HOW TO MAKE YOUR OWN OZEMPIC

Summary

In this insightful discussion, Dr. Rob Cyverus, the Carb Addiction Doc, dives deep into the physiology of GLP-1, a hormone released from the intestine in response to food. He explores how GLP-1 influences insulin release, fat storage, and satiety. Dr. Cyverus compares how carbohydrates and fats trigger GLP-1 release differently and how diet can manipulate GLP-1 levels for optimal metabolic health. He emphasizes the importance of understanding the body’s natural processes and how a balance of fat and a small amount of sugar can be key to maintaining metabolic health, reducing hunger, and optimizing body function.

Takeaways

• 😀 GLP-1 hormones are released from cells in the intestine and play a crucial role in digestion and metabolism.
• 😀 GLP-1s are found in two major populations: one in the upper intestine and another in the lower third of the small intestine.
• 😀 The upper intestine GLP-1s regulate gastric emptying speed, influenced by the vagus nerve and the presence of food.
• 😀 GLP-1 triggers insulin release in response to carbohydrates and sugars, contributing to blood sugar regulation.
• 😀 GLP-1 also inhibits glucagon release, helping to lower blood sugar after carbohydrate consumption.
• 😀 A ketogenic diet and high-fat meals stimulate a slower, prolonged release of GLP-1, promoting satiety and appetite control.
• 😀 Fat in the diet, especially saturated fat, triggers a gradual release of GLP-1 in the lower intestine, contributing to longer-lasting fullness.
• 😀 Insulin release from GLP-1 also helps store sugar in the muscles and liver, promoting glycogen formation and fat storage.
• 😀 The combination of fat and a small amount of sugar is considered optimal for human metabolism, as it maintains insulin levels and promotes satiety.
• 😀 Consuming lean protein alone does not trigger significant GLP-1 release, and people on a carnivore diet may feel hungrier due to lack of fat and prolonged insulin production.

Q & A

What role do GLP-1 hormones play in the human body?

GLP-1 hormones are released from cells in the intestine and play an integral role in signaling a hormonal cascade that aids in food processing, hunger regulation, and metabolic control. They influence the release of insulin, inhibit glucagon release, and help with nutrient absorption, facilitating a balanced metabolic response.

How does the GLP-1 hormone system react to food intake?

When food enters the stomach, it is broken down into basic components such as glucose, amino acids, and fatty acids. These components then trigger the release of GLP-1 in the intestine. The upper intestine releases GLP-1 in response to sugar, while the lower intestine releases it in response to fat, albeit in a more prolonged fashion.

Why is insulin essential when carbohydrates are consumed?

Insulin, triggered by GLP-1 in response to carbohydrates, helps regulate blood sugar levels by promoting the uptake of glucose into muscles and fat cells. It also plays a key role in storing glucose as glycogen in the liver, allowing the body to manage sugar efficiently.

How do GLP-1s affect gastric emptying?

GLP-1s influence the rate at which the stomach empties. The upper intestine GLP-1 reacts quickly to food intake, accelerating gastric emptying. Conversely, the lower intestine GLP-1 acts more slowly, leading to delayed gastric emptying. This helps regulate how long food stays in the stomach and the overall digestion process.

What happens when you consume a diet rich in carbohydrates in terms of GLP-1 release?

A carbohydrate-rich diet triggers a sharp spike in GLP-1 release from the upper intestine. This spike leads to a significant insulin release to manage the influx of sugar. However, this effect is short-lived compared to the prolonged response triggered by fat in the lower intestine.

What is the role of fat in GLP-1 release?

Fat, particularly saturated fat, triggers a slower, prolonged release of GLP-1 from the lower intestine. This gradual release aids in fat absorption into the lymphatic system, and more importantly, signals satiety to the brain, helping to suppress hunger.

How do GLP-1 injections affect the body, especially in terms of gastric emptying?

GLP-1 injections, like semaglutide, can delay gastric emptying, which is why they are often avoided before surgery. The delay in gastric emptying can lead to symptoms like nausea and reflux, particularly when high-carbohydrate foods are consumed, as they trigger a large GLP-1 response.

How does the combination of fat and a small amount of carbohydrates affect the body's metabolic response?

Consuming a small amount of carbohydrates along with a larger portion of fat optimizes metabolic response. The carbohydrates trigger an initial insulin spike, while the fat causes a prolonged release of GLP-1, promoting satiety and minimizing the risk of excessive insulin production. This combination supports fat utilization and appetite control.

Why does a high-fat, low-carbohydrate diet lead to prolonged satiety?

A high-fat, low-carbohydrate diet leads to prolonged satiety because the fat triggers a slower, sustained release of GLP-1, which activates the satiety center in the brain. This helps individuals feel full for longer periods, reducing the urge to eat and supporting appetite regulation.

What impact does insulin have on cholesterol absorption in the gut?

Insulin plays a role in regulating cholesterol absorption from the gut. When insulin is not triggered, as in the case of a pure carnivore diet, LDL and total cholesterol levels can rise due to increased absorption of cholesterol, which is normally blocked by insulin.