💉VOLUFILINE FOR FACE: LIP FILLER IN A BOTTLE? 💉 Dermatologist @DrDrayzday

Summary

In this skincare-focused video, board-certified dermatologist Andrea explores the claims of 'Volume Fill-In', a trademark ingredient by Soderma, said to naturally enhance bust and buttocks. She critically examines the ingredient's scientific basis, derived from plant extract, and its purported ability to stimulate adipocyte differentiation. Andrea expresses skepticism about its effectiveness, especially for facial use, citing concerns about safety and the lack of peer-reviewed studies. She concludes by suggesting that any perceived 'filling' effects may be due to skin hydration rather than actual fat cell changes.

Takeaways

• 📚 The video discusses 'Volume Fill-In', a trademark ingredient from Soderma, which is claimed to naturally fill the bust and buttocks.
• 👩‍⚕️ The speaker is Andrea, a board-certified dermatologist, who shares her professional opinion on the ingredient based on available information.
• 🌿 The main component of Volume Fill-In is a plant extract called Hena Asphodelus Root Extract, which is said to stimulate fat cells (adipocytes) to differentiate and fill in naturally.
• 🧪 The company claims are based on an industry study, not a peer-reviewed paper, but the study is available online for those interested.
• 🧬 In vitro studies showed that the ingredient could stimulate pre-adipocytes to differentiate into fat cells and increase fat uptake.
• 🔬 An in vivo clinical study was conducted with women applying the compound to one breast, showing an average increase of 2.2 percent in breast size.
• 🤔 The speaker expresses skepticism about the ingredient's ability to penetrate the skin and affect fat cell differentiation.
• 🚫 Concerns are raised about the potential for developing lipomas if the ingredient does indeed stimulate fat cell growth.
• 🧴 The ingredient is also found in other products, such as lip glosses, without claims of volumizing effects, suggesting it may not be unique in its purported effects.
• 🛒 The raw material of the ingredient is available for purchase online, which the speaker advises against using directly on the skin.
• 💡 The speaker concludes that while the ingredient may improve skin hydration, its claims of fat cell stimulation and volume increase are doubtful and require more research.

Q & A

What is the main topic of the video?

The main topic of the video is the discussion of a cosmetic ingredient called 'Volume Fill-In' or 'Volufeline', which is claimed to fill the bust and buttocks naturally.

Who is the speaker in the video?

The speaker is Andrea, a board-certified dermatologist who posts skincare content on YouTube and other social media platforms.

What does the ingredient 'Volume Fill-In' claim to do?

The ingredient 'Volume Fill-In' claims to enhance the bust and buttocks by stimulating adipocytes, which are fat cells, to differentiate and fill in, creating a natural filling effect.

What is the scientific basis for the company's claim about 'Volume Fill-In'?

The company's claim is based on an industry study involving in vitro and in vivo tests, where the ingredient was shown to stimulate pre-adipocytes to differentiate into fat cells and take up fat.

What is the chemical composition of 'Volume Fill-In'?

The chemical composition of 'Volume Fill-In' includes hydrogenated polyisobutene and a plant extract called NMR Asphodeloides root extract, which contains saponins and phytosterols.

How was the effectiveness of 'Volume Fill-In' tested in the clinical study?

The effectiveness of 'Volume Fill-In' was tested using a method called FOITS (Fast Optical In Vivo Topometry of Human Skin) to measure the 3D optical properties of the skin on women's breasts.

What was the average increase in breast size reported in the clinical study?

The average increase in breast size reported in the clinical study was 2.2 percent after using 'Volume Fill-In'.

What are the speaker's concerns regarding the use of 'Volume Fill-In' on the face?

The speaker is skeptical about the ability of 'Volume Fill-In' to penetrate the skin deeply enough to affect fat cell differentiation and is concerned about the potential for developing lipomas or other unintended side effects.

What is the speaker's opinion on the overall effectiveness and safety of 'Volume Fill-In'?

The speaker expresses doubt about the effectiveness and safety of 'Volume Fill-In', stating that it sounds too good to be true and that more peer-reviewed research is needed to confirm its safety and efficacy.

What other products contain the 'Asphodeloides root extract' mentioned in the video?

The 'Asphodeloides root extract' is found in other products as well, such as some Revlon lip glosses and several Asian skincare products, although they do not claim a volumizing effect.

Why does the speaker advise against buying and using the raw material of 'Volume Fill-In'?

The speaker advises against using the raw material directly on the skin due to the potential for irritation and uneven distribution when mixed with other skincare products.

Outlines

00:00

🧪 Introduction to Volufiline and Its Claims

Dr. Andrea, a board-certified dermatologist, introduces the topic of Volufiline, a trademark ingredient from Soderma that is claimed to naturally fill the bust and buttocks. The video aims to explore the science behind this ingredient, which is marketed as an alternative to cosmetic fillers. The main component of Volufiline is hydrogenated polyisobutene and a plant extract from 'Nmra henae aspho eloides root', which is said to stimulate adipocyte differentiation and increase fat cell volume. The company's claims are based on an industry study, not peer-reviewed research, and Dr. Andrea emphasizes that the information presented is her opinion based on available data.

05:01

🔬 Volufiline's Scientific Basis and Clinical Study

The script delves into the scientific research behind Volufiline, discussing in vitro studies that show the ingredient's potential to stimulate pre-adipocytes to differentiate into fat cells and increase fat uptake. A clinical study is mentioned, where the ingredient was applied to one breast of women to measure its effect on breast size using a technique called FOITS. The study reported a mean increase of 2.2 percent in breast size, with a more significant increase observed in a subgroup of 'best responders'. However, Dr. Andrea expresses skepticism about the ingredient's ability to penetrate the skin and affect fat cells, as well as concerns about potential side effects such as the development of lipomas.

10:01

🤔 Skepticism and Safety Concerns Surrounding Volufiline

Dr. Andrea raises questions about the methodology of the clinical study, questioning whether the technique used was appropriate for measuring changes in breast volume. She also discusses concerns about the safety and specificity of a topical application that claims to stimulate fat cell differentiation. The potential for uneven distribution and absorption if the ingredient is mixed with other skincare products is also highlighted. Dr. Andrea advises against applying the raw material directly to the skin and expresses doubt about the ingredient's effectiveness and safety.

15:03

💬 Final Thoughts on Volufiline and Recommendations

In conclusion, Dr. Andrea expresses her overall skepticism about Volufiline, stating that it sounds too good to be true and suggesting that it likely is. She reiterates the need for more peer-reviewed research to confirm the safety and efficacy of the ingredient. While acknowledging that the ingredient may improve skin hydration, she advises viewers to be cautious about such claims. The video ends with a reminder of the importance of sunscreen and an invitation for viewers to share their experiences with products containing Volufiline in the comments section.

Keywords

💡Volume Fill-in

Volume Fill-in refers to a cosmetic treatment that aims to increase the volume of certain body parts, such as the bust or buttocks, naturally without the need for surgical procedures like fillers. In the video, it is discussed as an alternative to traditional augmentation methods, with the focus on a specific ingredient trademarked by the company Soderma, which is claimed to have this natural filling effect.

💡Dermatologist

A dermatologist is a medical doctor who specializes in the diagnosis and treatment of skin conditions. In the video, Andrea, a board-certified dermatologist, presents herself as the expert discussing the topic of Volume Fill-in, lending credibility to the analysis of the ingredient and its purported effects.

💡Hydrogenated Polyisobutene

Hydrogenated Polyisobutene is a chemical compound mentioned in the video as part of the Volume Fill-in ingredient. It is a type of synthetic polymer that is used in cosmetics for its film-forming properties, which may contribute to the perceived plumping effect on the skin.

💡Adipose Cells

Adipose cells, also known as fat cells, store energy in the form of lipids and are a key component of body fat. The video discusses how the Volume Fill-in ingredient is claimed to stimulate the differentiation of these cells, potentially leading to an increase in fat cell volume.

💡Saponins

Saponins are a class of compounds found in plants that have a range of biological activities. In the context of the video, a specific saponin called sarsapogenin, found in the plant extract Hena Asphodeloides Root, is highlighted as a component of the Volume Fill-in ingredient, which is alleged to influence fat cell behavior.

💡In Vitro Studies

In vitro studies refer to scientific experiments conducted outside a living organism, often involving cells or tissues in a controlled environment. The video mentions in vitro studies on the Volume Fill-in ingredient, where human pre-adipocytes were exposed to the compound to observe its effects on cell differentiation.

💡In Vivo Studies

In vivo studies are conducted within a living organism, such as animals or humans, to observe biological effects. The video describes in vivo studies where the Volume Fill-in ingredient was tested on actual people to assess its impact on breast size.

💡FOITS

FOITS stands for Fast Optical In Vivo Topometry of Human Skin, a technique used to assess the skin's optical properties in a 3D manner. In the video, FOITS was used in a clinical study to measure the effect of the Volume Fill-in ingredient on breast size, comparing treated and untreated breasts.

💡Lipomas

Lipomas are benign fatty tumors that can occur in the body's subcutaneous tissue. The video raises a safety concern about the Volume Fill-in ingredient, suggesting that if it does stimulate fat cell differentiation as claimed, there could be a risk of developing lipomas.

💡Hyaluronic Acid

Hyaluronic acid is a naturally occurring substance in the body that is also used in skincare for its hydrating and volumizing effects. The video suggests that the perceived filling effects of the Volume Fill-in ingredient might be due to its hydrating properties, similar to those of hyaluronic acid.

💡Cosmetic Ingredient

A cosmetic ingredient is a substance used in the formulation of cosmetics to achieve certain aesthetic effects. The video emphasizes that the Volume Fill-in ingredient is a cosmetic ingredient and not a medical treatment, indicating that its effects should be taken with skepticism and not compared to standard care.

Highlights

Introduction to the topic of 'Volume Fill-In', a trademark ingredient from Soderma, claimed to naturally fill the bust and buttocks.

Volume Fill-In is an alternative to filler, often used under the eyes to combat signs of aging.

The main ingredient, Hydrogenated Polyisobutene and NMRHA Asphodeloides Root Extract, is said to stimulate adipocytes, or fat cells, for a natural filling effect.

The company claims a non-hormonal treatment to enhance fat cell differentiation and survival.

The information provided is based on an industry study, not a peer-reviewed paper.

The root extract contains saponins, specifically sarsapogenin, believed to influence fat cell gene expression without hormonal effects.

In vitro studies showed the compound stimulated pre-adipocytes to differentiate into fat cells and increased fat uptake.

Clinical studies involved using FOITS technology to measure the effects on breast size.

The study showed an average 2.2 percent increase in breast size with Volume Fill-In.

A subset of participants saw an 8.4 percent increase in breast size, indicating potential variability in results.

Doubts about the ingredient's ability to penetrate the skin and affect fat cells at a deeper level.

Concerns about the potential for developing lipomas if the ingredient works as claimed.

The study's methodology is questioned, particularly the use of FOITS for measuring breast size.

The possibility that the observed effects could be due to skin hydration and surface smoothing rather than actual fat cell changes.

The ingredient's presence in other products without claims of volumizing effects.

Recommendation against applying the raw material directly to the skin due to potential irritation.

A call for more research and peer-reviewed studies to validate the safety and effectiveness of the ingredient.

The final opinion on the ingredient's efficacy and a warning about the potential risks of using it as claimed.

Transcripts

well hey guys get excited we are

covering another highly requested topic

in today's video and that is value

fill-in voluphiline

volufeline however you want to say it if

you are new here welcome my name is

andrea i am a board certified

dermatologist i post skincare content

here on youtube that sounds of interest

to you consider subscribing or following

me over on instagram or tiktok as i post

there a lot as well now what exactly is

volume fill-in this is a trademark

ingredient from the company soderma and

it claims to fill the bust and buttocks

naturally people pursue this ingredient

as an alternative to filler a lot of

people are motivated to use it under

their eyes you'll recall from my video

on how our face changes with age that

with age we get hollows under the eyes

as the fat is redistributed and we have

bony resorption that also can make our

eyes look smaller so people are

motivated to do all sorts of things by

all sorts of products to put around

their eyes to make them look more

youthful more open

reduce under eye puffiness etc

that's why eye creams are so popular

even though you don't need one anyways i

digress this ingredient the company

claims can enhance the decollete fill it

in what exactly is this ingredient is it

you know it's the trademark volume

filling but what exactly is that

hydrogenated poly isobutene

and nmra henae aspho eloides root

extract that is a mouthful it is a plant

extract that this company claims

stimulates adipocytes which are the fat

cells to differentiate just thus having

a natural filling effect they claim that

this plant derived molecule is a

non-hormonal treatment to

enhance fat cell differentiation and

survival but also filling of those fat

cells and they claim that that is how it

can work to enhance your bust line or

act as a filling ingredient now

everything that they claim is based on

their

industry study not a peer-reviewed

published paper but you can find their

industry study online if you want to

read it i will link it down below that

is where the information in this video

is coming from the information in

today's video as a reminder or as a

point of emphasis is merely my opinion

based on what is available in terms of

information from this company but this

is not anything that is standard of care

it is a cosmetic ingredient so remember

that when you're watching this this is

based on my opinion so that root extract

it's got compounds in it called saponins

specifically one such saponin

sarsapogenin

quite abundant in many plants but it's a

phytosterol they claim or allege that it

has no hormonal effects meaning it won't

impact your testosterone levels your

estrogen levels progesterone levels or

any glucocorticoid hormones the compound

is dissolved in oil

now i think my understanding is they

identified this compound perhaps out of

a screen looking for compounds that

might influence

fat cell

gene expression differentiation i'm not

exactly sure honestly how they

discovered this particular compound but

they have done some studies on this

compound both in vitro which for the

record in vitro typically means looking

at cells in a dish whereas in vivo which

they also did means in actual either

animal models or an actual people all

right so they're in vitro studies they

took human

pre-adipocytes those are cells that want

to be fat cells but aren't quite fat

cells yet they incubated them in this

compound and they then did something

called gene expression profiling and

they identified that genes that are

expressed in adipocyte differentiation

meaning that pre-adipocyte becoming who

it wants to be a fat cell

those genes were turned on in the

presence of this compound and the

control cells that were not incubated in

the presence of this compound didn't do

that not only did this particular

compound stimulate those pre-adipocytes

to differentiate into a full-blown fat

cell and it also helped in stimulating

uptake of fat so these in vitro studies

kind of suggest that this compound can

help pre-adipocytes turn into fat cells

and stay that way for a period of time

at least and also take up fat and have

fat vesicles and why the heck would we

want that or breast augmentation which

is what really this trademark ingredient

originally was kind of

marketed or touted as that that would

help just kind of naturally fill in the

breasts to enhance

i guess fat cell differentiation in the

breast tissue so they then took this

compound into actual clinical an actual

clinical study in actual people women

and what they did was they used

something called foits which stands for

fast optical in vivo topometry of human

skin this is basically a method used in

the industry to

kind of look in a 3d fashion at the

optical properties of skin it's kind of

a way to measure wrinkle depth my

understanding i'm not an expert in this

technique but that is what i can glean

from reading about it different papers

online foits they had women put the

volume fill in compound on one breast

and not on the other women's breast size

fluctuates with the menstrual cycle

so basically each woman served as her

own internal control by comparing it to

the opposite breast now they originally

enrolled 32 subjects only 30 actually

ended up completing the study only 28

cases were evaluable at the end time

point i'm not sure why they excluded the

others they don't reveal why they looked

specifically at women ages 18 to 35. the

women could not be pregnant or

breastfeeding because obviously that

would influence breast size no

underlying hormonal issues and their

body weight had to have been stable for

at least three months prior to enrolling

in the study so they applied a five

percent cream gel of the volume in to

one breast twice a day or 56 days total

they were evaluated at 28 days and then

again at 56 days there was a somewhat

increase in size at 28 days as time went

on however that increase in size became

more noticeable so at the end of the

study there was a mean of 2.2 percent

increase in breast size with voluphillin

they pulled aside eight women who they

considered the best responders at 28

days there was a 6.6 increase in breast

size and at the end of the study they

got you know the best sort of results

this is a this little cohort of eight

women at the end of the study they had

eight point four percent increase in

breast size with the volume fill in but

again the average increase in breast

size across all was only 2.2 so that's

all well and good so should you go

putting this all over your face is it

going to fill in your face um i'm

skeptical of course that this is doing

anything to stimulate adipocyte

differentiation i mean just think about

it you're applying it to the surface of

the skin how is that compound actually

going to

penetrate all the way into the skin

across the dermis the deeper layers of

the skin into the subcutaneous that's

where the fat is to influence fat cell

differentiation i know it sounds

attractive to want to replace lost

volume in the face i get that question

all the time how can i restore volume

from fat loss in the face that happens

with age and it's really

attractive to try and do that with

something as simple as a cream gel that

you put on your skin but i mean think

about it would you really want to do

that in such a non-specific way to just

suddenly be stimulating fat cell

differentiation that could have some

negative consequences i mean how do you

how does the if this works the way that

they claim it does if it actually gets

into the skin and does this like they

like allegedly it does i mean how is it

controlled you know a concern i would

have if this did work the way they claim

it does is that you would end up

possibly at risk for developing little

fatty tumors that are actually pretty

common they're called lipomas they're

not dangerous but they bother patients

it can be cosmetically disfiguring

patients seek having them removed

they're easy to remove actually well

depending on the location they're pretty

easy to remove some of them can be

painful those are called angio lipomas

um sometimes people get a lipoma like

right here on the forehead so just

putting this on and you know thinking

that it's selectively going to cause

increase in fat cell mass exactly where

you want it and no more no less i find

that very very

doubtful suspicious questionable

i really just don't think that this does

what it claims it does now people will

say well how do you know if you never

tried it

i mean even if i tried it and i saw some

improvement i would still have this

reservation so that really doesn't

change anything while it's great they

have a study showing an increase in

breast size there's really a complete

dearth of

studies on this ingredient that are peer

reviewed to really say how safe this is

to be doing to the skin overall in the

study at least it appears like this

ingredient is well tolerated there

aren't really any you know i mean

they're not telling us about any adverse

effects although not everybody completed

the study and they don't tell us why so

i do question was that because of some

sort of side effect that they aren't

disclosing that being said you know

whenever there's a study people drop out

for their own personal reasons but you

can imagine that if people who were in

the study and not seeing any results

they may be more likely to get bored and

drop out prematurely so that's another

thing to factor in which we're not being

told as to why they they dropped out at

least that i could find in their report

but i don't think it actually penetrates

into effect change in fat cell mass

differentiation or what have you and

even if it did that seems questionable

in terms of safety the other issue that

i have with the way that they did this

study is again i'm not an expert on this

technique but my understanding is that

foits the fast optical in vivo topometry

of human skin study my understanding is

it's meant to assess in a 3d fashion the

skin not the sub cutis

basically

from what i glean in terms of how the

study is technique is used it's to study

wrinkle depth

which honestly putting something

moisturizing on the skin

will smooth out the skin surface and i'm

questioning are they really measuring an

increase in breast size here or are they

merely measuring a reduction

in

surface irregularity a skin smoothing

effect merely from applying an emollient

to one side versus the other i really

question why they elected this

particular technique as opposed to

something to image the breast tissue

itself like mammography or ultrasound i

mean you know something of that nature

to more objectively i guess quantify the

breast tissue as opposed to my

understanding this technique is really

just looking at the surface and i don't

know that you would actually be

detecting changes in breast volume with

this technique again i'm not an expert

but i do question if this really was the

best methodology to test for this type

of outcome and i suspect this probably

does have a hydrating effect for the top

of the skin and that can have a skin

plumping effect similar to any topical

humectant like hyaluronic acid or

peptides for example and it's a botanic

ingredients it may have

anti-inflammatory effects

antioxidant effects as well you could

speculate that maybe have a you know

help with moisture retention as well as

reducing oxidative stress that

contributes to discoloration and overall

that may give a more

skin brightening illuminating effect

but a lot of that could just be achieved

by using a basic moisturizer i've

noticed that this particular plant

extract not the trademark ingredient but

this particular uh plant extract the

nmrna

asphaloides uh extract root extract i've

noticed it's in other products

it's in for example i think revlon has

some lip glosses that contain this

ingredient i've seen it in a few other

just on a quick online search you will

find that particular root extract in

other products now they're not claiming

a filling effect a volumizing effect or

anything like that so

um i don't think that this trademark

combination is the only

only

only guy on the block but uh yeah i mean

it's interesting that they market it

this way but i guess what uh one other

thing that always gives me pause now on

you can go on amazon of course and you

can buy the raw material which i find

interesting you can buy a vial it looks

like of the volume filling ingredient

it's an oily it's in an oil on the

amazon site they tell you you know they

show this data that i've talked about

here

about the the breast size increase and

they tell you to just put a few drops in

your skin care product which i always

you know again i'm not a cosmetic

chemist but we're talking about an oily

substance here that you're going to put

into your skin care products how do we

know that it's going to

you know distribute evenly in that

product and then when you put it on the

skin that you're going to get even

uptake is it going to be patchy you can

imagine if you had a

again not a cosmetic chemist but i would

imagine that if you take an oily

substance like this if you have a more

water-based lotion that you're using is

it going to mix in i don't i honestly

don't know i'm not going to pretend to

to know about that kind of thing that

seems to me more of a compounding issue

but i do question like if you mix it in

with products is it actually going to be

evenly distributed on the skin and have

even penetration or are you going to get

clumping i really don't know much about

how this particular ingredient behaves

in in products so in the study they used

5

gel cream cream gel but if you just go

dropping this into your lotion

moisturizer serum what have you what's

the final percentage going to be i

certainly do not recommend applying the

raw material which is what it's sold as

directly to your skin that can be

incredibly irritating all right y'all

long story short what do i think of this

ingredient i think it sounds too good to

be true it likely is yes i know i've

never used it but honestly i would say

the same exact thing even if i used it

and all of a sudden you know came in

here with

like

my 16 year old eyeballs and you know

massive

filled lips or whatever which i doubt is

going to be what happens here be very

careful when it comes to claims like

this i i you know again this is my

opinion based on what the information

that they have presented this is my

opinion on the likelihood that this is

going to work the way that they say it

does um but i do think at the most you

will see an improvement in skin

hydration with this ingredient seems

plausible and i suspect that may

underlie some of the filling effects

that people are seeing

i would love to see more research with

this ingredient and then i would have

more confidence that it is not only safe

but effective in terms of doing what it

says it does but if it claims to

stimulate fat cell differentiation

we would want to do that in a controlled

fashion right i mean you could end up

with lipomas fatty tumors things that

you don't want so that's why i

questioned does this really work why are

we not seeing that type of outcome i

know rhodiola had a breast filling cream

breast plumping cream with this in it i

think they still have that actually so

that's one product that i'm aware of

that has this it's also in several asian

skin care products so let me know in the

comments have you used a product that

has this did you buy the raw stuff

online and try and mix it in with your

products did you see any magic filling

effect but that's what i can tell you

about this ingredient and my doubts as

to if it works the way that it's touted

to work again my opinion

but i hope you all enjoyed this video on

the end slate it's going to be my video

on how your face changes with age so

definitely check that one out if you

missed it but if you like this video

give it a thumbs up share with your

friends and as always don't forget

sunscreen and subscribe i'll talk to you

guys tomorrow bye

[Music]

you