Praktikum Teknologi Sediaan Farmasi Liquid dan Semisolid: Pembuatan Sediaan Krim Hidrokortison

Summary

This video provides a detailed guide on the formulation and evaluation of a hydrocortisone cream. It explains the step-by-step process of creating the cream by combining oil and water phases, followed by adding hydrocortisone. The evaluation includes various tests such as organoleptic testing for texture and scent, spreadability tests, adhesion tests, and protection against wetness. Additionally, the cream's pH level and emulsion type are assessed. These procedures ensure that the final product is both effective and safe for topical use, offering a comprehensive look into the production and quality control of topical creams.

Takeaways

• 😀 The first step in formulating hydrocortisone cream involves separating the oil and water phases.
• 😀 The oil phase is prepared by melting ingredients and heating them to 70°C.
• 😀 The water phase is also heated to 70°C before combining with the oil phase to form the cream base.
• 😀 Once the phases are combined, the mixture is stirred at 300 rpm until it thickens and forms a cream.
• 😀 Hydrocortisone is then added to the cream base once the initial emulsion is formed.
• 😀 Organoleptic testing is performed to evaluate the cream's texture, color, and fragrance.
• 😀 A spreadability test is conducted by measuring the cream's spread diameter under a 50g weight after 1 minute.
• 😀 The spreadability test is repeated with increasing weights up to 250g to observe how the cream spreads.
• 😀 An adhesion test checks how strongly the cream adheres to the skin, ensuring it doesn't easily rub off.
• 😀 A protection test is used to determine how well the cream protects against wet or acidic exposure by applying the cream to a filter paper.
• 😀 pH testing ensures the cream's pH is compatible with skin, typically falling between 4 and 6.
• 😀 An emulsion type test (using a viscometer or drop test) determines if the cream is oil-in-water or water-in-oil.

Q & A

What is the first step in preparing the hydrocortisone cream?

The first step is to prepare the oil phase by melting solid fats and mixing them with other necessary ingredients. This mixture is then heated to 70°C before setting it aside.

Why is it important to heat both the oil and water phases to 70°C?

Heating both phases to 70°C ensures proper emulsification when the water phase is gradually mixed into the oil phase. This helps achieve a smooth and consistent cream texture.

How is the emulsification process carried out in the formulation?

Once both the oil and water phases are heated to 70°C, the water phase is added to the oil phase gradually while stirring. This process forms the cream base.

What role does hydrocortisone play in the formulation?

Hydrocortisone is added to the cream after the emulsion has formed. It is the active ingredient, providing the cream with its intended therapeutic properties.

What is the purpose of the organoleptic test?

The organoleptic test evaluates the cream's texture, color, and odor, ensuring it meets cosmetic and sensory standards for use on the skin.

How is the spreadability of the cream tested?

The spreadability test involves applying a 50-gram weight on the cream to observe how far it spreads on a surface. The diameter of the spread area is measured after one minute.

What does the adhesion test measure?

The adhesion test measures how well the cream sticks to the skin by applying a weight and timing how long it takes for the cream to detach. A longer attachment time indicates better adhesion.

What is the protective efficacy test and how is it performed?

The protective efficacy test checks how well the cream protects against moisture and acidity. A piece of paper treated with the cream is exposed to a liquid, and the cream’s ability to block the liquid is observed.

How is the pH of the cream tested?

The pH of the cream is tested using universal pH paper. The pH should be between 4.5 and 6.5, which aligns with the natural pH of human skin.

What is the significance of determining the type of emulsion in the cream?

Determining the type of emulsion (oil-in-water or water-in-oil) is crucial for understanding the cream’s behavior on the skin. The emulsion type affects how the cream interacts with the skin and its overall effectiveness.