The Strongest Neurotransmitter in the World is NOT Dopamine or Serotonin - Dr. Scott Sherr MD
Summary
TLDRIn this informative discussion, Dr. Scott explores the critical role of GABA, a neurotransmitter responsible for relaxation and balance in the brain's neurotransmission. He delves into the causes of GABA deficiency, such as stress and poor diet, and its symptoms including anxiety and sleep disorders. Offering practical advice, Dr. Scott suggests lifestyle changes, dietary adjustments, and herbal supplements to support GABA production and overall mental well-being. He also introduces his collaboration with Thrive Market on a nut butter product line and shares insights on optimizing sleep and reducing stress through natural compounds and a holistic approach to health.
Takeaways
- 🧠 GABA is a crucial neurotransmitter responsible for relaxation and making the brain calm, accounting for 20% of the brain's neurotransmission.
- 🔄 The balance between GABA and glutamate is essential for mental health; glutamate is the excitatory neurotransmitter, while GABA is inhibitory.
- 💡 GABA deficiency can lead to various symptoms such as depression, anxiety, stress, poor sleep, and even severe issues like tremors and mood swings.
- 🤯 Stress and infections are common causes of GABA depletion, highlighting the importance of stress management and overall health maintenance.
- 🥜 The guest has collaborated with Thrive Market to create a nut butter product line, emphasizing high-quality, natural ingredients without fillers.
- 🌿 Natural ways to enhance GABA production include meditation, breathwork, yoga, and certain supplements like valarian and kava, which act as positive allosteric modulators of the GABA receptor.
- 🍄 Certain compounds like agarin from the Amanita muscaria mushroom act as GABA agonists, directly binding to the GABA site and promoting relaxation and sleep.
- 💊 Pharmaceutical substances like benzodiazepines and alcohol bind to the GABA receptor but carry risks of tolerance, withdrawal, and side effects due to their high affinity.
- 🛌 Sleep is significantly impacted by GABA levels, and optimizing GABA function can improve sleep quality and architecture, avoiding disruptions like vivid dreams or waking up frequently.
- 🥗 A balanced diet rich in nutrients like magnesium and vitamin B6, along with glutamine-containing foods, can support GABA production and overall brain health.
Q & A
What is the primary focus of the channel discussed in the transcript?
-The primary focus of the channel is to dive into topics that hold the most promise, particularly cutting-edge subjects that are upcoming and of interest to smart viewers who are keen on understanding future trends based on current literature and developments.
What is GABA and what role does it play in the brain?
-GABA (gamma-aminobutyric acid) is a neurotransmitter that is responsible for relaxation in the brain. It makes up about 20% of the brain's neurotransmission, counterbalancing the excitatory neurotransmitter glutamate, which accounts for 60%. Together, they maintain a balance crucial for relaxation, excitement, and recovery.
What are some symptoms of GABA deficiency syndrome?
-Symptoms of GABA deficiency syndrome can include depression, anxiety, stress, poor sleep, and in severe cases, tremors and difficulty urinating or with emotions and mood regulation.
How can one become depleted in GABA?
-One can become depleted in GABA due to chronic stress, infections, or other factors that deplete stressed neurotransmitters. High levels of stress can lead to an imbalance between glutamate and GABA, resulting in a deficiency.
What is the significance of glutamine in relation to GABA?
-Glutamine is an amino acid that is converted into glutamate in the brain, which is then converted into GABA. Therefore, a deficiency in glutamine can lead to a deficiency in GABA, affecting relaxation and stress response.
How can lifestyle factors contribute to GABA depletion?
-Lifestyle factors such as overtraining, overworking, poor sleep quality, and high stress levels can deplete GABA. These factors can lead to an imbalance between excitatory and inhibitory neurotransmitters, affecting overall well-being.
What is the role of magnesium and Vitamin B6 in GABA conversion?
-Magnesium and Vitamin B6 are necessary co-factors for the conversion of glutamate to GABA. Deficiencies in these nutrients can hinder the conversion process, leading to potential GABA imbalances.
What are some natural ways to enhance GABA production?
-Natural ways to enhance GABA production include meditation, breathwork, yoga, and certain herbal supplements like valerian root, kava, and compounds from certain mushrooms like agaricin from the Amanita muscaria mushroom.
How can adaptogens help regulate neurotransmitter functions?
-Adaptogens are substances that help the body adapt to stress and regulate neurotransmitter functions. They can positively influence the GABA system by binding to GABA receptors, enhancing the calming effect of GABA on the nervous system.
What is the importance of balancing the sympathetic and parasympathetic nervous systems?
-Balancing the sympathetic (excitatory) and parasympathetic (inhibitory) nervous systems is crucial for overall health and well-being. It affects sleep, stress response, recovery, and the ability to perform optimally. Enhancing GABA can help tip the balance towards a more parasympathetic state, promoting relaxation and recovery.
Outlines
🧠 Understanding the Role of GABA in Neurotransmission
This paragraph delves into the importance of GABA as a neurotransmitter, contrasting it with other well-known neurotransmitters like dopamine, epinephrine, and serotonin. It explains that while these are crucial, the majority of neurotransmission in the brain is actually a balance between glutamate and GABA. Glutamate is the excitatory neurotransmitter, promoting wakefulness and readiness, while GABA is responsible for relaxation and calming the brain. The speaker also discusses the potential consequences of GABA deficiency, such as irritability, anxiety, stress, poor sleep, and even more severe symptoms like tremors and mood instability. The paragraph emphasizes the need for balance between these neurotransmitters for optimal brain function and health.
🥜 Addressing GABA Deficiency Through Diet and Lifestyle
The speaker discusses how GABA levels can be depleted due to stress and other factors, leading to a deficiency that may manifest in various symptoms. The conversation turns to the role of glutamine in GABA production, as glutamate is converted from glutamine in the brain. The speaker mentions that a lack of protein or issues like a leaky gut can lead to glutamine deficiency, affecting GABA levels. The importance of magnesium and Vitamin B6 in the conversion of glutamate to GABA is also highlighted. The speaker then introduces his collaboration with Thrive Market to create a nut butter product, which aligns with his focus on diet and lifestyle as ways to address GABA deficiency.
🌿 Exploring Natural Methods to Enhance GABA Production
In this paragraph, the speaker explores natural methods to enhance GABA production, including the use of adaptogens and herbal supplements. He discusses the concept of positive allosteric modulation of the GABA receptor and provides examples such as valerian root, kava, and agaric acid. These substances are described as promoting relaxation and sleep by interacting with the GABA system in different ways. The speaker also cautions against certain pharmaceuticals that have a high affinity for the GABA receptor, such as benzodiazepines, alcohol, and barbiturates, due to the risk of tolerance and withdrawal. The focus is on finding safe and natural ways to support the GABA system for better sleep and stress management.
💤 Optimizing Sleep and Recovery with GABA Enhancement
The speaker emphasizes the importance of GABA for both sleep and recovery, explaining that a balance between sympathetic and parasympathetic nervous systems is crucial for optimal performance and health. He discusses the benefits of GABA-enhancing substances, such as nicotinyl-GABA, which can cross the blood-brain barrier when attached to Vitamin B3. The speaker introduces his company's product, Troom, which is designed to help with sleep and anxiety without causing tiredness during the day. The product is described as having a positive impact on sleep architecture, ensuring restful and restorative sleep without disrupting the natural stages of sleep.
🌄 Integrating GABA Support into Daily Life for Improved Well-being
The speaker concludes by discussing the broader implications of GABA support in daily life. He suggests that by integrating practices that enhance GABA production and balance, such as breathwork, yoga, and dietary adjustments, individuals can improve their overall well-being. He also emphasizes the importance of slowing down and finding ways to be more parasympathetic to support the GABA system. The speaker advocates for a holistic approach that includes lifestyle changes, diet, and supplementation to optimize health and reduce reliance on exogenous aids over time.
🤝 Finding and Utilizing GABA-Enhancing Resources
The speaker provides information on where to find resources for enhancing GABA levels, specifically mentioning his company, Tros Scripts, and its products like Troom and Troz. He explains the benefits of these products, such as the convenience of the dissolvable Troi, which can quickly affect the brain circulation without going through digestion. The speaker also mentions the educational resources available on the company's website, including blogs and protocols for optimizing health. The focus is on providing immediate help while also training medical professionals to improve health outcomes in the long term.
Mindmap
Keywords
💡GABA
💡Neurotransmitter
💡Glutamine
💡Stress
💡Magnesium
💡Vitamin B6
💡Adaptogens
💡Leaky Gut
💡Parasympathetic Nervous System
💡Nicotin GABA
Highlights
GABA is a neurotransmitter responsible for 20% of the brain's neurotransmission, playing a crucial role in relaxation and stress relief.
An imbalance between GABA and glutamate can lead to various symptoms such as irritability, depression, anxiety, stress, poor sleep, and even severe issues like tremors and difficulty urinating.
Stress is a primary factor in depleting GABA levels, leading to a deficiency syndrome that can manifest in numerous ways.
Glutamine is an amino acid that, when converted to glutamate in the brain, helps in the production of GABA. Deficiency in glutamine can lead to GABA deficiency.
Vitamin B6 and magnesium are essential for the conversion of glutamate to GABA, and deficiencies in these can disrupt the GABA system.
Certain supplements and lifestyle changes can help enhance GABA production and improve overall brain function.
Valerian root, a natural herbal supplement, acts as a positive allosteric modulator for the GABA receptor, promoting relaxation and better sleep.
Agaricin, a compound derived from the Amanita muscaria mushroom, is a long-acting GABA agonist that can support sleep over an extended period.
Nicotinyl-GABA, a combination of GABA and Vitamin B3, can cross the blood-brain barrier and support GABA function without causing tiredness.
The company Transcend Script offers Troi, a sublingual product that dissolves under the upper cheek and gums to support GABA levels and promote relaxation.
Troz, another product from Transcend Script, is designed to support sleep by modulating the GABA system and maintaining sleep architecture.
Corpin, a mushroom-derived compound in Troz, supports deep slow-wave sleep without disrupting sleep stages.
A balanced diet rich in nutrient-dense foods, including sources of glutamine, magnesium, and Vitamin B6, is essential for maintaining optimal GABA levels.
Lifestyle interventions such as stress reduction, breathwork, yoga, and sunlight exposure can significantly improve GABA capacity and overall well-being.
The importance of resetting the body's stress response with interventions like GABA supplementation, especially when lifestyle changes are not immediately feasible.
The potential negative impact of excessive screen time and phone usage on dopamine and GABA systems, highlighting the need for digital detox and relaxation techniques.
The concept of 'relaxed control' as a state of being in control while remaining relaxed, which is beneficial for cognitive functions such as learning and memory.
Transcripts
Dr Scott sh one of the things I like to
do on this channel is dive into things
that have the most promise the people
that watch this Channel or listen to
this channel are usually very smart
people that are interested in what's up
and coming not always just what's what
do we know retroactively over the last
10 years but things that we're saying
like hey this is what their literature
is and like this is where things are
going so I'd like to look at things that
are super Cutting Edge if you want to
call it that and you and I were talking
before we started filming about one
particular I guess you could call it a
supplement but really more of just a you
know compound I'll let you kind of it's
a neurotransmitter neurotransmitter yeah
and let's just Dive Right In like the
benefits of this where it could be
applied uh who could utilize it how we
become depleted in it uh I'll you take
it away yeah that's Rock so yeah we were
talking about Gaba so Gaba is a
neurotransmitter and most people have
heard of the Superstar neurotransmitters
I like to call them I've heard of
dopamine and epinephrine and serotonin
if you're across the pond it's neur
adrenaline and adrenaline but same thing
as epinephrine and
nephrine those are extremely important
but 80% of your neurotransmission has
nothing to do with those
neurotransmitters at all it's a balance
between two it's a balance between one
called glutamate and one called Gaba and
glutamate actually turns into Gaba in
the brain so Gaba is not made really
anywhere else except for a very small
amount in the pancreas that's a side
note but mostly all of your Gaba is made
in the brain and Gaba is responsible for
20% of your brain's
neurotransmission 60% is glit so that's
a total of 80% so glutamate is your
excited to a neurotransmitter this is
the one that makes you feel up it makes
you feel awake and ready and nephrine of
course plays a role in here but General
day-to-day glutamate is more important
Gaba is your neurotransmitter that's
responsible for relaxation for making
the brain relax allowing the brain to
relax so you need to have the balance
between these two neurotransmitters to
be able to be get excited and also to
relax and to recover if you don't have
enough Gaba around you're going to feel
irritable you're going to feel
potentially a lot of different symptoms
and so so some of those symptoms might
be so we call it it's called Gaba
deficiency syndrome and this is a lot of
things it could be things like
depression
anxiety stress poor
sleep it could even be severe things
like Tremors and difficulty urinating
and difficulty with your emotions and
libility with your mood going up and
down um it can also be as a result of
all this you can have of course this can
happen from a lot of different things
it's not just because of Gaba but people
forget that Gaba could be one of those
neurotransmitters that is depleted
because all of us are so stressed all
the time depleting our stressed
neurotransmitters depleting glutamate
and not recovering enough to be able to
get enough Gaba in the system so okay
with that how does one deplete glutamate
because that's probably what everyone's
wondering okay this sounds like me right
everyone's probably thinking that yeah
and honestly it sounds like me right it
sounds like okay I'm like overtrained
maybe overworked not sleeping well you
know running hot um and there's the
obvious things like okay I'm I'm
depleting it probably just from life
right but I how does one go about
depleting it more importantly how does
one replete it now I'm pretty stoked to
announce too that for the last couple of
years I have been working with Thrive
Market on creating my own product with
them and we had decided a couple years
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what you're getting is literally what I
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check them out and if you're already a
Thrive Market member I'll put a link
Down Below in the description that's
specifically for a Thrive Market member
that goes directly to that page as well
right so depletion happens because of
stress typically so if we have infection
we deplete glutamate if we have stress
on the system we deplete it as well um
I'm sorry we deplete Gaba excuse me so
we deplete Gaba as a result of stress of
of multiple things but I think before I
get there I think it'd be helpful so
glutamate is made from glutamine so
glutamine is an amino acid it's an amino
acid that's um very well known to most
people in the the bodybuilding
performance world is not something
that's very well appreciated I think as
we were talking about before we got on
but glutamine is the fuel for the colon
cells itself but glutamine gets
converted in the body to glutamate in
the brain and so if you're deficient in
glutamine mean you're not going to make
enough glutamate for your brain and if
you can't make enough glutamate then you
can't make enough Gaba and then if you
can't make enough Gaba you can't relax
the firing of your brain so in that case
who becomes deficient in glutamine lots
of different people will become
deficient of course if you are not
getting enough protein in your diet if
you're not getting sources of protein
from glut that has glutamine in them so
meat is going to be your biggest source
here typically typically people that are
vegan or vegetarian are going to have a
much harder time getting enough
glutamine in their diet if you are a
elite athlete and and you are always
training you're also probably going to
have a leaky gut and your gut is going
to be sucking up all your glutamine in
your gut itself to try to help fuel it
not a lot's going to get into your brain
and make glutamate and then very little
is going to get over to Gaba so you're
going to be Gaba deficient you're not
going to sleep well you're going to feel
irritable all the time you're um you're
going to have stress you're going to
feel anxious you're going to feel
depressed and like this is something
that a lot of athletes will complain
about if they're overtraining I mean
it's it sounds like it's a vicious cycle
too like you you become depleted in it
so then you don't sleep well so then you
become more depleted in uh you know all
these other things defeted in Gaba and
then you're trying to like fuel that
system and it's just like the spiral
yeah yeah and just to mention also like
to convert from glutamate to Gaba you
need magnesium you need Vitamin B6 so if
you're deficient in magnesium or
deficient in vitamin B6 you're not going
to convert glutamate to Gaba well and
that whole system is going to get mucked
up and you're GNA have more glutamate
and the most common example of people
that have glutamate is monosodium
glutamate or MSG right so if you go to a
Chinese restaurant and the food's
sweeter than you anticipated and you
immediately get a headache that's
because you have suddenly a huge
preponderance of glutamate compared to
Gaba and as a result of that you have
this headache that typically will happen
as a result of that excitability that
happens because of too much GL too much
glutamate so that's just something to
think about yeah no I I've used that
reference a lot yeah um sometimes it
really upsets people because I think
that it's the uh they like their MSG or
whatever but and I'm not even saying
it's good bad or ugly it's just what it
does right it's just like and I've
noticed personally anecdotally if I have
MSG I don't sleep for a couple days like
I mean it's bad right like I know when I
had Ms have MSG to the point where like
I'm getting weird dreams and I'm waking
up multiple times it's I'm very
sensitive to it and I'm very aware of it
and there's a lot of people I've seen
even in the comment sections when i'
done videos talking about that that have
very similar experiences yeah and so
just building up the glutamate right and
then you might have a harder time
because you might be on the depleted
side on the Gaba to replenish your Gaba
fast enough if you're depleted in
vitamin B6 or magnesium if you're highly
stressed if you have an infection so
we're talking about infection before
infection is also going to deplete
everything too it's going to be harder
for you to maintain your Gaba levels all
that going on too so if someone is let's
say they're restricting calories yeah
and they're having a hard time getting
enough protein in to begin with or maybe
they're unaware of it right because it
just happens sometimes um Can glutamine
supplementation help support this
because there's a lot of controversy
there because in the in the athletic
World glutamine has kind of been like
it's worthless don't bother with it
especially in the muscle building world
because it doesn't contribute to muscle
protein synthesis hardly at all um and
you know at the end of the day it's just
no just you know eat your meat whatever
so is there actually a practical app for
taking a glutamine supplement in that
case so my perspective here is that
glutamine is a great fuel for your
colonocytes or your colon cells and so
it's really important to fuel those with
a good amount of glutamine but the
problem is if you use glutamine to
repete Gaba you have a number of
different steps along the way so I don't
typically go that route I make sure
they're getting good amounts of
glutamine in their diet but I probably
wouldn't supplement with glutamine as my
way of increasing Gaba I would likely be
making sure they have vitamin B6 making
sure they have magnesium but then I'd
find natural ways to improve Gaba
production there's a number of different
ways to do that both pH
pharmacologically you know or supplement
wise um and natural herbals and things
like that and fungals even from a
certain mushroom that I was mentioning
before um or you can actually look at
various ways to enhance your gap of
production by things like meditation or
breathwork which also do what we're kind
of been dancing around here is that
balance your sympathetic and
parasympathetic nervous systems right if
you're always sympathetically dominant
you're going to deplete you know most
everything including Gaba so but what
you can do is you can enhance Gaba
production and the amount of Gaba in
there by becoming more parasympathetic
so by finding ways to relax of course by
meditation with breath work with yoga
there's actually been studies on yoga
increasing Gaba in the brain um exercise
to some degree can actually increase
Gaba as well because it helps balance
out the the the the balance the ratio
between glutamate and Gaba as well if
it's not if you're not overtraining as
well so but from uh from my perspective
I don't typically replete glutamine Gaba
by giving glutamine I will give
glutamine to people that are under high
stress that that their guts toxic they
have leaky gut that they just had
surgery and they're just they're just
kind of they need a lot more glutamine
if that's the case to help maintain
their gut lining I'll also do it one of
the interesting tricks that you may not
know about is that if you can if you're
young if you're over if you're about 30
years or younger and you can take
glutamine for about 30 days and it will
seal up your gut it's pretty well known
that you'll do that which if you have a
leaky gut and if you can take glutamine
at high doses for about 30 days you can
actually seal up your gut so I'll use it
for that reason but if I'm looking at
balancing out the Gaba system I'm
looking at the co-actors Magnesium B6
and I'm thinking about how I can give
Gaba directly typically so without going
into territory that we're not able to
talk about on YouTube yeah let's call it
an umbrella term of talking about sort
of an adaptogenic effect right um how
does that essentially work so when I say
adaptogens uh things that help regulate
those neurotransmitter functions right
like I mean common adaptogens it's not
necessarily related to this topic
that people heard of ashwaganda theyve
heard of Rola things like that are
adaptogenic and I know you mention you
know fungus and things like that yeah
what are some ways that people can
influence Gaba while still keeping it PG
for the sake of YouTube of course PG I
like PG so we have kids we have to keep
things PG we know how it do so when it
comes to Gaba you can think about Gaba
is um has a receptor in the brain it's
called the Gaba receptor shocking right
and the Gaba receptor Gaba can Bine to
the receptor ctor itself and increase
the amount of neurot neurotransmission
excuse me related to Gaba so what that
means is that actually when Gaba binds
the receptor it prevents the neuron that
it bound to from firing so that's what I
mean by calming down neuros system the
whole system from firing so you can have
Gaba actually itself bind or you can
actually have other things bind what are
called alisic sites to the Gaba receptor
that's a fancy word for meaning a
different site on the Gaba receptor can
bind something and then as a result of
it binding them if it's a positive
alisic modulator what's going to happen
is that it's going to positively affect
Gaba binding and then Gaba is going to
bind more and as a result of that you're
going to have less firing of that neuron
because you have more Gaba that's bound
so some of the most common things that
we use from an herbal perspective are
things like valan route everybody's
heard of valan valan is a is a positive
alisic modulator to the Gaba Gaba
receptor you take Gaba excuse me you
take valan and it can help you sleep
because valan is very well known to help
with relaxation and improve Gaba another
one that we know very well is Cava Cava
actually binds to another alisic site on
the Gaba receptor and Cava is from the
Cava root Cava plant from South the
South Pacific has been around for
thousands of years for stress for
relaxation it's enhancing the Gaba
system we also have something called
agarin agarin is a it's a Gaba Agonist
which means that it actually binds to
the Gaba site itself and this is really
cool agarin from the amonita musara
mushroom so it's a mushroom that's
gotten very famous from Allison
Wonderland and from mythology about
Santa Claus and causing psychedelic
experiences but it has two molecules in
there in the mushroom it has something
called agarin and has something called
ibotenic acid ibotenic acid is
neurotoxic that's what causes the
Psychedelic experiences but this other
one called agarin is a
fantastic compound for sleep because
it's a long acting Gaba Agonist it stays
on the Gaba receptor for a while it
increases Gaba firing so you have this 8
to 10 hour hours of a halflife so you
have a whole night where you can
actually get good sleep using something
like agrin or something to support the
system along the way there's other
there's other molecules and compounds
too um but the key to also just mention
is that there are some Pharmaceuticals
that are well known to be have a very
high affinity for the gab receptor that
you need to avoid things like
benzodiazapines and alcohol and
barbituates quids if anybody's old
enough to remember those but um but
those all actually bind to the Gaba
receptor as well but the difference with
those is that they're such a high
affinity for the binding and their pH
pharmacologic that you know there's a
high risk for tolerance for withdrawal
for for having bad side effects from
those drugs naturally enhancing the Gava
system with some of these other things
has has really shown to be very safe
overall interesting so and people might
look at this and they say okay well um
you know maybe from a performance aspect
and I asked this question like could
this be counterproductive like the uh
you know almost like a a sedatif like
effect and you know your answer with
that was pretty interesting and
it sounds like you can actually
potentially improve performance by
increasing that or parasympathetic tone
I think a lot of us are I'll use myself
as an example like if I'm running hot
like and I'm I have a hard time
diaphragmatically breathing I have a
hard time like I think we've all
experienced like when we go to the gym
and it's like why did my heart rate
immediately just go to 140 it's just
like you know you're just boom like you
start on the assault bike and you're
there right um compared to like oh this
is a day when I can get this good breath
and and that so it's not just something
to maybe l get to sleep like there's
there's daytime applications right yeah
I mean we all need Gaba throughout the
day as well and because it's that
balance between your sympathetic and
parasympathetic nervous systems the key
as you know is that when we work hard
for Recovery we need to get as
parasympathetic as fast as possible to
be able to give our body the time to
recover so that's why the worst thing
you can do at the gym as you know is if
you do your hard lift and then you're on
your phone like scrolling and doing this
and like just sympathetically just going
crazy right you need to be thinking
about your breath and calming down so if
you you have more Gaba on board you're
going to be able to change over to
parasympathetic faster as opposed to
taking longer to recover so it's well
known that this balance is hugely
important for Recovery it's hugely
important for performance as well and of
course if you're taking something that
to enhance Gaba system you may want to
take it at night because it may make you
feel more relaxed it may make you feel
more tired it may decrease stress you
can also tight treat the dosing and and
and you know I have a company called
transcriptions that that you know that
has these things called trokies that
that are tight tradable so you can start
off with a small amount like a quarter
then a half then a full and then kind of
figure out where your dose is we have
one particular compound that I forgot to
mention called nicotin Gaba and this is
a vitamin B3 attached to a Gaba molecule
and what's nice about this is that what
I didn't mention is that Gaba
supplements don't work if you take a
Gaba supplement over the counter Gaba
itself is too big of a molecule to get
across the blood brain barrier on its
own so Gaba supplements don't typically
work unless you have a leaky gut and
that means you have a leaky brain people
get scared when I say a leaky brain but
all I mean there is that you have a
leaky gut and so if people take Gaba
supplements and they're feeling much
more calm and relaxed on them it could
mean that their gut is leaky and that
their brain their bloodb brain barrier
is not working as well and so just to be
aware of that you if you're taking Gaba
supplements they don't typically work
and that's why it's really important to
find other things like the ones we've
been talking about your Cava your agarin
your um your your Valic acid and then
the something called nicotin Gaba that I
was just mentioning that's attached to a
vitamin B3 when it's attached to a
vitamin B3 gets across the blood the
yeah excuse me it gets across the blood
brain barrier and when it does that um
you have amount of Gab in there and you
have some vitamin B3 which is actually
nice because vitamin B3 is mildly
activating and so you don't feel too
tired on it so for people that want to
take some Gaba during the day but don't
want to feel tired this vitamin B3
attached to a Gaba can be pretty cool we
have a product called troom at
transcriptions that has this vitamin B3
attached to a Gaba it has Cava that can
help relax you without having without
making you feel like you're tired
because it has that vitamin B3 attached
to the Gaba molecule so you can take it
during the day if you're feeling
stressed but you don't want to feel
tired and you can actually titrate your
dose a quarter a half or a full of our
Troi it's called a buckle Troy goes
between upper cheek and gums and
dissolves and you can kind of figure out
where that sweet spot is for you so
sometimes what I'll do just take the
edge off is I'll just take a quarter and
then taking that edge off is just making
your brain feel better because we were
talking about the sympathetic
parasympathetic balance if you're
sympathetically dominant it's like being
in front of a huge room of people and
forgetting all your lines to your speech
to your whatever you're going to be
performing your brain is so
sympathetically dominant you can't
remember but as soon as you take the
edge off just a little bit you can think
again you can speak your words come out
much faster and more fluid and all those
kinds of things too so it's really nice
to have ways to modulate the Gaba system
without potentially making you feel
tired along the way and the way that
I've described what you're like talking
about is have you ever been driving down
the the freeway and you're having a
conversation with someone and you're all
of a sudden you see you just whiz past a
highway patrol and you're having a
conversation and you look in the rear of
your mirror and you see that and
sympathetic tone increases drastically
because you like look down on the
speedometer and you're like you know yep
you completely forget what you were
talking about and like it's completely
like everything just goes away real
quick right and it takes you a minute to
like come back from that and I use that
because everyone's kind of had that
experience just like you're having that
conversation you're like oh crap like
and that's a perfect example of like
what's happening sort of at like a uh
perhaps a more moderate rate you know or
moderate example I guess you know just
every day life when you're just kind of
stressed and all it takes you know
you're sitting at this level of
sympathetic tone all it takes is this
much more to push you over that edge
it's like you're all kind of flirting
with that zone all the time all the time
yeah like if your kid if your kid
suddenly starts screaming it's a good
example too like if you have a kid at
your home you're doing whatever maybe
you're cooking dinner and all of a
sudden you just hear like this blood
curdling scream like everything is just
goes blank right your mind goes blank
your sympathetic dominance goes way up
and as a result of that like your mind
is like you had no idea like you're
cooking you forget everything that you
were just doing it's same thing so if
you can take that edge off just a little
bit you can actually start thinking
again right and obviously breathing is
important and finding ways to learn how
to distress yourself but if you're in a
pinch it's nice to have kind of things
along the way that can help you and you
know for sleep as well I mean we have a
huge epidemic of people that can't sleep
anymore because I think it's about 20%
of the US population has some sort of
element of sleep related disorder and
they can't fall asleep they can't
maintain sleep or they wake up feeling
not rested and a lot of this I found at
least in clinical practice is that if
you can optimize vitamins minerals and
nutrients that goes a long way so your
magnesium level is your B6 but if you
can give them a little bit of Gaba along
the way and again not Gaba
supplementation maybe some of these
other uh these other compounds that
we've been mentioning we have something
called troz which is for sleep at
transcriptions and it's these it's eight
ingredients and all almost all of them
are working on the Gaba system in
various ways to help modulate it to help
improve it to help balance it so you
have more Gaba that can last you
throughout the evening so you can go to
bed you can maintain your sleep and you
can wake up feeling rested and it's it's
a fantastic formula especially for
people traveling jet lag if uh you know
for me personally I have a hard time
with induction sometimes that's usually
your type a brain people and like they
just can't once I fall asleep I'm good
so actually I can use troom for that
because it just quiets my mind enough
that I can fall asleep as opposed to I
have no trouble maintaining but I have a
lot of people that I work with that wake
up in the middle of the night and
they're just like looking at the wall
and they like their brain starts going
on fire and this is a there's like a
sympathetic spike it might be cortisol
actually that's doing this in a lot of
people but if you can actually have
enough Gaba in the system so Gaba helps
you maintain sleep so if you get these
spikes you won't wake up like so for
example we're talking about like vivid
dreams for example people will wake up
in their dreams because they're so vivid
but Gaba is helping you from not waking
up during your dreams because otherwise
you'd be acting at your dreams in
various ways which would be uncool as
you know so you w't have enough gab in
the system and of course there's
serotonin so you want have enough
serotonin we have 5 HTTP in that formula
we have a little bit of melatonin as
well there's some controversy on
melatonin but in general melatonin is a
fantastic way for Sleep induction helps
you get to sleep and also as we get
older we have less melatonin around U
that to help us maintain sleep so we
think there's in some people that wake
up in the middle of night there's a big
melatonin dip and that's one of the
reasons why they wake up so it's a
pretty comprehensive sleep formula but
in essence what we care about you know
what I care about as a clinician is like
what am I doing to fully optimize the
system so that it can stay maintained
over the long term and hopefully get
them off Gaba supplementation not Gaba
itself we talked about that that doesn't
work but things that enhance the Gaba
system and that's what I try to do with
all my patients and you know my my
company the transcriptions company is we
were founded initially as a nonprofit
organization training doctors and
practitioners on how to optimize health
and so our goal really is to get people
off of supplements and get them off of
things that help that are helping that
are exogenous that you can which I mean
is that you're actually taking instead
you're actually supporting a system with
good nutrition good diet sunlight
exposure you know light water magnetism
all that stuff right but on the path to
optimizing Health we all need help along
the way and these are things that can be
really really helpful so we can help you
sleep now we can help you with an with
your anxiousness now while you're on
that path to truly trying to optimize
your health over the long term I think
like one of the things that people don't
realize like there's so many people like
I'm all for living as close to the Earth
as possible Right but it's also not
always practical in today's world
because we're in climate controlled
environments we're in artificial light
we're in like I don't think there's like
for example I mean say what you want
about the guy but like Dave asprey takes
all these different supplements right
and people I see people like raining on
him his argument is always pretty honest
and pretty real it's like okay if you
want to have an honest approach to uh
you know living close to the Earth then
you need to be living out in the middle
of nowhere in the actual Woods living
close to the Earth yeah because it's the
only actual way so when you look at
these things like sometimes you do need
that intervention to get you started and
like you know I've been in situations
where I've been in sympathetic overdrive
for so long that you can't find your way
out of of it right and you're only going
to do yourself so much by saying okay
well I'm going to eat a certain way I'm
going to
it's you're going to drive yourself
crazy if you don't eventually have a
little bit of intervention whether it's
you know supplemental or you know
pharmaceutical or whatever it needs to
be to break that cycle and I think
people need to be okay with that knowing
that hey maybe this isn't a permanent
thing and if it allows you to get from A
to B to maybe to C to where you can
actually start deploying those lifestyle
interventions then you can eventually
move on it's so beautifully sad because
always talked about this with my
patients we need resets we just in in
life the way it's LED now with the
stress and the environment everything
you just described we just need reset
sometimes to get us off a train that is
going 100 miles an hour that we can't
stop and so sometimes these
interventions are really important and
sleep is a big one for people if people
don't sleep everything goes wrong and
their immune system is tanked their mood
is tanked their relationships are tank
their work is going to tank and so if
you can just reset their sleep but also
you know what's cool about tro and the
way we formulated this is it doesn't
mess with your sleep architecture so
sleep architecture is your stages of
sleep you have your deep sleep or you
have your REM sleep and your non-rem
sleep right your non-rem sleep is your
stages of sleep that's four of those
stages two of the last stages are deep
and you have your REM sleep which is
your your dreaming sleep right and what
happens a lot of times is that if you
take some of these pharmaceutical drugs
or you have something like for example
it messes up the Sleep architecture so
you don't get a lot of deep sleep on
these drugs and so in the short term
might be okay because you're actually
getting to bed somewhat but it's
actually ruining your sleep architecture
so you want to try to find things that
are going to naturally support your
sleep architecture we have one
ingredient in tros called corpin and
corpin is from the mushroom Corps
everybody knows mushroom Corps now from
the show The Last of Us on HBO that
takes and makes you a zombie but corpin
will not do that it does it to ants
actually so actually it's a real thing
in ant so this Corps mushroom will take
over the brain of of an ant and then
take control of it and make it a zombie
and it's actually a thing but corpin is
a fantastic mushroom uh it's the active
form of the corp's mushroom that helps
with deep slow wave sleep and it's well
regarded in that capacity it also has
interesting potential capacity for
immune system function for uh for
insulin regulation um they're using it
as an anti-cancer at high doses and
studies it's really interesting but so
you want to support your natural sleep
as much as possible it's and supporting
Your Capacity to have all of those
stages so be careful what you take
because some things might get you to bed
but might still have trashed sleep and
things like and like your benzo diazines
for example are examples of those even
alcohol is perfect example of course how
could I forget common one right yeah
alcohol trashes your sleep you get no
deep sleep on it most people wake up
after a couple hours and you know
trashes your immune system and so
alcohol definitely should be avoided for
sleep for sure yeah I mean if we
circumnavigate like kind of everything
here like independent of even the tros
scription stuff
what places or things should people be
putting in place
to influence Gaba as much as possible
just sort of as a end result of all this
conversation like what are the takeaways
that people can really deploy today well
I mean what comes to mind first is slow
the down everybody's got to slow down a
little bit right and because if you can
find ways to become more parasympathetic
if you find ways to relax more even if
it's just for five minutes at a time you
are going to start improving your
balance between this glutamate the
excited T your transmitter and Gaba so
that could be breath work it could be
yoga it could be light stretching it
could be um it can be just getting out
in the sunlight actually just relaxing
the body for a little while is going to
improve your Gaba capacity then you want
to think about are you giving yourself
the building blocks that are going to
make Gaba right are you getting good
sources of vitamin B6 in your diet are
you getting good sources of magnesium in
your diet I think like you know I was we
were talking about before with you know
being people being on this freight train
uh and just having so much stress and
not being able to calm down and like
they're trying so hard with their
nutrients and their diet but like it's
really hard to find uh most people are
magnesium deficient most people I think
80% of the US population I might be
slightly wrong there but it's it's high
it has some sort of element of magnesium
deficiency and your vitamins and
minerals like the foods that we're
eating now about 20 or 30% of the amount
of nutrients that they used to have 50
years ago so the the nutrient depletion
in our soil is real so um but you still
want to focus on nutrient-dense foods
that are going to help support the
system
so what are you thinking about you like
glutamine containing foods talking about
magnesium containing foods right this is
usually you know meat is the easiest way
to get this stuff and an organ Meats is
and liver is going to be probably your
best form of all this stuff because it's
going to be all activated and all ready
for you especially your B vitamins so
you want to be thinking about your diet
um making sure you're getting good
sources of glutamine you want to think
about um your lifestyle where you're
trying as much to be as par sympathetic
as possible finding breaks in your day
to try to relax and finding things that
you like that are relaxing so taking
recovery days um taking phone holidays
is a great one too because you know
we're always on our phones doing this
and our minds are always racing but it's
that's also depleting your excited toour
our neurotransmitters including
glutamate and you're you're also
depleting Gaba as well so you want to be
thinking about getting par sympathetic
working on your diet working on your
lifestyle and then supporting it with
things that are going to improve Gaba
and these are things that we've been
discussing already your herbals your
fungal um your ways to help improve your
sleep and your anxiousness throughout
the day
um that are just kind of supporting the
whole system but of course like you
don't want to do anything in a vacuum
you want to try to be think about doing
everything but not everybody's ready to
change their diet change their lifestyle
um so having some additional ways to
calm the system down immediately is
really helpful and then hopefully the
way I think about things in clinical
practice is that once people start
feeling better like oh it's not so bad
to have a recovery day it's not so bad
to have a little bit more gab around
maybe I want more of this maybe I can
change my diet maybe I can change my
lifestyle maybe I don't have to train 70
hours a week maybe I can train 30 and
still make gains and still have a better
balance as a result of that yeah and you
know one more thing before we wrap this
up that was very interesting when you
mentioned you know the phone sort of
even depleting like taking the phone
break are there parallels between things
that uh you know are taxing on our our
dopamine compared to Gaba like do they
do they seem to operate in tandem or
things can specifically deplete uh Gaba
that aren't necessarily influenced by
dopamine I mean it sounds like a lot of
the things that are also depleting Gaba
are also these high dopaminergic kind of
things yeah that's a great question I'm
glad you asked it because the amazing
thing about Gaba is that it is
everywhere in the brain okay it's widely
distributed in all areas of the brain
and but specifically it has this one
particular function in most locations
it's called an inter neuron i n t r
neuron which means it's between neurons
so it's actually between a lot of these
serotonergic and dopamine dopaminergic
neurons and regulating the flow of
information so if you are massively
taxing your dopamine system you're also
taxing your Gaba system because your gab
is trying to prevent the firing of all
this stuff that you're looking at like
oh God I'm looking at the next cat video
and oh God the next keto video and
whatever like and and Gaba is trying to
keep up yeah trying to keep up with you
because dopamine and serotonin and and
these neurons are being modulated by the
Gaba system so gab is so important for
learning for memory for skill
acquisition um and of course what really
important for skill acquisition but
dopamine as well but what Gaba does it
actually tries to stop all the firing
like and trying to regulate the
information that's coming in so you
actually can learn and so it's if you're
depleting dopamine you're depleting Gaba
to is what it comes down to yeah because
what what I've always heard is a a calm
brain is a fast brain yes yeah and it's
like the idea is people like cinate
cavate go go go go go it's like
sometimes it's just the opposite it's
like being able to calm you know and
it's like I work with the Special Forces
operat a lot this is exactly what they
teach them right it's not about amping
up you don't see a lot of marksmen going
forward and and like pounding caffeine
right that's not how they want their
brain to operate and I think if we could
all kind of take a lesson from that
right it's like when you look at the
things that make you feel good aren't
always the things that are are truly
good for you so it's like you have this
discussion I had this discussion a lot
with people say well you know like being
on my phone calms me down it's relaxing
and it's like well there's a difference
between
something that is pleasure seeking
behavior and what is genuinely relaxing
because I think we do deficient that's
problem that they're going for that
dopamine hit to get to some sort of
Baseline that they're missing I mean I I
love the the oper the uh The Operators
because what we talk about in our
company a lot is uh and just personally
in my in my practice is relax control
right the idea is that you're in control
of the situation but you're relaxed into
it right you're part of the situation
but you're not because you're
overstressed you're not going to be
operating at the highest level that you
want to be and so the deal with fully
looking at a whole person is looking at
yes we can give them supplementation we
can change their diet but like we have
to change their psychology and saying
the psychology is this we want to be in
a relaxed control we want to be free
from suffering of anxiety and stress and
depression of course but how do we do
that we have to start with the reversing
of the psychology of what it means to be
in those States and start there and then
build from there that's what we
typically do Amen to that man well Scott
where can everyone find you man so yeah
our compan is called tros scriptions
it's the word prescription and Troy in
the opposite way so Troy and
prescriptions together tros scriptions
we make something called a buckle Troi
and it dissolves from your upper cheek
and gums and dissolves over about 15 to
30 minutes what's nice about that is
that it goes directly into the brain
circulation and hits you in about 50 15
to 30 minutes so you get an initial feel
in that time frame and you don't have to
go through digestion when you digest
things it takes longer and people have
leaky guts and it may not work as well
so you can get a buckle Troy here
dissolve 15 to 30 minutes later getting
getting the effect so the company is
called tros scriptions it's tros
scriptions
docomo and yeah I mean we have a number
of different products we have one for
anxiousness and stress it's called troom
we have one for sleep it's called troz
shockingly but um yeah go check it out
and we have a great amount of
information on our website I write most
of the blogs myself uh with all the
scientific information we have a good
jetlag protocol for example that's great
we have great information all the
ingredients and all of our products and
it's just a really fantastic company to
be with because our focus is to help
people right now but we have a nonprofit
organization that's training doctors and
practitioners on how to optimize health
and this is part of my own clinical
practice working tele medicine wise with
people all over the world helping
optimize their health over the long term
while we're helping them now with
transcriptions right on man well as
always thank you brother thank you
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