Praktikum Farmasetika - Pembuatan Sediaan Pulvis

Summary

This instructional video guides viewers through the process of preparing a 'pulvis' (powdered medication), emphasizing safety and precision. The tutorial covers the proper use of personal protective equipment, including laboratory coats, gloves, and masks. It details the necessary tools and ingredients, such as zinc oxide, magnesium oxide, and talcum powder, while explaining each step: weighing, mixing, and sifting the materials to ensure the right consistency. The final product is evaluated for quality and labeled as an external-use medication. The video provides a thorough, step-by-step approach, ensuring the proper techniques are followed for effective pharmaceutical compounding.

Takeaways

• 😀 Proper use of Personal Protective Equipment (PPE) is crucial, including wearing a lab coat, mask, and removing accessories before starting the procedure.
• 😀 The necessary tools for preparing pulvis include a mortar and pestle, balance, spatula, stirring rod, and parchment paper.
• 😀 Key ingredients for pulvis preparation include zinc oxide, magnesium oxide, salicylic acid, lanolin (adeps lanae), and talcum powder.
• 😀 Weighing the ingredients should be done carefully, with an extra 10% added to each ingredient to account for losses.
• 😀 Magnesium oxide and zinc oxide must be sieved using a 100-mesh sieve to achieve the correct fineness for the preparation.
• 😀 Alcohol is used to prevent irritation, especially when handling salicylic acid and magnesium oxide during the mixing process.
• 😀 Ingredients should be added gradually, with thorough stirring after each addition to ensure a homogeneous mixture.
• 😀 When mixing, talcum powder should be added slowly to avoid clumping and ensure consistency in texture.
• 😀 After mixing, the ingredients must be passed through a finer sieve (44 mesh) to achieve the desired powder consistency.
• 😀 The final pulvis should be placed into a container, and a blue label should be attached, indicating that the product is for external use only.
• 😀 The process concludes with a final evaluation to ensure the preparation meets the required standards for consistency and labeling.

Q & A

Why is it important to wear proper Personal Protective Equipment (PPE) during this procedure?

Wearing proper PPE ensures safety by minimizing exposure to potentially harmful chemicals and substances during the preparation process. This protects the individual from accidents and ensures a safe working environment.

What is the first step in preparing the pulvis according to the script?

The first step is to wear the correct PPE, which includes a laboratory coat, gloves, and a face mask. Accessories like jewelry should be removed before starting the procedure.

What are the key tools used in the preparation of pulvis?

The key tools used include a distemper, mortar, balance, spatula, stirring rod, parchment paper, and a weighing bottle.

Why is it necessary to sieve the magnesium oxide and zinc oxide?

Sieving the magnesium oxide and zinc oxide ensures they are finely ground, which is important for achieving the desired consistency and ensuring the effectiveness of the pulvis.

How is salicylic acid handled in the preparation process to prevent skin irritation?

Salicylic acid is treated with alcohol before being added to the mixture. This helps to prevent skin irritation that could occur from direct contact with the acid.

What is the purpose of adding talcum powder in stages during the preparation?

Adding talcum powder gradually ensures that the powder mixes evenly with the other ingredients, creating a smooth and homogeneous mixture.

What is the significance of adding 10% extra weight during the weighing process?

Adding 10% extra weight during weighing helps to compensate for any potential loss of material during the process, ensuring that the final mixture contains the correct amount of active ingredients.

What role does alcohol play in the preparation of the pulvis?

Alcohol is used to dissolve or wet certain ingredients like salicylic acid and adeps lanae, helping to ensure proper mixing and preventing irritation from direct contact with some substances.

What is the purpose of sieving the mixed ingredients with a 44-mesh sieve?

Sieving the mixture with a 44-mesh sieve ensures that the pulvis has the required degree of fineness, which is crucial for its effectiveness and ease of use as a topical preparation.

What should be done after the pulvis is mixed and sieved?

Once the pulvis is mixed and sieved, it should be placed in a labeled container with a blue label indicating that it is an external preparation. This helps to clearly identify the product and ensure it is used appropriately.