The H pylori and SIBO Connection (Including New Research)
Summary
TLDRIn this health-focused video, Dr. Daniel Richardi explores the link between H. pylori and small intestinal bacterial overgrowth (SIBO). He discusses recent research suggesting H. pylori may increase SIBO risk, particularly in younger individuals. The video also examines the effectiveness of a common H. pylori treatment, quadruple therapy, in treating SIBO, showing a 66.7% remission rate. Dr. Richardi highlights the potential cost-effectiveness of this therapy compared to other SIBO treatments, providing valuable insights for those seeking to improve their gut health.
Takeaways
- 👨⚕️ Dr. Daniel Richardi is a health expert, licensed pharmacist, fitness enthusiast, and creator of the 'sibo shortcut' program designed to help eliminate small intestinal bacterial overgrowth (SIBO).
- 🔬 The video discusses recent research on the relationship between Helicobacter pylori (H. pylori) and SIBO, questioning if H. pylori is a risk factor for SIBO and if a common H. pylori treatment could also be effective for SIBO.
- 📊 A 2023 meta-analysis from the Chinese Medical Journal suggests that there is a higher prevalence of SIBO in individuals with H. pylori infection, with a stronger association in younger patients.
- 🦠 H. pylori is a spiral-shaped bacteria that can affect the stomach and small intestine, with the unique ability to survive stomach acid, and is estimated to be present in the majority of people at some level.
- 🏥 H. pylori overgrowth can lead to gastritis, peptic ulcers, and an increased risk of stomach cancer, but most people do not experience symptoms unless there is an overgrowth.
- 🌐 SIBO is characterized by an excessive amount of bacteria in the small intestine, causing digestive symptoms like bloating, constipation, diarrhea, and abdominal pain, as well as non-digestive symptoms.
- 💊 A 2022 study examined the effectiveness of quadruple therapy, a common treatment for H. pylori, on SIBO patients and found a 66.7% remission rate for SIBO after H. pylori eradication.
- 📉 The same study indicated that only 5% of SIBO-negative patients became SIBO-positive after H. pylori eradication with quadruple therapy, suggesting it is not a risk factor for developing SIBO.
- 💊 Quadruple therapy includes rabeprazole (a proton pump inhibitor), bismuth potassium citrate, amoxicillin, and metronidazole, taken over two weeks.
- 💰 The cost of treating SIBO with rifaximin (brand name Xifaxan) can be significantly higher than the quadruple therapy, which may be a cost-effective alternative.
- 🔍 Dr. Richardi encourages further research on the topic and suggests that the quadruple therapy may be a viable option for patients dealing with both H. pylori and SIBO.
Q & A
What is the main topic of Dr. Daniel Richardi's video?
-The main topic of the video is to discuss the relationship between H. pylori and SIBO, including whether H. pylori is a risk factor for SIBO, if a popular H. pylori treatment can also be effective for treating SIBO, and if the same treatment could be a risk factor for developing SIBO.
What is SIBO and what are its symptoms?
-SIBO stands for Small Intestinal Bacterial Overgrowth. It is a condition where there are too many bacteria in the small intestine, leading to digestive symptoms like bloating, constipation, diarrhea, abdominal pain, and gas, as well as non-digestive symptoms such as brain fog, mental health conditions, and skin problems.
What is H. pylori and how is it related to the stomach?
-H. pylori, also known as Helicobacter pylori, is a spiral-shaped bacteria that can affect the stomach and the small intestine. It has the unique ability to survive stomach acid, which many bacteria cannot do. An overgrowth of H. pylori can lead to conditions like gastritis, peptic ulcers, and an increased risk of stomach cancer.
What does the 2023 meta-analysis from the Chinese Medical Journal suggest about the link between H. pylori and SIBO?
-The 2023 meta-analysis suggests that individuals with H. pylori infection are more likely to develop SIBO, and this association is stronger in younger patients than in older ones.
What is quadruple therapy and what does it consist of?
-Quadruple therapy is a common treatment regimen for H. pylori that consists of four medications: a proton pump inhibitor (rabeprazole), bismuth potassium citrate, amoxicillin (an antibiotic), and metronidazole (another type of antibiotic), taken for two weeks.
What were the results of the 2022 study on quadruple therapy for treating SIBO?
-The study found that 66.7% of the SIBO-positive patients became SIBO-negative after the eradication of H. pylori with quadruple therapy. However, 5% of the SIBO-negative patients became SIBO-positive after the treatment, suggesting that the therapy does not increase the risk of developing SIBO.
How effective is quadruple therapy in eradicating H. pylori according to the video?
-Quadruple therapy is well-documented to work very well for eradicating H. pylori and the video suggests it may also be effective for treating SIBO.
What are the potential benefits of using quadruple therapy for treating both H. pylori and SIBO?
-The potential benefits include a two-for-one treatment approach, where eradicating H. pylori may also alleviate SIBO symptoms, and it could be a more cost-effective treatment compared to other SIBO treatments.
Why might the cost of rifaximin, commonly used for SIBO, be a concern for some patients?
-Rifaximin, or Xifaxan, can be very expensive, with some patients spending over $2,000 for a single two-week course, which can be a significant financial burden.
What is the cost comparison between rifaximin and quadruple therapy mentioned in the video?
-The video suggests that even without insurance, quadruple therapy in the United States would likely not cost more than $100, which is significantly less than the cost of rifaximin.
What is Dr. Daniel Richardi's recommendation for patients with both H. pylori and SIBO based on the discussed research?
-Dr. Richardi recommends that patients with both H. pylori and SIBO consider exploring quadruple therapy as a potential treatment option based on the research findings.
Outlines
🧬 H. pylori and SIBO Connection
Dr. Daniel Richardi introduces the video, discussing the potential link between H. pylori (Helicobacter pylori) and SIBO (Small Intestinal Bacterial Overgrowth). He outlines the video's agenda, which includes new research on H. pylori as a risk factor for SIBO, the effectiveness of a popular H. pylori treatment for SIBO, and the risk of developing SIBO from the same treatment. H. pylori is a bacteria that can survive in the stomach and small intestine, often asymptomatic unless overgrown, leading to gastritis, ulcers, and possibly stomach cancer. SIBO is characterized by excessive bacteria in the small intestine, causing digestive issues and potentially other health problems. The video aims to explore the relationship between these two conditions and their impact on health.
💊 Exploring Quadruple Therapy for H. pylori and SIBO
The video delves into a 2023 meta-analysis from the Chinese Medical Journal, which suggests a correlation between H. pylori infection and the development of SIBO, particularly in younger patients. A 2022 study is also discussed, examining the effects of quadruple therapy—a common treatment for H. pylori—involving rabeprazole, bismuth potassium citrate, amoxicillin, and metronidazole. The study found that 66.7% of patients with both H. pylori and SIBO tested negative for SIBO after treatment, indicating the therapy's potential dual benefit. Interestingly, only 5% of patients without SIBO developed it post-treatment, suggesting the therapy is not a significant risk factor for SIBO. The summary also touches on the cost-effectiveness of this therapy compared to other treatments like rifaximin, which can be prohibitively expensive. Dr. Richardi concludes by emphasizing the importance of ongoing research to provide the best recommendations for treating H. pylori and SIBO.
Mindmap
Keywords
💡Dr. Daniel Richardi
💡Small Intestinal Bacterial Overgrowth (SIBO)
💡Helicobacter pylori (H. pylori)
💡Meta-analysis
💡Quadruple Therapy
💡Proton Pump Inhibitor (PPI)
💡Bismuth Potassium Citrate
💡Amoxicillin
💡Metronidazole
💡Rifaximin
💡Gut Health
Highlights
Dr. Daniel Richard introduces himself as a health expert, licensed pharmacist, and creator of the 'sibo shortcut' program.
The video discusses three main topics: new research on H. pylori and its relation to SIBO, the effectiveness of a popular H. pylori treatment for SIBO, and the risk factors for developing SIBO.
H. pylori is a spiral-shaped bacteria that can affect the stomach and small intestine, with the unique ability to survive stomach acid.
Most people have some level of H. pylori in their body, but only experience symptoms if there's an overgrowth.
An H. pylori overgrowth can lead to gastritis, peptic ulcers, and an increased risk of stomach cancer.
SIBO (Small Intestinal Bacterial Overgrowth) is characterized by an excess of bacteria in the small intestine, causing digestive issues.
Many people suffer from SIBO symptoms for months or years without knowing they have the condition.
A 2023 meta-analysis from the Chinese Medical Journal suggests a correlation between H. pylori and SIBO.
The meta-analysis found that H. pylori infection is associated with a higher prevalence of SIBO, especially in younger patients.
A 2022 study examined the effectiveness of quadruple therapy, a common treatment for H. pylori, on SIBO.
Quadruple therapy includes a proton pump inhibitor, bismuth potassium citrate, and two types of antibiotics.
The study found a 66.7% remission rate of SIBO in patients who also had H. pylori after treatment.
Only 5% of patients without SIBO developed it after H. pylori eradication treatment, suggesting the treatment is not a risk factor for SIBO.
The study indicates that certain antibiotics used in quadruple therapy may be effective for SIBO.
Dr. Richard suggests that H. pylori could be a risk factor for SIBO and that quadruple therapy might be a potential treatment.
The cost of quadruple therapy is significantly lower than that of rifaximin, a commonly used antibiotic for SIBO.
Dr. Richard emphasizes the importance of ongoing research to provide the best recommendations for treating H. pylori and SIBO.
The video concludes with an invitation to like, subscribe, and follow for more health-related content.
Transcripts
what's up and welcome to the video my
name is Dr Daniel richardi got health
expert licensed pharmacist Fitness
Enthusiast and creator of sibo shortcut
the all-in-one program that helps you
eliminate sibo small intestinal
bacterial overgrowth quickly and easily
in this week's video we're going to
discuss three things number one brand
new research on whether H pylori AKA
helicobactor pylori is a risk factor for
sibo number two if a popular H pylori
treatment can also be effective for
treating sibo and then number three if
this same popular H pylori treatment is
also a risk factor for getting sibo very
quickly if you're not familiar with
these two conditions H pylori and sibo
helicobactor pylori AKA H pylori is a
spiral-shaped bacteria that can affect
the stomach and the small intestine one
of the unique things about it is that it
does have the ability to survive stomach
acid which is something that many
bacteria cannot do it's estimated that
the majority of people have some level
of hpylori existing in their body
however for most people unless this
level becomes in overgrowth they likely
will not experience any symptoms from it
when an overgrowth of hpylori does
happen this hpylori infection can lead
to conditions such as gastritis or
inflammation of the lining of the
stomach peptic ulcers either in the
stomach or in the upper portion of the
small intestine and it can even increase
the risk of getting stomach cancer sibo
AKA small intestinal bacterial
overgrowth is a condition where you end
up having too many bacteria in your
small intestine the majority of your
bacteria your microbiome lives in your
large intestine ideally so if you end up
with too many bacteria in your small
intestine it can cause a lot of
digestive symptoms such as bloating such
as constipation diarrhea abdominal pain
gas it can also lead to non-digestive
symptoms as well certain things such as
brain fog mental health conditions and
even skin problems unfortunately tons of
people go months or even years dealing
with sibo symptoms and if this wasn't
bad enough many of them don't even know
that they have sibo if you want to learn
how to get rid of sibo check out my
program sibo shortcut in this course I
give away all the proven science-based
strategies to heal your gut visit the
first link in the description below for
more info and now let's get back to the
video both H pilori and sibo are major
causes of a reduced quality of life for
a lot of people with that said let's
look at some research this 2023
metaanalysis from the Chinese medical
journal was just published less than 2
weeks ago a meta analysis looks at all
the past relevant medical research on a
particular topic and the idea is it
tries to give you a trend of what
generally seems to be happening in that
topic the purpose of this particular
meta analysis was to determine if you
have hpylori is it more likely that you
will also develop sibo they're probably
looking at this because hpylori has been
linked to a lot of other
gastrointestinal conditions such as IBS
such as ulcers atrophic gastritis and
coloral adenomas but up to this point
there hasn't been strong evidence that
it's also correlated with cbra the
results from this meta analysis
indicated in this systemic review and
meta analysis we pulled the results of
eight eligible observational stud
studies and found that compared to
adults without hpor infection those with
hpor infection were associated with a
higher prevalence of sibo and then it
goes on to report interestingly we found
that the association between H pylor
infection and sio was stronger in
younger than older patients for this
meta analysis it seems like having an
hpylori overgrowth will also make it
more likely that you'll develop sibo and
also in this case in this mete analysis
being younger is also worse this 2022
study also from the Chinese medical
journal studies quadruple therapy which
is a common regimen consisting of four
medications including rabi prol which is
a proton pump inhibitor which lowers
stomach acid this was taken 10 Mig twice
daily it included bismuth potassium
citrate 220 mg twice daily bismuth is
the active ingredient in Pepto Bismol
however the potassium citrate version
may be gentler on the digestive tract
than bismi silicate which is pepto
bismol it also included amoxicilin which
is an antibiotic at 1,000 Mig twice
daily and then finally metronidazol also
a different type of antibiotic but still
I would consider an antibiotic 400 mg
three times daily and this regiment was
done for 2 weeks it's well documented
that this quadruple therapy works very
well for h pylori now they're seeing if
it kind of provides that two for one
benefit where it also helps for sibo
results indicated that 66.7% or 20 out
of 30 people of the sibo positive
patients before eradication of hpylori
turned sio negative after eradication
indicating that sibo remission rate
after eradication treatment was 66.7%
while for sibo negative patients before
eradication 5% or one out of 20 people
after eradication the patient became
sibo positive there's a lot going on
here so basically this is what this
study is saying of the 30 patients that
had both H pylori and sibo to begin 20
of them became negative for sibo after
eradicating the hpylori with the krupal
therapy so 2/3 of people or 66% seem to
get this two for one benefit where it
did both also note of the 20 patients
that only had H pylori to begin and not
sibo after doing the treatment with
quadruple therapy only one out of these
20 people develop sibo two takeaways
that we're seeing are one this quadruple
therapy may be effective for sibo this
includes both hydrogen and methane
dominant so to give a further breakdown
the rate of people positive for hydrogen
went from 49% before to 15% after and
the rate of people positive for methane
went from 25% before to only 6% after
the study seem seems to suggest that you
are not at a greater risk of developing
sibo after eradication of hpylori with
this quadruple therapy I found this
relevant because there's a lot of data
suggesting that antibiotics are a risk
factor for sibo so on a surface level
this seems very surprising but if you
look a little bit deeper using
metronidazol bismuth and even research
on amoxicillin has shown that they can
be effective in their own ways for sibo
so it's not a huge shock that this
quadruple therapy seems to be favorable
in this study few conclusions from these
studies that we looked at number one H
pylori does seem to be a risk factor for
developing sibo number two quadruple
therapy which in the past has been
proven to be effective and very good for
eliminating hpylori also seems like it
may be effective for sibo and then
takeaway number three with Drupal
therapy which we looked at in the second
study does not seem to be a risk factor
for developing sibo and this is based on
the short-term followup that they did in
this study of 6 weeks knowing all this
information can be relevant because for
people with H pylori you can possibly
suspect that you may also be dealing
with sibo I'd like to continue to see
more research on this particular topic
but it seems like based on the research
that we looked at this quadruple therapy
may be an option to explore in the
future for patients that have both
hpylori and sibo the cost of treatment
may also be a potential plus different
practitioners use different treatments
for sibo but in terms of antibiotics a
product called rifaximin brand name is
zxin is probably the most commonly used
product and depending on what country
you live in what insurance you have and
a few other factors this rifaximin or
zxin can be really expensive I've known
people that have spent over $2,000 on
one single twoe course of refraim which
it's crazy that it's that expensive and
for my years of working in the pharmacy
I have a general idea what medications
will cost and this quadruple therapy in
the United States even if you didn't
have any insurance it probably wouldn't
cost you more than $100 and to be honest
it would probably be significantly less
than this I think it's exciting to keep
looking at the newest research studies
and see the new information available
this way we can keep making the best
recommendations we possibly can and help
the most people as possible that is all
for today if you enjoyed the video or
found it helpful please like And
subscribe to my channel for more related
content I post a new full length video
every Monday and YouTube shorts
throughout the week thanks so much for
watching and I'll see you in the next
video
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