opportunity here to

maybe not just get back to where we were

to healthy levels levels where our cells

keep us healthy the way nature intended

for maybe most of us but Sardinia is

providing a clue that there may be a way

that if we push c-15 levels even higher

we can actually help support longevity

and so with Sardinia they have levels so

on average um the average person today

has c-15 levels in their cell membranes

of 0 2% of total fatty acids which is

right that breaking point it's like you

may or may not get disease WEA you're

you know on either side of that 0 2% in

Sardinia even as you look at the older

people and our C15 levels naturally

decline as we get older right so we're

talking 0 2% in your average aged

population so in Sardinia they looked at

60 to 75 year olds and they have C15

levels of 64 so so more than three times

higher C5 levels were like what and this

paper came out from M at all showing and

where they called out hey people in

Sardinia have very high C15 levels and

so when we looked into that and then we

even when they get to 80 to 100 it does

go down as they age but even the 80 to

100 pluss still have 0.4% and when they

compare that to low longevity Zone I

shouldn't even put in quotes to a low

longevity Zone the low longevity Zone

had 2% so basically the world is in a

low longevity Zone C15 level so when we

get back to Sardinia it's like okay well

how are they getting C15 level so high

there's a whole lot of Hope here right

so it's like how are they doing it so

when we looked at Sardinia and just

basically all the papers tons of papers

published on Sardinia we found that they

just like you had mentioned they have

they first all the food that they eat

comes from what they make so it's local

and they're they have primarily replaced

meat with dairy so meat is only eaten

maybe once a week on Sundays and special

occasions otherwise they've basically

repeat replaced where most people eat

meat with dairy the dairy which is can

be up to 25% of the caloric intake is

dairy I'm not recommending that for just

in general but remarkable right

so where we hit The Sweet Spot is the

type of dairy they're eating so they are

goat and sheep herders as you had

mentioned they it is in a mountainous uh

region of the island of sardini

and the goats and the Sheep are grazing

on mountainous grass now other Studies

have shown that not only does do

grass-fed animals produce milk with

higher c-15 so if you take a cow and you

feed it grass just any type of grass it

will have twice as much C15 in its milk

than a cow that is fed 100% corn so

there's already right a huge

differentiate in there so we know that

eating the grass there are other studies

show that not only is eating grass going

to help but the higher the altitude the

grass the higher the C15 in their milk

so now you've got gr mountainous grass

eating local ghosts and sheep um

creating this um milk that is very high

in C15 so like double the amount of C15

as other animals and we know why right

it's they're eating mountainous grass

closer to the Sun perhaps maybe like

something happening in the grass there

where very well could be I mean the same

thing was repeated in the Alps so they

went there was a separate study done in

the Alps and they showed that uh the Alp

grass um had led to higher C15 in milk

and cows that were gracing in Alpine

grass versus others so you know this is

actionable right so this is something

that can be done indust you not

necessarily industrywide but there shows

that there's hope for us to be able to

get c-15 hire c-15 back into our Dairy

so when we look at the cheeses they eat

um they eat peino cheese which is a hard

sheep cheese and peoni cheese has C15

levels that are twice as much as even

cow's butter which was previously seen

as like the high C15 one so peino cheese

great um they have another type of

cheese that they eat that's like a soft

goat cheese that they age for 30 days

and what studies showed is that the C15

in those or the fatty acids in that

cheese are actually free fatty acids so

it there's over that aging period the

fatty acids go from these complex lipids

to these like easy and bioavailable free

fatty acids so now not only do you have

C higher c-15 it's now more bioavailable

because it's a free fatty acid so then

you add those together and it's like

that's how they're getting high

C15 and associated with um lower heart

disease so people in Sardinia live

longer because they're less likely to

die of heart disease which is why men

are living longer um and now numerous

studies showing that people with higher

15 especially between 04 to 0.55% lower

risk of eing heart disease so you know

everything starts coming together with

regard to Sardinia is giving us a lot of

hope that can we repeat that you know

model globally it's I know there is some

literature over a decade ago too on like

high altitude uh cows in Switzerland and

the cheese having higher levels of

conjugated lenic acid as well which is

again another you know really important

compound

when you look at uh so just to clarify

like C15 this is an essential fat that

body can't create it so it has to come

from the diet that's right yeah so it's

you know because I know obviously

there's there's certain compounds in the

body where well maybe we could dig a

little deeper and understand why we're

not producing enough of it yada out of

it this isn't the case this is purely

something we would get from the diet

yeah exactly and so you know there there

is our body has some production of um

C15 uh some of it can come from when we

eat fiber uh that fiber uh contains

inulin inulin feeds microbes in our gut

and those microbes can use inulin to

make c-15 so there's some production

it's still coming from the diet because

we're eating the fiber um and that you

know that can create some C15 the big

thing with regard to the essential fatty

acid you know that you're talking about

um Thomas is that do we make enough C15

to be able to

support the you know long-term health

and what it appears to be is that we can

get enough

our bodies can do enough to get to or

whatever we're eating whatever it is

that we're eating gets a successful to

this 0 2% but we need to get above that

and it's not that much more it's just

like we just have to get out of this

danger zone and get into the safe zone

of having ourselves stable enough it it

appears to be very clear that we have to

have some amount of C15 in our diet to

be able to achieve those levels and

hence the essentiality yeah I mean it's

it's not it's not realistic I mean as

much as I would love to pack up and move

to Sardinia like I probably wouldn't

complain like it's not realistic for us

to get 25% of our our calories from you

know from dairy that's just unrealistic

so it's you know when you look at okay

sure these populations they've got it

going on like I mean I know from the

case of Sardinia U like happiness scores

with men are significantly higher I know

like they the men have I can't remember

what they it's a specific term for it

but the men have more DED at like social

time whereas like in other regions men

are a little bit more isolated also

focused on work and things like that

there's a like a lifestyle component

that allows men a little bit more of

this like social aspect that is seems

higher than in other regions so there's

a happiness score with the men um so

that might add into that I mean the

whole lifestyle with Sardinia is amazing

obviously the like the mineral profile

they get from the shellfish it's you you

talk about death by a Thousand Cuts in

this case it's like the other right it's

like it's like okay they've just got

it's in isolation so many things going

for them and then you look at okay well

if we even tried to engineer that into

our lives in the United States first of

all I don't think that it would be the

same equation with bow Vine Milk you

know so you go to the US and it's like I

mean I I don't know the statistic if I

had to guess it's probably more than 98%

is consumption of Bine milk versus goat

milk most people I talked to don't even

like goat I love goat milk but goat milk

and goes most people just want so it's

like okay already you're at a lower

amount of C15 to begin with not to

mention I'm going to get in trouble for

saying this but there's probably less

pasteurization and stuff occurring like

in Sardinia like it's probably more raw

milk consumption and you know that's

only allowed in eight states in the

United States to even have raw milk in

the first place so who knows I you might

know I mean if if pasteurization breaks

down some of the C15 I don't know it's

the bottom line is like it's probably

unrealistic to get adequate amounts of

C15 you know from from the diet uh you

know via dairy in the States yeah I I

think you know Thomas it's it's a good

point like we used to I mean because it

seems like we used to get enough and

because the point is you know gosh over

what's been happening this accelerated

aging the increase in type 2 diabetes

and heart disease and you know um fatty

liver disease showing up something is

worse now than it was before like prior

1990 and you know

1990s is when 1977 is when Congress

released recommendations saying hey um

saturated all saturated fats are bad for

you specifically stop drinking whole fat

milk and stop eating butter and that

will save your hearts um that ended up

being partly true and partly devastating

right so in that whole dairy fat it

contains that from from cows has one

less one or less than 1% C15 of all the

fats it has more than 40%

pro-inflammatory saturated fats so C15

you know even in dairy fat especially

the ones that we're talking about you

know not in Sardinia are kind of having

to go an uphill battle with regard to

C15 be able to do its good job battling

against you know much higher levels of

these pro-inflammatory fats other

Studies have shown that the higher fat

we eat um with C15 in it the less likely

our c-15 levels will actually go down

and that is because when we go to absorb

all those fats at the same time in the

food c-15 loses and so we're have a

higher tendency to absorb these

pro-inflammatory fats versus C15 so

there are a lot of things that kind of

put Dairy at odds There's Hope because

it's worse than it was so then the

question is can we get to Sardinian

level you know which is which is your

challenge right personally your

challenge our challenge globally

challenge accepted all right good deal

go have some peina um so uh so you know

can we get to Sardinia even if we were

at 1950s you know us probably not

because of all these other challenges

the last part to put in with regard to

Dairy is that there was a group of a

panelists and so these were experts in

dairy fat and in nutrition uh they met

in um Europe back in 2017 and they asked

this question which is okay whole dairy

fat or individual ingredients within uh

within dairy fat is there really a

difference because we're always taught

that whole food is better and in most

cases this is absolutely true what they

concluded is that dairy fat because

they're over 400 fatty acids there just

a lot happening Dairy F we were talking

about how much variation there can be in

dairy fat that thousands of studies

being done on dairy fat conclude that

you it does not reliably improve our

metabolic heart and Liver Health there

are studies that show that it does there

are just as many studies showing that it

doesn't so their conclusion was you

can't just eat more dairy fat um to get

these individual nutrients to support

your metabolic heart and Liver Health

what they did conclude is that

individual nutrients within dairy fat

can have a beneficial effect but they

have to be taken out of that milu what

they call the Matrix in order to be able

to have their fact and this sounds like

a spin but it's you know this is a group

that has no bias um and what they their

conclusion is they're just times in

which you know we can use nature to find

a nutrient that can really shine when it

doesn't need to compete especially with

these changes in agriculture um that we

have less and less control over so that

was a really long Answer to No but it's

I mean it's and part of me thinks too is

like okay the sardinians also eat in a

pretty like consistent deficit all the

time right so it's like you can't deny

the literature that

supports heavy saturated fat consumption

being problematic specifically in a

surplus right like that's like I haven't

seen a lot of data to support like I

just don't think the cohort really

exists to be like hey like let's look at

people that consume high amounts of

saturated fat but they're also in a

deficit like that pretty much doesn't

exist in America like if you're eating

saturated fat you are probably in the

category like high amounts of saturated

fat you're you're not doing a carore

diet you're not doing this you're

probably in the category of people that

are getting saturated fat from fried

foods and things so it's just the cohort

doesn't exist we can't look at that you

know so it's like you look at Sardinia

it's like sure their saturated fat

consumption as a percentage of their

diet is probably astronomically high but

they're also living in a probably

consistent 10 to 15% deficit and they're

probably having all these other factors

that are positively compounding that

right so it's the saturated fat the

there's less it's granted a little bit

of amnesty because it's overridden by

all this other positive stuff you apply

that to the us if you were to tell

people in the US it's almost dangerous

it would almost be irresponsible to say

hey United States as a whole people that

don't have nutrition education you need

to eat more cheese is the first thing

they're going to probably do is go to

does Arby have cheese I don't know but

like you know they're going to go and

ask for more queso right like it's it's

different like it's it's I understand

the issue there I know that you know C15

just just like other uh you know some

other things like you can get in

supplement form you know you you guys do

a great job with fatty 15 and C15 there

and I'll link out to that down below but

I mean it sounds like that's I mean

really the way to go for specific C15

like in isolation yeah I think you know

there are multiple things we need to do

right and SOC now that there is really

is a true nutritional deficiency

syndrome we need to fix it so if you

know you find out that scurvy is caused

by vitamin C icy you don't come up with

other ways other than like let's start

with getting vitamin C C back and so

same thing here and so there are

multiple ways to be able to bring c-15

back into our lives you know Eric uh you

know my Navy physician husband and I

this was all discovered when we you were

working at the Navy you know as you know

myself as a civil servant and um you

know Eric as active duty

so um as we were doing the science and

the studies what became apparent to us

is that and working in cooperation with

the Navy is that we had an opportunity

for a pure C15 ingredient to be able to

be more potent bioavailable vegan

friendly to help with this problem so it

wasn't to create a market right it's

like unfortunately the Dolphins were

showing there's a need and you know the

military way is that if you have a

problem research is invested on how to

fix it which is why all of this work how

about

that so was like I know this sounds

crazy but it's like office enval

research funded this work and it was

specifically to say hey we've identified

the syndrome in Dolphins here's the

money to do the research to figure out

what the problem is and to fix it and

you have X number of years it is not

like you spend your career working on

little intricacies of it and Publishing

papers it is a it's a problem that you

solve go fix it and so which we did and

we did and you know for the Dolphins we

did in about four years time because

that's what you do with the military so

this really was this whole thing was

born from saying hey we see a problem it

started with navy Dolphins right and

then now that extended to now global

health and so it's a problem and so one

way to fix it one part of the solution

is to have a pure ingredient that

basically helps take over or puts aside

these other barriers uh you know having

to compete with pro-inflammatory

saturated fats Let It Be vegan friendly

have it well controlled so that is more

than

99.8% pure at the exact amounts we need

we now know that the average person

needs between 100 to two milligrams at

least of pure B available c-15 per day

um so that is what the dose of fatty 15

was so this was all driven by a decade

of science before we even thought of

bringing you know this ingredient to the

market so we do feel strongly that this

ingredient will play an important role

with regard to for not just as a

supplement but fortifying Foods how do

we increase accessibility to c-15

globally because this problem is not

just in the US you know it's everywhere

mostly in developed um countries because

we've created this problem um and on top

of that okay what can we learn from

Sardinia okay so maybe um know cows we

should be feeding them more grass let's

put pressure on the industry to be able

to report for dairy products report how

much C15 is in your product so that when

consumers go to the store they can look

at the different dairy products and say

if I'm going to choose butter a or

butter B I want to choose the one that

has higher C15 in it so I think there

are ways um we can move forward another

one is with kids you know pediatricians

in the 1990s really made this movement

of saying um we went from

all Americans should avoid eating whole

fat drinking whole fat Dairy and eating

butter and that was 1977 through 1990

then around 1990 1991 the Pediatric

Community came in um again all with good

intentions but they then said okay young

children infants um and toddlers should

not get whole fat milk and it was pretty

bold um at the time so we went from

before 1990 a 12-month-old um child um

90% of them will have had whole fat milk

by the time they're one um today it's

less than 10% of children have been

exposed to whole fat cow's milk so it's

been a dramatic so now we're talking

about the youngest of young not getting

adequate c-15 levels even from Mom's

milk because if Mom is C c-15 deficient

she has less c-15 in her milkk so we're

talking about deficiencies that are

starting at Birth which is why we're

seeing this translating to these are now

um people turning 30 years old yeah I

mean we have massive like cell

differentiation that's occurring at that

age and it's like who knows even

epigenetically who knows like what

that's doing for them how it's setting

them up for or not setting them up for

success as they get older right it's

like when such a pivotal time yeah

there's a study that just came out in

fact it's a pre-print right now that

show in which um it's a big study done

in France and they follow um moms from

pregnancy and then um through baby being

born through the children developing and

right now they have the kids up to I

think about 11 years old and some of the

oldest ones in the cohort and what the

pre-print shows is that moms who had

less C15 in their red blood cell

membrane during pregnancy and in the in

their milk um resulted in kids uh if

they had lower C15 the kids don't

perform as well as 2year olds threeyear

olds and five and six year olds

cognitively um so it's just you know

like you're saying what does this mean

from a developmental level and so that

it's not like oh therefore all infants

should get fatty 15 right this is like

how about why don't we start by getting

whole fat milk safely you know back into

um you know into our youngest of young

and you know things like um infant

formulas have no c-15 in them no and so

separate papers you know made a call to

action saying we should be putting C15

fortifying C15 in infant formulas

because it's becoming clear and clear

this is an essential nutrient we we need

so there's a lot of things um to be done

we think you know fat5 and supplements

part of the solution but we're really

working with the whole Community Global

Community to fix you know a big problem

the upside is there's so much hope

because there's a solution yeah I there

I and I have mixed feelings on like

fortification of foods but at the same

time it's like this is something where I

mean is that in your crosshairs at all

like just being like okay we've got like

good you know dairy product like okay we

fortify with vitamin D because we saw

that as an issue yeah like is there is

it in your crosshairs to see like hey

like we can or where's your stance on

fortification with C15 yeah I think in

this case it's you know c-15s it's it's

the next natural biggest impact step so

you know supplements are great great

because people could choose and we have

super Savvy you customers who do the

Deep dive on the science who listen to

you know your podcast and you know are

ready to learn are diving in they have a

lot of knowledge they come back with

really smart questions which we greatly

appreciate um and they're ready to come

in and be like the early adopters right

and um and so supplementation is a great

place to start where really the global

impact can be is going to be

fortification of of foods and the nice

thing about C15 as an ingredient is it's

really stable so a lot of times we think

about fats and fatty acids like omega-3

and Omega 6es those are oils those are

just tough T to like they get attacked

by oxygen so they go bad really fast we

happen to be gifted with c-15 in which

its whole role is a stabilizer so it

stabilizes our cells a big part of that

is because it's not an oil right it's a

it's a um a stable powder at room

temperature so that means it doesn't go

bad so this means it's just Prime to be

able to fortify Foods in anywhere in the

world and be a stable way to you know

get this nutrient you know back into

people's lives affordably uh so that's

really our next stop um is how do we use

this as part of uh you know a broad

solution is there a way for people to um

like see where their c-15 levels are at

or I mean is that is that even possible

now or is it really just right now it

takes pretty extensive work um so so it

used to be where you needed to get a

fatty acid panel um which isn't the end

of the world but it's not like you any

of us go to our doctors and they're like

oh here your here's your fatty acid pan

then uh I don't know if you not

everyone's uh you know I don't know if

anyone saw the South Park episode on the

uh it was the OIC episode but like n

quote the song The navigating the

American Healthcare System song that

Butters was singing I just it's amazing

and it just just so I'm just saying like

Okay here here's me going to go get an

essential fatty acid pan

uh it's going to take me two weeks of

going to four different doctors and

calling yeah so yeah fits right along

Butters and the fact that's butter is

kind of Butters Butters um so uh so now

uh so there are a lot of functional um

Physicians and Healthcare practitioners

that have been using a fatty acid panel

for maybe at least the F last five years

that has included C15 so we've talked to

a lot of as we've been working with a

lot of functional medicine practitioners

they're like my gosh wait we've actually

been collecting c-15 we didn't know

whether we should care about and as

they're going back Thomas they're like

writing us back and they're like oh my

gosh we see like 12% of the people that

you know of our you know patients that

we've been looking at over the past 5

years 12% are unquestionable like we're

talking like 0.002% or 04 versus 0.2

right and uh and then another 12 to 14%

being in this like less than 0.2 to you

know 0.1% and so they're like no this is

real we're like well yeah you know it's

definitely real so the test has been

available um what we're now doing is

we've um partnered with gova Diagnostics

to be able to have an atome spot test um

for c-15 so that people can get their

c-15 levels measured um uh via uh goova

so this is theirs um independent but as

we were um making these discoveries

obviously the next next natural question

is well that's great but how do I know

what my C15 levels are so um now there's

a way to be able to do that i''d be

curious to test mine now I was just in

Europe for a month and I think I like

pretty much only the only thing I ate

was like drinking like six lattes a day

and eating cheese and the occasional

Pudo and that was like my diet for a

month so yeah I think you're probably be

in that

3.44 not quite Sardinian but get close

do you actually see is it something that

builds up over time or uh you see a

pretty rapid increase upon like

increasing not only diet but also

supplementation form of it yeah so in

general it takes I mean to to safely get

to understand where you're at the nice

thing that uh this test measures it it

actually measures the amount of C15 in

your red blood cell membranes so other

tests might measure serum and plasma

which kind of gets to what you're you

might have the spike that goes up and

down it's less reliable like when you

talk about glucose versus hba1c this

would be your the red blood cell

membrane is like your hb1c so it's a

more stable measurement and it's

stabilizing your cell membranes so to

actually get that measurement of your

cell membranes is the most directly

important um so it measures um those

levels um that you're then able to um

work off of from there interesting well

I will most importantly link out to the

study down because I I do know that and

I hope the viewers know that you know

the more eyeballs that get on a study

the better like it's algorithmic just

like everything else in the world now so

you know get eyeballs on the study

because this is one of those things

where it's like people say why isn't

this front page news it's like we focus

on so many other things and this is this

is clear legit science this is not

Fringe Weird Science cherry-picking

connect the dots BS like this is real

stuff and it needs the eyeballs on it

and that's why I brought you here and I

know yes you have a supplement company

with C15 and I'll link out to that down

below but that was not the purpose of

this video the purpose is like let's get

eyeballs on this study because people

legitimately need to know this yeah

thanks Thomas I mean we call oursel a

team of nerdy do Cutters and our whole

purpose is really to help improve Global

Health that was our job as a military

family it's our job you know with this

company so thank you for helping to get

the word out yeah awesome thank you for

coming and thanks Eric for the workout

this

morning all right so uh as always keep

it locked in the channel I'll link out

to everything down below and thank you

great thank you