Praktikum Farmasetika - Pembuatan Resep Gel 9

Summary

In this video, the process of creating a topical formulation using carbomer and ketoprofen is demonstrated. The presenter begins by explaining the ingredients and their role, such as triethanolamine to adjust the pH and carbomer for thickening. The mixture is carefully blended, with the pH adjusted to achieve optimal consistency for the final product. The video concludes with the completed preparation being placed into packaging, ready for labeling and distribution. The process emphasizes the importance of correct pH balance and ingredient integration to achieve the desired product consistency.

Takeaways

• 😀 Introduction to the use of Carbomer in the preparation, with a focus on its behavior at neutral pH.
• 😀 The presence of Triethanolamine as an agent for pH adjustment, making the mixture more stable.
• 😀 Ketoprofen is introduced as an active ingredient, which is not water-soluble and requires the use of a solubilizer.
• 😀 The use of Nipagin as a solubilizer to enhance the dispersion of Ketoprofen.
• 😀 Carbomer begins to expand when mixed with Triethanolamine, indicating the desired consistency and structure.
• 😀 The importance of maintaining a neutral pH to allow for optimal expansion of Carbomer.
• 😀 The mixture undergoes the addition of water to achieve the final desired consistency.
• 😀 After proper dispersion and mixing, Ketoprofen is added to the formula.
• 😀 The final product is carefully inspected to ensure no clumps or separation of ingredients.
• 😀 The product is then placed in its final container, labeled, and prepared for distribution, completing the manufacturing process.

Q & A

What is the purpose of triethanolamine in the process?

Triethanolamine is used as an alkalizing agent to adjust the pH and ensure that the carbomer can expand effectively in a neutral pH environment.

What role does carbomer play in the process?

Carbomer acts as a thickening agent. It expands at a neutral pH to create the desired texture for the product being prepared.

Why is ketoprofen included in the formulation?

Ketoprofen is included as a key ingredient, likely for its anti-inflammatory properties, although it is not water-soluble and needs to be properly dispersed.

What is the purpose of using nipagin in the process?

Nipagin is used as a preservative and solvent to help in the dispersion and stabilization of the ingredients.

Why is it important to maintain a neutral pH during the process?

A neutral pH is crucial because it allows the carbomer to expand properly and ensures the stability and effectiveness of the final product.

How is the carbomer dispersed in the mixture?

The carbomer is added to the mixture and begins to swell as it interacts with the water, forming a gel-like consistency.

What happens when triethanolamine is added to the mixture?

When triethanolamine is added, it adjusts the pH, allowing the carbomer to fully expand and the mixture to achieve the correct consistency.

What does the final mixture look like after all ingredients are added?

The final mixture becomes a clear gel, with the carbomer properly dispersed and the ketoprofen incorporated into the gel without separation.

How is the final product packaged?

The finished product is packaged in containers, labeled with the appropriate stickers, and sealed for distribution.

Why is it important to check the consistency and clarity of the mixture before proceeding?

It is important to ensure that the mixture has the correct texture and clarity, as this indicates that the carbomer has been fully activated and the ingredients are properly combined.