New evidence proves finasteride protects your heart and can prolong your life
Summary
TLDRThe video script discusses the ongoing debate about the safety and benefits of finasteride, a drug often used for hair loss and prostate enlargement. It counters conspiracy theories and misinformation with evidence from clinical trials and research studies, highlighting the drug's potential cardiovascular benefits. The speaker emphasizes the need for further research and advises against self-medication, urging viewers to consult with healthcare professionals for personalized advice.
Takeaways
- 🧪 Finasteride and dutasteride, despite being off-patent, have had a significant amount of independent research confirming their safety and efficacy, as well as additional health benefits beyond hair loss and prostate enlargement.
- 🛡️ Contrary to conspiracy theories, substantial research indicates that 5α-reductase inhibitors, including finasteride and dutasteride, may have positive effects on heart health and could potentially prolong lifespan.
- 💊 The FDA approval process for drugs like finasteride ensures a robust body of research before approval, but it's important to note that while cardiovascular benefits are promising, they are not yet FDA-approved for heart conditions.
- ⚠️ The video emphasizes the importance of not self-medicating for serious conditions like heart disease and stresses the need to consult with a healthcare provider before starting any treatment.
- 🔍 Early studies on finasteride's effects on the heart were primarily concerned with ensuring the drug did not increase heart disease risk in older men with BPH, and these studies generally found no negative cardiac effects.
- 📉 A controversial study suggested an increased risk of heart failure with dutasteride, but subsequent research, including a large meta-analysis, did not confirm these findings and suggested they might have been a statistical anomaly.
- 🐁 Animal studies have shown that DHT can exacerbate heart muscle damage, and finasteride can mitigate this effect, suggesting a protective role against heart disease.
- 🧬 The rationale for using 5α-reductase inhibitors in heart disease prevention is based on the understanding that androgens, particularly DHT, may negatively impact longevity.
- 🇰🇷 A large-scale study from South Korea indicated that 5α-reductase inhibitors did not increase cardiovascular risk and, in long-term users, showed a significant reduction in cardiovascular disease.
- 📊 Human studies, including a retrospective analysis of patients with chronic heart failure, suggest that finasteride may reduce heart muscle thickness, indicative of a protective effect against cardiac hypertrophy.
- 📚 The latest research, combining both mouse studies and human data, indicates that finasteride may improve blood lipid profiles, which could contribute to a lower risk of heart attacks.
Q & A
What is the main topic discussed in the video script?
-The main topic discussed in the video script is the potential heart health benefits of finasteride and dutasteride, which are medications primarily known for treating hair loss and benign prostatic hyperplasia (BPH).
What is the claim made by the 'anti-finasteride mob' mentioned in the script?
-The 'anti-finasteride mob' claims that initial clinical trials on finasteride are outdated and suggests a conspiracy theory involving big pharmaceutical companies, which the script argues is unfounded given the amount of subsequent research conducted on these drugs.
Why do some people oppose the use of finasteride and dutasteride?
-Some people oppose the use of finasteride and dutasteride due to misinformation and conspiracy theories suggesting that these drugs have hidden negative effects, despite ongoing and substantial research indicating their safety and additional health benefits.
What is the role of 5-alpha reductase inhibitors according to the script?
-According to the script, 5-alpha reductase inhibitors, which include finasteride and dutasteride, are suggested to be beneficial not only for treating hair loss and BPH but also for potentially prolonging lifespan and protecting against heart disease.
What does the script say about the relationship between finasteride and cardiovascular benefits?
-The script indicates that while the data on cardiovascular benefits of finasteride is strong, it is still preliminary and has not been approved by the FDA for heart-related treatments, so it should not replace conventional treatments like statins or blood pressure medications.
What is the significance of the study published in 2002 mentioned in the script?
-The 2002 study is significant because it reviewed the association between ischemic heart disease and the use of finasteride and alpha blockers in men with BPH, concluding that there was no association between these drugs and the risk of heart disease.
What was the controversy surrounding the prostate cancer study mentioned in the script?
-The controversy arose from the study finding an increased incidence of heart failure in the group taking dutasteride, which was barely statistically significant. However, subsequent research and a meta-analysis suggested that the result might have been a statistical fluke and not indicative of an actual increased cardiovascular risk.
What does the script suggest about the role of DHT in heart disease?
-The script suggests that DHT, a hormone derived from testosterone, may worsen ischemic heart disease and heart failure, and that 5-alpha reductase inhibitors could potentially improve heart health by lowering DHT levels.
What is the relevance of the mouse studies discussed in the script?
-The mouse studies are relevant as they provide evidence that DHT may increase heart muscle damage and that finasteride can reduce this damage, suggesting a protective role of finasteride against heart disease.
What does the script conclude about the future use of finasteride for heart health?
-The script concludes that it is likely that further research will continue to confirm the heart health benefits of finasteride, and it may eventually be used clinically for this purpose, in addition to its current uses.
Outlines
🧪 Finasteride Research and Heart Health Benefits
The paragraph addresses misconceptions about finasteride, a drug often associated with hair loss treatment, and its purported outdated clinical trials. It highlights that extensive research has confirmed the safety and efficacy of finasteride and dutasteride, revealing additional health benefits beyond hair loss and prostate enlargement. The script emphasizes the role of 5-alpha reductase inhibitors as biohacking drugs, countering negative perceptions. It also introduces new research suggesting these drugs' potential in improving heart health, a point of contention in online discussions.
🔍 Debunking Myths: Finasteride and Heart Disease Studies
This section scrutinizes the anti-finasteride narrative by examining various studies on the drug's impact on heart health. It discusses a 2002 study that found no association between finasteride and heart disease, contrasting with a later study suggesting a potential risk with dutasteride. A 2013 meta-analysis refutes these concerns, concluding no increased cardiovascular risk with dutasteride. The paragraph also touches on the broader implications of 5-alpha reductase inhibitors in heart disease prevention, hinting at their potential benefits in longevity.
💔 The Impact of DHT on Heart Health and Finasteride's Role
The script delves into the relationship between dihydrotestosterone (DHT) and heart disease, suggesting that DHT may exacerbate conditions like ischemic heart disease and heart failure. It reviews rodent studies indicating that finasteride can mitigate heart muscle damage associated with DHT. The paragraph also addresses the limitations of rodent studies, particularly regarding neurological effects, which are not applicable to humans due to differences in finasteride metabolism.
📊 Human Studies on Finasteride's Cardiovascular Effects
This section presents human studies that reinforce the potential cardiovascular benefits of finasteride. A Korean study shows no increased cardiovascular risk with 5-alpha inhibitors and suggests a reduced risk with long-term use. Another study indicates that finasteride may decrease cardiac hypertrophy in men with heart failure. The paragraph also discusses a Canadian database study that found the lowest risk of heart failure with 5-alpha inhibitor use compared to other treatments for BPH.
🐁 New Research: Finasteride's Effects on LDL Cholesterol and Atherosclerosis
The paragraph introduces a new study combining mouse and human research on finasteride's effects on cholesterol levels and atherosclerosis. In mice, high doses of finasteride reduced cholesterol and atherosclerotic lesions. Human data from the U.S. healthcare database showed lower LDL cholesterol levels in men taking finasteride. The study suggests that finasteride may help improve blood lipids, potentially reducing the risk of heart attacks.
🚀 Conclusion: Finasteride's Promising Heart Health Prospects
The final paragraph synthesizes the research findings, concluding that DHT may worsen heart conditions, and finasteride, by lowering DHT levels, could improve heart health. It posits that finasteride's potential in treating heart disease might be confirmed in future research and could become a clinical treatment. The script ends on a note that those using finasteride for hair loss may inadvertently be benefiting their heart health as well.
Mindmap
Keywords
💡Finasteride
💡Dutasteride
💡5-alpha reductase inhibitors
💡Heart disease
💡Benign prostatic hyperplasia (BPH)
💡Cardiovascular safety
💡Meta-analysis
💡Dihydrotestosterone (DHT)
💡Ischemic heart disease
💡Cholesterol
💡Atherosclerosis
Highlights
Finasteride and dutasteride have been the subject of ongoing research beyond their initial clinical trials, with studies revealing additional health benefits beyond hair loss and prostate enlargement.
Contrary to conspiracy theories, subsequent research has confirmed the safety and efficacy of finasteride and dutasteride, independently of pharmaceutical company funding.
Finasteride and dutasteride, known as 5α-reductase inhibitors, have been found to potentially prolong lifespan and protect against major killers like heart disease.
The FDA approval process for finasteride and dutasteride ensures the drugs' safety and efficacy for hair loss and prostate health, but they are not yet approved for heart health treatments.
A study published in 2002 found no association between finasteride or alpha blockers and the risk of heart disease in men with BPH.
A controversial study suggested an increased incidence of heart failure in the dutasteride group, but subsequent research and a meta-analysis have not confirmed this risk.
Scientific evidence is mounting that 5α-reductase inhibitors may lower the risk of heart disease, supporting the rationale for their potential use in preventing heart disease.
Studies in rats have shown that DHT worsens heart muscle damage, and finasteride can decrease this damage, suggesting a protective role against heart disease.
A Korean study found that long-term use of 5α-reductase inhibitors in BPH patients was associated with a reduced risk of cardiovascular disease.
A retrospective analysis of patients with chronic heart failure suggested that finasteride may reduce cardiac hypertrophy, indicating potential heart health benefits.
A Canadian database study indicated that the use of 5α-reductase inhibitors did not increase the risk of heart failure and showed a trend towards improvement.
A recent study combining mouse and human data suggests that finasteride may improve blood lipid levels and reduce atherosclerosis, contributing to heart health.
The new study's findings on finasteride's potential to lower LDL cholesterol and reduce atherosclerotic lesions support its heart health benefits.
The overall research suggests that finasteride and dutasteride may not only be neutral but actively beneficial for heart health, challenging misconceptions.
The potential heart health benefits of finasteride indicate that it could eventually be used clinically for this purpose, extending its applications beyond hair loss and prostate health.
The video concludes that the use of finasteride may offer dual benefits of maintaining hair and potentially prolonging life through improved heart health.
Transcripts
sup Chums how y'all living hope
everything is Nova and you're all having
a preme week so if you've ever
encountered the anti finasteride mob
online what they'll often tell you is
that the initial clinal trials on
finasteride are outdated they'll say
that we need new research to uncover the
hidden big Pharma conspiracy theory that
MK Bill Gates Anthony fouchy and Jewish
lizard people from Proxima centuri have
been hiding from the masses for all
these years as part of their Sinister
plot to indoctrinate us with woke
culture when you look past this smokees
screen though what you'll often find out
is that there actually has been a lot of
subsequent research that has been done
on finasteride and dutasteride and in
fact there is a lot of ongoing research
on these drugs even today as we speak
both finasteride and dutasteride have
been off- patent for many years now so
this follow-up research has been
conducted independently in academic
centers and is no longer funded by
pharmaceutical companies at all not only
has this research confirmed both the
safe and efficacy profile of these drugs
but we've also come to discover that
both finasteride and dutasteride have a
long list of other tremendous health
benefits outside of just stopping hair
loss or stopping prostate enlargement it
turns out that five air Inhibitors are
the ultimate biohacking drugs which
makes it especially ironic that so many
biohacker influencers are against them
five air Inhibitors are not only our
best defense against the Norwood Reaper
but they may also be one of the best
defenses against the Grim Reaper too
that's right jumes there is strong
scientific evidence that shows that five
air Inhibitors can prolong our lifespan
and protect us against the biggest
killers of the human organism
specifically heart disease now this
isn't the first time I've actually
covered the subject but I think it is
time for an update since now there is
brand new research that further confirms
that finasteride and dutasteride are
Frontline Defenders of our heart health
now I'm not claiming that this research
on the effects of finasteride and dut in
the heart health is as solid as the
research we have on their effects on
hair loss and prostate health after all
finasteride is FDA approved for treating
hair loss just like it is FDA approved
for shrinking the prostate and men with
benign prostatic hyperplasia the FDA
approval process ensures that there is
both convincing basic research and human
studies before a drug can actually be
approved for a specific indication so I
want to be clear here CH that while the
data on finasterid cardiovascular
benefits is strong it is still
preliminary and faster hasn't been
approved by the FDA as a heart drug at
least not yet so it shouldn't be seen as
a replacement for treatments like
statins or blood pressure medications I
just wanted to throw that out there just
because heart disease is a very serious
issue we're talking about here Chums and
you absolutely shouldn't follow advice
on treating your heart health from some
YouTuber without at least discussing
your specific situation with your doctor
first now I'm not advising anyone that
they should take finasteride or toas
ride to prolong their life that is
unless of course you are Brian Johnson
however it is still good to know that
while you are treating your hair loss
you may be getting benefits to your
heart health as well speaking of Brian
Johnson some of this data on finasterid
cardioprotective benefits I already
discussed in my Brian Johnson videos
which I'll link below but some of the
data I'm about to go over today is brand
new and it further reinforces previous
data on finasterid and heart health
specifically one of my viewers recently
brought to my attention this new study
on finasterid and the heart that was
published just a few months ago it's
this one right here so we'll get to this
new study very soon but first let's go
ahead and take a few minutes to review
what is actually known about the effects
of five air Inhibitors on the heart
since finasterid was first approved in
1992 for treating benign prosthetic
hyperplasia also known as BPH there has
been a bit of a concern about what its
effects on the heart may be that's
because men with BPH are in general
older men who often have heart disease
or in the early stages of heart disease
so there are actually a lot of studies
investigating the effects of finasteride
and dutasteride on the heart in order to
make sure that these drugs don't inrease
the risk of heart trouble but actually
the Studies have shown the opposite
result as we'll see so one of the first
studies was this study here published in
2002 it's titled quote study the
association between ischemic heart
disease and the use of alpha blockers
and finasteride indicated for the
treatment of benign prostatic
hyperplasia unquote the study reviewed
4,414 men with a history of BPH and in
that group The investigators identified
220 cases of men who had episodes of
what's called es schic heart disease
the drugs they looked at were
finasteride and Alpha blocking drugs
which would be a drug like tamsulosin
tamsulosin despite also being used for
an large prostate is not at all related
to five a Inhibitors and it works
through a completely different mechanism
so the investigators concluded in the
study that there was no association
between finasteride or Alpha blocking
drugs and the risk of heart disease in
other words these drugs for treating BPH
seem to be perfectly safe for the heart
however another study specifically this
one here came to different conclusions
and of course this is the one study that
all the antiph finasteride fearmongering
people online love to quote constantly
even though recent data calls its
findings into question as you can see
this wasn't primarily a study of heart
disease it was a randomized control
doubleblind study of
6,729 men who were over 50 years old and
who were given either dutasteride at 0.5
MGS per day or Placebo the study show
that dutasteride just like finasteride
and other studies decreased the overall
risk risk of getting prostate cancer
however what we're more interested here
is the effects of dutasteride on the
heart the study found that there was an
increased incidence of heart failure in
the dutasteride group heart failure
isn't the same thing as es schic heart
disease it is a weakening of the heart
muscle that causes the heart to enlarge
it can have many different causes
sometimes it is caused by heart attacks
but it can also be caused by high blood
pressure diabetes viruses or could just
sometimes happen spontaneously even
anyways the study found that 30 men in
the dutasteride group developed heart
failure versus 16 men in the placebo
group this was an incidence of heart
failure of 0.7% with dutasteride versus
0.4% with Placebo although the absolute
difference was Tiny the difference was
just barely statistically significant
with a P value of
0.03 normally A P value less than 0.05
is considered a statistically
significant result in a study the study
found no increased risk of esic heart
disease with dutasteride nor did it find
an increased risk of death from heart
disease with dutasteride but this study
raised the question as to whether
dutasteride could have a negative impact
on the function of the heart however
there were other studies that had
already been done on dutasteride and
those studies had not shown any
increased cardiovascular risk so in
order to put this data into perspective
this study was published in 2013 3 years
after the prostate cancer study had been
published the study was a metaanalysis
of all the previous studies looking at
dutasteride effects on the heart and its
specific goal was to determine if the
increased heart failure found in the
prostate cancer study we just went over
was something we should be worried about
or if the result was just a statistical
fluke that just happened by chance so
this was a huge meta analysis that
included 12 randomized controlled
studies of dutasteride with a grand
total of
heart disease specifically it found no
association with myocardial infarction
which means having a heart attack it
turns out that even in the prostate
cancer study when the data was
reanalyzed by the FDA it was found that
some of the subjects had actually been
misclassified as having heart failure
when they really didn't and after this
reanalysis the difference between the
two groups was no longer considered to
be statistically significant so the
metaanalysis concluded that quote based
on the results of this metaanalysis
there is no confirmatory evidence at
present to suggest that dutasteride
confers an increased cardiovascular risk
compared with controls unquote so
despite this large meta analysis DHT
simps still quote the prostate cancer
study as being proof that dutasteride
causes heart problems and if dutasteride
causes heart problems then that must
mean finasteride does too right but as
we'll soon see the more we learn about
five a Inhibitors the more it looks like
that they aren't just neutral with
respect to the heart on the contrary the
evidence shows that they are beneficial
IAL for the heart there is mounting
scientific evidence that they lower the
risk of heart disease and that's why
more and more researchers are starting
to look into the use of five a
Inhibitors in preventing heart disease
the rationale behind using five a
Inhibitors to prevent heart disease and
prolonged life is the fact that in the
long run androgens and especially the
trash hormone DHT are bad for your
longevity in my Brian Johnson videos I
talk about the fact that in every
country on Earth women have a greater
life expectancy than men do one of the
theories why men have shorter lives than
women do is that androgens actually
decrease our lifespans now of course we
can't actually eliminate testosterone
without changing from men into trans
women but we do have the capacity to
safely diminish the amount of DHT in our
bodies if lowering DHD had a beneficial
effect on heart disease that would make
a big difference in mortality rates in
men especially since heart disease is
the number one cause of death on the
planet by far since DHT is a trash
hormone that doesn't have benefits in
adulthood that means we can suppress the
detrimental effects of androgens without
lowering our testosterone levels and
save our hair and prostates at the same
time so it is a win-win situation for us
here chims so like I said some of the
data is theoretical and some of it is
based on rodent studies but the data is
nevertheless very promising I have to
admit for example in this study right
here rats were given heart attacks by
temporarily tying off one of their
coronary arteries in the study the
amount of injury to the heart was
measured after after giving testosterone
or DHT the investigators also tested the
combination of testosterone with an
aromatase inhibitor and with finasteride
what was found was that when
testosterone was given during the heart
attack after 3 days of pre-treatment
with an aromatase inhibitor the amount
of heart injury increased however when
testosterone was given after
pre-treatment with finasteride the
amount of injury decreased markedly you
could see that in this figure right here
the First Column is testosterone alone
the second is testosterone plus the
aromatase inhibitor which is four
hydroxy anderin diione that is
abbreviated 4 h n the third column is
testosterone plus finasteride so even
though testosterone alone did not affect
the amount of heart muscle damage DHT
alone did increase the amount of damage
and finasteride decreased the damage as
you can see in this figure here so the
authors concluded that quote our results
strongly suggested that
dihydrotestosterone or a mechanism
related to its enzymatic synthesis was
responsible for the D serious effect
increased myocardial damage from
testosterone supplementation unquote
they also concluded that quote DHT
Administration clearly induced a
significant larger damage induced by
eskema and reperfusion furthermore when
the 5A reduct days when was inhibited
the miocardial protective effects of
testosterone became unmasked unquote so
far so good but I know what some of you
guys are thinking right now but Kevin
you always criticize anti finasteride
people for using rodent studies so why
are you using them now you're such a
hypocrite bro well let me try to clarify
my position on this one shums I don't
think that rodent studies are 100%
completely useless the problem though is
that anti-f finasterid people like to
dishonestly portray them as being strong
evidence to support their claims about
fides alleged dangers when they're not
and they never disclose the limitation
of these studies furthermore antiph
finasterid people will often use rodent
studies to make strong claims about the
asteroid's neurological side effects
which is extremely leading since we
already know that rodent brains they
metabolize finasteride differently from
human brains specifically finasteride is
a strong Blocker of the type 1 5 a
isoenzyme and rodents which is the
isoenzyme present in the brain and which
specifically is involved in the
neurosteroid Alo pregnanolone in the
brain however in humans finasterid is an
extremely weak type 1 5or isoenzyme
blocker so this is an interspecies
difference that is critical and it
renders studies on the effects of
finasteride on rodent Behavior
completely inapplicable to human
behavior so rodent studies already have
limitations as it is but when it comes
to subjects like neurosteroids and
finasteride rodent studies are
completely [ __ ] useless and the fact
that post finasteride syndrome
conspiracy theorists treat these rodent
studies as being strong evidence is very
misleading to say the least when it
comes to cardiovascular disease though
rodent studies are much more applicable
to humans because in these studies we
aren't looking at neurosteroids we're
looking at the effects of DHT itself
which we know both finasteride and
dutasteride reduce in both humans and
rodents so like I said this study showed
a delerious effect of specifically DHT
on heart muscle damage that was reversed
by the use of finasteride unlike many
Mouse studies the investigators didn't
use a super high dose of finasteride
like what happens in most finasteride
rodent studies they only used a
finasteride dose of about 0.1 Mig per
kilogram a day for 3 days that would be
a weight based dose of 7 milligram per
day in an average 7 kg man which is
about the same as a dose used in Men to
treat an enlarg prostate specifically 5
migs per day this is really a pretty low
dose but still the effect on decreasing
the size of the heart damage was very
impressive not only that the same group
of investigators did a similar study
looking at whether giving finasteride or
an aromatase inhibitor after a heart
attack reduce heart muscle damage it's
this article here in the article
castrated rats had a heart attack
induced by tying off one of their
coronary arteries like what was done in
the prior study this time the rats were
given testosterone Plus either an
aromatase inhibitor or finasteride for
30 days after that the amount of heart
muscle damage was assessed this time the
investigators used an even lower dose of
finasteride they used just 1.8
micrograms per kilogram given as a
subcutaneous injection once every 3 days
that works out to be an equivalent of
just 0.13 mg every 3 days in a man
weighing 70 kg despite this very very
low dose the study had the same results
as you can see adding finasteride
reduced the amount of heart muscle
damage while adding the aromatase
inhibitor
4A increase the damage the authors also
looked at inflammatory markers in the
amount of inflammatory cells in the
heart attack Zone and again they found a
beneficial effect of finasteride the
authors concluded that quote these
observations suggest that DHT is
responsible for the detrimental effects
on cardiac function and morphology
induced by testosterone unquote so these
studies on
the heart muscle of the hearts with
hypertrophy and that finasteride
decreased these DHT levels which is what
you'd expect of course but most
importantly finasteride inhibited the
development of cardiac hypertrophy in
the mice who had their aorta surgically
constricted so once again the authors of
the study concluded that it was DHT
causing these heart problems they wrote
quote these results imply an important
role of myocardial androgens more
specifically DHT for the induction of
adverse myocardial remodeling the this
is supported by the data from Human
weightlifters with anabolic androgenic
steroid use who are shown to develop
cardiac hypertrophy and systolic and
diastolic dysfunction unquote the
investigators felt that finasterid was
so beneficial in preventing cardiac
hypertrophy and heart failure that it
should be considered as a clinical
treatment they said quote because
finasteride was so effective in reducing
cardiac hypertrophy and failure in mice
and because of its clinical availability
we suggest that it should be evaluated
as a treatment option in heart failure
unquote so actually there are a number
of rodent Studies by different
investigators confirming these findings
and I'll link them below but what about
human studies well we have this article
from good Korea right here titled quote
cardiovascular safety and possible
benefit of five Alpha reductase
inhibitor among benign prostatic
hyperplasia patients a nationally
representative cohort of Korean men
unquote the study was based on a patient
database used in good Korea called the
Korean national health insurance service
Health screeing cohort since everyone
has health insurance automatically in
good Korea and has free health exams
every other year this is a very complete
database so from this database
29,7 192 men were studied including
41,9 7 with a diagnosis of BPH so the
main finding of the study was that use
of any 5air inhibitor whether it was
finasterid or dutasteride did not
increase the risk of cardiovascular
disease specifically heart attacks or
stroke how however in the group of BPH
patients who were on a 5 a inhibitor for
the longest period of time and who had
the greatest cumulative dose of the drug
there was a significant reduction in the
risk of cardiovascular disease so that's
not the end of the human data on
finasterid in the heart we also have
this study here titled quote
anti-androgenic therapy with finasteride
and patients with chronic heart failure
a retrospective propensity score-based
analysis unquote this study was a
retrospective review of 1,41 cases of
men with heart failure who were on
either finasteride or an alpha blocker
drug like tamsulosin the subjects were
matched to similar patients not on these
drugs the bottom line of this study was
that on echocardiogram measurements the
thickness of the heart muscle was
reduced in the patients on finasteride
versus those who were not on the drug of
course this is just a correlation and it
doesn't exactly prove that finasteride
caused this difference but it does still
nevertheless fit in with the other
research that shows that finasteride
does decrease cardiac hypertrophy now
this background in information would not
be complete without at least mentioning
another study that the anti- finasterid
crowd likes to pull out of their hats
it's this study right here this is
another database study this time from
Canada it looked at 175,176
the study found that any drug treatment
increased the risk of getting heart
failure compared to men not on any drug
for BPH however the increased risk was
lowest if you were taking a 5 a
inhibitor alone and it was highest if
you were taking an alpha blocker alone
you could see all this from this table
right here if you added a 5 a inhibitor
to an alpha blocker it actually lower
the risk of getting heart failure
compared to if you were just taking an
alpha blocker alone so the slight
difference in Risk between the group of
men taking five air blockers alone and
the men on no medication could be
ascribed to the men on no medication
just being a healthier group of men in
general However the fact that adding a 5
a inhibitor to an alpha blocker actually
lowered the risk of developing heart
failure that in my opinion is the real
important takeaway from this study if
five A inhibiting drugs make heart
failure worse the results of adding a
five a inhibitor to another drug that we
know causes heart failure should make
this combination worse not better so I
don't think the study in any way
invalidates the data we already have
gone over about the benefits of five air
inhibitors for preventing heart failure
however this study isn't the final word
on the effects of five a blockers on the
incidence of heart disease in humans we
also have this study from just last year
this one's also from Canada the study
also used a Canadian database and it
identified over 94,000 subjects with BPH
subjects on five air Inhibitors were
compared with those on no medications
the bottom line of this study was that
quote the use of five a Inhibitors was
not associated with with an increased
risk of hospitalization for heart
failure myocardial inunction stroke or
cardiovascular death compared with
nonuse unquote in fact looking at the
raw data here there appears to be trends
for improvement in all these heart
parameters so finally let's get to the
new study on this topic that was just
published last March it's this study
right here like I already mentioned this
is a mouse study and a human study the
mice used in the study were mice that
have been genetically engineered to
knock out their receptors for LDL
cholesterol this type of Mouse is widely
used to study atherosclerosis because
these mice develop atherosclerosis even
when given a normal Mouse diet and they
develop severe atherosclerosis when
they're fed on a typical Western diet so
these mice were fed a western diet for
12 weeks at the same time some of these
mice were given finasteride and the
doses used here were not small at all
Chums the doses of finasteride used in
the mice range from 10 Mig per kilog of
diet per day up to 1,000 mg per kg of
diet per day that's kind of a weird way
to calculate a dose but it worked out to
each Mouse getting about 2.5 Mig of
finasteride per day since the average
Mouse weighs about 25 G that's a
weight-based dose of about 100 milligram
per kilogram per day that's still much
higher than human dose though anyways
after 12 weeks the poor mice were sadly
sacrificed in the name of Science and
their blood vessels were examined for
atherosclerosis also a lot of other
blood tests were done on these mice so
what were the results of all these tests
well first of all finasteride did lower
total cholesterol levels though only at
the super high dose of 1,000 Mig per
kilogram there was no effect on the
so-called HDL good cholesterol though
the high dose also did lower serum
triglyceride levels faside at the
highest dose also decreased the size of
the atherosclerotic lesions in the blood
vessels it also reduced inflammatory
cells in the lesions finally it also
reduced total fat levels in the liver so
along with this mouse study the authors
did a huge study where they examined men
enrolled in What's called the N haes
database which is a healthcare database
that is located and used in the United
States the investigators ended up with
4,791 men in this part of the study from
these subjects there were
4,636 subjects who are at least 50 years
old and who had not taken finasteride
versus 155 subjects who had taken
finasteride as you can see the total
cholesterol levels in men taking
finasteride were consistently lower than
men who weren't taking finasteride so
LDL which is considered the bad
cholesterol was also lower in men taking
finasteride HDL which is consider the
so-called good cholesterol was not at
all affected by finasteride so what do
we make of this study well the authors
note that given the high dose of
finasteride used in the mouse study it
might be necessary to give a high dose
of finasteride in humans in order to get
the same effects on lipid levels and
atherosclerosis so the researchers
hypothesize that 5 migs of finasteride
per day might be enough in humans to
affect lipid levels but that probably 1
mgram per day might not be enough I
think that the dose used in the mouse
study is so much higher than any human
dose that it is difficult to extrapolate
the mouse data to human data but maybe
there are some species differences and
it may take a lot less finasteride to
have a beneficial effect on blood lipids
than it does in rodents we already saw
data where even doses of finasteride
used in rodents were a lot less than
those in humans and it still had
beneficial heart effects of course the
study didn't show that these subjects
with lower LDL cholester levels had a
lower risk of heart attacks but we do
know from many studies that the amount
of coronary artery blockage directly
correlates with LDL levels we also know
that actively lowering LDL cholesterol
levels with different drugs lowers the
risk of cardiovascular disease so I know
a lot of cholesterol deniers claim that
high LDL cholesterol doesn't cause heart
disease and some of them even go so far
as to say it's good for your heart but
I'm sorry you guys are just flat out
wrong saying that high LDL levels don't
promote heart disease is just as dumb as
saying that DHD doesn't cause hair loss
but that's a discussion for another day
and I will eventually do a complete
video explaining why cholesterol deniers
are wrong so you can save your
objections until I make that video but
anyways if you take all the research
that we reviewed as a whole today it is
pretty convincing that the trash hormone
DHT worsens ischemic heart disease and
heart failure and that five a blockers
can improve the situation by simply
lowering DHT levels and based on the new
study we just went over finasterid may
even help improve blood lipids which
would result in a lower risk of heart
attacks so I think it is very likely
that further research will further
confirm the heart health benefits of
finasteride and it will eventually be
clinically used for this purpose so if
you're on finast right now as you should
be you're already one step ahead of the
game which means that not only do you
get to keep your hair but you'll get to
live longer to enjoy it and that's a
pretty good deal if you ask me all right
Junes for those who are watching and who
are part of the dride master race fear
not my next video will be for you so
thank you all for watching here
switchers I'll see you all next time God
bless
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