How Fat Loss Works - Episode 3: Weight Loss vs. Fat Loss
Summary
TLDRThis video script delves into the intricacies of weight loss versus fat loss, explaining the biochemical processes of glucose, fatty acids, and amino acids within the body. It clarifies the common misconception that all weight lost is fat, revealing that a significant portion is actually lean body mass. The script emphasizes the importance of high-protein diets for preserving muscle during weight loss and discusses the effects of different macronutrient ratios on metabolic rate and hormone levels. It concludes with practical advice on setting dietary protein intake and balancing carbohydrates and fats for optimal fat loss without sacrificing muscle mass.
Takeaways
- 𧬠Glucose is first processed by the liver, where it can be converted into fat through de novo lipogenesis, although this process is typically minimal.
- π° Fatty acids enter the bloodstream through the lymphatic system and can be used for fuel or repackaged into lipoproteins in the liver.
- π Amino acids can be fluxed out of muscle tissue during times of caloric restriction to maintain blood glucose levels through gluconeogenesis.
- ποΈ Muscle synthesis and breakdown are always occurring; net muscle gain or loss is determined by the relative rates of these processes.
- π₯ During a caloric deficit, the body prioritizes burning fat to spare blood glucose and muscle glycogen, which are important for energy and muscle repair.
- π― Weight loss is not solely fat loss; it often includes a significant amount of lean body mass, which includes bone, organs, and muscle.
- ποΈββοΈ Weightlifters tend to lose a higher ratio of fat to lean body mass compared to those who do not engage in resistance training.
- π₯ A high-protein diet can help retain more lean body mass during weight loss by stimulating muscle protein synthesis and having a higher thermic effect of food.
- π« Extremely low-fat diets can lead to hormonal imbalances and essential fatty acid deficiencies, so a moderate fat intake is recommended.
- π₯¦ Fiber intake should be considered for its high thermic effect and contribution to overall diet quality.
- π The ratio of carbohydrates to fats in the diet does not significantly affect metabolic rate or lean body mass retention within a normal range.
Q & A
What is the main focus of the video series 'How Fat Loss Works'?
-The main focus of the video series is to explain the mechanisms of fat loss, the difference between weight loss and fat loss, and how nutrients like glucose, fatty acids, and amino acids interact within the body during the process of losing fat.
What is the initial destination of glucose after it enters the body?
-Glucose initially goes to the liver, where it can be converted into glycogen or fat through a process called de novo lipogenesis, although the latter is typically a small amount.
How do fatty acids enter the bloodstream and what happens to them once there?
-Fatty acids enter the bloodstream through the lymph system, and once in the bloodstream, they can be directed to the liver, adipose tissue, or muscle tissue, where they can be used for fuel, repackaged, or broken down and repackaged into different lipoproteins.
What is the role of amino acids in the context of muscle breakdown and synthesis?
-Amino acids play a crucial role in muscle breakdown and synthesis. Muscle breakdown is always occurring, and the relative rates of synthesis and breakdown determine net muscle gain or loss. During caloric restriction, the rate of amino acid flux from muscle is typically elevated to maintain blood glucose levels.
Why might a high-protein diet help in retaining more lean body mass during weight loss?
-A high-protein diet helps retain more lean body mass because protein stimulates muscle protein synthesis, aiding in muscle repair and turnover. Additionally, protein has a higher thermic effect of food (TEF) compared to carbohydrates or fat, which means more calories are burned during digestion and metabolism.
What is the significance of the ratio of weight lost from fat versus lean body mass during weight loss?
-The ratio of weight lost from fat versus lean body mass is significant because the goal of weight loss is to minimize the loss of lean body mass while maximizing fat loss. A higher ratio of fat loss to lean body mass indicates a more effective weight loss strategy.
What is the recommended protein intake per kilogram of lean body mass for optimal muscle retention during weight loss?
-The recommended protein intake for optimal muscle retention during weight loss is between 1.8 to 3.0 grams per kilogram of lean body mass.
Why might a very low-fat diet be problematic for hormone levels and essential fatty acid intake?
-A very low-fat diet can be problematic because it may lead to decreased sex hormone levels like testosterone if fat intake is less than 15% of total calories. Additionally, it could result in deficiencies in essential fatty acids, which are crucial for health.
How does the thermic effect of food (TEF) differ between protein, carbohydrates, and fats?
-The thermic effect of food (TEF) is higher for protein, which is about 30%, compared to carbohydrates at about 6-8% and fats at about 2-3%. This means that protein requires more energy for digestion and metabolism, which can aid in weight loss.
What is the recommended minimum fiber intake per thousand calories to enhance weight loss?
-The recommended minimum fiber intake is at least 15 grams of fiber per thousand calorie intake to enhance weight loss due to its high thermic effect of food, similar to protein.
Why might a ketogenic diet be difficult to maintain for long-term weight loss?
-A ketogenic diet might be difficult to maintain long-term because it requires a moderate protein intake and a very low carbohydrate intake, which can be challenging to adhere to. Additionally, the high fat intake may not be sustainable for some individuals, leading to a higher relapse rate and weight regain.
Outlines
π Understanding Nutrient Flux and Fat Loss
The speaker introduces the topic of nutrient flux and fat loss, explaining how glucose, fatty acids, and amino acids are processed in the body. Glucose enters the bloodstream and is first sent to the liver, where it can be converted into fat through de novo lipogenesis, although this process is typically minimal. Fatty acids enter through the lymphatic system and can be utilized by the liver, adipose tissue, or muscle. The liver can use fatty acids for fuel or repackage them into lipoproteins. Amino acids play a role in muscle synthesis and breakdown, with the rate of synthesis determining muscle gain or loss. During caloric restriction, amino acids are fluxed out of muscle to maintain blood glucose levels through gluconeogenesis. The speaker emphasizes the importance of understanding these processes for effective fat loss.
ποΈββοΈ Weight Loss vs. Fat Loss and Impact of Exercise
The discussion shifts to the difference between weight loss and fat loss. The speaker clarifies that when people lose weight, it's not just fat but also lean body mass, which includes all non-fat tissues like bones and organs, not just muscle. For individuals who don't exercise, the loss is typically 60% fat and 40% lean body mass. However, for those who lift weights, the ratio can be closer to 80-20 in favor of fat loss due to the body's emphasis on muscle repair and remodeling. The speaker also mentions that for natural bodybuilders trying to get extremely lean, the ratio might be around 70% fat to 30% lean body mass, reflecting the challenges of reaching very low body fat percentages.
π½οΈ Optimizing Diet for Lean Body Mass Preservation
The speaker explores how to optimize diet for preserving lean body mass during weight loss. They suggest not dieting too quickly, as losing more than 1% of body weight per week can negatively impact lean body mass. Eating a high-protein diet, specifically more than 1.8 grams per kilogram of lean body mass, is recommended to stimulate muscle protein synthesis and retain more muscle. The speaker also discusses the importance of fiber and adequate water intake, and cautions against very low-fat diets, which can lead to hormonal imbalances and essential fatty acid deficiencies. They conclude that there's no superior macronutrient ratio for weight loss, but a high-protein, high-fiber diet seems to be most effective for preserving lean body mass and losing fat.
π« The Challenges of Ketogenic Diets for Body Composition
The speaker addresses the ketogenic diet, noting that while it can be effective for fat loss, it requires a moderate protein intake, which might be challenging to maintain long-term. They mention that very low-fat diets can lead to hormonal issues and essential fatty acid deficiencies, while very high-fat diets don't necessarily increase hormone levels. The speaker advises against extreme diets and emphasizes the importance of consistency and adherence. They suggest setting a total calorie intake based on the desired weight loss, thenει ating protein first, followed by carbohydrates and fats as preferred, ensuring not to go below 15% of calories from fat for health reasons.
πββοΈ Final Thoughts on Macronutrient Distribution for Fat Loss
In the final paragraph, the speaker summarizes the key points, emphasizing that for effective fat loss, one should focus on a high-protein diet with an adequate amount of fiber. They reiterate that there's no significant difference between high-carb, low-carb, high-fat, or low-fat diets in terms of metabolic rate or lean body mass retention. The speaker advises setting total calories for weight loss, then distributing macronutrients in a way that fits one's lifestyle and preferences, as long as it's not very low in fat. They conclude by encouraging viewers to ask questions and engage with the content, and express their intention to continue providing educational content in future videos.
Mindmap
Keywords
π‘Fat Loss
π‘Weight Loss
π‘Glucose
π‘Fatty Acids
π‘Adipose Tissue
π‘Muscle Synthesis and Breakdown
π‘Amino Acids
π‘Gluconeogenesis
π‘Ketogenesis
π‘Protein Sparing
π‘Thermic Effect of Food (TEF)
Highlights
The video discusses the difference between weight loss and fat loss, emphasizing that not all weight loss is fat loss.
Glucose is first processed by the liver and can be converted into fat through de novo lipogenesis, though this is typically a minimal amount.
Fatty acids enter the bloodstream through the lymph system and can be used by the liver, adipose tissue, or muscle.
In the liver, fatty acids can be used for fuel, repackaged, or broken down and repackaged into different lipoproteins.
Amino acids play a role in muscle synthesis and breakdown, affecting net muscle gain or loss.
During caloric restriction, the rate of amino acid flux from muscle increases to maintain blood glucose levels.
High protein intake can prevent exiting ketogenesis due to the gluconeogenic nature of amino acids.
The glycerol molecule from fats can be used for gluconeogenesis or repackaged into triacylglycerols.
Ketones can be formed in the liver from ketone substrate byproducts when glucose levels are low.
For non-lifters on a diet, the average weight loss is a 60/40 ratio of fat to lean body mass.
Lean body mass includes all non-fat tissues, not just muscle, and can be misleading when measuring weight loss.
Weightlifters on a diet tend to lose more fat and less lean body mass due to muscle remodeling.
The 'repeated bout effect' explains why experienced lifters retain more muscle mass during dieting.
Natural bodybuilders aiming to get lean typically lose 70% fat and 30% lean body mass.
Newer lifters or those with more body fat can lose almost entirely fat and may even gain muscle while dieting.
The ratio of weight lost from adipose tissue versus lean body mass can be influenced by diet and exercise.
Diets should not exceed a 1% weight loss per week to prevent excessive lean body mass loss.
High-protein diets greater than 1.8 grams per kilogram of lean body mass are recommended for better lean body mass retention.
The thermic effect of food (TEF) is higher for protein and fiber, which can aid in weight loss.
Carbohydrate to fat ratios do not significantly affect lean body mass retention or metabolic rate.
Very low-fat diets can lead to hormonal imbalances and essential fatty acid deficiencies.
The ketogenic diet is a moderate protein diet and can be difficult to maintain long-term.
Fiber intake should be at least 15 grams per thousand calorie intake for its high TEF.
The video concludes that any diet's effectiveness is based on adherence and maintaining a caloric deficit.
Transcripts
[Music]
hey guys welcome back to my new series
how fat loss works and how lose fat so
today in episode three we're gonna talk
about weight loss versus fat loss and if
you're looking on here
you're probably like holy crap what the
hell is that
well first it's basically I'm just
showing you guys how different nutrients
are fluxing okay you've got your inputs
here so this is what you eat glucose and
fatty acids and I guess you would have
some amino acids as well okay now first
we're going to talk about glucose all
right glucose comes into the bloodstream
actually technically it goes to the
liver first and their glucose cannot be
stored as glycogen in the liver it can
be converted to you know fat through
Genoa lipogenesis however de novo
lipogenesis is typically a very very
very small amount of fat so you also
have it fluxing out of the liver or
being delivered into the bloodstream as
glucose that can then go to fatty acids
or sorry adipose or into muscle now
there's other tissues that can go to as
well but for our purposes we're just
focusing on these three organs liver
adipose and muscle now fatty acids when
they come in they come in through the
lymph system as we discussed in the last
video when they come into the
bloodstream they can go to the liver the
adipose or the muscle and we talked
about how they have to be unpackaged and
repackaged okay now in the liver there's
a few different things that can happen
they can be used for fuel they can also
be repackaged they can be broken down
and repackaged into vldls LDLs HDL that
can be repackaged into these different
life of proteins and shipped to adipose
or ship to other tissues that need them
like heart and skeletal muscle alright
and from fat once those are stored there
they can be liberated as free fatty
acids bound to albumin and they can go
to muscle or liver or other tissues
interestingly amino acids can flux too
if if muscle breakdown is it is
occurring or you know what it's not let
me let me be clear
muscle breakdown is always occurring
muscle synthesis is always occurring the
relative rates of both determine whether
there is a net muscle gain or net muscle
loss so when the rate of synthesis
exceeds the rate of breakdown you have a
net muscle gain when the rate of
breakdown exceeds the rate of synthesis
you have a net muscle loss during times
of caloric restriction and negative
energy balance the rate of flux of amino
acids out of the muscle is typically
going to be elevated alright and the
reason for that is to create substrates
for maintaining blood glucose and the
way it's going to do that is by sending
gluconeogenic amino acids to the liver
okay so leukemia Genesis is basically
the formation of glucose from other
molecules namely amino acids about 60%
or more of amino acids are gluconeogenic
this is why when we talk about a
ketogenic diet if your protein is too
high it can actually kick you out of
ketogenesis
because if 60% of those amino acids are
gluconeogenic if your proteins too high
you're making too much glucose you're
not ketogenic anymore so it can send
amino acids to liver for Klink ania
genesis remember also that adipose which
is stored in fats and adipose restored
as triacylglycerols the glycerol
molecule from fats is actually
gluconeogenic as well so when you
liberate 3 fatty acids from a try so
glycerol that glycerol molecule is I'd
either repackage and still restored as
tri so glycerides
or it can be sent to the liver for
gluconeogenesis now
the other thing that can happen is as
you are breaking down fats if your if
your carbohydrate or your glucose level
is not high enough we'll talk about this
more in the next video but you cannot
regenerate some of the Krebs cycle
intermediates that are required to keep
the Krebs cycle progressing as per
normal and what happens is you start to
get more ketone byproducts or sorry
ketone substrate byproducts and these
can leave the muscle or whatever other
tissue they're in and go to liver where
ketogenesis can be performed so ketones
are formed and deliver and then can be
delivered to other tissues if you're in
a ketogenic state so that was kind of a
important thing to put together to help
you understand how these molecules flux
throughout these organs okay now I want
to talk about weight loss versus fat
loss when we dye it we talk about losing
weight and most of us assume that all of
that weight is going to be fat but
scientific evidence tells us otherwise
all right so for people for your normal
people who don't lift weights and who
diet typically what you lose is a 60/40
ratio of fat - that's incorrect I'm
sorry - lean body mass okay I'm gonna
collaborate in that in a minute so you
lose 60% fat 40% lean body mass lean
body mass not the same thing as muscle
I'll say it again lean body mass is not
the same thing as a muscle all right
lean body mass encompasses all non fat
tissues so if you do a DEXA you do a
calipers you do bod pod whatever method
all it's doing is measuring your body
fat and subtracting that and then
everything that's left over is your lean
body mass that includes your bone weight
your organ weights in addition to your
muscle weight now muscle weight is a
pretty big part of that
but it's not just muscle so in reality
it may be more like 10% of actual
skeletal muscle they're losing we don't
exactly have exact figures but I'm
guessing here now why are they losing so
much lean body mat compared to body fat
well you have to think about the
emphasis to store amino acid in muscle
and prevent it from as much flux so when
you lift weights and you create muscle
damage you have to remodel that tissue
so you're breaking down some of this in
order to remodel that you require amino
acids thus there is a greater emphasis
on remodeling that skeletal muscle
preventing it or sorry remodeling it
repairing it and that requires amino
acids okay so you have decreased flux
and you're gonna retain more muscle mass
now what is it like for people who lift
weights let me go ahead and clean that
up a little bit well it's different for
everybody my gosh am i spelling you can
put that in the outtakes I think I'm
trying to write the letter after the B
uh we looked at around 80 to 20
FATCA lean body mass okay now why not
100% why not 100% fat well some people
can lose 100% fat for the most part it's
people who one haven't been training
very long and so the emphasis is on
remodeling that skeletal muscle your
body has a few things it really wants to
do the first thing is it wants to spare
blood glucose okay
one of the reasons you burn fat is
because by burning fat okay in a caloric
deficit that is as your blood glucose
starts to get lower you will start
burning more fat to spare blood glucose
right the other thing it's also going to
try and do is spare muscle glycogen
for the task that it means muscle
glycogen to do so again you'll burn more
fat to spare that muscle glycogen
further in order to spare or actually
repair the muscle if you're giving a
signal to the muscle of damage or stress
that is going to override the effect of
some of the catabolic nature of dieting
so when we lift weights we create this
damage we create this signal to retain
more muscle by emphasizing the
remodeling of the muscle so for people
who are just starting to lift weights
that signal is going to be much stronger
than somebody who has been doing it for
a long period of time okay it's called
the repeated bad effect and just general
plateaus alright so for somebody if we
look at case studies of natural
bodybuilders for example this is an
average here if we look at case studies
and natural bodybuilders who are trying
to diet to get absolutely shredded so
we're dealing with people who probably
are near the peak of their muscle mass
genetically they're trying to get really
lean so they're trying to squeeze every
last a little bit of body fat out and
they've been lifting for a long period
of time so that growth signal is not as
strong it's going to look more like 70%
fat 30% lean body mass okay so it's
going to take a little bit more why
because they have to get leaner so it's
gonna require losing more lean body mass
to squeeze out that last little bit of
body fat and they've been training for
longer closer to their maximal genetic
potential for muscle so as you can see
for somebody trying to get really lean
who's already near the peak of their
muscle mass they're gonna lose a little
bit more lean body mass okay now again a
lot of this is water a lot of lean body
mass is just simply water your cells
your lean muscle cells are two-thirds
water so it's not like you're losing 30
percent like tissue weight all right
now but what about people who
are who are newer to weightlifting who
maybe are a little bit more obese I
talked about this in a video so if you
have more body fat sores
it's kind of a little bit different well
you can actually lose almost 100 percent
to zero and actually you can gain a
little bit of muscle while you're
dieting so especially if you're new
lifter because that growth signal is so
strong so now the other thing we have to
think about is this I'm gonna I'm gonna
erase all this stuff take a picture
except for your adipose your muscle and
then well let's just say lean body mass
in general so if we're losing weight we
have two primary depots we lose it from
we lose it from adipose or we lose it
from lean body mass and the ratios of
those change how much we lose from each
or what we do changes those ratios okay
now how can we optimize this well one
thing so let me let me go back if we
lost if we lost 30 kilos that's a lot of
weight right and let's say it was 80/20
well then 20% lean body mass would be 6
kilos and it would be 24 kilos of
adipose awesome so any diet that is
going to somehow be superior to whatever
we're doing has to do one of two things
it either has to spare lean body mass
better because if you're sparing more
lean body mass let's say we could make
this ninety ten well now we change this
to three kilos lean body mass loss and
by default we change this to 27 kilos of
body fat lost okay boss
same not wait because the kaliya soon
the caloric balance was the same we lost
the same amount of weight but we lost
same amount of weight but because we
spared more muscle and the caloric
deficit was the same we lost more fat
which is what we're concerned with ok I
want you to keep this in mind so any
diet that's going to be superior either
has to produce one a greater negative
energy balance okay to the other way you
can do it is to spare more lean muscle
because if you spare more lean lean body
mass you burn more fat by default ok
well if we look at the studies on
different diets there's a few things we
can do so the first thing we can do is
don't diet too quickly the case studies
on natural bodybuilding seem to suggest
greater than 1 percent of weight loss
per week seems to be negative for lean
body mass seem to start to shift towards
more seems to be sure to shift towards
more lean body mass loss if you're
losing faster than that number 2 we can
eat higher protein a high-protein diet
and specifically greater than 1 point 8
grams per kilogram of lean body mass
okay protein is calculated per unit lean
body mass because lean body mass are the
tissues that mostly require protein okay
now for a lot of you that you're gonna
look at this and say that's actually a
low mount protein if you're bodybuilders
our fitness fanatics you probably a neat
way more protein than that well that's
fine you can actually go up to up to 3
grams per kilogram lean body mass has
been shown to be pretty darn safe there
doesn't seem to be any downsides
associated with it as well
drinking enough water in those sorts of
things so this is a pretty pretty high
protein amount now why does protein seem
to have this effect well one it
stimulates muscle protein synthesis
stealing that muscle turnover helps
repair tissue seem to retain more lean
body mass number two remember
protein has a higher TEF than
carbohydrate or fat so by doing higher
protein so if you're doing you know 3000
if you're doing 2,000 calories and half
of those calories and a fourth of those
calories are from protein versus another
diet where half of those calories are
from protein you're going to get a
greater thermic effect of food so if it
was a thousand calories from protein
total versus 500 calories from protein
and this is this equates to 125 grams or
250 grams I'm not saying do these exact
amount of protein I'm just giving you an
example but if it has a 30% greater TEF
then we're looking at a 150 kcal burn
greater versus a 300 kcal greater burn
so you're getting so not only are you
getting a greater thermic effect of food
you're retaining more lean body mass
this is why high-protein diets tend to
have better outcomes in terms of sparing
lean body mass losing more body fat now
that said before you all go out and just
honk down 3 kilos of chicken a day and
don't eat anything else everything has a
limit 3 grams per kilogram lean body
mass you don't need to go higher than
that and the other thing to consider is
adherence most people have difficulty
being adherent to a dietary protein
intake that high ok because by default
if half your calories are protein then
you have way less carbs and fats to
distribute calories to ok now
once we set protein if we have our total
calorie intake we set protein first and
then we figure out our carbohydrate fat
distribution because carbohydrates and
fats are what are left now again the
ratio of carbohydrate to fat if one's
going to be preferential versus another
that means either they're going to ink
one is going to increase per tablet
metabolic rate more than the other or
one is going to cause you to
preferentially spare lean body mass and
thus you lose more body fat if we look
at all the studies comparing high carb
low carb high fat low fat and everywhere
in between there doesn't appear to be
any difference on lean muscle rich or
lean body mass retention or metabolic
rate I'll say it again there doesn't
appear to be any difference on lean body
mass retention or metabolic rate thus
physiologically none of none of them in
that range are superior there are a few
things to consider however
if you eat very very low-fat and I'm
talking very low-fat less than 15% of
your kcals you could have decrease in
sex hormones like testosterone and
whatnot
okay now people argue with me on this
however if you look at the research data
but just increasing fat up to a crazy
high amount does not further increase
hormones but if you eat a normal amount
of fat you will get your hormones back
to normal but if you eat like a crazy
high amount of fat you don't get crazy
high amounts of hormones that's not how
it works the other thing to consider is
you could start to become deficient in
some essential fatty acids which could
cause some negative health outcomes okay
so we won't want to go to low fat so I
don't really recommend typically diets
under 15% of calories from fat okay now
on the other end of that spectrum we
have the ketogenic diet now one of the
problems with the ketogenic diet I would
say is you can't get protein too high so
it's kind of a moderate protein diet the
the range that you want to keep protein
at nikita's unit diet is right here oh
sorry I always get ahead of myself
so Kido 1.2 to 1.8 grams per kilo lean
body mass this is a relatively high
protein intake from four for most
Americans but it's still not as high as
the 22.5 3.0 that's a downside miller
downside is most people find it to be a
very hard lifestyle to maintain people
can maintain it for a few weeks a few
months by maintaining it for years at a
time becomes very difficult and what we
tend to see is a pretty high amount of
relapse in terms of people regaining the
body fat they lose which we don't want
that either we want to lose body fat and
keep it off so now if you check it again
my whole spiel if you choose keto that's
fine
if you can stick with it it fits your
lifestyle and you enjoy it and you can
be in here into it and consistent with
it that's fine there don't seem to be
any negative downsides in terms of fat
loss with Kido so basically if we're
looking at how to distribute
carbohydrate versus fat set your total
calories based on the energy deficit you
require to lose weight or how much
weight you want to lose per week no more
than 1% per week set your protein we
prefer a high-protein diet and then
distribute your carbohydrate and fat
calories basically however you like as
long as it's not a very low fat diet ok
and the other thing to consider is fiber
remember fiber has a high TEF similar
protein and so I recommend at least 15
grams of fiber per thousand calorie
intake one final thought it's not
surprising that we see this with
carbohydrate versus fat there TEF SAR
very similar the thermic effect of food
is very similar carbohydrates are about
6 to 8 percent fat about 2 to 3 percent
not very different between the two of
them it sounds it's also unsurprising
then that we see typically better
results for higher protein and higher
fiber because they're TEF sauron 30% so
if you think about it that makes sense
it also makes sense that we see a little
better lean body mass retention with
protein if we have higher protein we're
giving more amino acids to let the
muscle repair flux more amino acids into
muscle so I hope this video has been
helpful for you guys
if you have any questions please ask
them below like and subscribe to my
channel and share this video and I will
catch you guys next time
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