Polycystic Kidney Disease Breakthrough (New Research in PKD) - 2024
Summary
TLDRDr. Ken Barry discusses a groundbreaking study on polycystic kidney disease (PKD), suggesting a ketogenic diet and intermittent fasting may slow its progression and improve kidney function. He emphasizes the lack of scientific evidence supporting common dietary restrictions for PKD and highlights the importance of avoiding sugary drinks and maintaining low insulin levels. The video provides actionable dietary advice for those affected by or at risk of PKD, urging viewers to consider the new research before following traditional medical guidance.
Takeaways
- 🧬 Polycystic kidney disease (PKD) is the most common inherited kidney disease, characterized by enlarging cysts in the kidneys that can lead to decreased kidney function and the need for dialysis.
- 👨👩👧👦 PKD is a genetic condition, so family history is important. If relatives had unexplained kidney disease, individuals should consider getting tested.
- 🚨 Symptoms of PKD can include decreased kidney function, urinary tract infections, kidney stones, and blood in urine, but also non-kidney related signs like high blood pressure and liver cysts.
- 🐀 Previous animal studies have shown that ketosis can slow down or improve PKD, and a new human study supports these findings.
- 🥗 A ketogenic diet, which is high in fat and low in carbs, is suggested to potentially prevent or slow the progression of PKD.
- ⏱ Intermittent fasting, or time-restricted eating, may also play a role in managing PKD by potentially improving kidney function.
- 📉 A recent randomized control trial in humans found that a ketogenic diet can reduce the size of polycystic kidneys and improve kidney function.
- 🚫 The PKD Foundation's website does not yet reflect the new findings, still suggesting the DASH diet without research support for PKD.
- 🍖 Contrary to common medical advice, there is no research supporting the idea that limiting protein, red meat, or caffeine is beneficial for PKD.
- 🍹 Alcohol should be avoided, especially sugary drinks, as they can spike blood sugar and potentially worsen PKD.
- 💊 Supplements like potassium or magnesium citrate may slow down the progression of PKD, and smoking should be avoided for overall health.
Q & A
What is polycystic kidney disease (PKD)?
-Polycystic kidney disease is the most common inherited kidney disorder, characterized by the development of enlarging cysts in the kidneys, which can eventually lead to decreased kidney function and may require dialysis.
Why is it important to be aware of family history in relation to PKD?
-A family history of kidney disease can indicate a genetic predisposition to PKD, making it crucial for individuals to get checked if they have relatives who had unexplained kidney issues, as early detection can help manage the condition more effectively.
What are some signs and symptoms that might indicate PKD?
-Signs and symptoms of PKD include decreasing kidney function, repetitive urinary tract infections, kidney stones at a young age, blood in urine, high blood pressure without an apparent cause, liver cysts, diverticulosis, and unexplained abdominal or flank pain.
How have animal studies contributed to understanding PKD and its treatment?
-Animal studies, particularly in rats and cats, have shown that ketosis can slow down the progression of PKD and improve kidney function, providing insights into potential dietary interventions for human patients.
What is the significance of the recent human study published in Cell Reports Medicine?
-The study is significant as it is a randomized control trial in humans that found a ketogenic diet induced ketosis can shrink the size of polycystic kidneys and improve kidney function in people with PKD, offering a potential therapeutic approach.
What dietary recommendations are suggested for individuals with PKD based on the script?
-The script suggests starting a whole food, one-ingredient ketogenic diet and implementing intermittent fasting to potentially prevent or slow down the progression of PKD.
What is the role of intermittent fasting in managing PKD according to the script?
-Intermittent fasting, such as fasting for 16 to 18 hours a day and having one or two ketogenic meals within a 6 to 8-hour window, may help preserve kidney function and slow down the progression of PKD.
Why is avoiding sugary drinks and maintaining low blood sugar levels important for PKD patients?
-High blood sugar levels can cause the cysts to grow faster in PKD patients, so avoiding sugary drinks and maintaining low blood sugar levels can help slow down the disease progression.
What are some common misconceptions about diet and PKD that the script aims to clarify?
-The script clarifies misconceptions such as limiting protein or red meat intake, reducing salt, and avoiding caffeine, which are not supported by research and may not be beneficial for PKD patients.
How does the script differentiate between the PKD Foundation's recommendations and the research findings?
-The script points out that the PKD Foundation's recommendations, such as the DASH diet, are not based on research specific to PKD, whereas the script's recommendations are based on animal studies and a human randomized control trial.
What lifestyle changes are advised for individuals at risk of PKD or those who have it?
-The script advises individuals at risk of PKD or those who have it to adopt a ketogenic diet, practice intermittent fasting, avoid alcohol and smoking, and maintain a normal water intake to keep urine light yellow, which can help manage the condition.
Outlines
🧬 Polycystic Kidney Disease (PKD) Breakthrough
Dr. Ken Barry introduces a breakthrough in the management of polycystic kidney disease (PKD), the most common inherited kidney disease. He explains the hallmark symptom of enlarging cysts in the kidneys and the risk factors, including family history. Dr. Barry also discusses early signs and symptoms of PKD, such as decreased kidney function, urinary tract infections, and unexplained blood in urine. He highlights the potential benefits of ketosis and time-restricted feeding in slowing down the progression of PKD, based on studies in animals, and introduces a recent human study that supports these findings.
🥗 The Impact of Ketogenic Diet on PKD
This paragraph delves into the results of a human randomized control trial published in November 2023, which found that a ketogenic diet can reduce the size of polycystic kidneys and improve kidney function in PKD patients. Dr. Barry emphasizes the importance of starting a ketogenic diet early and possibly combining it with time-restricted eating to prevent or slow down the progression of PKD. He also expresses disappointment with the PKD Foundation's recommendations, which do not align with the new research findings.
🚫 Debunking Common Misconceptions about PKD Diet
Dr. Barry addresses and refutes several common dietary recommendations for PKD patients that lack scientific evidence, such as limiting protein, red meat, salt, and caffeine intake. He suggests that these recommendations are not based on research and instead advises against alcohol consumption, especially sugary drinks, to prevent spikes in blood sugar that could accelerate PKD progression. He also mentions the potential benefits of potassium or magnesium supplements and the importance of avoiding smoking.
🍽 A Day of Eating for PKD Patients
In the final paragraph, Dr. Barry provides a detailed dietary plan for individuals with PKD or at risk of developing it. He recommends a whole food, one-ingredient ketogenic diet with two meals a day or one large meal, emphasizing the importance of high-quality protein and healthy fats. He also advises against snacking between meals to maintain low blood sugar and insulin levels. Dr. Barry concludes by encouraging viewers to share the video with those affected by PKD and to consult the research provided in the show notes for further information.
Mindmap
Keywords
💡Polycystic Kidney Disease (PKD)
💡Ketosis
💡Ketogenic Diet
💡Intermittent Fasting
💡Cysts
💡Dialysis
💡Genetic Predisposition
💡Randomized Control Trial (RCT)
💡Dietary Intervention
💡DASH Diet
💡Protein Intake
Highlights
Polycystic kidney disease (PKD) is the most common inherited kidney disease, characterized by enlarging cysts in the kidneys that can lead to kidney failure and the need for dialysis.
PKD can be inherited, so family history of kidney disease should prompt individuals to get checked for the condition.
Early symptoms of PKD include decreasing kidney function, urinary tract infections, kidney stones, and blood in urine.
Non-kidney related symptoms such as high blood pressure, liver cysts, and abdominal hernias can also indicate PKD.
Animal studies have shown that ketosis can slow down the progression of PKD and improve kidney function.
Intermittent fasting, like feeding animals once a day, has been linked to improved kidney health in PKD models.
A recent human study in November 2023 demonstrated that a ketogenic diet can shrink kidney size and cysts in PKD patients.
The study suggests that a ketogenic diet and time-restricted eating could prevent or slow down PKD progression.
The PKD Foundation's website does not currently recommend a ketogenic diet or intermittent fasting despite the study findings.
Genetic testing can identify predisposition to PKD, which is crucial for early intervention.
A whole food, one-ingredient ketogenic diet is recommended for those with or at risk of PKD.
Intermittent fasting, with 16-18 hours of fasting and a 6-8 hour eating window, is suggested to protect kidney function.
Common medical advice such as limiting protein, red meat, and caffeine is not supported by research for PKD management.
Potassium or magnesium supplements may help slow down PKD progression, as suggested by some research.
Alcohol, especially sugary drinks, should be avoided as it can worsen PKD by increasing blood sugar and cyst growth.
Smoking is detrimental to health and should be avoided, although its direct link to PKD progression is not established.
A sample day of eating for someone with PKD includes two ketogenic meals with a focus on protein and low-carb vegetables.
The dietary recommendations are based on research across multiple species and a recent randomized control trial in humans.
The video emphasizes the importance of following evidence-based dietary changes for PKD management.
Transcripts
I've been researching polycystic kidney
disease for over 4 years now and there's
a recent breakthrough randomized control
trial study in humans that is going to
revolutionize the way that people with
polycystic kidney disease or their loved
ones take care of themselves in the
future I'm Dr Ken Barry a family
physician let's talk about polycystic
kidney disease it is the most common
inherited kidney disease in modern
society the Hallmark finding of
polycystic kidney disease is enlarging
cysts in the kidney that eventually take
over the entire kidney if the disease is
not managed and decreasing kidney
function it's one of the leading causes
of inst stage kidney diseases and the
need for dialysis as well this is an
inherited condition of the kidney so if
you have any parents grandparents or
anyone in your family back up your
family tree who had some weird kidney
disease that caused them to die early
then this is something you should
probably get checked for because most
young people have no idea they have
polycystic kidney disease until the
symptoms start and at that point a lot
of damage has already been done the
signs and symptoms to look for are
decreasing kidney function when your
doctor checks for your kidney function
repetitive urinary tract infections
having a kidney stone young in Life or
having multiple kidney stones uh also
blood in your urine for no apparent
reason now there are some signs and
symptoms that have nothing to do with
your kidney so if you've had any of
these then you probably need to see your
doctor and get checked for polycystic
kidney disease as well and that includes
high blood pressure for no real reason
especially young in life uh left
ventricular hypertrophy any kind of cyst
on your liver yeah
diverticulosis a lot of people with
diverticulosis don't understand that
there's a there's a potentially related
kidney disease as well abdominal hernas
for no real reason inguinal hernas for
no real reason or just abdominal or
flank pain any of these can be early
morning signs of polycystic kidney
disease now for years researchers have
known in studies in Rat studies and in
cat studies that being in ketosis slowed
down the progression and in many cases
actually improved kidney function in
these animals that they used as
polycystic kidney disease models and so
most animals in research studies are fed
once a day because you've got these
animals in a cage and you don't want to
spend all day feeding them three meals a
day with snacks in between so you feed
them once a day now a lot of the early
studies with rodents this once a day
method of feeding they would restrict
their calories as well and so they
initially thought well it's because of
the calorie restriction but what some
smart researchers said well you know
you're only feeding them once a day so
actually what you're also doing is a
Time restricted feeding Model A so it
could be that the intermittent fasting
of the animals eating one meal a day
that could be improving their kidney
function and slowing down polycystic
kidney disease progression it could be
the fasting and indeed we now have a new
study looking at polycystic kidney
disease in hum a randomized control
trial and we're going to talk about that
trial in just a second so that you can
understand the good news that this study
gives us but you have to first
understand that even back in 2019 it was
well known when studying animal models
that the animals being in ketosis
prevented polycystic kidney disease or
reversed polycystic kidney disease it
actually Shrunk the size of the cyst and
it improved the kidney function of these
animals now if in the animal models of
polycystic kidney disease both Tim
restricted feeding which in humans we
would call intermittent fasting slow the
progression and improve kidney function
and feeding them a diet that put them
into a therapeutic state of ketosis in
humans this would be analogous to eating
a ketogenic diet actually decreased the
progression and improved kidney function
and decrease the size of the cysts in
the the kidneys of these animals that
they were using to model polycystic
kidney disease now on to the new study
published in November of 2023 in cell
reports medicine this was a randomized
control trial in humans so this is the
study that I've been waiting four years
to happen so that I could actually make
a video about polycystic kidney disease
and what you should do about it and what
you should not do about it in this
randomized control trial they found that
being in ketosis because you're eating a
ketogenic diet Shrunk the size of
polycystic kidneys Shrunk the size of
the cysts and improved the function of
kidneys from people suffering from
polycystic kidney disease this is a
human study not an animal study and it's
a randomized control trial so it's
really hard for anybody to argue at this
point that if you have polycystic kidney
disease or you had a a loved one a
father mother grandparent who had
polycystic kidney disease and you're at
risk because it is genetically
transmitted the
predisposition if you start a ketogenic
diet early enough in life and then going
from the animal models also includes
some degree of Tim restricted eating
eating in a a six-hour window so having
one or two meals a day and making those
one or two meals a day a ketogenic diet
type meal very very low in carbohydrates
you are most likely to be able to
prevent polycystic kidney disease from
ever rearing its ugly head in your life
at the best now at the very worst case
scenario is that your polycystic kidney
disease is going to progress much less
slowly you're going to have much less
kidney damage done you're going to
preserve kidney function for years
longer than you would have have done
otherwise if you were eating the the
standard Western diets and you're going
to put off having to be on dialysis due
to endstage renal disease you could
potentially put that off by DEC AES by
eating a ketogenic diet very strictly
and by doing some degree of Tim
restricted eating now I was super
excited about these findings and so I
rushed over to the PKD foundation's
website figuring that they'd already
updated their website and we're
recommending a ketogenic diet and
intermittent fasting for everyone with
PKD and when I get to their site I find
that under nutrition they say there's
really no evidence that any Di dietary
intervention has any effect on it and
they go on later on the page to
recommend the DASH diet which there's
literally no research that that in any
way protects kidney function if you have
polycystic kidney disease so I'm not
real sure what I got that from let me
kind of sum up everything we know about
polycystic kidney disease so far and
everything that you should do and should
not do if you have polycystic kidney
disease or if you are the child or the
grandchild of someone who had polycystic
kidney disease now there are genetic
tests for this but most doctors don't do
them very often and and would have to
look it up to see what the test is but
if you are at risk if you think well you
know great granddaddy had that weird
kidney disease nobody could figure out
you should probably talk to your doctor
about getting tested genetically to see
if you have a predisposition for
polycystic kidney so now the question
what should I do what should I not do if
I have PKD or if I think I might have
the G genes that predispose me to PKD so
the first recommendation based on not
only animal studies and three different
species of animal plus now a randomized
control trial in human beings if you
have PKD or suspect that you do you
should immediately start a whole food
real one ingredient ketogenic diet I've
got a ton of videos on my YouTube
channel here about what a ketogenic diet
is and how to do that in a healthy
manner you should also Implement some
degree of intermittent fasting whether
that's you you fast for 16 hours a day
and then have an 8 Hour feeding window
where you eat two ketogenic meals a day
you could even tighten that up even more
if you really wanted to put off the
disastrous complications that come from
PKD you could fast for 18 hours a day
and then have two meals in a 6-hour
window or then some people love just
eating one meal a day that's perfectly
appropriate if you have PKD or if you
have are at risk of it is to just eat
one ketogenic meal a day and then fast
for the remainder of the day now keep in
mind that a carnivore diet is a subset
of a ketogenic diet and it's going to
keep you in ketosis for the vast
majority of the day so if you're like
well I love meat and eggs I could just
eat one huge meat and egg meal a day and
be very happy absolutely that's going to
be very therapeutic for you if you have
PKD or are at risk of developing it now
things that doctors very often give
patients advice that's just wrong this
not based on any research whatsoever
there's no science that bears out these
recommendations is oh you should limit
the amount of protein that you eat or
limit the amount of red meat no research
back set up whatsoever number two oh you
should cut back on salt or limit your
salt or avoid salt again in PKD there is
zero research to recommend a low salt
diet to you that's not going to help you
at all next is oh you should either
drink lots of water or limit your water
intake the goal seems to be because of a
PKD you're at increased risk of kidney
stones right the goal seems to be is to
drink enough water each day so that your
urine is a very light yellow color you
don't need to drink enough water for it
to be completely clear like water you
also don't want it to be moderate or
dark yellow you want it to be light
yellow that's the sweet spot for
avoiding the kidney stones also you
don't want to overwork your kidneys by
just drinking too much unnecessary water
the next is caffeine a lot of docs will
tell you to limit caffeine or avoid
caffeine literally no research bears
that out if you want a cup of coffee in
the morning or a glass of unsweetened
tea at lunch absolutely there's no
problem with caffeine at all now there
is some research showing that potassium
citrate or magnesium citrate seems to
slow down the progression and so talk to
your doctor about a potassium or a
magnesium supplement and see if they
that they like that idea because that's
also something that's been shown in some
research to slow down the progression a
little bit what about alcohol you need
to avoid alcohol the worst thing you can
do in PKD is to have a sugary mixed
drink like a Manhattan or a Shirley
Temple or whatever your poison of choice
is you need to avoid all alcohol if you
want to have one drink on your birthday
or your anniversary that's probably fine
but it needs to be a sugar-free zeroc
carbohydrate drink because the thing
that's going to destroy your kidney
function and make the cyst grow faster
according to this research is if you
drink or eat anything that spikes your
blood sugar that increase of glucose in
your bloodstream is going to cause the
cyst to grow faster so you want to keep
your blood sugar as low normal as low as
you can keep it for as many hours a day
as you possibly can and the last thing
is if you're smoking right now come on
stop smoking that's dumb there's no
research showing that smoking hastens
PKD damage or causes in stage renal
disease quicker but we know smoking is
really bad for you so just don't do that
now on the PKD foundation's website they
list a couple of example days of eating
and since they recommend the DASH diet
which is based on no research for PKD
I'm not sure where they got these meal
recommendations from but I'm going to
give you just a day of eating for
somebody with PKD so you're going to
wake up and you're either going to have
breakfast and lunch or you're going to
have lunch and dinner you're going to
skip you're going to have just two meals
a day or you can have just one big meal
a day and both of those are ideal for
preventing the progression for
protecting your kidney function so
you'll wake up let's say you're going to
have breakfast and lunch and skip dinner
wake up you're going to have bacon and
eggs or steak and eggs for breakfast
remember the protein does is not bad for
your kidneys at all there's no research
to support that red meat is good for
your kidneys it's not bad for your
kidneys so if you want steak and eggs
every morning fine have at it and what
that's going to do the help healthy fat
and healthy protein are going to keep
you saet keep you full for many hours so
that it makes it much easier for you to
do the 16 or 18 hour intermittent fast
that you want to do every day to protect
your kidney function now the second meal
a day we'll say is lunch you could have
any kind of meat any kind of eggs with
the yolk always with the yolk and then
you could have a serving of low carb
vegetables with that you could have a
few low carb nuts with that and a few
low carb berries for your dessert and
what you definitely don't want to do is
snack in between meals you want to keep
your blood sugar and your insulin levels
as low as you can for as many hours a
day as you possibly can so now what if
you just want to eat one big meal a day
that meal of the day for me personally I
would have that in the afternoon because
that just works better for my life my
family my social but whatever meal of
the day works best for you you could
have as many eggs with bacon as many
eggs with steak you can have if you want
chicken that's fine if you want pork
that's fine but you're going to have
steak meat and egg
and that's it you're going to eat until
you can't eat another bite and then
you'll fast until the next day when you
eat that a meal like that again so now
keep in mind my dietary recommendations
are based on studies in mice in rats and
in cats and now a randomized control
trial in human beings the most important
animal at all of all when it comes to
you and your health as always I've
linked all the studies that I use to
make this video down in the show notes
below if you go to a a primary care
doctor or a kidney specialist and they
say limit meat limit protein limit
caffeine any of the stuff I talked about
here or to eat the DASH diet or to eat
you know a plant-based diet realize
immediately that their recommendations
are based on not a shred of research
whatsoever there is research in humans
in a randomized control trial showing
that a ketogenic diet which by
definition is going to include lots of
meat of some kind because you you if
you're not going to eat carbs you got to
eat something two meals a day or one
meal a day with somewhere between 16 and
22 hours of fasting each day that is
going to protect your kidney function
and add years to your life and keep you
off dialysis for potentially decades the
research is down in the show notes I
hope this video helps if you know
someone who has PKD or a family who's
had that I would share this video with
them so that they can start now before
the PKD gets out of hand and has done
permanent kidney damage hope this video
helps this is Dr Barry see you next time
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