I Analyzed EVERY NMN Human Study (Including MIB-626). The Facts (‼️2024‼️)
Summary
TLDRThis video script delves into the efficacy of NMN, an anti-aging supplement, through a comprehensive review of 16 clinical trials. It highlights the lack of significant impacts on health metrics such as blood sugar, cholesterol, and blood pressure, despite increasing NAD levels. The script also discusses the potential benefits on exercise performance and sleep quality in older adults, while expressing skepticism about NMN's geroprotective claims due to mixed and inconclusive results.
Takeaways
- 🧪 NMN (Nicotinamide Mononucleotide) is a popular anti-aging supplement with various human clinical trials investigating its effects.
- 🔍 The speaker is not affiliated with any supplement or pharmaceutical company, ensuring unbiased review.
- 🏥 Initial safety studies on NMN showed it raised NMN metabolites without affecting heart rate or blood pressure, indicating short-term safety.
- 📈 A peculiar finding was a 51% increase in bilirubin levels in some subjects, though still within normal range, and not consistent across studies.
- 🚫 No negative side effects were reported in a larger safety study involving 31 participants given 1,250 mg of beta-NMN daily for 4 weeks.
- 💊 Beta-NMN did not lower cholesterol, LDL, or triglyceride levels, despite the dosage, suggesting no impact on these health markers.
- 🚶♂️ A 2-month study with 66 participants found no side effects from the Uthever brand of NMN, but it also did not improve walking distance or well-being significantly.
- 🩸 A clinical trial with diabetic patients showed a 25% increase in muscle insulin sensitivity with NMN but no significant improvement in blood sugar levels.
- 💉 A study involving NMN infusions (not supplements) in healthy individuals showed a temporary drop in triglyceride levels, suggesting different mechanisms of action.
- 🏃♀️ Among amateur runners, NMN supplementation improved ventilatory threshold but not VO2 Max, muscle strength, or endurance.
- 👴 In older adults, chronic NMN supplementation showed mixed results with some reporting improved sleep and daytime function, but no significant impact on cognitive tests or physical performance.
Q & A
What is Nicotinamide mononucleotide (NMN) and why is it popular?
-Nicotinamide mononucleotide, known as NMN, is an anti-aging supplement that has gained popularity due to its potential to increase levels of NAD+ in the body, which is associated with various health benefits and slowing the aging process.
What was the outcome of the first safety study on NMN involving 10 healthy men?
-The first safety study found that NMN raised metabolites of NMN without affecting heart rate or blood pressure. However, it reported a 51% increase in bilirubin, which remained within the normal range, and this increase was not observed in other studies.
What was the dosage and duration of the safety study involving 31 healthy individuals?
-In the safety study with 31 healthy individuals, they were given 1,250 mg of beta-NMN or a placebo daily for 4 weeks.
What were the effects of the Uthever brand of NMN on the NAD to NADH ratio in a 2-month study?
-The Uthever brand of NMN increased the NAD to NADH ratio by about 40% in the 2-month study involving 66 healthy men and women.
Did NMN show any significant improvements in blood sugar levels in the clinical trial involving 35 overweight women with elevated blood sugar levels?
-No, the clinical trial showed that while NMN increased insulin sensitivity by about 25%, there were no significant improvements in blood sugar levels.
What was the result of the 3-month study involving 11 healthy men and women taking 250 mg of NMN daily?
-The study found that NMN raised plasma NMN levels but failed to lower blood sugar, hemoglobin A1c, cholesterol, LDL cholesterol, or triglyceride levels. Interestingly, it reported a doubling of triglyceride levels after one month, which returned to higher than normal levels by the end of the study.
What was the focus of the cardiovascular disease study involving 34 men and women in their late 40s?
-The study aimed to determine if NMN could improve the health and functioning of blood vessels, but it found no significant differences in arterial stiffness between the placebo and supplement groups.
What were the findings of the study on NMN and exercise performance in amateur runners?
-The study found that NMN supplementation improved the ventilatory threshold, indicating that runners could exercise harder before feeling difficulty. However, it did not improve VO2 Max, oxygen saturation, muscle strength, muscle endurance, or flexibility.
What was the observation regarding telomere length in the small study involving 8 individuals taking NMN for 3 months?
-The study reported a significant increase in the length of telomeres in white blood cells after 3 months of NMN supplementation, suggesting a potential impact on aging at the cellular level.
What was the outcome of the study involving 80 middle-aged men taking different dosages of beta-NMN for 2 months?
-The study showed that 600 mg of beta-NMN was more effective at raising NAD levels than 300 mg, but 900 mg did not outperform 600 mg. Participants reported improved quality of life, with those on 600 and 900 mg doses noticing benefits within 30 days.
What is the general consensus on the side effects of NMN based on the clinical trials presented in the script?
-The general consensus from the clinical trials is that NMN does not report any significant negative side effects.
What is the author's overall stance on NMN as a geroprotective supplement after reviewing the clinical trials?
-The author remains skeptical of the claims for NMN as a geroprotective supplement based on the results of the clinical trials presented.
Outlines
🧪 Initial Safety and Metabolism Study on NMN
The first paragraph introduces the focus on human clinical trials of NMN, an anti-aging supplement. It discusses an initial safety study involving 10 healthy men, who were given varying doses of NMN. The study found that NMN increased its metabolites without affecting heart rate or blood pressure. However, it noted a 51% increase in bilirubin, which, despite being within normal range, was an unexpected finding. The speaker also mentions being unbiased, not affiliated with supplement or pharmaceutical companies.
🔎 Expanded Safety Studies and Beta-NMN Effects
This section continues the safety discussion with a larger study involving 31 participants receiving 1,250 mg of beta-NMN daily for four weeks. No negative side effects were observed, and there were no changes in cholesterol, LDL, or triglyceride levels. Another study with 66 participants taking 300 mg of NMN daily showed no side effects and a 40% increase in the NAD to NADH ratio but did not improve walking distance or overall well-being significantly. A clinical trial with diabetic patients showed a 25% increase in insulin sensitivity but no significant improvements in blood sugar levels, blood pressure, body fat, or weight.
🏃♂️ NMN's Impact on Exercise Performance and Long-Term Supplementation
The paragraph explores NMN's effects on exercise performance in a study with 48 middle-aged runners. It found that NMN supplementation improved the ventilatory threshold at higher doses but did not affect VO2 Max, muscle strength, endurance, or flexibility. An interesting note was the improvement in balance at a 600 mg dose. The paragraph also discusses long-term supplementation in 34 participants, noting no improvements in arterial stiffness or blood sugar levels, and a study on NMN infusions in 10 middle-aged individuals that showed a temporary drop in triglyceride levels.
👴 Effects of NMN on Older Adults and Telomere Length
This section examines NMN's effects in older populations, with a study involving 40 older men showing no significant improvements in fat reduction, insulin sensitivity, cholesterol, blood pressure, or cognitive function. However, it did report an increase in gate speed. Another small study on telomere length in 8 individuals found a significant increase in telomere length after 3 months of NMN supplementation, suggesting potential anti-aging effects.
🛌 Sleep and Daytime Functioning with NMN Supplementation
The paragraph discusses a study involving 80 middle-aged men given varying doses of beta-NMN, reporting improved quality of life and quicker perceived benefits at higher doses. No significant changes in cholesterol, LDL, triglycerides, or bilirubin were observed. Another study with 60 older adults reported improved walking distance and self-reported better sleep and daytime functioning with NMN supplementation.
💊 Evaluation of MIB-626 and NMN Effects in Older Diabetic Men
This section presents data on MIB-626, a proprietary form of beta-NMN, showing increased NAD levels in overweight individuals at dosages of 1,000 to 2,000 mg daily. Another study reported reductions in body weight and cholesterol with MIB-626 but no improvements in muscle strength, aerobic capacity, insulin resistance, or fat reduction. A long-term study with older diabetic men found no improvements in grip strength, walking speed, or diabetes management with NMN supplementation.
🕒 Timing of NMN Intake and Its Overall Effectiveness
The final paragraph discusses a study on the timing of NMN intake in older adults, with no clear impact on sleep quality but suggestions that longer-term use may improve sleep and daytime function. A potential difference was observed between afternoon and morning intake regarding drowsiness. The speaker concludes by summarizing the findings from 16 clinical trials, expressing skepticism about NMN's effectiveness as a geroprotective supplement.
Mindmap
Keywords
💡NMN (Nicotinamide Mononucleotide)
💡Anti-Aging Supplement
💡Clinical Trial
💡Safety Study
💡Metabolites
💡Cholesterol and LDL Levels
💡Insulin Sensitivity
💡Ventilatory Threshold
💡Telomeres
💡MIB-626
💡Geroprotective
Highlights
NMN is a popular anti-aging supplement with ongoing human clinical trials to assess its safety and efficacy.
Initial safety studies on NMN showed no changes in heart rate or blood pressure, indicating good tolerability.
An increase in bilirubin levels was observed in one study, but it was within normal range and not replicated in other studies.
A larger safety investigation found no negative side effects from 1,250 mg of beta-NMN daily for 4 weeks.
NMN supplementation did not lower cholesterol, LDL, or triglyceride levels in studied populations.
A 2-month study showed no side effects from a specific brand of NMN called Uthever, and a 40% increase in the NAD to NADH ratio.
NMN did not improve walking distance or overall well-being in a well-being test according to one study.
In a study with diabetic patients, NMN increased insulin sensitivity by 25% but did not significantly improve blood sugar levels.
A 3-month study showed NMN raised plasma NMN levels but did not decrease them after stopping the supplement.
NMN supplementation in one study doubled triglyceride levels temporarily, but this effect was not consistent across studies.
Long-term NMN supplementation showed no significant improvements in arterial stiffness or cardiovascular health.
A study on NMN infusions in healthy individuals showed a temporary drop in triglyceride levels, but the effect was not sustained.
NMN supplementation in amateur runners improved ventilatory threshold but did not affect VO2 Max or muscle strength.
Chronic NMN supplementation in older adults showed nominal improvements in grip strength and walking speed.
A small study suggested that NMN supplementation may increase telomere length in white blood cells.
MIB-626, a proprietary form of NMN, raised NAD levels but did not improve muscle strength, endurance, or insulin resistance in short-term studies.
The longest NMN study conducted in older men with diabetes showed no improvements in grip strength, walking speed, or diabetes management.
A study on the timing of NMN supplementation suggested potential benefits for sleep and daytime function, but results were inconclusive.
Overall, the clinical trials presented do not strongly support the claims of NMN as a geroprotective supplement.
Transcripts
Nicotinamide mononucleotide, better known as NMN, continues to be one of the most popular
anti-aging supplements on the market today. Get comfy because now we're going to take a deep
dive into every human clinical trial on NMN I was able to locate oh and by the way I don't work for
any supplement company and I don't work for big Pharma either. Okay, so before we go any further,
there have been some safety studies of NMN to make sure it's safe, so let's begin our discussion
by looking at those. so we have this paper which is probably the first safety study ever done it
was involved 10 healthy men they're in their late 40s and they're given between 100, 250 and 500 mg
of NMN each day or a placebo. 5 hours later they give these guys some tests and they notice that
the NMN did in fact raise metabolites of NMN and that's good however there were no changes in heart
rate or blood pressure. that's good as well; didn't make heart rate go up and didn't make
blood pressure go up so that's a good thing. now one oddity of this paper that I wanted to call
your attention to is that this paper also reported that bilirubin increased by about 51% in those who
took NMN supplements although the increase in bilirubin was still within the normal range.
now I bring that up in case you have your blood test done and this happens to you although I do
think this is going to probably be a fluke because having looked at all the other studies that were
about to talk about I don't see a rise in bilirubin in any of those studies that actually
measured that compound. next up we have this safety investigation which was a bit larger.
we have 31 healthy men and women they're in their mid 30s and they're given a whopping 1,250 mg of
beta NMN or a placebo each day for 4 weeks oh and by the way if you're wondering, beta-NMN is often
said to be the active form of this compound. so the good news here is that after 4 weeks of use
beta NMN did not cause any negative side effects there were also no changes in cholesterol levels
or bad cholesterol LDL levels or triglycerides either. And while that is good that the values
did not increase it is also true from this paper that 1250 mg of beta n NMN did not lower
these values either. next up is this next safety investigation which has a very wordy title as you
can see where 66 healthy men and women they're in their late 40s and they're given 300 mg of
nicotinamide mononucleotide or placebo and they take the supplement or the placebo every day after
breakfast and the study lasts 2 months. oh and by the way in this study they're actually testing a
specific brand of NMN called Uthever which is a pretty catchy name if you ask me. now the good
news here is that there were no side effects reported from the Uthever supplement .that's
really good and if we drill down further, we also see that this supplement increased the NAD to NADH
ratio by about 40%. that's good too. However on the flip side, the NMN supplement did not increase
walking distance when people did what was called the six-minute walk test. now these people were
also given a well-being test called the S-36 test and while some of them appeared to show that their
overall well-being appeared to improve, when they were taking the NMN supplement the differences
be between the supplement takers and the placebo takers again was not clinically meaningful. As for
blood pressure, the supplement did not lower blood pressure any better than a placebo. there were no
significant differences there and additionally, there were no significant improvements in insulin
sensitivity, in other words how well insulin can lower blood sugar levels. However, these people
were generally healthy and so I wouldn't expect it to have a significant effect in people who don't
have diabetes for example. Speaking of diabetes, we have this clinical trial that investigated the
effects of NMN supplements in people who had elevated blood sugar levels for 10 weeks 35
overweight women who were in their 60s who also had elevated blood sugar levels were given 250
milligrams of NMN or a placebo each day and as they do state in the title of this investigation
the insulin sensitivity of muscles was increased by about 25% and that is good; however, there were
no significant improvements in blood sugar levels. Furthermore, there were also no reductions in
blood pressure or body fat or body weight either. here's a sample of some of the before and after
results that occurred in this investigation feel free to stop the video at this point and zoom in
and take a closer look at what happened. They also gave these people before and after grip strength
test to gauge how well NMN might have made these people stronger however it didn't. ironically too,
there were no improvements in muscle mitochondrial function either. I bring that up because one of
the things that NMN is supposed to do is help the mitochondria work better. in this paper, it
didn't. next up is this study that lasted 3 months it involved 11 healthy men and women they took 250
milligrams of NMN or a placebo each day in the morning and as the title does indeed tell us
NMN supplements did raise plasma NMN levels that's good. However those levels began to decline after
about a month of not taking the supplement any longer and that's to be expected once you stopped
taking these things, your NAD levels would be expected to go back down again as we can see from
this before and after table NMN also significantly raised insulin levels after just 2 months now
insulin is responsible for lowering blood sugar however in this paper it is also reported that
NMN failed to lower blood sugar or hemoglobin A1c likewise NMN supplements did not lower cholesterol
levels or bad LDL cholesterols either however the weirdest thing in my opinion that was reported in
this study is what happened to triglyceride levels after just one month; triglyceride levels doubled
from about 80 to 186 mg/dl by the end of the study the triglycerides had declined a bit down
to 155 mg/dl but that's still higher than when is normally recommended for healthy people. Now to be
fair, this is the only clinical trial I located showing that triglyceride levels skyrocket after
taking NMN supplements so it might be a fluke however if you ask me this finding should have
been in the title of this investigation. next up is this interesting investigation of what
they call long-term NMN supplementation where we have 34 men and women they're in their late 40s;
they are given 250 milligrams or placebo each day for 3 months and they're basically looking at
whether NMN can improve the health and functioning of the blood vessels. so this is essentially a
cardiovascular disease study although they did also measure some other things as well
For example these researchers report that NMN significantly raises nicotinamide levels in the
serum and that makes sense because NMN contains nicotinamide, which is also known as niacinamide,
the no flush version of niacin. now moving on to arterial stiffness which I think is the main focus
of the study there were no significant differences in arterial stiffness between placebo takers and
supplement takers and something else they point out is that this lack of improvement also seemed
to carry over to whether or not the people had high blood pressure or not so again you would
think that might not work as well in people with normal blood pressure but there didn't
appear also to be any significant Improvement in arterial stiffness in people who had high blood
pressure either. Additionally these researchers also tell us that NMN supplements also did not
have any Improvement on lowering blood sugar levels or lowering bad LDL cholesterol levels
it didn't raise HDL levels or triglycerides and it didn't raise testosterone or other hormones either
however, on the plus side, it's also reported that there were no increases in liver enzymes
either so that is good. next up is this paper which tells us from the title that NMN is not
only safely broken down in the body but it also significantly lowers triglycerides too. now that
statement is bound to get everybody's attention especially those who have elevated triglycerides;
however there is a word that they did not include in the title of this study. this clinical trial
in involved 10 healthy middle-aged men and women they were in their 40s and they were given 300 mg
of NMN that was dissolved in 3.5 ounces of water. That solution was then injected into these people;
in other words they gave these people infusions of nicotinamide mononucleotide which is very
different than taking an NMN dietary supplement. Another limitation of the study in my opinion,
is that they gave these people before and after blood tests 5 hours before and up to 5 hours after
they gave them the infusion; in other words, this study only lasted 10 hours. And, as I pointed out
in my original review of this investigation, the triglyceride levels began to drop quickly
after the NMN infusion. they went from around 80 mg/dl all the way down to 20 mg/dl in about an
hour after getting the infusion. however -and this is an important point -those triglyceride levels
began to rise again after about 3 or 4 hours. Now I've heard that people are getting infusions of
NMN and this paper might be one of the reasons why that's happening however I do want to point
out a few problems with this study .number one, the people were healthy; in other words, they
didn't have elevated triglyceride levels to begin with so that's one problem. The othe problem with
this study is that there was only 10 people so it was a small investigation. There was no placebo
group. Something else is that the NMN infusions were given to people after an overnight fast,
so what would happen if you had breakfast and then went and got your infusion? Would the same thing
happen with triglycerides or anything else? We're not sure yet. And also, because the study lasted
just 10 hours, this can't prove that infusions of NMN will indeed lower triglyceride levels
long-term. Now let's switch gears and talk about whether NMN can improve your exercise performance,
and we have this paper, nicotinamide mononucleotide supplementation enhances
aerobic capacity in amateur runners: a randomized double-blind study. Here we have 48 middle-aged
men and women; they are runners. They're actually part of a running group in China and they are
given three different dosages of NMN - 300 mg 600 mg and 1200 mg- or a placebo each day and
the study lasts for 6 weeks. everybody works out 5 to 6 days a week for between 40 and 60 minutes
per exercise session and I also want to point out that the placebo in the study that was used was a
combination of cranberry powder and maltodextrin, so kudos to the researchers for telling us what
the placebo is. we'll stick a pin in that for right now I want to circle back and talk about
that in a moment so the first thing that I would say is that NMN failed to promote any superior
losses in body fat or body weight. However the supplement was reported to improve what's called
the ventilatory threshold and higher doses of NMN appear to increase ventilatory threshold better
than lower doses. And if you're unfamiliar with that term ventilatory threshold is the point of
exercise when you start breathing harder and exercise begins to start to feel difficult
for you. It's also associated with the buildup of lactic acid in the body during exercise in other
words, NMN supplements appeared to help these runners work harder/ exercise harder before they
started to feel the exercise getting difficult and that is actually really interesting. However,
I will point out that even though ventilatory threshold is associated with the buildup of
lactic acid, unfortunately, they did not measure lactic acid in this study. I also want to point
out that NMN did not improve VO2 Max or oxygen saturation in these runners either. VO2 Max is
essentially the maximum volume or amount of oxygen that you can consume into the body and turn that
oxygen into energy and oxygen saturation is essentially how much oxygen is saturating
your blood. and while no improvement was seen in the study I really can't fault on this because
we are looking at highly conditioned runners who already likely have a very high VO2 Max to start
off with and because they're also healthy their oxygen saturation is also extremely high as well.
Now they also perform some fitness testing on these runners as well and it's reported that
NMN supplements did not improve muscle strength or muscle endurance and it didn't improve flexibility
of the muscles either. One odd result is that NMN did appear to improve balance,
however that was only seen in those who were taking the 600 mg dose. Now, I want to circle
back for a moment and talk about that placebo that was used in this study. if this study is ever
replicated my hope Is that the cranberry powder is taken out of the placebo and that is because
there is some research suggesting that cranberries may have an exercise benefit. Let's switch gears
and talk about the effects of NMN in older adults and let's begin with this paper involving chronic
long-term supplementation which they define as 3 months. Here we're dealing with 40 older men;
they're in their 70s and they're given either a placebo or 250 mg of NMN each day. Here's
the various tests they did on these people at the beginning of the study. To me it looks like their
hemoglobin A1c values look a little bit on the high side, so some of these individuals may be
moving into pre-diabetes. Now the other thing I want to point out with this paper is that it
does suffer from what I think as a big problem and that is they began their study originally
with 42 people but only 20 people completed the investigation and the reason is that after the
study it was recognized that the supplier of the placebo and the supplements made an error which
resulted in 11 of the supplement takers getting placebos and 11 of the placebo people getting the
actual NMN supplements. So those 22 people had to be removed from this study. Okay so all that
said what happened? So no surprise, NMN raises NAD levels and levels of NMN itself also as well
as its metabolites so that's good one interesting finding here however is the observation that NMN
also increased levels of nicotinamide riboside. Nicotinamide riboside is the other big player
in this NAD booster arena and I will link to my videos on nicotinamide riboside below so you can
see more about the research on that. we see from the results that NMN supplement did not reduce fat
from either the liver or the spleen and likewise, there were no improvements in insulin sensitivity
either. Additionally as pointed out in other studies, NMN failed to produce any improvements
in cholesterol, LDL cholesterol triglyceride blood sugar hemoglobin A1c or fasting glucose levels
either. Likewise there was no improvement in blood pressure or blood vessel health and before
and after cognitive tests showed no improvement in learning or memory either. Now they did point out
that hearing seemed to improve -in the right ear only -however, it wasn't a clinically significant
effect so it might have just been a fluke. Now as for the effects of NMN on muscle, well,
there were no improvements in muscle mass in these people however there was a somewhat Improvement
in grip strength in the left hand only in the people who were taking the supplements. however
it wasn't clinically significant; it was said to be a "nominal improvement." On the flip side these
researchers did see a significant improvement in gate speed where the people taking the supplement
did appear to be able to walk a little faster. Next up we have this interesting investigation
involving telomere length. It's a small study involving only 6 men and 2 women; they're between
the ages of 40 and 60 and they take 300 milligrams of NMN in the morning, 30 minutes after breakfast,
with warm water. They do this each day for 3 months. For me, the most interesting part of
this study was where they report that 3 months of NMN supplements -again at 300 milligrams a
day - caused a significant increase in the length of the telomeres in white blood cells. Telomeres
are found at the ends of the chromosomes and as we get older, telomeres begin to shorten, and so some
associate shorter telomes with increased aging. Next up is this study which has a really long
title where 80 middle-aged men in their late 40s are given either 300, 600, or 900 mg of beta NMN
daily versus a placebo and the study lasts for 2 months. oh, and by the way it's pointed out that
they're testing a specific brand called AbinoNutra NMN. One of the interesting -and odd- parts of
this study is where they state that NAD levels in the blood rose more (went higher) when people took
600 mg, more than when they took 300 mg; however you didn't see this when people took 900 mg of
NMN. in other words 600 mg raised NAD better than 300 mg did but 900 didn't work any better than
600. Everybody who was taking the supplement said that their quality of life had improved by the end
of the study and those who were taking the 600 and 900 milligram dose actually started feeling better
within just 30 days. moving on to the blood tests here are some of the before and after values that
were reported in this study and as you can see there were no significant changes in cholesterol,
LDL, cholesterol, triglycerides, or insulin resistance. notice here also that bilirubin
did not go up either which contradicts the outcome of that other study I told you about previously
which stated that bilirubin increased 51%. this study contradicts that and so again reinforces
my thought that the original finding was a fluke. Leaving that paper and moving on to the next one,
we have this clinical trial and again involving beta nicotinamide mononucleotide where 60 older
people took 250 mg of beta NMN or placebo again the study lasts for 3 months. Results
of this study revealed that there was no improvement in the step test; in other words
how many times people could step up and down in a period of time. However the people taking the
supplement could walk a bit further than those who took placebos. It's also reported that those
who took the supplements stated that they slept better and that they appeared to function better
during the daytime hours and I thought this was interesting because several people have told me
privately that NMN seemed to help them sleep better so this may be some evidence for that
although I do want to point out that I wasn't able to read this full study when I posted this video
and in the process of getting it now so when I do get this investigation I will do a follow-up more
in-depth video on this investigation. next up is what I believe is the very first clinical trial
on MIB 626. MIB-626 is a proprietary version of beta nicotinamide mononucleotide that was
developed by Metro International Biotech. Here we have 31 overweight people and they're between the
ages of 55 and 80. They're given 1,000 milligrams of MIB-626 either once a day or twice a day for
two weeks. So in other words these people are taking between 1,000 and 2,000 mg of MIB 626
daily. Results show that the 1,000 mg dose of MIB 626 raised blood levels of NAD about 1.7 times
above baseline while those taking the higher dose of 2,000 milligrams each day saw a bump of about
3.7 times higher NAD relative to what it was a baseline. And while that is nice do you notice
what they didn't do? In the study, they didn't compare MIB 626 to regular NMN. Now we also have
another investigation of MIB 626. Here it is 30 overweight people are given either placebo or
1,000 mg of MIB 626 NMN each day for 28 days. Here they are reporting that not only did NAD levels
rise, but also there were significant reductions in not only body weight but also cholesterol,
LDL and non-HDL cholesterol as well, and let's reiterate these benefits showed up after just
28 days. However when they tested these older adults, they found that MIB 626 failed to improve
muscle strength or muscle endurance; it didn't help aerobic capacity or stair climbing and it
didn't reduce insulin resistance or liver fat or abdominal fat either. The next paper I want
to show you is this investigation of NMN in older men with diabetes 14 men who are in their 80s are
given 250 milligrams of NMN or a placebo for 6 months. To my knowledge this is the longest
NMN supplement study that I was able to find and while this is indeed a small investigation, I like
it because we're dealing with older, frail people which is a great population to test an anti-aging
supplement on. results from the study showed that NMN failed to improve grip strength which is again
a common indicator of muscle strength and it also didn't help these older people walk faster either.
Likewise there was no improvement in diabetes in these people either. by the way I was also
unable to get a hold of this study by the time I made this video when I do get it I'll make a more
in-depth video on this paper too. And, if you're still with me fantastic, now we come to the very
last clinical trial that I have for you today and it involves 108 older men and women they are in
their 70s they take 250 milligrams of NMN each day or a placebo and this study lasts for 3 months and
to see if it is better to take NMN in the morning or in the evening they actually broke people up
into am and PM groups and just to be more clear here they defined the AM group as taking NMN any
time from when they awoke up to 12:00 p.m. and the PM group was defined as anywhere from 6:00 p.m. on
to bedtime. The results of this study reveal that the quality of sleep didn't appear to be impacted
by NMN however the longer they took the supplement the better their sleep was and daytime function
scores were in other words the longer they took the supplement appeared to play a role in their
sleep and their daytime functioning something else that's reported that is worth mentioning is
that there may have been a difference in the time effects here where people taking the supplement
in the afternoon appeared to have less drowsiness compared to people who took this supplement in the
morning. However it's also reported that there was a placebo effect that was observed here as well so
what this means is we're still not sure whether it's better to take NMN in the morning afternoon
or in the evening. Okay if you're still with me phenomenal we're almost done I know I presented an
awful lot of information here so let's see if we can make some sense out of the results of all of
these studies now the first thing I would say is that pretty much all the studies don't report any
negative side effects so that is a good thing and also pretty much all of them state that when you
take the supplement, NAD levels and metabolites of NAD also increase as well that's good. However,
I would also point out that the study researchers usually only measure NAD levels in a couple places
like plasma, blood, skeletal muscle cells, etc. in other words we still don't know if taking
these supplements increases NAD levels throughout the body, although that is the assumption. now I
couldn't show you all the studies on the screen at one time because there's just too many of them,
so let's break this down and begin by looking at these studies of what I call diabetes and
heart health so if we look at these four clinical trials that I'm showing you right now we can see
some things in common here such as at dosages of between 250 and 300 milligrams per day,
NMN does not appear to have any effects on lowering triglycerides lowering cholesterol or
bad cholesterol levels it doesn't appear to lower blood pressure it doesn't appear to lower blood
sugar or hemoglobin A1 either. we also see the same lack of effect in other studies too and so
far only one clinical trial revealed a significant decline in triglyceride levels but again that was
for intravenously used NMN which is not really relevant to people who take NMN as a dietary
supplement. now if we move over to the exercise effects of NMN I found only one clinical trial
involving high-functioning healthy people who were exercising and taking NMN supplements the study
that you're looking at here does appear to show that at dosages of between 600 and 1200 milligrams
a day, NMN may improve ventilatory threshold after several weeks of use. this as well as other
studies also reveal that NMN does not seem to improve muscle strength or muscle endurance or the
flexibility of muscles either now if we transition to those studies of older folks who take this
supplement well these also add evidence that at dosages between 250 and 1,000 mg taken for several
weeks NMN does not appear to have any significant effects on lowering blood sugar, triglycerides LDL
or improving insulin levels either. Likewise NMN does not appear to improve muscle mass in older
folks either and from what we know so far this supplement may or may not improve walking speed
walking distance or grip strength as for the two studies of the MIB- 626 form of NMN these studies
are ongoing but from the two clinical trials I was able to find the longest of these studies
lasted just 28 days which is not very long. neither study revealed any side effects and both
revealed that at dosages between 1,000 and 2,000 mg per day, NAD levels do indeed go up; however,
these short-term studies also reveal that MIB 626 doesn't appear to have any beneficial effect
on blood pressure, cholesterol, LDL cholesterol, liver fat or insulin resistance. Moving forward
researchers should also compare MIB 626 effects to regular NMN as well as the already well-known
health benefits of regular exercise. So if I would have boil this down into one statement
this would be it: based on the results of the 16 different clinical trials I just presented,
I remain skeptical of the claims for NMN as a geroprotective supplement but what do you think?
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