What all dieters need to know about Ozempic

Menno Henselmans
19 Jun 202409:10


TLDRThe video explores GLP-1 receptor agonists, dubbed the 'magic weight loss pill,' highlighting their effectiveness in reducing appetite and body weight, with semaglutide as a popular example. While these drugs offer significant weight loss and health benefits with minimal side effects, they are not a cure-all. The script addresses concerns about nutritional deficiencies, muscle mass loss, high costs, side effects, and the necessity for lifestyle changes to prevent weight regain post-treatment. It emphasizes the importance of considering long-term implications and the role of sustainable lifestyle changes for lasting weight management.


  • 💊 The 'magic pill' for weight loss is now available in the form of GLP-1 receptor agonists, such as semaglutide under the brand names Ozempic, Wegovy, and the oral form Rybelsus.
  • 💉 These drugs mimic the effects of the GLP-1 hormone, which has appetite-suppressing effects by slowing gastric emptying and reducing the release of glucagon.
  • 🚫 Originally developed as anti-diabetes medications, they are now also marketed for weight loss due to their effectiveness in reducing appetite and promoting weight loss.
  • 🔢 Most people taking these drugs can expect to lose around 10% of their body weight over six months, making them one of the most effective weight loss treatments available.
  • 🛡️ The medical consensus is that these drugs are safe, with a low rate of serious adverse side effects and significant health improvements for most users.
  • 📈 The popularity of these weight loss drugs has led to a significant increase in the stock prices of the companies that sell them.
  • 🏋️‍♂️ The reliance on appetite suppression instead of sustainable lifestyle changes can exacerbate nutritional deficiencies and lead to lean body mass loss.
  • 💰 The cost of these drugs is high, which may be a barrier for some individuals without insurance coverage.
  • 🤢 While generally safe, these drugs are not without side effects, which can include nausea, heartburn, and digestive issues.
  • 🔄 The benefits of these drugs are temporary; most people regain the weight after stopping the medication if lifestyle changes are not made.
  • 🏋️‍♀️ Sustainable lifestyle changes, including diet and exercise, remain crucial for long-term weight loss success, regardless of the use of these drugs.
  • 🏥 GLP-1 receptor agonists are currently prescription-only, and their availability over the counter may change in the future.

Q & A

  • What is the 'magic pill' referred to in the script for weight loss?

    -The 'magic pill' mentioned in the script refers to GLP-1 receptor agonists, with semaglutide being the most popular form, available under the brand names Ozempic and Wegovy, and in oral form as Rybelsus.

  • How do GLP-1 receptor agonists work in the body?

    -GLP-1 receptor agonists mimic the effects of the GLP-1 hormone produced by our intestines. They release insulin, inhibit the release of glucagon, suppress gastric emptying, and have potent appetite-suppressing effects, which make people feel fuller and eat less.

  • Why were these drugs initially developed?

    -These drugs were initially developed as anti-diabetes medicines due to their effects on insulin and glucagon release. Their effectiveness in weight loss was discovered later due to their appetite-suppressive effects.

  • What percentage of body weight can be lost by using these drugs over six months?

    -Most people can lose around 10% of their body weight over the span of approximately six months when they start taking these drugs.

  • How do these weight loss drugs compare to bariatric surgery and traditional gym and diet methods in terms of effectiveness?

    -These drugs are the most effective weight loss treatment currently available, other than bariatric surgery, and are more effective than traditional gym and diet methods.

  • What are some of the potential side effects of using GLP-1 receptor agonists?

    -Potential side effects include nausea, heartburn, diarrhea, constipation, and sometimes more serious issues. However, the rate of serious adverse side effects is considered very low.

  • Why might relying on GLP-1 receptor agonists for weight loss be problematic?

    -Relying on these drugs without sustainable lifestyle changes and healthier food choices can exacerbate nutritional deficiencies, lead to significant lean body mass loss, and result in weight regain once the drugs are stopped.

  • How does the loss of lean body mass affect an individual's health and weight loss journey?

    -The loss of lean body mass can reduce energy expenditure and metabolic rate, which can make it harder to maintain weight loss. Additionally, any muscle lost is fat that is not being lost, which can impact overall health.

  • What is the cost consideration for using GLP-1 receptor agonists?

    -These drugs are very expensive, costing about a thousand dollars per month, which can be a serious consideration for those without insurance coverage.

  • What is the sustainability issue with using GLP-1 receptor agonists for weight loss?

    -The sustainability issue is that once the drugs are stopped, the benefits cease, and most people regain the weight they lost. This requires a lifestyle change and different food choices for long-term weight loss success.

  • Why might these drugs be more suitable for bodybuilders preparing for a contest rather than for general weight loss?

    -These drugs could be more suitable for bodybuilders because they can help reduce body fat quickly for a contest, which is an inherently unsustainable practice. However, this is not recommended as it is similar to using anabolic steroids without exercise.

  • Are there any ethical considerations regarding the use of these weight loss drugs in bodybuilding or other competitive arenas?

    -Yes, there are ethical considerations, as using these drugs to lose fat quickly for a competition without sustainable lifestyle changes can be seen as cheating, similar to using anabolic steroids for muscle growth.

  • What is the current availability of GLP-1 receptor agonists in terms of prescription and over-the-counter access?

    -GLP-1 receptor agonists are currently only available on prescription and are not over-the-counter drugs. The availability may change in the future.



💊 The Emergence of GLP-1 Receptor Agonists as Weight Loss Miracles

This paragraph introduces the new class of weight loss drugs known as GLP-1 receptor agonists, which have the potential to revolutionize the fitness industry. The drugs, exemplified by semaglutide under the brand names Ozempic and Wegovy, and the oral form Rybelsus, mimic the effects of the GLP-1 hormone produced by the intestines, leading to appetite suppression and weight loss. Initially developed as anti-diabetes medications, these drugs have proven to be highly effective for weight loss due to their ability to reduce appetite and increase feelings of fullness. The paragraph highlights the significant weight loss experienced by users, averaging around 10% of body weight over six months, positioning these drugs as the most effective non-surgical treatment for weight loss. The safety and positive health outcomes associated with these drugs are also emphasized, noting the low rate of serious side effects and the overall net positive impact on health and quality of life, especially for individuals with blood sugar issues.


🚨 The Drawbacks and Considerations of GLP-1 Agonist Weight Loss Drugs

The second paragraph delves into the potential issues associated with the use of GLP-1 receptor agonists for weight loss. It addresses five major concerns: nutritional deficiencies, significant loss of lean body mass, high cost, side effects, and the risk of weight regain after stopping the medication. The paragraph explains that relying on appetite suppression without sustainable lifestyle changes can exacerbate existing nutritional deficiencies. It also points out that users may lose a disproportionate amount of lean body mass due to the reduced food intake caused by the drugs. The high cost of these medications is noted as a barrier for some individuals, especially those without insurance coverage. Side effects, while not usually serious, are common and can affect quality of life. Finally, the paragraph discusses the challenge of maintaining weight loss after discontinuing the drugs, as the body tends to return to its previous state without lifestyle changes. The comparison to anabolic steroids is made to illustrate the temporary nature of the benefits and the importance of a sustainable approach to weight management.



💡Weight Loss

Weight loss refers to the reduction of body mass, often through diet and exercise. In the video's context, it is the primary goal of the audience and a central theme. The script discusses various methods and products, including GLP-1 receptor agonists, that have been used or proposed for weight loss, emphasizing the search for an effective 'magic pill'.

💡GLP-1 Receptor Agonists

GLP-1 receptor agonists are a class of medications that mimic the action of the GLP-1 hormone, which is naturally produced by the intestines. The script highlights these agonists as the new frontier in weight loss drugs, explaining their mechanism of action and their effectiveness in reducing appetite and promoting weight loss.


Semaglutide is a specific GLP-1 receptor agonist mentioned in the script as a popular medication for weight loss, available under the brand names Ozempic and Wegovy. It is presented as a significant development in the weight loss industry due to its efficacy.

💡Ozempic and Wegovy

Ozempic and Wegovy are brand names for semaglutide, a medication discussed in the script as being highly effective for both diabetes treatment and weight loss. The script positions these drugs as game-changers in the fitness industry.


Rybelsus is an oral form of a GLP-1 receptor agonist mentioned in the script. It is significant because, unlike injectable forms, it offers a more convenient method of administration for those seeking the weight loss benefits of these drugs.

💡Anabolic Steroids

Anabolic steroids are synthetic substances related to the male hormone testosterone. The script draws a parallel between anabolic steroids and weight loss drugs, noting their similar mechanisms of action and the potential for muscle gain or loss when used or discontinued, respectively.

💡Appetite Suppression

Appetite suppression refers to the reduction of hunger, a key effect of GLP-1 receptor agonists as described in the script. It is central to how these drugs facilitate weight loss by making individuals feel fuller for longer, thus reducing food intake.

💡Bariatric Surgery

Bariatric surgery is a type of weight loss surgery for obese individuals. The script mentions it as a comparison point, stating that GLP-1 receptor agonists are the most effective non-surgical weight loss treatment available.

💡Nutritional Deficiencies

Nutritional deficiencies refer to a lack of essential vitamins and minerals in the body. The script warns that relying on appetite suppression for weight loss can exacerbate these deficiencies, as reducing food intake may also reduce the intake of necessary nutrients.

💡Lean Body Mass

Lean body mass is the total body mass minus adipose tissue, primarily consisting of muscle, bone, and organs. The script discusses the potential for significant lean body mass loss when using GLP-1 receptor agonists, especially if combined with inadequate dietary protein intake.

💡Sustainable Lifestyle Change

Sustainable lifestyle change involves adopting long-term healthy habits, such as improved diet and regular exercise. The script emphasizes the importance of these changes for achieving and maintaining weight loss, rather than relying solely on medication.


The emergence of GLP-1 receptor agonists as a revolutionary weight loss solution.

Popularity of semaglutide under brand names Ozempic and Wegovy, and its oral alternative Rybelsus.

GLP-1 receptor agonists mimic the effects of the naturally occurring GLP-1 hormone in the intestines.

The multifaceted action of GLP-1 agonists including insulin release and appetite suppression.

Origin of these drugs as anti-diabetes medications and their subsequent effectiveness for weight loss.

The remarkable average weight loss of about 10% of body weight within six months of drug use.

The safety profile of these drugs with a low rate of serious adverse side effects.

Significant health improvements and quality of life enhancements due to weight loss.

The impact of these drugs on the fitness and medical industries, with investors' hesitancy.

Five serious problems associated with the use of GLP-1 agonists for weight loss.

The risk of exacerbating nutritional deficiencies through appetite suppression without dietary changes.

Significant lean body mass loss observed in trials due to reduced food and protein intake.

The high cost of GLP-1 agonist drugs posing a financial burden for uninsured individuals.

Common side effects of GLP-1 agonists including digestive issues and their inherent nature.

The challenge of weight regain after stopping the use of these drugs due to lifestyle habits.

Comparison of GLP-1 agonists to anabolic steroids in terms of sustainability and lifestyle impact.

The necessity of lifestyle changes for long-term weight loss success, independent of drug use.

The current prescription-only status of GLP-1 agonist drugs and potential future changes.

Theoretical solutions to overcome the problems with GLP-1 agonists through medical advancements.

A call to consider long-term effects, side effects, and costs when contemplating the use of these drugs.

An objective and balanced perspective on GLP-1 receptor agonists for weight loss based on scientific consensus.



For decades, massive industry has revolved around weight loss.


The search for the magic pill has included snake oil supplements,


fad diets, bio-hacks, bro-science fat burners.


Nothing has delivered on its lofty promises until now.


The magic pill is upon us and the fitness industry may change forever.


magic pill comes in the form of GLP-1 receptor agonists.


The most popular form of that is currently semaglutide.


It's available under the brand names Ozempic and Wegovy.


It’s also available in oral form because the others are injectables right now.


it's called Rybelsus.


In this video I'll review what everyone that wants to lose weight needs to know


about these new miracle weight loss drugs based on the scientific




First, let's talk about how these drugs work.


GLP-1 receptor agonists, as the name implies, mimic GLP-1.


GLP-1 is a hormone that's produced by our intestines.


The drug has the same effect as the hormone in our intestines,


just like injecting testosterone


has the same effect as the testosterone that's produced by our own bodies.


As we'll see later, there are actually multiple similarities


between anabolic steroids and these weight loss drugs.


The effects of GLP-1 are to release insulin


to inhibit the release of glucagon, to suppress gastric emptying,


meaning it slows down the rate at which food leaves your stomach,


and as a result of those effects it has potent appetite suppressing effects.


It reduces your appetite, makes you feel more full, makes you eat less.


Originally these drugs were developed as anti-diabetes medicines,


but it turned out that


they were very effective for weight loss due to the appetite-suppressive effects.


And now the drugs are


equally marketed as weight loss drugs as anti diabetes medicine.


These drugs really work.


Most people lose around 10% of their body weight over the span


of approximately six months when they start taking these drugs.


That makes these drugs the most effective weight loss treatment


currently available on the planet other than bariatric surgery


and, you know, actually going to the gym and dieting.


These drugs are also very safe.


The rate of serious adverse side effects is very low


and the medical consensus is that these drugs are certainly a net positive.


Most people experience significant health improvements in most of their health


biomarkers and their quality of life because the positive effects of the weight


loss completely overshadow any negative effects of the drugs.


This is particularly true for people with blood sugar issues


because the drugs are very effective to control your blood sugar.




the stock prices of the companies selling these drugs have absolutely skyrocketed


over the last years.


Many investors are even reluctant to invest in fitness and other


medical industries because the thought is that these drugs can basically cure


the obesity pandemic just by taking a pill or taking an injection once per week.


If that's the case, if you can just take a pill once per day,


you can do a small injection in your abdomen once per week,


why would anyone still go to the gym?


Why do people still hire a personal trainers?


Why still invest in all of these other medical technologies for weight loss


or for other medical conditions that are often caused by being overweight?


Well, it turns out that GLP-1 agonists are not without problems.


There are, in fact, 5 very serious problems with their use.


The first problem of using GLP-1 agonists to lose weight


is that by relying purely on appetite suppression rather than sustainable


lifestyle change and healthier food choices for your weight loss is that you


exacerbate any nutritional deficiencies that you may have.


Most people actually have at least one or multiple nutritional deficiencies


Their deficiency rates of iron, vitamin D and magnesium, for


example, are very high.


So if you take a random individual off the street,


it's very likely that they have at least one micronutrient deficiency.


If this


individual's on their current diet, just start eating less of the same food,


they will exacerbate whatever deficiencies they currently have.


The second major problem of using GLP-1 agonists to lose weight


is that lean body mass loss is very significant.


In many of these trials, people lose a third


or up to 40% of their weight from lean body mass.


That's much more than the normal 25% or so that we see in most literature.


And it's much more than the 0% that you would like to see in people


when they actually exercise and they have a high protein diet.


But because people eat significantly less due to the appetite suppression


many people essentially involuntarily crash diets and often do so


on relatively low protein intakes.


If you combine excessive weight loss without high protein diets


and without exercise, that is a recipe for lean body mass loss.


So it's not that GLP-1 agonists inherently cause muscle loss


is just a combination of the weight loss that they produce with generally


a poor diet that results in lean body mass loss.


And that is a significant problem even if you don't care about muscle loss


because it will also reduce your energy expenditure, your metabolic rate


and any muscle that you'll lose is fat that you're not losing


because you're only losing the energy from the body in one form.


Third problem with GLP-1 receptor agonists is that they're very expensive.


At about a thousand per month it's fair to say that these drugs are exy.


If you're covered by insurance


that's fine, but for people that are not that's a serious consideration.


Problem 4 is that while these drugs are safe,


they are not free from side-effects.


In fact, the vast majority of individuals on these drugs


do report side-effects, usually ranging from things like nausea,


heartburn, diarrhea and constipation to sometimes more serious issues.


But usually they're at relatively low grade.


Just because they're not serious medical events, though,


doesn't make them pleasant.


And it's also very hard not to have these side-effects


because it's part of the inherent mechanism of action.


As discussed, GLP-1, the hormone produced in your intestines


is responsible for slowing down


the passage of food and drinks from your stomach to the intestines.


That's inherently part of the mechanism of action,


and it's part of the reason why have the appetite suppression.


So some of these digestive side-effects


will probably be very difficult for medical technology to resolve.


This problem is bigger than it may seem because we're not talking about


some side effects for a small period of time.


Problem number 5 is that if you stop


using these drugs you stop reaping the benefits.


And most people, when they go off these drugs,


they regain all of the weight that they lost slowly over time.


This is exactly the same problem people experience with any type of fat diet:


when they go off the diet and they haven't sustainably changed their lifestyle,


they're going back to the diet that got them fat in the first place,


they're going to get fat again. That's how the body works.


The body is merciless with the physics.


If you're not changing your lifestyle, you're not making smarter food choices


and you're just relying on the drug to eat less of the same foods


that you're currently eating, what happens when you stop taking the drug?


Your appetite goes back to normal, your food intake increases


and you will reach an equilibrium at the same weight that you were at before


you started taking the drug.


So sustainable lifestyle change and making different food choices, exercising...


These things are still important for long term weight loss success


unless you plan on using the drug for life.


In this sense, these weight loss drugs are very similar to anabolic steroids.


Using anabolic steroids without exercising will put some muscle on you,


but if you stop using the drugs you’ll lose the muscle mass.


Similarly, if you don't change your lifestyle


and you use these weight loss drugs,


you're going to regain the weight after you stop using them.


So ironically, while these drugs were originally designed for overweight


individuals, some people with diabetes, there's actually an argument to be made


that these drugs are more suitable for bodybuilders


preparing for a contest because that's inherently an unsustainable practice.


So then you might as well do it with less hunger.


Of course, a strong argument can be made that just like using anabolic steroids


for muscle growth is cheating,


so can it be called cheating to use these weight loss drugs


to lose fat, at least for something like a bodybuilding show.


This unsustainability of using the drug itself purely


for the weight loss makes them a complete Band-Aid solution.


Of course, it's still better to lose weight, at least periodically,


than to be overweight all the time.


But that's not what most people have in mind when they start taking these drugs.


It's also worth noting that these drugs


are currently only available on prescription.


That may change in the future, but they're currently


not available over the counter.


Now, most of these problems


can be overcome, theoretically, at least by medical technology.


If these drugs get cheaper


because the market moves away from the current oligopoly,


where we have only a few major suppliers of all the drugs,


and if the drugs become better in terms of managing side-effects,


maybe it will be suitable for people to actually stay on them for life.


However, I would strongly advise people to really consider it


a long term effects and think of the long term future.


Do you plan on using these drugs for life?


Are you okay with the level of side-effects


and the possible economical costs?


And importantly, are you going to change your lifestyle?


Without sustainable lifestyle change, you're not going to reach optimal health,


and you're going to have to stay on these drugs essentially for life to stay lean.


And if you are going to change your lifestyle,


then why do you need the drugs in the first place?


I hope this gives you an objective and balanced perspective on the use


of GLP-1 receptor agonists for weight loss based on the scientific consensus.


If you like this type of evidence based content,


I'd be honored if you like and subscribe.

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Related Tags
Weight LossGLP-1 AgonistsHealth IndustryMedical InnovationDiabetes ControlAppetite SuppressionLifestyle ChangeNutritional DeficiencyFitness ImpactDrug SafetyLong-Term Effects