AMA #1: Leveraging Ultradian Cycles, How to Protect Your Brain, Seed Oils Examined and More

Andrew Huberman
2 Nov 202224:57

Summary

TLDRIn this AMA episode of the Huberman Lab podcast, neurobiology professor Andrew Huberman discusses the science of ultradian rhythms and their application for focused learning and skill improvement. He explains how these 90-minute cycles can be leveraged for cognitive and physical tasks, emphasizing the importance of aligning work blocks with peak alertness periods for optimal learning and performance. Huberman also highlights the premium channel's role in funding human-centric research and the Tiny Foundation's dollar-for-dollar match program to amplify research support.

Takeaways

  • πŸŽ“ Andrew Huberman is a professor of neurobiology and ophthalmology at Stanford School of Medicine, hosting a podcast discussing science-based tools for everyday life.
  • πŸ’° Huberman Lab podcast has a premium channel supporting the free standard channel and funding research at universities, with subscription options available at hubermanlab.com/premium.
  • 🧠 The podcast episode is an AMA (Ask Me Anything) focused on ultradian rhythms, which are biological cycles shorter than 24 hours, often discussed in terms of 90-minute periods.
  • πŸ•’ Huberman uses ultradian rhythms for focused mental work, aiming for one or two 90-minute focus blocks per day for learning and cognitive tasks.
  • 🚫 The maximum number of sustainable focus blocks per day is likely four, but it's rare and may not be suitable for most people.
  • πŸ‹οΈβ€β™‚οΈ Huberman does not typically take breaks from his ultradian rhythm sessions, even on weekends, to maintain focus circuits through regular access.
  • ⏰ The timing of ultradian cycles can be personalized; Huberman suggests starting a focus block when you feel most alert post-waking, typically around 9:30 AM to 10:00 AM.
  • πŸ’‘ Ultradian rhythms are tied to cortisol fluctuations, which peak in the morning and can be influenced by factors like sunlight, caffeine, and exercise.
  • 🧐 Huberman emphasizes that the first 10-15 minutes of a focus block is a mental warm-up period, with the following hour being optimal for intense focus and learning.
  • πŸ” The rewiring of neurons and consolidation of learning occur during deep sleep or Non-Sleep Deep Rest, not during the focus blocks themselves.
  • πŸ’Ό The principles of ultradian rhythms can be applied to both cognitive learning and physical skill learning, making them valuable for a wide range of activities.

Q & A

  • What is the purpose of the Huberman Lab podcast's premium channel?

    -The premium channel was launched to raise support for the standard Huberman Lab podcast channel and to fund research, particularly human-based research aimed at developing protocols for mental health, physical health, and performance.

  • How much does it cost to subscribe to the Huberman Lab podcast premium channel?

    -The subscription cost for the premium channel is $10 a month or $100 a year, with a lifetime subscriber option available.

  • What is an Ask Me Anything (AMA) episode?

    -An AMA episode is a part of the premium subscriber content where Andrew Huberman answers questions from his audience.

  • What are ultradian rhythms as discussed in the podcast?

    -Ultradian rhythms are any biological rhythms that occur with a period shorter than 24 hours, typically around 90-minute cycles.

  • How does Andrew Huberman use ultradian rhythms in his daily work?

    -Andrew Huberman uses ultradian rhythms to engage in focused bouts of mental work once or twice, or sometimes three times per day, leveraging these rhythms for learning and memory enhancement.

  • What is the maximum number of focus blocks Andrew Huberman performs sustainably per day?

    -The maximum number of focus blocks Andrew Huberman performs sustainably per day is likely four, but for most people, one or two, or maybe three, is more typical.

  • Does Andrew Huberman take vacations or extended breaks from his ultradian rhythm sessions?

    -No, Andrew Huberman tries to engage in ultradian rhythm focused learning sessions every day, even on weekends.

  • How does Andrew Huberman suggest scheduling focus and recovery from ultradian rhythm sessions?

    -Andrew Huberman suggests scheduling focus by identifying the most alert times post-waking and using those periods for focused learning. Recovery is implicit as the ultradian rhythm naturally allows for rest between focus periods.

  • What is the significance of the glucocorticoid system in relation to ultradian rhythms?

    -The glucocorticoid system, which regulates cortisol release, triggers the onset of ultradian cycles. These cycles are associated with periods of alertness, focus, and energy, making them ideal for learning and cognitive tasks.

  • How can one determine their optimal ultradian rhythm for learning?

    -By monitoring one's peak alertness and energy levels during the day, one can identify the optimal times to schedule ultradian work blocks for focused learning.

  • Can ultradian rhythms be leveraged for physical skill learning as well as cognitive learning?

    -Yes, ultradian rhythms can be leveraged for both cognitive learning and physical skill learning, as they facilitate neuroplasticity which is essential for learning and skill improvement.

Outlines

00:00

πŸŽ“ Introduction to Huberman Lab Podcast and AMA

Andrew Huberman, a professor of neurobiology and ophthalmology at Stanford School of Medicine, welcomes listeners to the Huberman Lab podcast. He introduces the AMA (Ask Me Anything) episode, which is part of the premium subscriber content aimed at supporting the free standard podcast and funding research at universities. He invites premium subscribers to download the premium podcast feed and mentions that non-subscribers can listen to the first 15 minutes of the episode. Huberman emphasizes his commitment to answering questions clearly, succinctly, and thoroughly within the time constraints of the AMA format. He also assures that unanswered questions might be addressed in future AMAs.

05:01

πŸ•’ Leveraging Ultradian Rhythms for Learning

The discussion begins with a question about ultradian rhythms, which are biological cycles shorter than 24 hours, typically around 90 minutes. Huberman explains his personal use of ultradian rhythms for focused mental work, aiming for one or two 90-minute focus blocks per day. He suggests that while four blocks are theoretically possible, it's unusual and typically one to three blocks are more sustainable. He also shares that he does not take extended breaks from these sessions, even on weekends, to maintain focus circuits through regular access.

10:03

🌞 Scheduling Ultradian Rhythms for Maximum Productivity

Huberman details how to schedule ultradian rhythms for increased focus, emphasizing the importance of recognizing individual peak alertness times post-waking. He explains that ultradian cycles are influenced by the glucocorticoid system and cortisol levels, which can be affected by factors like sunlight exposure, caffeine, and exercise. He advises setting a 90-minute block for focused learning starting at the peak of mental alertness, acknowledging it may take 10-15 minutes to enter deep focus within that period.

15:03

πŸƒβ€β™‚οΈ Enhancing Ultradian Rhythms with Early Morning Routines

The segment explores how adjusting morning routines, such as waking up earlier and engaging in brief high-intensity exercise, can shift ultradian cycles earlier, allowing for an additional early morning focused work block. Huberman illustrates how this can lead to capturing three ultradian work blocks throughout the day, explaining the rarity of achieving four due to sleep needs. He stresses the importance of aligning work blocks with natural cortisol fluctuations for optimal learning and performance.

20:04

πŸ’‘ Applying Ultradian Rhythms to Cognitive and Physical Skills

Huberman concludes with the application of ultradian rhythms to both cognitive learning and physical skill development. He clarifies that while these cycles are beneficial for cognitive tasks like language learning or writing, they also apply to physical skills that require focus and coordination. He encourages listeners to detect their personal ultradian cycles for enhanced learning and performance, emphasizing the value of these biologically offered periods for improvement.

πŸ”— Supporting Research and Concluding the AMA

In the final part, Huberman invites listeners to subscribe to the premium channel for full AMA access, transcripts, and unique research-funded content. He reiterates the dual purpose of the premium channel: to support the free standard podcast and to fund human-centric research aimed at developing mental, physical health, and performance protocols. He announces the Tiny Foundation's dollar-for-dollar match on research funds raised, encouraging subscriptions to amplify research support.

Mindmap

Keywords

πŸ’‘ultradian rhythms

Ultradian rhythms refer to any biological, physical, or mental cycles that occur more frequently than once every 24 hours, typically around 90 minutes. In the context of the video, Dr. Huberman discusses leveraging these rhythms for focused mental work and learning. He mentions that these rhythms are naturally present in humans and can be used to maximize productivity and learning efficiency.

πŸ’‘neuroplasticity

Neuroplasticity, also known as brain plasticity or neural plasticity, is the brain's ability to change and reorganize itself throughout a person's life. In the video, Dr. Huberman explains how using ultradian rhythms can enhance neuroplasticity, which is crucial for learning and memory consolidation. He suggests that focused work during certain ultradian cycles can lead to more effective learning.

πŸ’‘AMA (Ask Me Anything)

AMA stands for 'Ask Me Anything,' a format where the host takes unscripted questions from the audience. In the video, Dr. Huberman hosts an AMA session as part of his premium subscriber content, answering questions related to science and self-improvement.

πŸ’‘cortisol

Cortisol is a hormone produced by the adrenal glands that plays a role in stress response, immune system modulation, and regulation of blood sugar levels. Dr. Huberman explains that cortisol fluctuations are linked to ultradian rhythms and are essential for alertness and focus, which in turn are critical for effective learning during ultradian cycles.

πŸ’‘cognitive material

Cognitive material refers to the content or information that one needs to process, understand, and remember, typically in an academic or learning context. In the video, Dr. Huberman discusses how to use ultradian rhythms to accelerate learning of cognitive materials such as languages, mathematics, and history.

πŸ’‘focused bouts

A focused bout, as discussed in the video, refers to a period of intense concentration and effort dedicated to a specific task, often used in the context of learning or skill development. Dr. Huberman suggests using ultradian rhythms to schedule these bouts for optimal learning and performance.

πŸ’‘Non-Sleep Deep Rest

Non-Sleep Deep Rest refers to periods of rest that are not sleep but are still deeply restorative. Dr. Huberman mentions that while focused work blocks are important for triggering learning, it is during deep rest that the brain consolidates learning through processes like memory consolidation and synaptic strengthening.

πŸ’‘glucocorticoid system

The glucocorticoid system is part of the endocrine system and is involved in the body's stress response and regulation of glucose metabolism. In the video, Dr. Huberman explains how fluctuations in the glucocorticoid system are tied to ultradian rhythms and impact alertness and focus, which are ideal for learning and cognitive tasks.

πŸ’‘BDNF (Brain-Derived Neurotrophic Factor)

BDNF is a protein that supports the growth, survival, and differentiation of neurons. It is essential for neuroplasticity. Dr. Huberman mentions BDNF in the context of how the molecules that control neuroplasticity fluctuate according to ultradian cycles, which is why scheduling focused work during these cycles can enhance learning.

πŸ’‘physical skill learning

Physical skill learning refers to the process of acquiring and improving physical abilities or skills that require motor coordination and cognitive input. In the video, Dr. Huberman points out that ultradian rhythms can also be used to enhance physical skill learning, not just cognitive learning.

πŸ’‘premium subscriber content

Premium subscriber content refers to additional or exclusive material provided to subscribers who pay for a premium service. In the video, Dr. Huberman mentions that the AMA episode is part of the premium subscriber content for the Huberman Lab podcast, which includes extra episodes and research support.

Highlights

Introduction to the Huberman Lab podcast and its focus on science-based tools for everyday life.

Explanation of the premium subscription model to support the free podcast and research at universities.

Details on how to subscribe to the premium channel and access the premium podcast feed.

Andrew Huberman's approach to using ultradian rhythms for focused mental work.

The importance of leveraging ultradian rhythms for learning and memory.

Practical advice on incorporating a 90-minute focus block into daily work.

The maximum number of sustainable focus blocks and how often they can be performed.

Andrew's personal routine of daily ultradian rhythm sessions, including weekends.

The concept that focus circuits are enhanced through regular access to focus.

A detailed tool for scheduling focus and recovery using ultradian rhythms.

Dispelling the common myth about the 90-minute focus cycle and how to leverage it effectively.

The role of glucocorticoid system fluctuations in triggering ultradian cycles.

How to determine the optimal start time for an ultradian learning cycle.

The typical pattern of two major peaks in the glucocorticoid system during waking hours.

Strategies for capturing a third ultradian work block by adjusting morning routines.

The rarity of capturing four ultradian work blocks and the importance of sleep for learning.

The application of ultradian work blocks to physical skill learning and exercise.

Encouragement to treat the 90-minute ultradian cycles as valuable opportunities for learning.

Information on how to support the Huberman Lab podcast and research through the premium channel.

Details on the Tiny Foundation's dollar-for-dollar match on research funds raised through the premium channel.

Transcripts

play00:00

ANDREW HUBERMAN: Welcome to the Huberman Lab podcast, where

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we discuss science and science based tools for everyday life.

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[MUSIC PLAYING]

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I'm Andrew Huberman and I'm a professor

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of neurobiology and ophthalmology

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at Stanford School of Medicine.

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Today is an Ask Me Anything or AMA

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episode, which is part of our premium subscriber content.

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Our premium channel was launched in order

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to raise support for the standard Huberman Lab podcast

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channel, which still comes out once a week every Monday,

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and of course, is zero cost to consumer.

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The premium channel is also designed

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to support exciting research being

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done at major universities like Stanford and elsewhere.

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Research that's done on humans that

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should lead to protocols for mental health, physical health

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and performance in the near future.

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If you'd like to check out the premium channel subscription

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model, you can go to hubermanlab.com/premium

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and there you can subscribe for $10 a month or $100 a year.

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We also have a lifetime subscriber option.

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For those of you that are already Huberman Lab podcast

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premium subscribers and you're watching and/or hearing this,

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please go to hubermanlab.com/premium

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and download the premium podcast feed.

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And for those of you that are not already

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Huberman Lab Premium podcast subscribers,

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you will be able to hear the first 15 minutes or so

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of this episode and hopefully that

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will allow you to discern whether or not

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you would like to become a premium subscriber.

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Without further ado, let's get to answering your questions.

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And as always, I will strive to be as clear as possible,

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as succinct as possible, and as thorough as possible while

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still answering as many questions per AMA episode

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as I can without these sessions becoming unreasonably long.

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I should also point out that if you asked a question

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and it was not answered this AMA,

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it may very well be answered in the next AMA.

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So the first question, which had a lot of upvotes--

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meaning many people wanted the answer to this question--

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came from Jackson Lipfert.

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And the question was about so-called ultradian rhythms.

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For those of you that are not familiar with ultradian

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rhythms-- ultradian rhythms are any rhythms

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that are shorter than 24 hours.

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And typically when people ask about

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or talk about ultradian rhythms, they

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are referring to 90-minute rhythms.

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I've talked about these on the podcast before.

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And Jackson's question was-- how do you use ultradian rhythms

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in your daily work?

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There's more to the question, but first off, I

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do use ultradian rhythms-- that is,

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I leverage the fact that these do exist in all of us

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as a way to engage in focused bouts of mental work

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once or twice, or sometimes three times per day.

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However, I use them in a way that's

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grounded in the research on ultradian rhythms for learning

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and memory in a way that might not

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be obvious just from their name that they

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are 90-minute rhythms.

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So I'll get into the details of how to use ultradian rhythms

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to best capture neuroplasticity--

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that is the brain's ability to change in response

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to experience-- and in a way that should allow you to get

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one or two, or maybe even three focused bouts of learning per

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day, which can greatly accelerate learning

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of cognitive material, languages, mathematics,

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history--

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for sake of school or work, or maybe

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just a hobby, or a personal interest of some sort--

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and for skill learning in the physical domain as well.

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Jackson then went on to ask--

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you've mentioned before that you try

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to include at least one 90-minute focus block per day

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as part of your work and overall mission.

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And indeed, that is true.

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I tried to get at least one of these focused ultradian rhythm

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blocks per day.

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That is a period of about 90 minutes

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where I'm focused on learning something or doing something

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that's cognitively hard, although typically I

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aim for two of these sessions per day.

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He then goes on to ask-- what is the maximum number of blocks

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you can perform sustainably?

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The answer to that is probably four.

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And I say probably because some people have schedules,

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lifestyles, in which four 90-minute blocks

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of focused learning is possible per day,

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but that's highly unusual.

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For most people, it's going to be one or two, maybe three--

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four, I would place in the really extraordinary end

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of things, maybe if you're cramming for exams

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or you've managed to go on a writing retreat or a learning

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and retreat of some sort where you can devote essentially,

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all of your non-sleeping, non-eating time to learning.

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But most people simply can't organize their life that way.

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So the short answer is--

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for me, it's one or two per day is the target

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and three would be the maximum.

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You then went on to ask-- do you take vacations

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or extended breaks from these ultradian rhythm sessions?

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And the short answer is no.

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Typically, I try and do this every day-- and yes, even

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on the weekends.

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But on the weekend, the ultradian rhythm

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focused learning bout might just be

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reading a book for about 90 minutes

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or so, which might not be as cognitively difficult as it

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is for other sorts of work that I perform during the week.

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I occasionally miss a day entirely

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for whatever reason-- travel, obligations

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related to family, et cetera.

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But in general, I try and do this every day.

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I do think that the circuits for focus are,

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I guess the non-biological way to put it would be kept warm.

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But essentially, that accessing the circuits for focus

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is made easier by accessing them regularly

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and that's because the circuits for focus

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are indeed themselves amenable to neuroplasticity.

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In other words, the more you force yourself to focus,

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the easier focusing gets.

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I'll now answer the last part of the question

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and then I will go through and emphasize some tools

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that anyone can use in order to leverage ultradian rhythms

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toward learning bouts-- either cognitive learning

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or physical skill learning, or a combination of the two.

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The last part of the question Jackson asked

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was-- if you knew you needed to drastically increase

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the amount of focus you do daily, how would you schedule

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that focus and recover from it?

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That's an excellent aspect to this question.

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And I will now give you the details

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of how I would use and schedule ultradian rhythms.

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I'll offer you a tool--

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I've never talked about this tool in the Huberman Lab

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podcast.

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And I will dispel a common myth about ultradian rhythms that

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points to a, believe it or not, an easier way to leverage

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them for maximum benefit.

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OK.

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So as I mentioned before, ultradian rhythms are

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these 90-minute cycles that we go through from the time

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that we are born until the time we die.

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Indeed, even during sleep, we are

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experiencing and more or less governed

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by these ultradian rhythms.

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This question and this answer is not so much about sleep.

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But just know that when you go to sleep at night until you

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wake up in the morning, every 90 minutes or so,

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your patterns of sleep-- that is the percentage or ratio rather

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of slow wave sleep to light sleep to rapid eye movement

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sleep changes in a way such that each 90-minute cycle gates

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the next cycle.

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It flips on switch for the next 90-minute cycle

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then that 90-minute cycle ends, flips

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on switch for the next one, and so on and so forth.

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I mentioned all that because during the daytime,

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the same thing is true.

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But most people don't know when the 90-minute all trading

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cycles begin.

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Because if you think about it, you

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could wake up on the basis of an alarm clock

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or noise in the room, or simply because you naturally

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wake up in the middle of an ultradian 90-minute cycle.

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So does that mean, for instance, that if you wake up 60 minutes

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into an ultradian cycle that the next 30 minutes

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of your waking--

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right, because that 60 minutes needs

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to continue to 90 to complete an ultradian

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cycle-- that the next 30 minutes after waking

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are related to the ultradian cycle

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that you were still in during sleep, or does

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it start a new ultradian cycle.

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And the answer is the former.

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That ultradian cycle continues even if you wake up

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in the middle of it.

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And so a lot of people who want to leverage ultradian cycles

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for learning will say, "Well, how do I know when to start?

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When does it start, when I hit my stopwatch?

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Can I just set a clock and work for 90 minutes?"

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And the short answer is no.

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And that might seem unfortunate, but the good news

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is that you can figure out when your first proper ultradian

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cycle of the day begins simply by asking yourself when are

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you most alert after waking.

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That is if you were, say to wake up at 7:00 AM

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and let's say that's the end of an ultradian cycle or perhaps

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you're in the middle of an ultradian cycle--

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doesn't matter.

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What you need to watch for or pay attention to

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for a day or so is when you start

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to experience your greatest state of mental alertness

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in the morning.

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And here, we can discard with all the issues and variables

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around caffeine or no caffeine, hydrating or no hydrating.

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Exercise is one variable that we'll consider in a moment.

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But here's the deal--

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these all trading in cycles are actually triggered

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by fluctuations in the so-called glucocorticoid system--

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the system that regulates cortisol release.

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And as some of you have probably heard me say before--

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cortisol, even though it's often discussed as a terrible thing,

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it's chronic stress, cortisol, cortisol, et cetera-- cortisol

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is essential for health and every day we

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get a rise in cortisol in the morning that is associated

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with enhanced immune function, enhanced alertness, enhanced

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ability to focus, so on and so forth.

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In fact, the protocol that I'm always

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beating the drum about that people

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should get sunlight in their eyes

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as close to waking as possible-- that actually enhances

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or increases the peak level of cortisol that's

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experienced early in the day.

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And that sets in motion a number of these ultradian cycles.

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So for instance, if you wake up at 7:00 AM

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and you find that for the first hour after waking,

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you tend to be a little bit groggy,

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or you happen to be groggy on a given day,

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but then you notice that your attention and alertness starts

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to peak somewhere around 9:30 AM or 10:00 AM,

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you can be pretty sure that, that first ultradian

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cycle for learning is going to be optimal to start

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at about 9:30 or 10:00 AM.

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How can I say about if it's indeed a 90-minute cycle?

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Well, this is really where the underlying neurobiology

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in these ultradian cycles converge to give you

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a specific protocol.

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The changes in cortisol that occur throughout the day

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involve--

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yes, a big peak early in the day if you're

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getting your sunlight and caffeine and maybe even some

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exercise early in the day.

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But typically, that peak comes early.

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And then across the day the baseline jitters a little bit,

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it comes down, but it bounces around a little bit.

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It's not a flat line, if we were to measure

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your glucocorticoid levels.

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Each one of those little bumps corresponds to a shift

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in these ultradian cycles.

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So if you find that you are most alert at 9:30

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or starting to become alert at 9:30,

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and then typically you have a peak of focus and concentration

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around 10:00 AM, that is really valuable to know.

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Because the way that the molecules that

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control neuroplasticity-- that is the changes in neurons

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and other cell types in the brain that

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allow your nervous system to learn and literally

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for new connections to form between neurons, which

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is basically the basis of learning--

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those fluctuate according to these ultradian cycles.

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What does this mean?

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This means if your peak in alertness and focus

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and energy--

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could even be experienced as physical energy occurs

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at about 9:30 AM, I would start your first ultradian cycle

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for learning somewhere around there.

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Certainly 9:30 AM would be ideal,

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but 10:00 AM would be fine as well.

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And then you have about one hour to get

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the maximum amount of learning in even

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within that alternating cycle.

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This is where there's a lot of confusion out there,

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people think, oh, ultradian cycles are 90 minutes,

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therefore, we should be in our peak level of focus

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throughout that 90 minutes.

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In reality, most people take about 10 or 15 minutes

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to break into a really deep trench of focus

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and then periodically throughout the next hour,

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they'll pop out of that focus, now

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have to deliberately refocus.

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This is why, if possible, you want

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to turn off Wi-Fi connections and put

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your phone in the other room or turn it off.

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If.

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You do need your phone or Wi-Fi, just

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be aware of how distracting those things

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can be to getting into a deep trench of focus.

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But the point is this--

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these 90-minute cycles occur periodically

play11:44

throughout the day, but there is going

play11:46

to be one period early in the day--

play11:47

and here, I'm referring to the spirit of starting

play11:50

at about 9:30 or 10:00 AM-- and then likely

play11:52

another one in the mid to late afternoon that are going to be

play11:56

ideal for focused learning.

play11:59

And that focus learning bout should ideally

play12:02

have you set your clock--

play12:04

a stopwatch or something-- to measure 90 minutes, but do

play12:08

assume that there's going to be some jitter at the front end

play12:11

where you're not going to be able to focus

play12:13

as deeply as you would like.

play12:14

Then you'll get about an hour of deep focus

play12:16

and then you really start to transition out

play12:18

of these ultradian cycles.

play12:20

How do when the afternoon ultradian cycle occurs?

play12:23

Well, just as in the morning, it occurs

play12:25

because there's a brief, but significant increase

play12:28

in the glucocorticoid system in the mid to late afternoon.

play12:32

I wish I could tell you it's going to be 2 PM

play12:34

or it's going to be 3:00 PM-- that's really going

play12:38

to depend on the individual.

play12:39

When you ingest caffeine, some of the other

play12:41

demands of your day.

play12:42

But you can learn to recognize when

play12:45

these two periods for optimized learning

play12:48

will occur and here are the key principles.

play12:50

Watch for a day or two-- meaning pay attention

play12:52

to when you have your peak levels of physical and mental

play12:55

energy in the morning-- that is between waking and noon,

play12:58

and then again between noon and about 6:00 or 7:00 PM.

play13:02

Although I'm sure that there are some late shifted folks that

play13:04

will experience their peak in focus somewhere around 6:00

play13:07

or 7:00 PM, especially if they're waking up

play13:08

around 10:00 or 11:00 AM, as I know some people out there are.

play13:12

Once you know where those peaks in focus

play13:14

occur on your schedule, set a stopwatch

play13:18

for one ultradian cycle in the early part of the day.

play13:21

In this example, I was saying 9:30,

play13:23

but if you can't hop on it until 10, that's fine.

play13:26

Set it for 90 minutes, consider that block wholly--

play13:28

meaning rule out all other distractions.

play13:30

But assume that within that 90-minute block,

play13:33

you are only going to be able to focus intensely

play13:35

for about one hour.

play13:37

And just know that the molecules that control neuroplasticity--

play13:40

and these things have names.

play13:41

And yes, Brain Derived Neurotrophic Factor or BDNF

play13:44

is the most famous of those, but there are others as well.

play13:47

In fact, the very receptors that control

play13:49

synaptic strength, the connections between neurons,

play13:52

some of the neurotransmitters and modulators involved

play13:54

in synaptic plasticity, they undergo regulation

play13:57

by these ultradian changes in glucocorticoid.

play14:01

And then try and capture a second ultradian

play14:05

learning block in the afternoon.

play14:07

Again, just knowing that the first 10 or 15 minutes,

play14:09

consider it mental warm up, and then you

play14:11

get about an hour-- it's not exactly 60 minutes, but about

play14:14

an hour to maximize learning.

play14:15

So if you're trying to learn something,

play14:17

really capture it during that phase as well.

play14:19

Now, is there a third opportunity

play14:21

or a fourth opportunity?

play14:22

This relates to Jackson's question directly.

play14:25

And the short answer is not really,

play14:27

unless you're somebody who requires very little sleep.

play14:30

Within the 12 or 16 hours that one

play14:32

tends to be awake during the day or 18 hours

play14:34

that one tends to be awake, there are really only two

play14:37

of these major peaks in the glucocorticoid system that

play14:39

trigger the onset of the circadian cycles.

play14:41

Again, there's a ramping up and a ramping down

play14:45

of glucocorticoids throughout the day.

play14:47

But the real key here is to learn

play14:48

when you tend to be most focused based

play14:51

on your regular sleep, wake cycle, caffeine

play14:53

intake, exercise, et cetera.

play14:54

And again, that's going to vary from person to person.

play14:56

And you really only have two opportunities or two ultradian

play14:59

cycles to capture in order to get the maximum focus

play15:03

challenging work done a.k.a.

play15:05

learning.

play15:06

So for somebody that wants to learn

play15:08

an immense amount of material or who has the opportunity

play15:11

to capture another ultradian cycle,

play15:14

the other time where that tends to occur is also early days.

play15:18

So some people by waking up early

play15:21

and using stimulants like caffeine and hydration

play15:23

or some brief high-intensity exercise,

play15:25

can trigger that cortisol pulse to shift a little bit

play15:29

earlier so that they can capture a morning work

play15:31

block that occurs somewhere, let's

play15:33

say between 6:00 and 7:30 AM.

play15:35

So let's think about our typical person--

play15:37

at least in my example that's waking up around 7:00 AM.

play15:41

And then I said, has their first ultradian work cycle really

play15:44

flip on because that bump in cortisol around 9:30 or 10:00

play15:47

AM.

play15:48

If that person were say to set their alarm clock for 5:30 AM,

play15:53

then get up, get some artificial light-- if the sun isn't out,

play15:57

turn on bright or artificial lights,

play15:59

or if the sun happens to be up that time of year,

play16:02

get some sunlight in your eyes.

play16:04

But irrespective of sunlight, were

play16:07

to get a little bit of brief high intensity

play16:09

exercise maybe 10 or 15 minutes of skipping rope or even

play16:12

just Jumping Jacks or go out for a brief jog, what

play16:15

happens then is the cortisol pulse starts to shift earlier.

play16:18

And so the next day and the following day

play16:20

and so on and so forth-- provided they're still doing

play16:22

that exercise first thing and ideally getting some light

play16:25

in their eyes as well--

play16:26

well then they have an opportunity

play16:28

to capture an increase in cortisol that

play16:30

is now shifted from about 7:00 AM to about 8:30 AM.

play16:34

So they can capture an hour of work there

play16:35

and then they will also still be within that rising

play16:40

phase of cortisol in the 9:30 to 10:00

play16:42

AM block that lasts until about 11:30 or so.

play16:47

They might have lunch.

play16:48

Perhaps after lunch, they do a Non-Sleep Deep Rest--

play16:50

maybe they, don't maybe you're a napper or maybe you're not--

play16:52

doesn't really matter.

play16:53

And then in the afternoon--

play16:56

and I would suspect it would now be

play16:58

in the earlier afternoon sometime around 2:00 or 2:30

play17:01

would be typical.

play17:02

Although again, that exact time will vary person to person.

play17:06

Then they would want to schedule another 90-minute work block.

play17:09

So that's how you can capture three.

play17:11

Now you can start to see also why

play17:13

capturing four ultradian work blocks

play17:15

would be exceedingly rare.

play17:16

It's just not typical that people are awake

play17:19

for that much of the day, you have to sleep at some point.

play17:22

And I should mention that if you're going to force yourself

play17:23

to wake up earlier on a consistent basis,

play17:25

you probably should be trying to get to sleep

play17:27

a little bit earlier as well.

play17:28

Because it's not just the quality,

play17:30

but the duration of quality sleep that really

play17:32

matters for learning.

play17:33

And I should also remind everybody

play17:36

that the actual rewiring of neurons

play17:39

does not occur during any focused work block,

play17:41

it actually occurs during deep sleep the following night

play17:43

and the following night, and during Non-Sleep Deep Rest.

play17:46

This is why Non-Sleep Deep Rest can accelerate

play17:48

learning because it's in states of rest

play17:50

that the actual connections between neurons

play17:52

strengthen or weaken or new neurons

play17:55

are added in a way that allows for what we call learning.

play17:58

OK.

play17:58

So one or two all trading work blocks per day is typical,

play18:02

three would be really exceptional,

play18:05

and four would be extraordinary.

play18:07

Look for them-- meaning look to see when you are feeling most

play18:12

focused and alert typically in the period

play18:15

before waking and noon and typically

play18:17

in the period between noon and bedtime,

play18:20

given your standard intake of caffeine and exercise

play18:23

and other life events.

play18:26

Please also remember that even though it's

play18:29

an ultradian 90-minute work block,

play18:31

the neuroplasticity is going to be best triggered

play18:34

within a 60-minute portion of that.

play18:37

And there's no way to know exactly when that 60

play18:39

minutes begins and ends until you actually

play18:42

begin the work block.

play18:43

So this is really designed to be empirical,

play18:45

you need to actually go do this.

play18:46

What you'll notice again is that it's

play18:47

hard to focus at first then you'll

play18:49

drop into a state of focus.

play18:50

You may get distracted, that's perfectly normal.

play18:52

You refocus, get back into triggering

play18:54

learning-- that's really what you're doing,

play18:55

you're triggering learning-- and then there'll be some taper

play18:58

and then you'll be out of the ultradian work block.

play19:00

Now, it's also a key to understand

play19:03

that myself and other people should not

play19:05

expect that they're only working during these 90-minute work

play19:08

blocks.

play19:09

It's just that a lot of the sorts of demands of our day,

play19:11

including cooking and shopping for groceries, and email,

play19:17

and text messaging, and social media-- a lot of those things

play19:19

don't require intense focus of the sort

play19:21

that I believe Jackson is asking about maximizing,

play19:24

and that I'm referring to when I talk about these ultradian work

play19:26

blocks.

play19:27

And then as a final point, I've been

play19:29

talking about these ultradian work blocks and focus,

play19:31

et cetera, in a context that brings to mind ideas

play19:34

about cognitive work.

play19:36

So learning a language, learning math, writing,

play19:38

or creating, doing something related to music, et cetera.

play19:41

But these 90-minute ultradian work blocks

play19:44

also directly relate to physical skill learning as well

play19:48

and to physical exercise as well.

play19:50

So if you are somebody who's really interested in improving

play19:53

your fitness and your fitness requires

play19:55

a lot of focused attention--

play19:57

so for instance, when I go out for a long run on Sundays,

play20:00

which is part of my fitness routine,

play20:02

I deliberately not thinking about much,

play20:04

I'm just trying to cruise along.

play20:05

I might focus a little bit on my pace

play20:06

in stride, maybe an audiobook I'm listening to or a podcast.

play20:10

But typically, I'm just cruising along,

play20:12

it's low cognitive demand work.

play20:14

These ultradian work blocks can really

play20:16

be maximized for pure cognitive work--

play20:20

book type work, et cetera, music, et cetera, or they

play20:23

can also be leveraged toward skill learning.

play20:26

So if you're trying to learn how to dance

play20:29

or how to perform a particular athletic move

play20:31

or you're trying to get better at some skill that requires

play20:34

a lot of focus and alignment of muscular movement and cognitive

play20:39

demands, et cetera, well then these

play20:41

are also going to be ideal for triggering neuroplasticity

play20:44

to get better in the motor skill based domain as it's called,

play20:49

et cetera.

play20:50

If you'd like to learn more about ultradian

play20:52

shifts in neuroplasticity and ultradian work bouts,

play20:56

I will certainly do more on this in the standard Huberman Lab

play20:58

podcast.

play20:59

But the key words to look up if you

play21:01

want to explore this further online--

play21:03

it's not something that a lot of people about,

play21:05

it's called iterative metaplasticity.

play21:08

It's a vast literature and one that I'd

play21:10

be happy to teach you in a standard podcast episode.

play21:12

But in the interest of getting to more questions from you

play21:16

all, hopefully the answer I've given

play21:18

you now has been complete enough, yet clear enough,

play21:23

and yet succinct enough that you can start

play21:26

to leverage these really powerful aspects

play21:28

of iterative metaplasticity and ultradian rhythms for learning.

play21:32

And I'd just like to point out that these opportunities

play21:35

for focused learning that occur in these 90-minute ultradian

play21:39

cycles are really terrific opportunities.

play21:42

They are offered to you at least twice every day

play21:45

and you can really learn to detect when they occur

play21:48

and when they're likely to occur.

play21:50

You can certainly learn at other times in the 24-hour cycle.

play21:54

But for anyone who's tried to stay up late at night cramming

play21:57

for an exam or for somebody who's

play21:59

tried to learn during the sleepiest time

play22:02

of their afternoon, we can be very familiar with the fact

play22:07

that there are times of day in which we are best at learning.

play22:10

And as I've just described, there

play22:12

are ways to capture those moments

play22:14

and they are valuable moments.

play22:16

So even though it's just about three hours per day

play22:19

or really only two hours per day because of the 60

play22:21

to 90-minute thing that I talked about a few minutes ago, learn

play22:24

to know when these occur and really treat them as valuable,

play22:28

maybe even wholly in the sense that they are really the times

play22:31

that are offered up to you each day

play22:32

by your own biology in ways that will allow you to get

play22:35

better pretty much at anything.

play22:37

Thank you for joining for the beginning

play22:39

of this Ask Me Anything episode.

play22:41

To hear the full episode and to hear future episodes of these

play22:45

Ask Me Anything sessions, plus to receive transcripts of them

play22:48

and transcripts of the Huberman Lab podcast standard channel

play22:51

and premium tools not released anywhere else,

play22:54

please go to hubermanlab.com/premium.

play22:57

Just to remind you why we launched the Huberman Lab

play22:59

podcast premium channel--

play23:01

it's really twofold.

play23:02

First of all, it's to raise support

play23:04

for the standard Huberman Lab podcast channel, which

play23:07

of course, will still be continued to be released

play23:09

every Monday in full length.

play23:11

We are not going to change the format

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or anything about the standard Huberman Lab podcast.

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And to fund research-- in particular,

play23:18

research done on human beings.

play23:20

So not animal models, but on human beings,

play23:22

which I think we all agree is the species

play23:23

that we are most interested in.

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And we are going to specifically fund

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research that is aimed toward developing

play23:30

further protocols for mental health, physical health,

play23:32

and performance.

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And those protocols will be distributed

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through all channels.

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Not just the premium channel, but through all channels--

play23:38

Huberman Lab podcast and other media channels.

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So the idea here is to give you information to your burning

play23:44

questions in depth and allow you the opportunity

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to support the research that provides those kinds of answers

play23:50

in the first place.

play23:51

Now an especially exciting feature of the premium channel

play23:53

is that the Tiny Foundation has generously

play23:56

offered to do a dollar for dollar match

play23:58

on all funds raised for research through the premium channel.

play24:02

So this is a terrific way that they're

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going to amplify whatever funds come in through the premium

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channel to further support research for science

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and science related tools for mental health, physical health,

play24:11

and performance.

play24:12

If you'd like to sign up for the Huberman Lab Premium channel,

play24:14

again there's a cost of $10 per month

play24:16

or you can pay $100 up front for the entire year.

play24:19

That will give you access to all the AMAs

play24:21

you can ask questions and get answers to your questions

play24:24

and you'll of course get answers to all the questions

play24:27

that other people ask as well.

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There will also be some premium content such as transcripts

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of the AMAs and various transcripts and protocols

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And again, you'll be supporting research

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for mental health, physical health, and performance.

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You can sign up for the premium channel by going

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to hubermanlab.com/premium.

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Again, that's hubermanlab.com/premium.

play24:49

And as always, thank you for your interest in science.

play24:53

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