Does Primobolan Act As An AI? Estradiol Blood Work Before And After

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6 Oct 202007:19

Summary

TLDRIn this video, Derek from Placementrates.com discusses the impact of adding 200 milligrams of Primobolan to a testosterone regimen on estrogen levels. He uses the example of 'Vigorous Steve' to illustrate how Primobolan, a DHT derivative, can act as a natural anti-estrogen by competing with testosterone for binding at the aromatase enzyme. This competition may reduce the need for aromatase inhibitors (AIs) and affect the design of hormone protocols, providing insights into optimizing health and performance.

Takeaways

😀 The video discusses the effects of Primobolan (primo) on estrogen metabolism, using a case study from 'Vigorous Steve'.
🔍 'Vigorous Steve' followed a TRT protocol with 250mg of testosterone per week and used DHEA and Pregnenolone to backfill steroidogenesis pathways.
📉 When 'Vigorous Steve' added 200mg of Primobolan to his regimen, his estradiol levels dropped from 73 to 38.4 pg/mL, despite the same dose of testosterone.
🤔 The drop in estrogen levels suggests that Primobolan has anti-estrogenic properties, similar to Masteron, which inhibits estrogen-induced RNA transcription at the receptor site.
💡 The script suggests that Primobolan and other DHT derivatives may compete with testosterone for binding to the aromatase enzyme, thus affecting estrogen production.
🚫 It's important to consider the inherent anti-estrogenic effects of anabolic steroids when designing a protocol to avoid unnecessary use of AIs (Aromatase Inhibitors).
💡 The use of DHT derivatives might negate the need for AIs or allow for higher doses of aromatase substrates without inducing estrogenic side effects.
📚 The video emphasizes the importance of understanding how hormones interact in the body to design optimal protocols for performance enhancement and health.
🔄 The script highlights that Primobolan's interaction with aromatase is more complex than previously thought, involving competitive binding rather than no interaction at all.
📈 The case study indicates that Primobolan has a built-in anti-estrogenic component, which is worth considering when using it for performance enhancement.
👍 The video encourages viewers to subscribe, follow the blog at placementrates.com, and engage on social media for more in-depth discussions on hormone interactions.

Q & A

What is the main topic discussed in the video script?
-The main topic discussed in the video script is the interaction of Primobolan (a type of anabolic steroid) with aromatase and its effects on estrogen metabolism.
Who is the person mentioned as sending their blood work results for discussion?
-The person mentioned is 'Vigorous Steve', who is known on YouTube and has sent his blood work results to Derek from placementrates.com.
What is the significance of the blood work results shared in the script?
-The blood work results are significant as they demonstrate a decrease in estrogen levels when Primobolan was added to the user's protocol, providing insights into the anti-estrogenic effects of Primobolan.
What is the role of DHEA and Pregnenolone in the context of the script?
-DHEA and Pregnenolone are used to backfill steroidogenesis pathways that may be deficient due to the use of exogenous hormones, helping to maintain hormonal balance.
What was the initial estrogen level before adding Primobolan?
-The initial estrogen level, specifically estradiol, was 73 picograms per milliliter before adding Primobolan.
What was the change in estrogen level after adding 200 milligrams of Primobolan?
-After adding 200 milligrams of Primobolan, the estrogen level dropped to 38.4 picograms per milliliter.
What are DIM and Calcium D-Glucarate, and why were they added to the protocol?
-DIM (Diindolylmethane) and Calcium D-Glucarate are supplements that were added to the protocol to control estrogen levels as a natural, over-the-counter means of handling estrogen metabolism.
How does Primobolan affect estrogen metabolism according to the script?
-Primobolan appears to have an anti-estrogenic effect, possibly by competitively binding to the aromatase enzyme, thus reducing the conversion of testosterone into estradiol.
What is the takeaway message regarding the use of Primobolan in hormone protocols?
-The takeaway is to consider the anti-estrogenic component of Primobolan and other DHT derivatives when designing hormone protocols, as they may reduce the need for additional anti-estrogenic drugs.
What does the script suggest about the interaction of DHT derivatives with aromatase?
-The script suggests that DHT derivatives, such as Primobolan, may have a competitive action for binding with the aromatase enzyme, affecting estrogen metabolism at the enzyme level itself.
Why is it important to understand the interaction of hormones in the body as discussed in the script?
-Understanding the interaction of hormones in the body is important for designing optimal protocols that are conducive to one's goals and health, and for maximizing progress while minimizing potential side effects.

Outlines

00:00

💉 Hormonal Impact of Primobolan and Aromatase Inhibition

Derek from placementrates.com discusses a case study involving 'Vigorous Steve', who shared his blood work results. The video focuses on the hormonal effects of Primobolan (primo) and its interaction with estrogen metabolism. Steve's TRT protocol included 250mg of testosterone per week, along with DHEA and Pregnenolone to support natural hormone production. When he doubled his DHEA and Pregnenolone dosage and added 200mg of primo, his estradiol levels dropped from 73 to 38.4 pg/mL, despite the same dose of testosterone. The video suggests that primo, like Masteron, has anti-estrogenic properties that inhibit estrogen-induced RNA transcription at the receptor site, thus reducing estradiol levels. This insight is crucial for those considering the use of DHT derivatives in their hormone protocols, as it may reduce the need for aromatase inhibitors (AIs) or allow for higher doses of substances that are substrates for aromatase without causing estrogenic side effects.

05:02

🔬 Aromatase Enzyme Interaction and Estrogen Metabolism

This paragraph delves deeper into the interaction of DHT derivatives, such as Primobolan, with the aromatase enzyme and estrogen metabolism. It challenges the previous assumption that because DHT derivatives are not substrates for aromatase, they do not interact with the enzyme at all. The video posits that there is a competitive action for binding at the aromatase enzyme level, suggesting an inherent anti-estrogenic component in DHT derivatives. The discussion emphasizes the importance of understanding these hormonal interactions for designing optimal protocols that balance performance enhancement with health considerations. Derek highlights the need to consider the built-in anti-estrogenic effects of anabolic steroids when formulating a hormone protocol, as it may influence the decision to use AIs or the dosage of other hormones. The video concludes with a teaser for a more detailed exploration of the topic in a future video.

Mindmap

Keywords

💡Primobolan

Primobolan, specifically Primobolan Depot, is an anabolic steroid that is less androgenic than testosterone and is used to promote muscle growth and strength. In the video, it is mentioned that adding 200 milligrams of Primobolan to a regimen resulted in a significant drop in estrogen levels, indicating its anti-estrogenic properties.

💡Estrogen

Estrogen is a group of hormones responsible for the development of female secondary sexual characteristics. In the context of the video, it is discussed how Primobolan and other DHT derivatives can affect estrogen levels, with a focus on estradiol, the most potent form of estrogen, which is linked to various health issues when levels are too high.

💡Testosterone

Testosterone is the primary male sex hormone responsible for the development of male reproductive tissues and promoting secondary sexual characteristics. The script discusses how testosterone interacts with the aromatase enzyme to convert into estradiol, and how Primobolan may affect this process.

💡Aromatase

Aromatase is an enzyme that catalyzes the conversion of androgens like testosterone into estrogens. The video explains how Primobolan and DHT derivatives may competitively inhibit the aromatase enzyme, thus affecting estrogen production.

💡Estradiol

Estradiol is the main form of estrogen in humans, particularly in males where it is derived from testosterone. The video script highlights a case where estradiol levels dropped significantly with the addition of Primobolan, suggesting its anti-estrogenic effect.

💡DHEA

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands that can be converted into both androgens and estrogens. In the script, DHEA is mentioned as part of a protocol to backfill steroidogenesis pathways that may be deficient due to the use of exogenous hormones.

💡Pregnenolone

Pregnenolone is a hormone produced in the adrenal glands and serves as a precursor to other steroid hormones. The video mentions the use of pregnenolone alongside DHEA to support hormone production in the body.

💡DIM (Diindolylmethane)

Diindolylmethane (DIM) is a compound found in cruciferous vegetables that is believed to help the body process estrogen. In the video, it is mentioned as part of a regimen to control estrogen levels naturally.

💡Calcium D-Glucarate

Calcium D-Glucarate is a compound that helps the body get rid of excess estrogen through the liver. The video script discusses its inclusion in a health protocol to manage estrogen metabolism.

💡Anti-Estrogenic

Anti-estrogenic refers to the property of a substance that opposes the effects of estrogens. The video explains how Primobolan and other DHT derivatives have anti-estrogenic effects by competing for binding at the aromatase enzyme, thereby reducing the conversion of testosterone to estradiol.

💡Masteron

Masteron, or Drostanolone Propionate, is an anabolic steroid that is known for its ability to significantly inhibit estrogen-induced RNA transcription at the receptor site. The video script compares the anti-estrogenic effects of Masteron with those of Primobolan.

Highlights

Derek from placementrates.com discusses the interaction of primobolan with aromatase and estrogen metabolism.

Vigorous Steve's blood work results show a significant drop in estradiol levels when adding primobolan to his TRT protocol.

Primobolan's anti-estrogenic effect is compared to that of masteron, which inhibits estrogen-induced RNA transcription at the receptor site.

The addition of 200 milligrams of primobolan led to a decrease in estradiol levels from 73 to 38.4 pg/mL.

Primobolan and DHT derivatives may compete for binding with aromatase, affecting estrogen metabolism.

The importance of considering the anti-estrogenic component of anabolic steroids in hormone protocols is emphasized.

Use of calcium D-glucorate and DIM for controlling estrogen levels in conjunction with anabolic steroids.

The potential for DHT derivatives to negate the need for aromatase inhibitors (AIs) in certain protocols.

The impact of DHEA and pregnenolone supplementation on steroidogenesis pathways and estradiol levels.

The role of estradiol, estrone, and estriol in assessing hormonal balance and the effects of anabolic steroids.

The concept that EQ and primobolan may not act as AIs but still have anti-estrogenic effects at the aromatase enzyme level.

The idea that DHT derivatives might competitively inhibit testosterone from aromatizing into estradiol.

The practical implications of understanding hormonal interactions for designing optimal protocols.

The potential health benefits of maximizing progress while maintaining health through smart hormonal protocol design.

The importance of not overlooking the inherent anti-estrogenic properties of certain anabolic steroids.

A call to action for further exploration of the blood test results and hormonal theories in an upcoming video.