Is Topical Dutasteride The Holy Grail? - AS GOOD As Oral Dutasteride WITHOUT The Side Effects!?

Summary

The video discusses topical dutasteride as a treatment for hair loss, comparing it to oral administration and exploring its potential benefits and drawbacks. It delves into the pharmacological effects of dutasteride, the impact of metabolites, and the possibility of localized scalp DHT inhibition without systemic side effects. The speaker shares anecdotal evidence and personal insights, suggesting that topical dutasteride could be a promising alternative for those seeking hair loss solutions with fewer side effects.

Takeaways

• 🧪 Topical dutasteride is being explored as a method to achieve localized 5-alpha reductase (5AR) inhibition with minimal systemic absorption, which is a novel approach in hair loss treatments.
• 💊 The molecular weight difference between finasteride and dutasteride may affect their topical application efficacy, with dutasteride's higher molecular weight possibly allowing for more targeted scalp treatment.
• 📉 Topical dutasteride might offer a more favorable reduction in scalp DHT levels compared to serum DHT levels, which is a desirable outcome for treating hair loss.
• 🚫 Oral dutasteride has more side effects than topical or mesotherapy applications, suggesting that topical administration could be a safer alternative.
• 🔬 Clinical studies show oral dutasteride outperforms mesotherapy and topical dutasteride, but the side effects and systemic absorption are significant considerations.
• 🌡️ The first-pass metabolism of oral medications creates metabolites that may have their own 5AR inhibiting properties, which are bypassed when using topical applications.
• ✂️ Topical administration allows for greater dosage manipulation, offering the potential for microdosing and tailored treatments.
• 🧬 Dutasteride's metabolites, such as 6-hydroxy dutasteride and 4-hydroxy dutasteride, have their own pharmacological effects, which may influence the overall treatment outcome.
• 📈 Topical dutasteride could potentially lead to quicker returns to baseline DHT levels compared to oral administration, which may be beneficial for managing side effects.
• 🤔 There is a need for more research and data on the long-term effects and efficacy of topical dutasteride, as current evidence is largely anecdotal.
• 🛑 The script suggests that a comprehensive hair loss treatment protocol might involve a combination of topical dutasteride and anti-androgens to address both DHT reduction and androgen receptor activation.

Q & A

What is the main topic of discussion in the provided script?

The main topic of discussion is topical dutasterides, specifically its potential as a treatment for hair loss and the various aspects related to its use, including different administration techniques, molecular weight considerations, and its effects compared to oral administration.

What are the different administration techniques for dutasteride mentioned in the script?

The script mentions several administration techniques for dutasteride, including topical solutions, liposomal formulations, and mesotherapy, which is an intradermal injection of dutasteride into the scalp.

What is the goal of using dutasteride in a topical format or mesotherapy?

The goal is to achieve a high level of localized 5-alpha reductase (5AR) inhibition with a relative lack of systemic absorption, potentially offering a more targeted approach to hair loss treatment.

What is the difference between the molecular weight of finasteride and dutasteride, and why is it significant for topical application?

Finasteride has a molecular weight under 400 daltons, while dutasteride is around 500 daltons, which influences its ability to penetrate the skin effectively for topical use.

Outlines

00:00

🧪 Topical Dutasteride: A Novel Approach to Hair Loss Treatment

The speaker explores the concept of topical dutasteride as an alternative to oral administration for hair loss treatment. They discuss various methods of administration, including liposomal formulations and mesotherapy, highlighting the goal of achieving high localized 5-alpha reductase (5AR) inhibition with minimal systemic absorption. The speaker also compares the molecular weights of finasteride and dutasteride, suggesting that dutasteride's weight over 500 daltons might make it a more viable topical treatment. They delve into the pharmacological effects of dutasteride and its metabolites, emphasizing the potential benefits of topical application in avoiding first-pass metabolism and systemic side effects.

05:02

📊 Topical vs. Oral Administration: Metabolites and Their Impact

This paragraph delves into the differences between topical and oral administration of dutasteride, focusing on the impact of first-pass metabolism and the production of metabolites. The speaker explains how topical application can lead to a disproportionate increase in the parent compound compared to its metabolites, which might contribute to the drug's efficacy and reduced side effects. They discuss the potential for a quicker return to baseline DHT levels with topical application and speculate on the effects of various metabolites, such as 6-hydroxy dutasteride and 2-hydroxy dutasteride, on the pharmacological profile of the treatment.

10:03

🔬 Dutasteride's Molecular Weight and Topical Application Theories

The speaker discusses the theory behind dutasteride's molecular weight and its potential effectiveness as a topical treatment. They suggest that dutasteride's molecular weight being just over 500 daltons might allow for some penetration into the scalp, but not enough to cause systemic issues. The paragraph also touches on the importance of the vehicle used in topical formulations to manipulate penetration and achieve the desired local effect. The speaker shares anecdotal evidence and blood work observations that indicate promising results for topical dutasteride, including reduced scalp DHT levels with minimal systemic impact.

15:04

💊 Dosage Manipulation and Topical Dutasteride's Advantages

The speaker compares the flexibility of dosage manipulation between finasteride and dutasteride, highlighting the limitations of dutasteride's soft gel capsule form. They argue that topical dutasteride offers more control over dosage and frequency of application, which could be beneficial for individuals who are risk-averse or concerned about side effects. The paragraph also discusses the potential for a more rapid return to normal DHT levels with topical application, as opposed to the longer-lasting effects of oral dutasteride.

20:04

🤔 Exploring Topical Dutasteride: Risks, Benefits, and Individual Considerations

In this paragraph, the speaker reflects on the potential of topical dutasteride, considering its risks and benefits. They suggest that it may be a viable option for those who are prone to side effects from other treatments or who are seeking a less aggressive approach to DHT inhibition. The speaker also raises questions about the long-term effects of topical application on neural steroid production and the need for further research to understand the full implications of this treatment method.

25:04

🧩 Broadening the Treatment Perspective: Beyond DHT Inhibition

The speaker expands the discussion to consider the broader implications of inhibiting DHT, particularly the potential for increased scalp testosterone levels. They suggest that a comprehensive treatment protocol might involve the use of anti-androgens or selective androgen receptor modulators to address the complex interplay of androgens in the body. The paragraph concludes with a call for a holistic approach to hair loss treatment, considering the entire steroidogenesis cascade and the potential need for additional interventions such as microneedling or minoxidil.

📈 Conclusion: The Promise of Topical Dutasteride and Future Directions

The speaker concludes by summarizing the potential of topical dutasteride and suggesting it as a promising avenue for further exploration. They acknowledge the need for more data and research but express optimism based on anecdotal evidence and personal observations. The speaker also mentions their interest in potentially working with a compounding pharmacy to make topical dutasteride more widely available. They end with a reminder of the importance of a comprehensive approach to hair loss treatment and a plug for their associated products and services.

Keywords

💡Dutasteride

Dutasteride is a medication used to treat hair loss in men, specifically by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), a hormone linked to male pattern baldness. In the video, it is discussed in various forms, including oral and topical applications, with a focus on its potential benefits and side effects compared to other treatments like finasteride.

💡Topical Dutasteride

Topical Dutasteride refers to a form of the medication applied directly to the scalp, as opposed to being taken orally. The script discusses the potential advantages of topical application, such as localized 5-alpha reductase (5AR) inhibition with minimal systemic absorption, and the possibility of achieving high levels of scalp DHT reduction without the side effects associated with oral intake.

💡5-alpha reductase (5AR) inhibition

5AR inhibition is the process of blocking the enzyme 5-alpha reductase, which converts testosterone to DHT. The video discusses the importance of 5AR inhibition in treating hair loss and the different methods of achieving this, including oral and topical administration of dutasteride.

💡Systemic absorption

Systemic absorption refers to the process by which a substance is absorbed into the bloodstream and distributed throughout the body. The script contrasts the systemic absorption of oral dutasteride, which can lead to side effects, with the more localized effects of topical application, which may reduce systemic exposure and side effects.

💡Mesotherapy

Mesotherapy is a method mentioned in the script where dutasteride is injected directly into the scalp tissue. This technique is used to achieve a high level of localized 5AR inhibition, and it is part of the broader discussion on innovative treatments for hair loss.

💡Pharmacokinetics

Pharmacokinetics is the study of how a drug moves through the body, including its absorption, distribution, metabolism, and excretion. The script discusses the pharmacokinetics of dutasteride, particularly the impact of topical application on the levels of the drug and its metabolites in the body.

💡First-pass metabolism

First-pass metabolism is the initial breakdown of a drug that occurs as it passes through the liver after oral administration. The script explains that topical application of dutasteride allows for a higher concentration of the parent compound to reach the scalp, bypassing first-pass metabolism and its associated production of metabolites.

💡Metabolites

Metabolites are the substances produced when a drug is broken down in the body. The script discusses specific metabolites of dutasteride, such as 6-hydroxy dutasteride and 4-hydroxy dutasteride, and how their production and effects differ based on whether the drug is taken orally or applied topically.

💡Molecular weight

Molecular weight is the mass of a molecule, and it can affect a substance's ability to penetrate the skin when applied topically. The script notes that dutasteride's molecular weight is over 500 daltons, which is considered a threshold that may limit its penetration and systemic absorption when applied topically, potentially enhancing its efficacy as a topical treatment.

💡Microdosing

Microdosing refers to the practice of taking a very small dose of a substance, often a drug, to achieve a specific effect without experiencing full-blown effects. The script suggests that the topical application of dutasteride could allow for microdosing to potentially achieve hair loss prevention with minimal systemic inhibition of DHT.

💡Androgen receptor activation

Androgen receptor activation is the process by which androgen hormones, like testosterone and DHT, bind to androgen receptors to exert their effects in the body. The script discusses the broader implications of reducing scalp DHT levels, such as the potential for increased scalp testosterone levels and the need for other treatments to manage androgen receptor activation.

Highlights

Topical dutasteride is being explored as a potential treatment for hair loss with less systemic absorption than oral forms.

Different administration techniques for topical dutasteride include solutions, liposomal formulations, and mesotherapy injections directly into the scalp.

The goal of topical 5α-reductase inhibitors is to achieve high localized 5α-reductase (5AR) inhibition with minimal systemic absorption.

Oral dutasteride has been shown to outperform mesotherapy and topical dutasteride in clinical studies, but with more side effects.

The molecular weight of dutasteride (over 500 daltons) may make it a more viable topical therapy compared to finasteride.

Topical application of dutasteride might allow for more precise control over dosage and frequency compared to oral administration.

Dutasteride metabolites, such as 6-hydroxy dutasteride and 4-hydroxy dutasteride, have their own 5AR inhibiting properties and contribute to the drug's effects.

Topical dutasteride might offer a more favorable scalp to serum DHT reduction ratio compared to finasteride.

Some users report a quicker return to baseline DHT levels with topical dutasteride than with oral forms.

Topical dutasteride could potentially have less side effects due to reduced systemic exposure to metabolites.

The speaker suggests that topical dutasteride may be a promising option for those who are risk-averse or concerned about side effects.

Dutasteride's half-life and the half-lives of its metabolites are important factors to consider when evaluating the drug's effects over time.

The speaker discusses the potential for a disproportionate decrease in scalp DHT with topical dutasteride, possibly leading to increased scalp testosterone.

Topical dutasteride might be a good preliminary treatment for those considering oral dutasteride to assess tolerability.

The speaker mentions the possibility of using compounding pharmacies to create lower dosage tablets of dutasteride.

The transcript explores the broader implications of scalp DHT reduction, including the need for strategies to manage increased scalp testosterone.

The speaker concludes that while more data is needed, topical dutasteride shows promise and is worth exploring for hair loss treatment.

Transcripts

so the same thing with dutaster is going

to apply you're going to have

when you apply it to your head you're

going to get less

of a disproportionate rise in this six

hydroxy dutas right four hydroxy

dutasteride one two dihydro dutasteride

is that a good or bad thing though are

those the things that are

literally responsible for the majority

of the long-term pharmacologic effects

you know i think this sort of reinforces

why

the topic will do tasks right

what's up guys derek for

playsmartdates.com today we're going to

be talking about

topical dutasterides so you know there's

different

administration techniques even among

topical dutasteride

intervention in general there is um just

straight up

topical solutions there are liposomal

formulations there are

something called mesotherapy where it's

literally um

an intradermal injection of dutasteride

into the scalp itself to achieve

well the goal of it is to achieve um

like a high level of localized 5ar

inhibition with a relative lack of

systemic absorption

and this is one of the most uh you know

forward thinking

of the i don't know treatments involving

5ar inhibition

and it's uh picking up a lot of steam

lately or at least in the niche

niche community that researches this

[ __ ] it's picking up steam i guess

um so anyways due task right has been

looked at in a lot of ways and obviously

orally as well

so i kind of want to just give my stance

on it from what i've seen

over the past couple years of looking

into this um

anecdotal findings reports from people

in the community that i'm friends with

or

other anecdotes from random people who

follow my stuff you send me messages

i've received just like hordes of [ __ ]

over the past

years of hair loss stuff now for do task

right in particular

not a lot of people use it topically it

is sort of a

new um relatively uncharted waters i

guess

reason being is oral works very well so

most people are going to just use oral

and if you actually look at the clinical

studies comparing oral versus topical

or even mesotherapy oral dutasteride

outperforms mesotherapy and topical

dutasteride however this does not come

with

without downside obviously because there

is more side effects

found in the oral groups now this is

different

than the if you could see the topical

finasteride versus the oral finasteride

studies you find that

any kind of like disproportionate

advantage it seems to have seems to

essentially

disintegrate upon reaching steady state

concentrations in the body it goes

systemic just the same

and seems to pretty much do the exact

same [ __ ] as far as systemic versus

scalp dht inhibition

however the molecular weight of

finasteride versus dutasteride is

different this is sort of where

it gets a bit bro-sciency but also is

like part of the

theory behind dutasteride topically

being potentially a more

viable therapy in a topical format

versus oral of finasteride versus two

tasks right finasteride has a

molecular weight under um 400 daltons

and dutasteride is like 528 daltons or

something like that

so you know the classic rule is that if

it's under 500

daltons then you can apply it in a

topical solution and get it into

the scalp to do what it's supposed to do

locally and if the molecular mass

is over 500 daltons then you know it's

thought

that it's not going to be able to um

penetrate and

you know yield a pharmacological effect

whatsoever

which sort of actually is part of the uh

theory around dutaster that sort of

reinforces its efficacy as a topical

solution

is its molecular weight being over 500

daltons so they think well some people

speculate it's not like anyone actually

knows

um that it's sort of like

um gets like sort of in there but like

not enough that it gets like deep enough

to be problematic but it's

enough to produce the pharmacologic

effect we're seeking because it's like

right on the brink of 500

and we can sort of manipulate the

penetration

with different vehicles to kind of

achieve getting right where we want it

to without getting like

two in there which you know like what is

the likelihood of us actually being able

to do that

you know it's [ __ ] tough to speculate

about but

some of the blood work does sort of

reinforce um

it as a potentially viable solution for

a lot of people in my opinion i'm gonna

sort of get into my reason why

after but i'm sort of just like checking

off all the boxes in terms of all the

points

that are like commonly brought up when

it comes to dutasteride versus

finasteride

the efficacy of topical solutions and

blah blah blah so finasteride like i

said we see a pretty much

equivalent scalp and serum dht reduction

now does that mean that topical

finasteride has no merit

and that it should not be opted for

instead of oral like not necessarily

because there is like we've seen even

with uh topical testosterone

applications when you apply it scrotally

you know you can get a disproportionate

spike in dht concentrations just by the

local

5ar activity of the application site so

why could we not leverage the exact same

mechanism via your scalp you know

theoretically if you can

disproportionately increase dht

relative to your t dose by applying it

under your nut sac

why can you not get a disproportionate

decrease in dht by applying

a 5ar inhibitor to your scalp right at

the other place where there is a

disproportionately high amount of

5ar you know you would think that sort

of makes sense in practical application

with the topical finasteride we don't

really see that play out in the blood

work or the scalp biopsies though

however with dutasteride maybe it's a

bit different and something to note as

well

is first pass metabolism when you apply

something topically

you skip first pass and the oral

bioavailability

of finasteride and due task right is not

100 it is if i recall correctly

somewhere around

somewhere around 60 to 65 i believe

finasteride is

65 due taster it's like 60 or something

like that so anyways

when it goes through metabolism and

uh gets metabolized by the liver there

is

metabolites that are produced when you

take finasteride you take deutastroid

and especially with do taste right these

produce unique

and um unique metabolites with their own

inherent 5ar inhibiting properties so

part of the pharmacological effect of

deutastrite

is provided not just by the parent

compound itself but perhaps by its

metabolites during first pass metabolism

so

when you apply something topically you

skip first pass you get a

disproportionate

increase in the parent compound as well

relative

to the metabolite so you're actually

getting less

of the um what are the metabolites i'm

going to pull up the

wikipedia thing right now so i can

remember them um

do test right let's see

pharmacokinetics

um okay so for six hydroxy dutas right

four hydroxy dutas right and one two

dihydrotasteride so

these are uh the three major metabolites

um that form via um first pass

so it's almost like you know when you

look at oral estradiol versus

transdermal versus iv versus sublingual

there's a reason you see a

disproportionate spike in estrone

relative to estrogen levels

when you take oral estradiol when you

take it sublingually or apply it

transdermally or inject it though

you have a more physiologic

representation of a balance between

normal amounts of estrogen

relative to estrone because you are

skipping that first pass metabolism so

the same thing with dutaster is going to

apply you're going to have

when you apply it to your head you're

going to get less

of a disproportionate rise in this six

hydroxy do test right four hydroxy dutas

right one two dihydrodutastride

is that a good or bad thing though are

those the things that are

literally responsible for the majority

of the long-term pharmacologic effects

you know i think this sort of reinforces

why

the topical due tasterite may have a lot

of promise because if you're skipping

this production of these metabolites to

a significant extent you have to keep in

mind they have their own inherent

half-lives they have their own inherent

um ability to bind to favor

5ar with a certain affinity a certain

binding constant a certain dissociation

rate there's these things

that are associated with all these

compounds this is an entirely new thing

that you're looking at for each

metabolite it's not just what is the

dutasteride doing

it's also what's happening with all this

[ __ ] like this is why um

even with oral steroids like half the

time

like the [ __ ] that you're taking it's

not even necessarily

the parent compound yielding the effect

that you're getting and you're trying to

get out of it like sometimes

you know with anadrol i speculate that

the standalone conversion in the liver

might be like

a lot of the adrenergic signaling you

get out of a pre-workout like maybe

that's why it even works to begin with

maybe the parent compound

[ __ ] sucks as a pre-workout you know

there's a lot of things that come via

that metabolism process that you're

losing out on

or winning out on potentially when you

use it in a different format of

administration

so with dutastride in particular the

thing that interests me

is that when i see blood work before and

after i see

return to baseline a lot quicker than i

do with oral

which is interesting but as well it's

also guys who are not letting it

reach steady state they're not using it

consistently on a day-to-day basis

they're using it like once a week so

you know that might play into it i

speculate that maybe it might play into

the

relative lack of these major metabolites

that are being produced during first

pass and maybe

it's yielding in a more i don't know a

more uh

not elastic but like i don't even know

what the word is like a shorter overall

drug burden slash half-life overall

because you're not dealing with also

metabolizing

to as much of a degree these other

metabolites which are also

very potent five ar inhibitors like

let's see uh d6 di hydroxy detached

right has a similar potency

as a 5ar inhibitor 2 dutasteride so you

know if you're dealing with the

half-life of deutaceride

and then you have to deal with six

hydroxy dutasteride two after because of

oral

you know that's like a whole new you

know layer of metabolization that has to

be worked out of your system before you

can then return to

normal dht levels so theoretically by

applying it topically we might be able

to get back to baseline

quicker and potentially have a more

i don't know the body might be more

resilient to side effects because you're

not dealing with like

unknown amounts of metabolites at the

same time that are also

producing pharmacologic effects in

satellite you know satellite

interactions and [ __ ] that you can't

even predict

so you know maybe you're making the drug

more

manageable and gain gaining more

leverage over the compound in terms of

how you can manipulate it manually when

you're using it topically too

because you're not getting this

disproportionate spike in the

metabolites

you're dealing with mainly the parent

compound at this point so that's where i

think it has a lot of promise

topically as well and it sort of seems

to be reflected in the blood work like i

said like going back to it a little bit

i see returns of serum dht levels

quicker than i do with oral just on the

minor amounts of blood work i've seen

that's what i'm seeing in addition

as far as how it is affecting scalp dht

levels versus

serum dht levels it seems to be more

favorable

than that of finasteride now i don't

know if that's actually the case or if

it's just a result of

you know like with minoxidil like some i

was speculating before that maybe

minoxidil

you might be able to yield the exact

same effect as topical minoxidil just by

taking like a micro dose orally that

would otherwise yield the exact same

side effect profile but then again

it circles back to the thing of

intra-tissue specific concentrations of

compounds definitely yield a localized

effect

like with the scrotal testosterone and

you know reverse engineering that on

your scalp

so you know a lot of times like the

theories in my head

i'm sort of like going to [ __ ] ramble

and uh i'm trying to like circle back to

my point and make it a cohesive [ __ ]

summary here but basically

i've had a handful of people reach out

to me with before and after blood work

the blood work looks solid in that when

you take oral due to asteroids what

happens is you

nuke your dht levels like you get

systemic

inhibition of 5ar to a point where you

are literally

like a prepubescent child after you use

it with topical dutastra i've seen

people use

upwards of like double digit milligrams

on their head

which would otherwise be an amount

orally

which would nuke your dht now obviously

topically you're not gonna get the same

absorption as you would orally you know

just like with minoxidil you're using

like five percent solution you're using

50 milligrams on your head

if you took orally 50 milligrams you get

[ __ ] destructed

with due to asteroid though if you took

you know in the double digits

um you would expect like a significant

reduction in dht

like serum not not just your scalp but

what we do see is a disproportionate

decrease in the scalp

dht and the lesser of a decrease

systemically

now is that just a lag effect or

is that actual like intra-tissue

localized effects going on that we're

actually trying to seek and sort of like

actually capitalizing

on the reverse engineering the scrotal

testosterone thing and actually having

it work up here

um i don't know for sure but what i do

see in the blood work seems good you

know it's guys who are getting uh

you know like 60 to 70 to 80 percent

scalp dhd inhibition

with 20 to 40 percent of serum dhc

inhibition

using dosages that you would otherwise

think would go systemic and [ __ ] them up

and it just doesn't seem to be the case

and these are guys that are used to get

side effects from using

even topical finasteride and then they

take topical dutasteride

and paradoxically they don't experience

side effects so

it's just really interesting to me you

know maybe the molecular weight plays

some role in it

maybe it has to do with the uh

application

frequency and the half-life and the

relative lack of metabolite production

because with finasteride

like all of these compounds are their

own compounds too like when finasteride

is metabolized and it goes through the

liver

it makes its own metabolites too so as

far as like the inherent 5ar inhibition

potential of all the finasteride

metabolites due tasterite metabolites

the half-lives of those compounds how

they affect other satellite interactions

in the body

how they affect other enzymes and other

physiologic processes that are going on

at the same time

you know you can't predict any of this

[ __ ] we only know what's going on with

the parent compounds and we barely even

[ __ ] know that

like that's that's how much we're

[ __ ] extrapolating here as we're

trying to predict with relative accuracy

what's going on with a parent compound

with a novel administration technique

and then predict downstream what's going

to happen with all of the cascades of

metabolite

compounds that are being produced and

what they're going to do and what their

half-lives are and what their inherent

potential is to do blah blah blah

so again we can just go off a [ __ ]

anecdote essentially and whatever

studies we have available

and in the studies available they're not

too useful to be honest

and in the anecdotes available they're

very limited to be honest however it

does look promising and i think it has

not only in all of the things i

mentioned but also in the ability to

manipulate your dosage

with suit with dutasteride you don't

have the advantage of finasteride where

it's

a pressed tablet at least with

finasteride you can [ __ ]

break it up into pieces you can

literally crush it into dust you can

literally

do whatever the [ __ ] you want to it and

make it into a micro dose if you wanted

to

actually titrate up and be you know

risk-averse and kind of like

get the you know greatest effect with

the lowest dose and

if you look into the finasteride data

you can see you can get a significant

amount of dht inhibition with a dose way

lower than the one milligram pressed

tablet

you get as a propecia tablet with

dutasteride though you're given a 0.5

a 0.5 milligram soft gel what the [ __ ]

do you do with that you have no choice

but to pop the 0.5 milligram soft gel

unless you come up with some real

creative [ __ ] most people are popping

the 0.5 milligram soft gel

and getting full nuke dht serum

scalp everything you know you have no

manipulation of your dosage

where and it's not like it comes in a

format that's different like with

finasteride

there's a lot of manipulation you can do

you know you can even

opt for um well this is probably a new

thing that's gonna be coming up but you

know

opting for compounding pharmacies to

make lower dosage

um pressed tablets you know going for

you know a 0.2 milligram press tablet

instead of a zero instead of a one

that's something i'm going to be looking

into with my hrt clinic is if

if that's even [ __ ] possible and it

should be i don't see why it's not but

with dutasteride and these soft gels and

the avo dark capsules

you're looking at 0.5 milligrams like

that's what's available there's nothing

[ __ ] else available so

giving yourself the ability and that's

sort of like you know where topical

finasteride can be advantageous too like

at least

at least you have a press tablet though

you can manipulate if you're doing

orally but even when you start to cut it

into quarters

the [ __ ] can turn into dust pretty quick

and make it kind of problematic

like quarters is kind of doable but

you know like even for that like some

people if you're getting a pro scar

tablet for example it's five milligrams

you're cutting into 1.25

where do you go from there if that's

what you have available to you you know

it's not like you can cut that into

smaller pieces

and with you taps right you have no

manipulation at all so you know this is

where the topical has

advantage too because you can literally

manipulate the amount

and the concentration of the solution

based on what you need and not be kind

of like subjected to whatever the

um pharmaceutical giants have

essentially deemed as the dose you need

to be taking regardless of what you want

or what

don't want to do so you know with

dutaster you can use as low as

[ __ ] whatever you want and you can

use it as

frequently or and frequently as you want

it's like obviously you could use oral

do tasks right you know infrequently

just like these detached right

mesotherapy protocols

but you're you can't avoid that like

significant

[ __ ] crash in dht whereas with the

mesotherapy

and with the just i don't know topical

in general you have

you have a choice between what you're

applying to your head it's not just like

you have to use 0.5 milligrams and

that's [ __ ] all you can deal with

you have a choice so as far as uh

you know it's merit it is promising and

i think you know for a lot of people

like if you are risk-averse obviously do

doing a topical dutasteride experiment

before going to oral

makes a lot of sense obviously if you

were somebody who was going to go down

the rabbit hole of dutasteride to begin

with

you know going the topical route makes a

lot of sense in my opinion before

jumping like full board into a oral

treatment that you know produces these

metabolites that are going to linger

and the entire compound plus metabolites

is going to have a half-life of

[ __ ] four to five weeks like

once you get on oral dutasteride like

you're in it dude you're in it for a

while

because this [ __ ] lasts so with topical

it seems like it doesn't last

as long perhaps the metabolite thing you

have more manipulation of your dosage

you can get to a more micro dose not

have to deal with a massive

you know dis just [ __ ] nuke your

system overnight kind of thing

and um you may get a disproportionate

decrease in scalp dht relative to serum

you know

this might be the first off 5ar

inhibitor that actually is able to

achieve that you know so

you know more data needs to come out for

us to have any definitive conclusions

but for me

it's kind of like a no-brainer if you

have it available to you to

go with that before oral like at least

if you were

side effect prone or worried about side

effects significantly if you don't want

to go the full

like like dude oral due task right i

would consider

like part of the most like

it's not like nuclear like i always talk

about these nuclear options but it's

kind of like

the most aggressive of dht inhibition

you can really do as well as

neurosteroid inhibition so it's like

some people don't care enough to want to

step by step you know put on the

training wheels before getting there

but then there's some people who want

the minimum effective dose

with the least side effects which

obviously makes the most [ __ ] sense

because if you can get

hair loss prevention with i don't know

like one

tenth of the systemic inhibition of dht

and

potentially neurosteroids then why not

then that begs the question though too

is if you're applying something right

onto your [ __ ] head where your brain

is

does that have a disproportionate

decrease in your neural steroid

neurosteroid production

you know there's a lot of unanswered

questions and

a lot of this is kind of just like bro

science theory

um at the end of the day but it's new

new

[ __ ] you know we're learning new [ __ ] as

we go and this is this is what i've seen

to date i think if you're somebody who

is looking at dutastride then

topical is definitely worth exploring

first to you know assess your

tolerability of it from a more like

micro dose perspective

in addition i think some people who

don't tolerate finasteride very well

um are going to get [ __ ] if they used

oral dutasteride obviously so they can't

do that like why would you can't go to a

more aggressive therapy if

you used oral finasteride or topical and

had problems with it

however i have heard of people using

oral finasteride

topical finasteride getting sides and

then going to a

really really like moderate dose of

topical dutasteride

and having no side effects it's really

interesting so you know i think it has a

lot of promise for

a lot of people potentially you know it

may not just be for people who want to

go aggressive like everyone thinks oh

detaster it's the strongest

5ar inhibitor so if if i'm fine with

finasteride like why would i even bother

or if i don't want to go above the you

know intensity of finasteride why would

i bother

it's like it might have less intensity

than finasteride for all we know from a

serum

dhc inhibition context then again there

are

you know like token individuals who

claim that it's gonna do the exact same

thing as finasteride does and eventually

it's going to reach

enough inhibition systemically to

essentially

you know do the same [ __ ] that topical

uh finasteride does

there's not really any data to reinforce

anything we just have anecdotal findings

and [ __ ] some blood work from

a handful of dudes to be honest so for

me

i take the word of guys that i respect

in this community and guys that i uh

you know uh defer to on certain things

that even i'm less knowledgeable about

and some of them i've seen good results

so

you know for me that's promising enough

and the theories i've come up with

through the

manipulation of five ir on the scalp

localized activity you know

even talking about like the topical

nandrolone in the past

disproportionately spiking

dihydromandrel in concentration sarms

etc

all these things have a lot of

therapeutic promise and i've seen it

play out enough times now to know that

there is some [ __ ]

that is worth exploring further when it

comes to localized concentrations of

drugs so

for me you know the first pass thing

skipping the metabolites as much you

know the manipulation of the half-life

potentially i'm getting a microdosing

that you otherwise wouldn't be able to

do

um the disproportionate decrease in

scalp dht relative to serum like there's

so many [ __ ]

things that make this so promising that

it's just a no-brainer to explore

further and

for who this is viable for i can't say

like you should try this but

like you're gonna have to you're gonna

have to decide if it's a good uh if

you're a viable candidate or not because

it's not like

anyone it's not like there's any kind of

like prescription criteria for this [ __ ]

to begin with

even oral due taster like i'm pretty

sure it's only approved for hair loss in

like

a handful of countries or some [ __ ] and

it's definitely not in north america so

yeah dude you know you have to figure it

out yourself like i said though

at least the one criteria i can say is

some guy who is thinking about

graduating to do tasteride but is

worried about the side effects

that individual would be wise to you

know explore some of the topical

stuff or mesotherapy practices before

diving headfirst

into a four to five week half-life oral

treatment that is going to keep them

and their neuro their neurosteroid

production and their dht production

like really [ __ ] hindered for months

on end so

anyways that is my stance on i think it

has a lot of promise

and i think it is uh definitely worth

looking at

so and again though keep in mind this is

not a turnkey solution this is dealing

with

scalp dht has nothing to do with scalp

testosterone has nothing to do with any

of the other circulating androgens in

your body

which there are other ones not just dhc

not just dht not just testosterone there

are other androgens too

the steroidogenesis cascade does not

yield

just two things that are androgenic and

have affinity for ar

and have their own inherent binding

constant dissociation rates and their

own

um response elements that they elicit

when they bind and activate the ar and

do a bunch of [ __ ]

this is stuff that has to be accounted

for from a more

broad spectrum perspective um

if you're very prone to hair elastic

obviously maybe if you just you know

inhibit dht enough yeah sure maybe

you'll get through the majority of your

life with no issues but at the end of

the day

when you're using especially if you get

this disproportionate decrease in scalp

dht

do you know what that's gonna lead to

too a disproportionate spike in scalp

tea

like you're gonna get a giant spike in

scalp testosterone

if we're getting what we're trying to

get out of this stuff like if we're

succeeding

in nuking scalp dht levels 80

think of what that's doing to your scalp

testosterone all that 5ar

where your tea would otherwise be going

through the dhc is now left as tea and

it's just chilling in your scalp and

what do you have to deal with that what

do you have to clean that up with

well now you're looking at ar inhibitors

now you're looking at

selective androgen receptor modulators

now you're looking at other ar agonists

that compete or

ar whatever you want to [ __ ] do

whatever your mod

your preferred modality of dealing with

androgen receptor activation and

selective androgen receptor degraders

you know there's so many [ __ ] things

that are worth exploring but in general

anti-androgens are going to be the

modality that most people

would probably you know resort to first

as it's the most uh i don't know tried

and true

most well understood most uh like we

actually know what the [ __ ] it's doing

we know how to predict exactly what it's

going to do to our hormone profile based

on if it's a non-steroidal anti-androgen

or a steroidal anti-androgen and what

kind of downstream

effects it may or may not have and there

are actual compounds being evaluated in

the clinical setting right now that are

actually you know designed to deal with

this [ __ ] too so obviously

that's really promising too so you know

the classic kind of uh

first line of defense would be you know

if you inhibit your scalp dht that much

you've dealt with that

now we have to deal with broad spectrum

ar activation to begin with so now we

have you know

cb0301 um ru58841

florida whatever it is that you choose

whatever it is your preferred

anti-androgen of choice is

based on what you deem cost efficient

um most effective least side effect

written

most clinical data backing its efficacy

and safety profile whatever it is that

is your criteria for what is the

ideal anti-androgen like that would be

the next step to deal with it from a

broad spectrum perspective but

i do believe that that is a very

comprehensive protocol and would serve a

lot of people to

like fully protect them to be honest you

have a topical dutastride plus an

anti-androgen that would be a very you

know thoroughly well thought out

protocol in my

opinion and then from there if you

needed to re-regain ground like i feel

like that would be enough to stave off

further loss and if you needed to regain

ground

you know that's where you would

intervene with you know microneedling

minoxidil whatever it is that you decide

is your growth agonist of choice there's

other things you can do too obviously

that i've discussed on my channel many

times but

that is the sort of like you know that

is how topical dues asteroid would be

used

in a very broad general way like not

actually digging into the dosages not

digging into which application

technique or vehicle or whatever you

should be using because frankly that's a

[ __ ] five-hour video

probably trying to describe all of the

different ways this thing can be

leveraged like it's very uh

there are a lot of different theories

going around right now but at the end of

the day like i said

it definitely does work like when you

actually look at the mesotherapy results

they're very good

when you look at the topical results

they're very good um

they're not as good as oral but you

would expect as such without as much

systemic absorption like you're not

getting the [ __ ] 99

inhibition you're getting i don't know

70 80 scalp inhibition it seems like but

that's [ __ ] great you know if you can

get away with it side effect free you

know that's what some people need

so anyways take from that way you will

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