Dutasteride or Finasteride for Hair Loss (ENGLISH)💊
Summary
TLDRتناقش المقالة الصوتية المقدمة عن علاج الفقدان الرأسي، وتناقش الفرق بين دواء فيناستيريد والدواء دو توستريد، وتأثيرهما على مستويات DHT في الجسم. يناقش النص الاستخدام الشائع للأدوية وDosage المقترحة للمرضى، ويذكر الاختلاف في التأثير السلبي للأدوية على المرضى. ويشدد على أن الأدوية قد تكون آمنة وفعالة، ولكن يجب التعامل معها بحذر واختيار الDosage التي تتناسب مع حالة كل مريض على حدة.
Takeaways
- 😀 تناقش النص النص ال録ي المتابعة لمناقشة الフィットنس التي جرت أمس، حول الاختيار بين الأدوية المنتهية للاستخدام أم لا.
- 🏥 سيناقش اليوم الاستخدام للأدوية التي ت称作 'butas' وكيفية تحطيم المقارنة مع 'finasteride'.
- 💊 سيناقش النص الDosage للـ 'finasteride' و 'dutasteride' وكيف تتقارن الDosages في النهاية.
- 🔗 يُذكر أن الرابط لمناقشة البارحة متوفر في الوصف أسفل النص.
- 📚 يُناقش النص التأثير السلبي لـ 'dutasteride' والتأثير الإيجابي على تقليل مستويات DHT في الجسم.
- 🚫 يُذكر أن 'dutasteride' لم يحصل بعد على الموافقة من FDA لاستخدامها في الفقدان الرأسي.
- 📈 يُناقش النص الاختلاف في الDosage التي يستخدمها المرضى بشكل منفصل، وتأثير ذلك على النتائج.
- 👨⚕️ يُذكر أن الأدوية يجب أن تكون مخصصة لكل مريض بناءً على احتياجاته وتحمل المخاطر.
- 📊 يُذكر أن الدراسات يمكن أن تكون مربكة وتجعل المرضى يشعرون بالارتباك حول الDosage التي يجب اتخاذها.
- 🌙 يُنصح بالأخذ من 'finasteride' في المساء قبل العشاء بسبب دورة حياة الهرمونات في الجسم.
- 💡 يُذكر أن زيادة مستويات التستوستيرون في الجسم قد لا تؤدي إلى تحسن أداء الرياضة أو بناء العضلات.
- 📚 يُنصح بأخذ استشارة طبيب متخصص قبل اتخاذ أي قرارات طبية جديدة.
Q & A
ما هي المناقشة التي جرت في النص حول دوا التناسب؟
-النص يناقش دوا التناسب التي تسمى فينشستريد (تسمى أيضاً بروسكار أو بروفشيا) و دوا دو توستريد (تسمى تحت الاسم التجاري أ摸着 آرك). كلا الأدوية هما من عزل الـ DHT ويستخدمان في حالات الهزال الرأسي.
ما هي الفرق بين فينشستريد و دو توستريد؟
-فينشستريد يمنع نوع 2 من 5 alpha reductase، في حين أن دو توستريد يمنع جميع الأنواع 1، 2، و 3 مما يقلل من مستويات DHT أكثر من فينشستريد.
لماذا يفضل بعض المرضى استخدام دو توستريد على فينشستريد؟
-بعض المرضى يفضلون دو توستريد لأنه يقلل من مستويات DHT أكثر، مما قد يؤدي إلى زيادة نمو الشعر أكثر من فينشستريد.
لماذا لم يحصل دو توستريد على الموافقة الرسمية في الولايات المتحدة؟
-الموافقة الرسمية لم ت被授予 لأن شركات الأدوية التي تصنع فينشستريد (مرك) و دو توستريد (جلاسكو سميث كلاين) تشعران بالحذر بسبب القضايا القانونية التي تواجهها.
ما هي التأثيرات الجانبية التي يمكن أن تحدث من استخدام فينشستريد؟
-من التأثيرات الجانبية التي يمكن أن تحدث من فينشستريد انخفاض الشهوة، ومشاكل في الوظيفة الجنسية، وانخفاض كمية الejaculate.
هل الزيادة في مستويات التستوستيرون يؤدي إلى زيادة أداء الرياضة؟
-لا، لأن فينشستريد يزيد من مستويات التستوستيرون بـ15% فقط، مما لا يؤدي إلى زيادة أداء الرياضة أو بناء العضلات.
ما هي الDosage التي ينصح بها النص لـ فينشستريد؟
-النص ينصح بـ 1 ملغم من فينشستريد يومياً لمدة ستة أشهر بعد العمليات الجراحية.
ما هي الDosage التي ينصح بها النص لـ دو توستريد؟
-النص ينصح بـ 1 ملغم من دو توستريد يومياً، مع تجاهل الDosage بأسبوع واحد وأخذ 0.5 ملغم من دو توستريد في ذلك اليوم.
لماذا يجب تناول فينشستريد في المساء؟
-لأن مستويات التستوستيرون في الجسم ترتفع في الليل، والنصف النشط لفينشستريد قصير، لذا يجب تناوله في المساء لتغطية فترة الذروة التستوستيرونية.
هل الأدوية الطبية لمنع الهزال الرأسي آمنة؟
-نعم، الأدوية الطبية لمنع الهزال الرأسي تعتبر آمنة، مع أن التأثيرات الجانبية تكون نادرة وتختفي بعد التوقف عن الدواء.
لماذا يفضل بعض الأطباء تجنب تجنب الأدوية الجديدة مثل دو توستريد؟
-بعض الأطباء يفضلون الحذر وتجنب تجنب الأدوية الجديدة لأن لديها تاريخ استخدام قصير ولا يمكن التقييم النهائي للتأثيرات الجانبية الطويلة الأجل.
Outlines
💊 Hair Loss Medication Discussion
The script begins with a discussion on the continuation of a previous conversation about fitness trade, which is likely a mispronunciation of finasteride, a medication used to treat hair loss. The speaker addresses whether one should take finasteride or not and introduces the topic of dutasteride, another DHT blocker. The speaker clarifies the difference in the mechanism of action between the two drugs, with dutasteride being more potent in reducing DHT levels. The historical context of both drugs is provided, including their FDA approval for different uses. The speaker also touches on the controversy surrounding the FDA approval of dutasteride for hair loss and the potential legal implications. The paragraph concludes with a note on the importance of individualized dosage and the role of anecdotal evidence and clinical experience in treatment decisions.
📊 Dosage Variations and Patient Experiences
This paragraph delves into the complexities of dosage variations for finasteride and dutasteride, highlighting the lack of standardized dosages and the prevalence of patient self-experimentation. The speaker discusses the challenges of maintaining consistent dosage when cutting tablets and the potential inaccuracies this introduces. The paragraph also addresses the economic factors that influence patient decisions, such as the cost of brand-name versus generic medications. The speaker shares anecdotal evidence of patients who have reported better results with variable dosages and those who take the medication on alternate days or in reduced doses. Key points about the effectiveness and side effects of both drugs are summarized, emphasizing the differences in DHT reduction and the longer half-life of dutasteride compared to finasteride. The speaker concludes by emphasizing the importance of a doctor's advice and the need for a personalized treatment plan based on the patient's needs and safety.
🕒 Optimal Timing and Dosage Recommendations
The final paragraph focuses on the optimal timing for taking finasteride and dutasteride, with a specific recommendation for finasteride to be taken at night due to its shorter half-life and the body's peak testosterone levels. The speaker also discusses the impact of these medications on testosterone levels, with dutasteride causing a more significant increase. The potential benefits and limitations of increased testosterone levels are explored, including the role of estrogen levels and the use of aromatase inhibitors for muscle mass enhancement. The paragraph concludes with the speaker's recommended dosages at their clinic, emphasizing the importance of long-term safety and the cautious approach to prescribing dutasteride due to its shorter history of use and less understood long-term side effects. The speaker acknowledges the higher rate of side effects associated with dutasteride and the preference for finasteride based on extensive patient experience and studies.
Mindmap
Keywords
💡Fitness trade
💡Finasteride
💡DHT blockers
💡5 alpha reductase inhibitors
💡Benign prostatic hyperplasia
💡FDA approval
💡Dosage
💡Side effects
💡Circadian rhythm
💡Aromatase inhibitors
💡Anecdotal evidence
Highlights
Discussion on whether to take finasteride or not for fitness trade.
Comparison of finasteride and dutasteride in terms of their effects on DHT levels.
Finasteride, also known as Proscar or Propecia, and dutasteride, under the trade name Avodart, are the most commonly used DHT blockers.
Difference in the mechanism of action between finasteride and dutasteride.
Finasteride was originally discovered to treat benign prostatic hyperplasia and later used for hair loss.
Dutasteride has not received FDA approval for hair loss treatment due to legal concerns.
The importance of personal experience and anecdotal evidence in hair loss treatment.
Confusion regarding dosage due to various patient experiments and lack of clinical trials.
Individual differences in metabolism, risk tolerance, and mental robustness affecting treatment compliance.
Some patients prefer the word of the doctor over statistics for treatment decisions.
Issues with cutting tablets and the resulting dosage variations.
Different patient strategies for taking finasteride and dutasteride, such as alternate days or half tablets.
Key points differentiating finasteride and dutasteride in terms of DHT blockage and side effects.
Long-term use of finasteride showing a decrease in effectiveness after 2 to 5 years.
Combination of dutasteride with finasteride can enhance the effects of each other.
Dutasteride's shorter history on the market makes it harder to assess long-term side effects.
Recommended dosages for finasteride and dutasteride at the speaker's clinic.
The importance of caution when prescribing dutasteride due to its higher rate of side effects.
Discussion on the impact of finasteride and dutasteride on testosterone levels and athletic performance.
The use of aromatase inhibitors in conjunction with finasteride for muscle mass benefits.
The speaker's approach to advising patients on treatment plans based on safety and individual needs.
Transcripts
hello now the race talk is in
continuation of yesterday's talk we were
discussing fitness trade yesterday and
whether you should take finished rate or
not and today we're going to talk about
butas today and how to destroy compares
with finished ride and today I'm also
going to discuss with you the dosage of
finis right and the dosage of do toss
tonight and how they compare in the end
I will go through the dosage that I
recommend for my patients the link for
yesterday's talk is in the description
below
and you can see it if you want to
electrons to yesterday stock I keep
receiving so many emails from my
patients regarding what is the dosage
whether they should take notice trade
off in a strain and the Mail's are so
many that I decided that I must publish
this video and since because of the
Kovach close down I have all the time to
do it so here I am presenting to you
whatever knowledge that I have
though many missions today are advocates
of finestra and some are advocates off
to destroyed there is a second category
of patients who a little cautious they
do not want to use a blow torch to
extinguish a candle finished right which
is also referred to as proscar or
propecia and to toss right which comes
under the trade name of a mood arc are
the most commonly used DHT blockers
which are used in hair loss today both
of them are 5 alpha reductase inhibitors
so therefore the testosterone levels in
the body increase whereas the DHT levels
decrease there is a fine difference
between the mechanism of action of
finasteride on one hand and to trust
ride on the other where is finished
right inhibits type 2 5 alpha reductase
to thirst right inhibits all three ice
low signs that is type 1 type 2 and type
3 so in so doing it reduces the amount
of DHT much more than finasteride does
but on the downside you have more side
effects from Reuters right then from
finished finished trade was originally
discovered as a drug to treat benign
prostatic hyperplasia that is prostatic
disorders in 1976 it was only 1992 that
it was its use started in hair loss
patients but it was only as laid back as
in 1997 that it was FDA approved as an
exception
therapy for hair loss patients the
approval of goethe stride for benign
prostatic hypertrophy follow the same
route Dukas trade was FDA approved for
prostatic disorders in 2001 but till now
it has not been able to get FDA approval
for its use in hair loss medicine it is
very likely that it will never get in
the near future
why because with so many laws for
against Merck there's makers of propecia
Glasco Smith Kline the makers of avid
art that is do tough terrain are
cautious now to get this approval FDA
will think twice before recommending
another hair loss medication after so
many cold cases 1000 and 100 against
Merck the makers of propecia so it is
not likely in the near future that you
destroyed it is going to get FDA
approval
however it has got government sanction
in countries like Japan and Korea not
having FDA approval does not mean that
you trust right is not effective in hair
loss there are so many papers today on
the use of in Australia in Australia TT
treating hair loss that one it leaves
one confused so at the end it is only
the experience the anecdotal evidence
the experience in a clinical setting
what the doctor has to feel a doctor who
has been practicing here historic
surgery and who has been prescribing to
destroyed and fenestrated for a long
time and a patient who has been taking
these medicines these people count more
than any scientific study the field of
dosage II is equally confusing why
because patients have been experimenting
with various combinations and
permutations and over a period of time
there are certain laid down dosage
combinations which are nowhere in
clinical trial which never have been
studied in a paper which have been
established by hearsay so to say in the
mind of hair loss sufferers it is very
interesting that many clinics also
follow certain dosage regimes which are
not corroborated by any study as such
this is very interesting how crowd
behavior has evolved with the use of
data spread and finished fried over a
period of time patients interact with
one another and there are so many media
on which they interact social platforms
one-to-one basis through the doctors and
this is involved a very peculiar
strategy to handle hair loss and the
dosages of
finis
and distress trade are equally very
quaint we need to note here that every
patient is different every patient has
different metabolisms everybody does not
have the same risk tolerance
people have different mental robustness
and this is very important to understand
because for compliance is very crucial
too many patients have observed 90%
maintenance of hair and some amount of
regrowth with 5% chances of side-effects
is more acceptable than just 70% of
maintenance of hair and regrowth and 1%
side-effects and the reverse is also
true
so everybody is made up differently
everybody has different risk tolerance
and so every medicine every regime that
we make one patient his tailor cut to
that patient's requirement and that
patient's risk tolerance and how the
particular drug is having an effect on
him one dosage for every patient will
not work it has never worked till now
and there is a majority of patients who
don't even look towards statistics for
them the word of the doctor is enough
and these are the patients who are the
happiest amongst all these people there
many people who are taking proscar
taking the 5 milligram tablet cutting it
into 4 pieces and using them when you
cut a tablet there's breakage of the cut
module and powder formation the sum
amount of the tablet is lost so people
think that they are making 1.25
milligram pieces but they actually not
like that one day they will be taking
1.25 milligram the other day they're
taking 1 milligram and some other days
they are taking 1.5 milligram as well so
there is a wide variation when you cut a
tablet a 5 milligram tablet into four
pieces
now how this started when propecia came
into the market it was exorbitantly
priced because the company had rights to
this medicine and nobody else could
maybe genetic forms for 5 years after 5
years of a lot of generic formulations
came into the market and the costing of
finesse trial
reduced to a great extent but still
there is a category which cannot afford
propecia and still divides 5 milligram
proscar into 4 parts and use it with
this considerable variation of dosage of
1.25 milligram of cross scar there was
considerable variation but there are
some patients who have reported that
they do better with this variation on a
daily basis then if they took one
every day so this is just an anecdotal
incident and there is no research that
has gone into it neither is a paper
being published
there is another subset of patients who
takes these medicines on alternate days
there's another one who splits the
tablet into half the one milligram
tomato to half and takes 0.5 milligram
tablets every day there are others also
who have discovered that their hair is
maintained even if they take one tablet
every third or fourth day important
points to note about do toss right and
finished right are number one that
finasteride blocks 70% of the DHT
whereas bucha strike rocks 94% of the
DHT on a milligram 2 milligram is so it
has obtained that to destroy promotes
more hair growth also Dukas try has a
longer half-life of 4 to 5 months as
compared to that of finasteride which is
only 5 to 6 hours this is very important
side effects whereas in the case of
finasteride 1.9 percent of the page
complain of decreased libido and 1.3
percent of the patients complain of
erectile dysfunction 1.2% patients
complain of decreased ejaculate now in
the case of 2 destroyed this is much
higher so while taking finasteride a lot
of papers have proof that it is a safe
drug the side effects are rare they are
transient that is they disappeared after
you discontinued the drugs all the
papers also prove that the drug is due
passed right on double-blind trial on
self-assessment and on clinical
observations provides more hair
thickness after menu ating global
photograph so in my experience of using
finasteride alone I have seen that most
patients when they take it for a long
time after 2 to 5 years it is variable
the effects of finasteride start to wane
away and this is when I discovered that
a combination of rooters to ride with
finished friend both these drugs were
used together and they complement one
another and enhance the effect of each
other then the medicine to destroyed has
been in vogue only for the last 10 to 15
years and more so it has been popular
only in the last about 5 years of 7
years I'm going to say so this period of
time in the history of a drug is not a
time period in which you can assess the
long-term side effect
that you can get by constant long-term
use use of Medicine in asteroid has been
in the market for a long time and
there's a long history of its use so we
feel that it is a safer drug and it's
safer to recommend to the patient and a
patient in the long term may not have
significant side therefore this is the
reason why some doctors like me too are
hesitant in prescribing do test aligned
to the patient it is always better to
earn on the side of caution than to be
sorry so studies can be very confusing
there is one study of 1999 which
confuses the maximum this study
concludes that finished ride is almost
as effective at 0.05 milligram per day
dosage as it is at 1 milligram per day
or 5 milligram per day when it comes to
scalp skin DHT levels and point 2
milligram per day is almost as effective
as 1 milligram per day or 5 milligram
per day when it comes to serum DHT
levels now this study is not helpful at
all and there is a host of studies which
are so confusing and therefore patients
who are unfinished right they don't know
what to do at the end of the day after
this searched and searched and searched
the internet they get a reading so that
is where the doctor has to step in and
advise a treatment plan best suited to
the needs of the patient and the safety
of the patient now what time should
finished right or just right we take now
as far as to destroyed is concerned it
has a long half-life you can take it any
time of the day but finesse trial should
be only taken at night before dinner why
because the peak testosterone level in
the body happens at 1:00 a.m. this is
the circadian rhythm and since the
half-life of finasteride is only six to
eight hours or even lesser so it may not
cover that period when the peak of
testosterone takes place if we are
taking the drug in the morning another
fact about finasteride versus do
destroyed that you should know is that
finish tried increases the testosterone
levels by only 15%
whereas in the case of root Australia it
is much more so many because to student
levels go up estradiol levels also go up
by 15% increase of testosterone
by 15% is not very alarming as it is we
take testosterone supplementation after
the age of 50 but complete research has
not been done to establish that use of
finasteride for increased testosterone
levels is beneficial for supplementation
and can be used in place of testosterone
supplementation many patients also ask
since testosterone levels have gone up
will it boost my athletic performance
will it boost my muscle building no it
is not so because it also increases the
level of e star dial in your body so to
have the benefits of muscle mass
increase or the other added benefits of
testosterone you also have to have an
East retire inhibit so some patients
know this and the doctors advise them to
take aromatics aromatics is a drug which
decreases the level of Easterner in the
body and if you are retreat it improves
your muscle mass because the eastern our
level is degree but if you have to take
it you have to consult an
endocrinologist or your physician before
embarking on this journey so the
recommended dose at my clinic causes
starting one milligram finished right
immediately after the hair transplant
once the five-day medicines of
antibiotics etcetera over and this one
milligram finasteride is taken every day
for a duration of six month which is
mandatory beyond this period it is up to
the patient in consultation with me if
he wants to continue further as native
thinning hair do toss to ride in my
clinic is used very sparingly but I have
had good results in patients who take
one milligram tablet of philostrate
everyday but once a week they omit that
dose and take
0.5 milligram of crude rose tonight this
is a combination which is increasingly
proving beneficial to me till now
on one hand 3 million people have taken
finish tried so we are fully aware of
the side effects the possible side
effects that finish trade has given to
some patient whereas in the case of
utah's tried not more than hundred
thousand patients have been on route us
tonight so to evaluate the possibility
of long-term side effects is a little
bit difficult in the case of the test
track so based on many studies and
anecdotal evidence it is guaranteed that
do describe Bill Cosby
on the other hand it is also true that
it has higher rate of side-effects than
a proven drug which is finasteride or
propecia thank you very much
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