缺叶酸,类似辐射伤害!自然疗法,柏格医生dr berg

柏格医生 简体中文 官方頻道
8 May 202409:24

Summary

TLDR维生素B9(叶酸)缺乏可能导致DNA损伤,进而引发癌症。叶酸是帮助制造RNA和DNA的辅酶,对细胞功能至关重要。叶酸不足不仅会导致DNA损伤,还会影响DNA修复过程。教授Bruce Ames的研究揭示了叶酸缺乏与X射线辐射造成的损伤相似。叶酸的合成形式(叶酸酸)广泛用于孕妇的产前维生素中,有助于预防神经管缺陷,但过量摄入可能存在风险,尤其是携带MTHFR基因突变的人群。这种基因突变会影响叶酸酸转化为活性形式的能力,导致未代谢的叶酸酸积累,可能增加患癌症和自闭症的风险。B9(叶酸)还与新癌细胞的生成有关,但只有在过量摄入时才会出现问题。解决这一问题的方法是摄入不需要转化的B9形式,如甲基叶酸。此外,叶酸过量还可能掩盖B12缺乏,导致同型半胱氨酸水平升高,增加心脏病和中风的风险。建议通过食用富含天然叶酸的食物,如深色绿叶蔬菜,来维持健康。

Takeaways

  • 🚨 叶酸(维生素B9)缺乏可能导致DNA损伤,进而引发癌症。
  • 🌟 叶酸是一种辅酶,帮助制造RNA和DNA,对细胞功能至关重要。
  • 🧬 DNA复制过程类似于高速旋转的拉链,涉及三维结构的精确复制。
  • 🛠️ DNA修复机制非常强大,能够通过多层校对来修复错误。
  • 🍃 叶酸缺乏会破坏DNA修复机制,导致多种疾病。
  • 🤰 孕妇常服用的合成叶酸(folic acid)有助于预防神经管缺陷。
  • 🧬 MTHFR基因突变会影响叶酸转化为活性形式的能力,可能导致未代谢叶酸积累。
  • 💊 合成叶酸(folic acid)过量可能与某些健康问题相关,如增加自闭症风险。
  • 🌱 推荐食用富含天然叶酸的食物,如深色绿叶蔬菜。
  • 🔄 叶酸和维生素B12共同作用,叶酸过量可能导致B12缺乏。
  • 🚫 高同型半氨酸(homocysteine)水平可能增加心脏病和中风的风险,并影响血管健康。
  • 💊 对于有MTHFR基因突变的人来说,使用不需转化的活性形式B9,如甲基叶酸(methylfolate),可能是更好的选择。

Q & A

  • 维生素B9缺乏可能导致什么健康问题?

    -维生素B9缺乏可能导致DNA损伤,这种损伤可能进一步导致癌症。

  • 为什么维生素B9对DNA复制和修复过程很重要?

    -维生素B9是一种辅酶,帮助制造RNA和DNA,这些是细胞内的蓝图,是构建整个身体的指令。叶酸缺乏不仅会导致DNA断裂和损伤,还会损害DNA修复过程。

  • DNA修复机制是如何工作的?

    -DNA修复机制通过多层校对和纠错过程来确保DNA复制的准确性。如果发现错误,会有专门的单元介入修复,有时需要切除并替换一部分,有时则只需稍微调整代码以确保准确无误。

  • 叶酸和合成叶酸(维生素B9的合成版本)有何不同?

    -叶酸是维生素B9的天然形式,而合成叶酸是其合成版本。合成叶酸被广泛用于预防神经管缺陷等出生缺陷,但对某些基因突变的人来说,合成叶酸可能无法有效转化,甚至可能积累为未代谢的叶酸酸,导致问题。

  • MTHFR基因突变与维生素B9有什么关系?

    -MTHFR基因突变涉及一种酶,该酶负责将合成叶酸转化为活性形式以供身体使用。如果这个基因出现问题,身体获取活性维生素B9的能力会大大受限。

  • 为什么甲基叶酸(methylfolate)对于有MTHFR基因突变的人来说是一个更好的选择?

    -甲基叶酸是一种不需要酶转化即可被身体使用的维生素B9形式,因此对于有MTHFR基因突变的人来说,它更容易被吸收,不会受到基因问题的影响。

  • 合成叶酸在食品供应中的作用是什么?

    -合成叶酸被添加到多种食品中,如谷物、面包、意大利面、饼干、能量饮料等,作为营养强化的一部分,以预防某些健康问题,如贫血。

  • 合成叶酸摄入过多可能导致哪些问题?

    -合成叶酸摄入过多可能导致未代谢的叶酸酸积累,对于有MTHFR基因突变的人来说尤其如此。此外,还有研究表明,孕妇摄入过多的合成叶酸可能会增加孩子患自闭症的风险。

  • B9和B12之间有什么关系?

    -B9(叶酸)和B12(钴胺素)共同工作,如果一个人有遗传问题并且摄入大量的合成叶酸以预防贫血或其他问题,可能会导致B12缺乏,从而可能增加同型半胱氨酸水平,这是一种与心脏病和中风风险增加有关的不良化合物。

  • 同型半胱氨酸水平升高会带来哪些健康风险?

    -同型半胱氨酸水平升高可以增加心脏病和中风的风险,影响血管内皮组织,抑制一氧化氮的产生,可能导致高血压和其他健康问题,包括勃起功能障碍。

  • 如何确保不摄入过多的合成叶酸?

    -由于合成叶酸被添加到许多食品中,选择未添加叶酸的食品是一个方法。更重要的是,增加天然富含维生素B9的食物摄入,如深色绿叶蔬菜。

  • 为什么维生素B9对于预防癌症很重要?

    -维生素B9有助于保护DNA免受编码问题的影响,如果体内有适量的B9,它可以保护DNA免受可能导致癌症的损伤。

Outlines

00:00

😀 叶酸缺乏与DNA损伤及癌症风险

本段讨论了叶酸(维生素B9)缺乏可能导致DNA损伤,进而引发癌症的问题。提到了叶酸在DNA复制和修复过程中的重要作用,以及叶酸缺乏如何影响这一机制,造成DNA损伤累积,增加癌症风险。同时,还探讨了合成叶酸(叶酸酸)与天然叶酸(叶酸)的区别,以及MTHFR基因突变对叶酸代谢的影响,建议通过食用富含天然叶酸的食物,如深色绿叶蔬菜,来补充叶酸,并注意避免过量摄入合成叶酸可能带来的风险。

05:02

🧬 叶酸、癌症发生与基因突变的关系

这段内容深入讨论了叶酸(B9)在预防DNA损伤和癌症发生中的作用,以及过量叶酸可能带来的风险。强调了正确量的B9对保护DNA免受损伤的重要性,并指出过量叶酸可能促进癌细胞生长。对于携带MTHFR基因突变的人来说,合成叶酸可能无法有效转化,因此推荐使用甲基叶酸(methylfolate),它不需要酶转化即可被身体利用。同时,指出过量合成叶酸可能与自闭症风险增加有关,并且可能掩盖B12缺乏,导致同型半胱氨酸水平升高,增加心脏病和中风的风险。最后,建议通过食用天然富含叶酸的食物来补充,而不是依赖食品中的合成叶酸。

Mindmap

Keywords

💡维生素B9

维生素B9,也称为叶酸或folate,是一种水溶性维生素,对DNA的合成和修复至关重要。在视频中,维生素B9的缺乏被提到与DNA损伤有关,可能导致癌症。它作为辅酶帮助制造RNA和DNA,是细胞功能和身体构造的基础。

💡DNA损伤

DNA损伤指的是DNA分子发生的任何破坏,这可能会影响其正常的复制和功能。视频中提到,叶酸缺乏会导致DNA损伤,增加癌症风险,因为DNA是细胞复制和身体构造的蓝图。

💡X射线

X射线是一种电磁辐射,常用于医学成像,如X光片和CT扫描。视频中提到,人们通常对X射线的辐射有所顾虑,但叶酸缺乏造成的损伤与X射线产生的电离辐射损伤相似。

💡DNA修复

DNA修复是指细胞机制识别并修复DNA损伤的过程。视频中描述了DNA修复机制的复杂性和高效性,以及叶酸缺乏如何干扰这一过程,导致错误累积,可能引发疾病。

💡合成叶酸

合成叶酸是维生素B9的合成形式,常作为补充剂使用,特别是在孕期以预防神经管缺陷。然而,视频中提到,合成叶酸可能不适合所有人,尤其是那些有MTHFR基因突变的人,因为他们的身体难以将合成叶酸转化为活性形式。

💡天然叶酸

天然叶酸是维生素B9的自然形式,存在于某些食物中,如绿叶蔬菜。与合成叶酸相比,天然叶酸不需要通过MTHFR酶转化即可被身体利用。视频中强调,对于有MTHFR基因突变的人来说,天然叶酸或其活性形式甲基叶酸可能是更好的选择。

💡甲基叶酸

甲基叶酸是叶酸的一种活性形式,可以直接被身体利用,不需要经过MTHFR酶的转化。视频中提到,对于那些有MTHFR基因突变的人来说,甲基叶酸是补充B9的理想选择,因为它可以绕过潜在的代谢障碍。

💡MTHFR基因突变

MTHFR基因突变是一种常见的遗传变异,影响MTHFR酶的功能,该酶负责将合成叶酸转化为活性形式。视频中讨论了这种突变如何影响叶酸的代谢,并可能导致叶酸缺乏和相关健康问题。

💡神经管缺陷

神经管缺陷是一类出生缺陷,涉及脊髓和脊柱的不完全闭合。视频中提到,补充合成叶酸可以预防这类缺陷,但同时也强调了个体差异和基因突变对叶酸需求的影响。

💡同型半胱氨酸

同型半胱氨酸是一种氨基酸,其水平过高与心脏病和中风的风险增加有关。视频中指出,B9和B12的不平衡可能导致同型半胱氨酸水平升高,影响血管健康,甚至可能导致勃起功能障碍。

💡B12缺乏

B12是一种必需的维生素,与叶酸一起在红细胞生成和神经系统健康中发挥作用。视频中提到,如果一个人因为大量摄入合成叶酸而掩盖了B12缺乏,可能会导致健康问题,因为这两种维生素在体内共同工作。

Highlights

维生素B9(叶酸)缺乏可能导致DNA损伤,进而引发癌症。

叶酸缺乏造成的损伤与X射线的电离辐射造成的损伤相同。

叶酸是一种辅酶,帮助制造RNA和DNA。

叶酸不足不仅会导致DNA断裂和损伤,还会损害DNA修复过程。

DNA是身体的蓝图,其复制过程非常复杂且精确。

DNA修复机制非常强大,能够扫描并修复错误。

叶酸缺乏会导致DNA修复机制出现大量错误,可能引发各种疾病。

合成叶酸(维生素B9的合成形式)与天然叶酸之间存在差异。

孕妇常服用的孕前维生素含有合成叶酸,有助于预防神经管缺陷。

MTHFR基因变异影响叶酸转化为活性形式,可能导致叶酸缺乏。

合成叶酸(叶酸酸)积累可能导致问题,尤其是对于有MTHFR基因变异的人。

适量的维生素B9可以保护DNA免受损伤,预防癌症的发生。

过量的叶酸酸可能促进癌细胞生长,尤其是有MTHFR基因变异的人。

甲基叶酸(methylfolate)是一种无需转化即可被身体使用的维生素B9形式。

合成叶酸被广泛添加到食品中,可能造成过量摄入。

推荐食用富含天然叶酸的食物,如深色绿叶蔬菜。

MTHFR基因变异的人如果摄入过多的合成叶酸,可能会掩盖维生素B12的缺乏。

同型半胱氨酸(homocysteine)水平升高可能增加心脏病和中风的风险。

同型半胱氨酸还可能影响血管内皮组织,导致高血压和其他问题。

Transcripts

play00:00

now I've talked about this topic uh I

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think two years ago at my Summit um it

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may be in other videos but I wanted to

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create one video just on this one topic

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because it's actually very very

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important I think you're going to find

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it very very interesting but

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fate vitamin B9 deficiency has a

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potential to cause DNA damage which can

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then lead to cancer when you go to the

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hospital you get an x-ray do you have

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any concern about getting x-rays or a

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cast scan do you mind them taking an

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x-ray um does it bother you and if the

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answer is yes then the question is why

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why are you concerned about getting

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x-rays well probably because it has

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radiation correct did you realize that a

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folate deficiency creates the same

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damage as ionizing radiation from

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x-rays yes there's an interesting story

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about this by Professor Bruce Ames I put

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a link down below for that but full

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eight is a vitamin that is a co-enzyme

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so it's a helper enzyme specifically to

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help you make RNA in DNA so RNA is a

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copy of DNA and DNA is the blueprints

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that are in your cells that are the

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instructions to make the entire body so

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when a person is deficient in folate not

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only are you going to get all sorts of

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DNA breaks and damage but it's also

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going to impair the DNA

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repair process which can then lead to

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cancer now here we have the DNA the

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blueprints of your body These Blueprints

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actually are the building blocks for

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your entire all your body tissue now

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what we're looking at is These

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Blueprints going through this amazing

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machine you have this machine that is

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like a zipper and it's unzipping these

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two little strands that are connected

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called DNA

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okay and and this zipper is spinning at

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a speed that's equivalent to a jet

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engine and what's happening here is your

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DNA is being copied in a very

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interesting way one strand is going one

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way but it's not just copying a piece of

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paper it's copying something in three

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dimensions fascinating and on top of

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everything else you have several layers

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of airor Correction or proof reading

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going on so it's kind of like this

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little program that will scan the code

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to look for errors and it's extremely

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accurate and if there is an err another

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unit will come in there and fix it so

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there's several types of errors that can

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happen and sometimes it'll have to cut

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out a section and replace it um and

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other times they can just manipulate the

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code a little bit to make sure it's

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exact so as you can see this DNA repair

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mechanism is simply awesome and just by

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a simple vitamin deficiency like a

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folate deficiency you're going to create

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massive errors in this um mechanism and

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these errors can lead to all sorts of

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diseases so I hope this demonstration

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gave you a little more motivation to eat

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healthier let's talk about the

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difference between folic acid and I'm

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talking about the synthetic version of

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vitamin

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B9 as well as folate the natural version

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are they the same you know so many women

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while when they're pregnant they start

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taking a prenatal that is just loaded up

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with this synthetic folic acid and

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there's a lot of data to show that that

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can help prevent things like neurot tube

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defects which is an incomplete closure

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of the spinal column and so it's true it

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does do that but uh with more more

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people recognizing that uh they may have

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a mutation with a certain Gene that

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relates to uh B9 uh I think we should

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talk about it there's a very common

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problem with a gene that is called

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MTHFR it involves an enzyme in

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converting um folic acid into the active

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form so your body can use it so if you

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have a problem with this Gene your

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ability to get this um active form of B9

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is greatly inhibited and if you end up

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taking this synthetic version which

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called folic acid

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you can have a lot of problems because

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it can accumulate as uh

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unmetabolized folic acid now it probably

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is not going to become a problem unless

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you take large amounts but the fact that

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if you have this mutation you're going

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to be deficient so there's this delicate

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balance of getting just the right amount

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of this B9 because here's the thing B9

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actually does a lot of things it

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protects against the initiation of

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cancer because B9 helps to protect the

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DNA against um problems with the code

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and if you have just the right amount of

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B9 it can protect this damage within the

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DNA that can potentially then lead to

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cancer B9 also is involved in the

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initiation of new cancer cells that

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sounds like it's kind of conflicting on

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one hand it prevents the initiation of

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new cancer cells but on the other hand

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it can actually help grow this canc

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cells but based on the data that I read

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it's really when you have way too much

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of this folic acid so this complicates

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things because with this mutation you

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need more than you normally should have

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yet you don't want to get too much so

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the solution of to this problem is to

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take a type of

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B9 that doesn't have to be converted

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okay it doesn't require this enzyme so

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in other words this mutation is a no

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issue why because it's ready to be used

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and can be easily absorbed in the body

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and that is called methylfolate and

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there's other long names for it but

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basically it's a type of Bine that's

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easily absorbed and it doesn't require

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these other enzyme reactions like the

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synthetic folic acid now sometimes

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you'll hear reports and studies that

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show that regardless of this mutation

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you still need to take this synthetic

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folic acid to prevent uh neural tube

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defects because there is no studies

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comparing this synthetic folic acid to

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this methyl folate and that's true and

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they're not going to do studies because

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to do that on humans right it's too

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dangerous it's too unethical so it's not

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going to be done so you're just going to

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have to use common sense if even if you

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compare these two uh versions of B9 it's

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going to be more effective for you to

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get enough B9 in your blood using the

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methyl folate version the other thing is

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if you have this mutation there's some

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studies to show that if you're taking

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way too much synthetic folic acid or the

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mother's taking way too much that can

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increase the risk of autism by a factor

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of

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17x and this synthetic folic acid cannot

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fix this mutated Gene in fact it can

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block the natural version of fate and

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potentially increase your risk of

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getting cancer so that being said the

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question is how do I make sure I'm not

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getting uh too much of this synthetic

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version well unfortunately it's put in

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our food supply it's as part of the

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fortification for all cereals okay that

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kids eat also adults it's used in all

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the breads the pasta the cereal the

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crackers the biscuits the energy drinks

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a lot of the synthetic vitamins as well

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as uh fortified nutritional yeast that's

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why I always recommend to get the

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unfortified version of that even more

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importantly is to start to consume the

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foods that are high in this natural B9

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which is consuming more dark leafy green

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vegetables the last point I want to

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bring up is that if a person has this

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genetic problem and they're taking a lot

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of FC acid to prevent let's say anemia

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or some other problem what can happen is

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they can end up chem caging a B12

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deficiency because B9 and b12 work

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together and that can create problems

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with an increase of something else that

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I want to kind of just summarize very

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simply it's called homosysteine

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homocystine is a a bad compound that can

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increase your risk of getting heart

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attacks and strokes and homosysteine

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also affects the inside of the artery

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the endothelial tissue it inhibits um

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this nitric oxide o side that then can

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cause you to have high blood pressure

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and create all sorts of problems but

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it's not just a problem inside your

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heart it can affect other areas as well

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because if there's a diminished nitric

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oxide you can end up with erectile

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dysfunction now since you're on this

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topic if you have not seen my video on

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B12 that would be the next video to

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watch check it out

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维生素B9叶酸DNA损伤癌症风险合成叶酸叶酸酸基因突变MTHFR孕妇营养神经管缺陷天然叶酸甲基叶酸食品强化心脏健康同型半胱氨酸
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