David Sinclair’s 2024 REVISED Supplement Protocol | Critical Changes!!

Summary

In this video, viewers are updated on Dr. David Sinclair's latest supplement routine changes, focusing on anti-aging and health. Sinclair has dropped quercetin and possibly trimethylglycine (TMG), while continuing with resveratrol, NMN, spermidine, and metformin. He's added new supplements like Elysium's torine and experimented with rapamycin. The video also discusses the importance of magnesium, provides a free report on quercetin, and suggests resources for further research on supplements like torine.

Takeaways

• 🔬 Dr. David Sinclair, a prominent figure in the field of aging and longevity, frequently updates his supplement routine based on the latest research and personal experimentation.
• 📉 In recent updates, Dr. Sinclair appears to have discontinued the use of quercetin, a supplement he previously took for its potential to combat senescent cells.
• 🍇 Resveratrol, found in grapes, and pterostilbene, found in other plants, are still part of his regimen, typically taken in the morning, with Sinclair suggesting a range of half a gram to 1 gram.
• 🧪 Sinclair's early research focused on alpha-lipoic acid, a supplement he's likely been taking for over 20 years, and he continues to include it in his routine, often in a dose of about 300 mg.
• 🍄 Spermidine, a molecule that has shown potential in extending lifespan, is currently part of Sinclair's protocol, with a daily intake of 1 to 2 milligrams.
• 💊 NAD+ boosters like NMN are a staple in his routine, with Sinclair taking 1 gram daily to support cellular energy and health.
• 🐁 He has recently added Elysium Health's Basis supplement to his regimen, which includes two grams of the amino acid taurine per day, based on promising longevity research.
• 🧗‍♂️ Sinclair also takes metformin, a drug used to manage blood sugar levels, and has recently started taking rapamycin, an experimental longevity drug, despite previous reservations.
• 🍏 While not explicitly mentioned, it's suggested that Sinclair may still be taking vitamin D and K2, as well as fish oil, for general health and longevity benefits.
• 📚 For those interested in following Sinclair's lead, the video provides a detailed summary of his current supplement routine and offers additional resources for further research and supplementation guidance.

Q & A

What are the two major changes Dr. David Sinclair made to his supplement routine in the recent year?

Dr. David Sinclair dropped one of the supplements he used to take, possibly quercetin, and he added a new supplement, Elysium's torin, to his routine.

Why did Dr. Sinclair decide to take Fisetin and Quercetin?

Dr. Sinclair took Fisetin and Quercetin to target senescent cells, which are cells that have stopped dividing and can contribute to aging. He ran an experiment on himself based on the idea that these compounds could help kill off these cells, at least in mice and potentially in humans.

What is the recommended daily intake of Resveratrol and Physan according to Dr. Sinclair?

Dr. Sinclair takes between half a gram and 1 gram of Resveratrol and Physan in the morning.

Why did Dr. Sinclair drop Quercetin from his supplement routine?

It is suggested that Dr. Sinclair dropped Quercetin due to its potential side effects when taken in excess, such as inhibiting ceramides which promote longevity, inhibiting Nrf2, a potent longevity mechanism, and reducing glutathione.

What is the significance of alpha-lipoic acid in Dr. Sinclair's supplement routine?

Alpha-lipoic acid is significant because it was the subject of Dr. Sinclair's PhD research and is known for its benefits to cellular energy. He has likely been taking it for over 20 years.

How much spermidine does Dr. Sinclair take daily, and what is the source of his intake?

Dr. Sinclair takes 1 to 2 milligrams of spermidine daily. He takes it as a supplement, but it's also found in foods like mushrooms, broccoli, and green peas.

What is the current daily dose of NMN that Dr. Sinclair takes?

Dr. Sinclair takes 1 gram of NMN every day with water in the morning.

Why did Dr. Sinclair start taking spermidine?

Dr. Sinclair started taking spermidine because it has been shown to extend the lifespan of various animals, likely by stabilizing the epigenome.

What is the current status of Dr. Sinclair's supplement routine regarding Torin (Elysium Health's product)?

Dr. Sinclair added Elysium Health's torin to his routine in 2023, taking 2 grams a day to see how it works with him.

What are the two longevity drugs that Dr. Sinclair is currently taking?

Dr. Sinclair is currently taking Metformin and Rapamycin for longevity. He takes Metformin for its potential benefits in preventing diabetes and its mimicry of fasting benefits, and Rapamycin for its potential to allow more protein intake without overstimulating mTOR.

What is Dr. Sinclair's stance on taking TMG (Trimethylglycine)?

Dr. Sinclair used to take TMG to counteract the potential depletion of methyl groups caused by NAD boosters, but it is uncertain if he still takes it as he did not mention it in his latest interviews.

Outlines

00:00

🌿 Dr. David Sinclair's 2022 Supplement Updates

This paragraph discusses Dr. David Sinclair's recent updates to his supplement routine, highlighting two major changes. It mentions that Sinclair used to take both Fisetin and Quercetin but seems to have dropped Quercetin. It also discusses his use of Resveratrol and Physan, which are plant compounds that target senescent cells. Sinclair's daily intake of Fisetin is estimated to be 500 milligrams, based on a past comment. The paragraph also introduces a bonus report that provides further insights into Sinclair's protocol, including the optimal dosage and timing for supplements like Fisetin.

05:01

🍇 Sinclair's Longevity Supplements: Spermidine and NMN

In this section, the focus is on two supplements that Dr. David Sinclair takes for longevity: Spermidine and NMN. Sinclair has been taking Spermidine, which extends the lifespan of various animals and stabilizes the epigenome, for about two years. He corrects himself on the dosage, stating he takes 1 to 2 milligrams daily. The paragraph also discusses natural sources of Spermidine, such as mushrooms, green peas, and broccoli. NMN is another supplement Sinclair takes daily, with a consistent dosage of 1 gram, which he times with his natural circadian rhythms. The segment ends with a teaser about Sinclair's latest supplement addition, which is a surprise to many.

10:01

💊 Dr. Sinclair's Pharmaceutical Longevity Routine

This paragraph delves into the pharmaceutical aspect of Dr. David Sinclair's longevity routine. It mentions that Sinclair takes Metformin, a drug used to treat diabetes, for its potential longevity benefits and because of his family's history with the disease. The paragraph also discusses the addition of Rapamycin to his routine, a drug that targets the mTOR pathway and has shown promise in extending lifespan. Sinclair's experimental approach to Rapamycin is highlighted, along with his caution regarding its use. Lastly, the paragraph mentions other supplements and drugs that Sinclair takes, such as fish oil, vitamin D, and vitamin K2, without specifying exact doses.

15:02

🧪 Latest Research and Personal Experiments in Sinclair's Protocol

The focus here is on the latest research and personal experiments that Dr. David Sinclair has incorporated into his supplement routine. Sinclair has added Elysium's Torin, an amino acid shown to improve health and extend lifespan in mice and monkeys. He takes 2 grams of Torin daily, which is an experimental addition. The paragraph also discusses the potential mechanism of Torin's action, which may involve the mTOR pathway. Sinclair's reasoning for taking Torin and the scientific basis for its use are explored, along with the potential benefits and concerns associated with its use.

20:03

🔬 Comprehensive Overview of Dr. Sinclair's Longevity Routine

In the final paragraph, a comprehensive overview of Dr. David Sinclair's longevity routine is presented. It includes a detailed list of supplements and drugs that Sinclair takes, such as NMN, Elysium's Torin, Spermidine, Resveratrol, Fisetin, and others. The paragraph also mentions magnesium, a crucial supplement that Sinclair does not discuss but is important for health and longevity. The video concludes with a call to action for viewers to subscribe for more information on Sinclair's protocol and to access additional resources on supplements like magnesium.

Keywords

💡Supplement

A supplement in the context of the video refers to vitamins, minerals, or other nutrients that are added to one's diet to enhance health. Dr. David Sinclair's routine includes various supplements aimed at longevity and health optimization. For instance, he mentions taking NMN (Nicotinamide Mononucleotide), a supplement associated with increasing NAD+ levels, which is linked to anti-aging benefits.

💡Senescent cells

Senescent cells are cells that have stopped dividing and are associated with aging and age-related diseases. The video discusses how Dr. Sinclair has experimented with supplements like Fisetin and Quercetin, which are believed to target and reduce the activity of senescent cells, potentially contributing to longevity.

💡Resveratrol

Resveratrol is a chemical compound found in plants that are under stress, such as grapes. It is highlighted in the video as one of the supplements Dr. Sinclair takes for its potential anti-aging properties. The script mentions that Sinclair takes between half a gram and 1 gram of Resveratrol.

💡NAD+

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells and is essential for cellular respiration. The video emphasizes the importance of NAD+ in aging, as Dr. Sinclair takes NMN to boost NAD+ levels, which is believed to have positive effects on health and longevity.

💡Spermidine

Spermidine is a naturally occurring polyamine involved in cell growth and regulation. The video discusses how Dr. Sinclair includes spermidine in his supplement routine, taking 1 to 2 milligrams daily, due to its potential role in extending lifespan and stabilizing the epigenome.

💡Metformin

Metformin is a drug primarily used to treat type 2 diabetes but is also considered for its potential anti-aging effects. Dr. Sinclair mentions taking Metformin in the video, highlighting its use for both diabetes prevention and longevity.

💡Rapamycin

Rapamycin, also known as Sirolimus, is an immunosuppressive drug that has been studied for its potential to extend lifespan. The video notes that Dr. Sinclair has recently added Rapamycin to his routine, taking it on and off, despite previous discomfort, due to its promising longevity effects.

💡Alpha Lipoic Acid

Alpha Lipoic Acid is an antioxidant that plays a crucial role in energy production within cells. Dr. Sinclair has been taking Alpha Lipoic Acid for over 20 years, as mentioned in the video, possibly for its role in maintaining cellular health and energy.

💡Fish Oil

Fish oil is a supplement rich in omega-3 fatty acids, which are essential for health and have anti-inflammatory properties. The video suggests that Dr. Sinclair takes fish oil, aligning with other health experts who recommend it for general health and longevity.

💡Vitamin D and K2

Vitamin D and K2 are essential nutrients for maintaining bone health and preventing cardiovascular diseases. The video includes these vitamins in Dr. Sinclair's routine, emphasizing their importance for overall health and possibly for longevity.

💡Taurine

Taurine is an amino acid that has been shown to have health benefits similar to those associated with longevity. The video discusses Dr. Sinclair's recent experiment with Taurine, taking 2 grams daily, noting its potential to improve health and extend lifespan.

Highlights

Dr. David Sinclair has updated his supplement routine with two major changes.

Sinclair used to take both Fisetin and Quercetin, but it seems he has dropped one of them.

Resveratrol and Physan are compounds from stressed plants that Sinclair takes for their potential anti-aging effects.

Sinclair may have stopped taking Quercetin, focusing instead on Fisetin for targeting senescent cells.

Excess supplementation of certain compounds can have negative effects on longevity.

Sinclair's daily supplement intake includes a range of compounds like Fisetin and Resveratrol.

Alpha Lipoic Acid is a supplement Sinclair has been taking for over 20 years, based on his PhD research.

Spermidine is a supplement Sinclair added to his routine, shown to extend lifespan in various animals.

NMN is a key supplement for Sinclair, taken daily to raise NAD levels and support cellular health.

Sinclair's supplement stack includes a variety of compounds aimed at longevity and general health.

Fish oil is a recent addition to Sinclair's routine, important for inflammation and general health.

Vitamin D and K2 are supplements Sinclair takes for their cardiovascular and bone health benefits.

Sinclair has added Elysium's Torin, an experimental supplement, to his routine for potential health benefits.

Metformin is a longevity drug Sinclair takes, known for its potential to mimic the benefits of fasting.

Rapamycin is an experimental drug Sinclair has recently added to his routine, targeting mTOR for longevity.

Sinclair's routine also includes magnesium, a crucial supplement for health and longevity.

Transcripts

in this video you'll discover Dr David

Sinclair newest updates to his

supplementary routine if you've been

following Dr David Sinclair you know

that he updated supplement protocol from

time to time and this year he has made

two major changes that most people have

missed but it's extremely difficult to

track his changes some supplements he

used to take and he stopped others he

recently added what does he used to take

what has he changed and his new

experiments and also I'm going to give

you a bonus that is going to allow you

even further to copy what he's doing

everything simplified in one place this

is supplement number

[Applause]

[Music]

one from 2020 to 2022 Dr David Sinclair

used to mention that he takes both ftin

and quartin but first let's start with

why he decided to take them in the first

place and the experiment that he ran on

himself the the one that I'm testing out

is physi and now shown that it's Center

IC it kills off the ccent cells in the

body at least in mice probably in humans

based on some human data so I've added

cortin which is also uh suppresses the

activity of senescent cells however

recently it would seem to me that he

dropped one of these can you guess which

it

is now let's go to a clip from middle

2023 so Resveratrol and physan are

chemical compounds from plants that are

stressed Resveratrol you find in grapes

physan is found in uh other uh plants

that are stressed and so I take usually

between half a gram and 1 gr of these

chemicals as well in the morning David

Sinclair usually mentions quartin and

fistin together since they serve similar

purpose targeting Cent cells however he

didn't mention quaratine not only with

fistin but at all so it sounds to me

like it stopped taking quatin he may

still cycle it for killing Cent cells we

don't know and based on the data on

quartin and I believe that he knows

exactly what he's doing it makes sense

to me if you've been subscribed to my

newsletter you probably know it too

because you received my coting report

which include conclusions from analyzing

over 250 studies it says in the report

rule number one avoid quity in

supplement for longevity under age 60

you already receed the optimal dose in

your diet here is why excess unnecessary

supplementation of cortin will have side

effects inhibiting cerin 6 which

promotes longevity inhibiting Nrf2 a

poent longevity mechanism and reducing

glutathione all of these will hurt your

longevity now you can get this report

for free I'll tell you when to take

wordstine for longevity the doses and

the timing you can find the link in the

pined comment again it's absolutely free

so the verdict I suspect that every day

it only takes fistin how much does it

take Sinclair said he takes between 500

milligram to 1,000 milligrams per day

but I think it's 500 milligrams based on

a past comment from 2021 FID in and

cured in half a gram in the yogurt if

you feel more clarity about Dr David

sinair protocol please subscribe to my

channel subscribe now and stay ahead in

the Race Against Time and aging the next

supplement very few people even know

that Sinclair takes for whatever reason

he keeps it as a secret it doesn't

appear in his book and he hardly ever

mentioned that in any of his interviews

but he did his PhD on it and probably

have been taking it over 20 years in

fact this could be the very first

supplement that Dr David Sinclair has

begun taking years back do you know what

it is it's not

[Applause]

[Music]

Resveratrol and alpha lipoic acid I did

my PhD on this molecule coincidentally

and it is a molecule that is very good

for the energy in cells actually the

thing that turned me onto that was uh I

spoke to

denim Harmon's family so denim Harmon

you may know him he's the father of the

oxidative stress theory of a I I was

fortunate to win an award with his name

on it and I went out there and his

family were very generous to host me and

he was still alive at the time he passed

for a few years ago but he was still

healthy and going into work at 92 and so

I said what is what's his secret oh

lipoic acid what about the dose he fails

to mention his exact dose but a standard

dose of alpha aoic acid is about 300 mg

either once a day or twice a day also

you're going to get a better absorption

if you take it on empty stomach so

probably lipoic acid is the first

supplement that Dr David Sinclair ever

taken as we move to the next supplement

let me remind you that today we're going

to also cover sinlar longevity drugs and

there is one addition that surprised me

and I'm going to create a special

summary for you to simplify everything

that we learned today about Dr David

Sinclair protocol this is also an

interesting experiment he had this is

his last

[Applause]

[Music]

experiment this is sperming Dr David

Sinclair started taking sperming two

years ago let's hear him speaking about

that just the last few months I've added

that to my protocol and we'll have to

see how my numbers look on inside

tracker does he still take it today this

segment is from 2023 I'm asked this

question every day David what do you

take spermidine is a very interesting

molecule and you can buy it as a

supplement and it's been shown to extend

the lifespan of many different animals

and probably it works by stabilizing the

epigenome so yes it continues to take

spermidine how much does it take how

much of that are you taking uh a gram as

well okay even though in this video Dr

David cair mentioned it takes one gr of

spodine later in the comment section he

said correction I said I take one gram

of spermidine but the active ingredient

in the capsules is 1 to 2 Mig I

apologize for the confusion so the

verdict about spermidine is 1 to 2

milligram taking every day in the

morning now if you to consider to take

spermidine maybe there is a safer and

cheaper way to get spadine and many of

my subscribers ask me how to get

spermidine from food this study measure

how much spermidine in each type of food

and rank them from the highest

concentration to the lowest I'm quoting

from this study spermine concentration

in Foods was as follows mushroom the

highest 88.6 mg per kilo of food green

peas 65 mg per kilo of food and broccoli

32 Mig per kilo of food so as you can

see there is a bunch of spermidine in

mushrooms but also in broccoli and green

peas these levels coming from food more

than satisfy or at least similar to the

levels of spermidine that Dr Sinclair

takes in a supplement form and also

there is another certainty about the

safety of spermidine in those foods of

course the highest food in spermidine is

wheat germ which wasn't measured in the

experiment so we have seen one major

change that he has made but the next

supplement is one of the most consistent

that he has been taking for many years

what is not consistent is its legal

status can you guess what it

[Applause]

[Music]

is and so nmn is is what I take each day

I take a gram of it I know a gram is

likely to be raising my en levels during

the day I also try to time it with my

natural Cadian rhythms so NAD will go up

during the morning getting ready but if

I take it at night I'm actually starting

to interfere with my sleep patterns in

2023 he spoke about the dose Ned

boosters I talked about nmn there are

other ones such as NR I take a gram

1,000 milligrams of NN every day in the

morning the verdict he still takes one

gram of nmn every day with water in the

morning the next supplement Dr David

Singler started taking after la acid

this is the famous or inFAMOUS

[Applause]

[Music]

ratol so let's go back in 2019 book he

mentioned I take one gr of NN every

morning along with 1 G of resol shaken

into my homemade yogurt does he still

take the same dose in 2022 in his very

long interview in his channel he

confirmed un quoting I've been taking

one gram of R trol since 2004 and in a

recent segment from 2023 I showed you

with fistin he mentioned that res veral

again with the exact dose 1 G per day so

it's the same exact dose the one he

wrote in his book confirmed of course if

you follow Sinclair it's not just how

much rator it takes but also how now

that has been evolved over the years so

I showed you in the book that he

mentioned in 2019 that he mixes rol with

yogurt he changed that protocol and then

began to mix with veratrol with olive

oil however I was pretty surprised to

see that he also changed that protocol

as well let's hear from him what he's

doing now I've even tried I like to mix

up my diet like anybody else I've tried

olive oil plus a bit of vinegar and a

Basil Leaf in the morning it's like

drinking a uh what do you call it salad

dressing in the morning uh that one

lasted for about a month I've given up

on that I now like this coconut yogurt

that you've turned me on to actually the

verdict Wang gram of his veratrol mixed

in coconut yogurt in the morning the

next two supplements that Dr Davis L

Stakes they cover both longevity but

also Health General

[Applause]

[Music]

Health the next one is fish oil omega-3

this 2023 segment is one of the few

segments where you mentioned fish oil

the fish oils those are very important

for inflammation and it turns out one of

these molecules activates certain one

and maybe that's why these are good for

health since it wasn't included in his

book perhaps he only added this

supplement to his routine very recently

what about the dose Dr David Sinclair

never mentioned the dose but I don't

want to keep you in the dark on that so

I collected for you what other doctors

are doing Dr Peter Atia Dr Ronda Patrick

and Dr Andrew uberman and all of them

kind of take the same exact amount so by

taking four of these capsules a day I'm

taking roughly two G of EPA a day and

probably a gram and a half of DHA now

let's hear from Dr Ronda Patrick how

much she takes so I take four grams a

day I take two in the morning two gs in

the morning and I take two grams in the

evening Rhonda said that she takes four

GR in total now let's hear from Dr

Andrew uberman my understanding is that

we need to hit a threshold level of EPA

in order to derive these important

benefits I try and get two grams per day

of EPA from supplementation note that

they all consume omega-3 in a supplement

form only as a fish oil I'm going to

create another addition specifically on

fish oil for longevity in General Health

CU they subscribing now to get the

special edition on omega3 when it's

going to come

[Applause]

[Music]

out similar to fish oil vitamin D and K2

are basic supplements that cover not

only longevity but basic health and in

2019 in his book Sinclair mentioned that

he takes vitamin D and K2 does he take

them today in mid 2023 he mentioned them

vitamin D3 and K2 these are very

important of course in places where we

avoid the Sun or we cannot get enough

sunlight K2 is not very well known

vitamin K2 will protect your

cardiovascular system from calcium

deposits and put the calcium into your

bones rather than your arteries and

usually those supplements come together

in the same pill so I take that what

about the dose of those two supplements

I never found one interview where he

mentions specific doses of those two

supplements a standard dose of vitamin D

is between 2,000 to 5,000 units and and

a standard dose of vitamin K2 is

somewhere between 50 to 120 micrograms

so I estimate that his dose fall within

this range the verdict he still takes

vitamin D in K2 and the dose is unknown

the next supplement is the latest

personal experiment Dr David Sinclair

added to his protocol what is it and how

much does it

[Applause]

[Music]

take I think torine is super interesting

this amino acid was shown in the science

paper from last week to when you give it

to mice they have a lot of health

benefits that are similar to what I just

described in humans and they even gave

it to monkeys and found that their

health improved but the big deal was

that those mice lived 12 to 16% longer

it was a significant extension of

lifespan which is a big deal because if

it had a negative side effect they

probably wouldn't have lived longer I'm

currently taking uh two grams a day and

to see how that works with me so

Sinclair started in 2023 three to take

ill torine and he said that it takes two

grams a day it seems uncertain because

it doesn't fully understand the impact

of torine on Amor thing that confuses me

and the literature right now and

scientists is torine is also known to

activate mtor things to provide

longevity despite activating mtor How

could a supplement that supposedly

stimulate aor actually increases

longevity I happen to interpret the

exact study on which Sinclair based his

decision to take El Torin and when I

delved into the data I found something

interesting about mtor maybe it's going

to help you as well this is from my El

torine research video mtor is an

important mechanism for accumulating

protein and amino acids necessary for

muscle growth and this study

specifically investigated a Tor in the

muscles of the mice that were not

exercising but were supplemented with

toine and they compared these mice with

mice without toine they analyze the

metabolism inside their muscles so let's

take a look at what they have

found here in the upper right you can

see this P

s6p just assume this represents mtor

activation now let's compare the minus

without toine and the plus with torine

can you see how dull the toring column

is this means that a lack of this

activation of aor in the muscles of the

mice supplemented with torine in fact if

you look to the left you will see also

the liver and brown fat exhibited

similar results a suppression of mtor

activation this suggests that highd dose

chronic torine prevents mtor from

becoming fully activated what does this

mean to you El Torin possibly activates

a Tor but only in the early stages and

what really accelerates aging is

probably the last stage of entor

activation and this full activation

could have the negative impact that Dr

David Sinclair is afraid of so the

verdict is this Dr David Sinclair added

two grams of ill torine per day but it's

only an experiment if you want to be

more certain about your situation I

suggest watching my ill torine research

video which I'm going to put in the

pinned comment and in the description so

this was his recent experiment the

following is the last supplement on our

list and then we're going to move to the

drugs and I'm going to create a special

summary for you to simplify everything

that we learned today about Dr David

Sinclair protocol this last supplement

he takes probably because he also takes

NN can you guess what it

is

TMG now we are getting more into the

controversial stuff let's hear Dr David

Sinclair explain on why he used to take

TMG the reason that I take glycine

actually specifically trimethyl glycine

is to counter what I think might be

going on with an NAD booster we see in

animals and even in humans that the

levels of nicotinamide go up quite

rapidly after taking an MN or NR and two

two high levels of nicotinamide are not

good um in part because the nicotinamide

gets excreted through the kidneys but

the concern that's that's been talked

about in social media especially is is

this drain of methyl nicotinamide a

problem the methyl groups are are needed

for the body we need methyl for a whole

range of things including antioxidants

and so as a precaution I take trimethyl

glycine so that uh I continue to give my

body a source of meth groups I take it

as a precaution because I know that

triog glycine is not going to hurt me

glyc

and the other thing is methy glycin also

known as betane which on human cells is

very good for them including protecting

them against stress so I don't I don't

see any downside it's not an expensive

molecule and the upside is that I'm

preventing my body from being drained of

methyl groups but the reason that I

can't say for sure that it's NE

necessary actually is that our bodies

can make methyl groups there's a whole

pathway in fact I did a PhD on it when I

was in Australia now Dr David Sinclair

didn't mention team TG in his last

interviews as he stop taking TMG your

guess is as good as mine but as we can

see how he adds and Stack Up supplements

the likelihood that it doesn't stop

taking them unless there is a very good

reason or risk of taking them and TMG is

a pretty safe supplement how much does

it take he never said but the standard

dose is about 500 milligram the verdict

about TMG is yours based on what he said

you can make up your own mind if you

want to add this supplement to your

supplement routine now let's move to Dr

David Sinclair longevity

[Applause]

[Music]

drugs here I was surprised to discover

that Dr David Sinclair added recently a

drug that he said that in the past made

him feel unwell this drug is the drug

that Brian Johnson takes too and it's

going to be the last on today's list but

first for medical health Dr David

Sinclair Takes Two drugs the first one

is cholesterol lowering drug my

understanding is that he takes that for

is genetic cholesterol disposition not

for slowing down aging another Medical

Health drug is baby aspirin which he

mentioned here on his book now he also

takes two drugs for longevity the first

aging targeting drug is MIT Forin I try

to take a couple of Metformin pills um

for two reasons one is that my family

has a history of diabetes and Metformin

is very effective at treating diabetes

and even preventing it so I do that for

disease reasons but also because the

work of many Labs has pointed to um not

just animals but tens of thousands of

people in clinical trials benefiting

from that drug which seems to uh enhance

and mimic the the benefits of fasting he

said he takes one gram of in Forin every

day does it still take one gram of

Metformin today this segment is from

2023 four and a half years after the

publication of his book berberine and

Metformin are two molecules that either

separately or together work to to lower

blood sugar levels which as I mentioned

is very important for longevity and so I

take 1,000 mg of Metformin most days of

the week so one gr it is the last drug

targets aging and it's also the latest

addition to his routine this segment is

from late 2023 here Sinclair disclosed

that he takes a levic drug that he Shun

in the past rap mein yeah are you taking

it uh on and off um

yes I I'm taking six milligrams once a

week so the drug he takes is Ramy and it

works by targeting amtor I think what is

interesting about this drug that it

possibly allows us to eat more protein

to recover from intense exercise routine

without overstimulating a tour so I

think it's a very promising longevity

drug but it's pretty experimental

personally I do not take it worth noting

that Brian Johnson also combined this

drug with high intens the exercise so

maybe also try to consume enough protein

to recover from his intense exercise

routine but also use Ramy to Target a

tour simultaneously what about the dose

Sinclair did not mention the dose and

specifically I do not want to touch the

dose because such an experimental drug

anyhow now let's organize everything

let's simplify everything that Dr cair

does into his longevity routine so you

can decide if you want to implement that

in your

lifestyle

so in the morning with water 1 gram of

NN 2 GS of El torine 1 to 2 migam of

spermidine and possibly 500 mg of TMG

with yogurt either coconut or milk

yogurt 1 gram of

resol and 500 milligrams of fistin

without cortin Dr David Sinclair

probably take these supplements with a

meal vitamin d and vitamin K2 those

unknown alphalipoic acid possibly 300 to

600 milligram and fish oil unknown dose

but I showed you what other experts are

doing today this is Dr David Sinclair

drug list mid forming 1 g at night and

it skips in the nights before exercise

the second is rapamycin those unknown

but usually it's taking once a week for

medical health conditions it takes baby

aspirin and cholesterol lowering drugs

we are not done yet because there is a

supplement that Dr David Sinclair fails

to mention it's super important for your

Health and Longevity it's called

magnesium if you want to check what

other experts are doing with magnesium

which types they're taking the brands I

have a specific video that is the most

popular in my channel this going to

complement your supplement routine so

let's summarize the call to actions you

can do

[Applause]

[Music]

next to fully integrate Dr David

Sinclair changes these are the call to

action that I suggest Dr David Sinclair

has probably dropped quity if you want

to know why and to get the qu in report

that I mentioned go to Wellness messiah.

comom there you can download the report

for free second Dr David Sinclair wasn't

sure about touring if you want to feel

more certain about your touring

supplementation I suggest checking the

touring research I'm going to put this

in the pin comment and in the

description and lastly a supplement that

Dr D failed to mention is magnesium I

suggest checking the Magnesium video to

see what other experts are taking the

forms and the types and even the brands

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