Understanding The Role Of Polynucleotides In Aesthetic Medicine #polynucleotides
Summary
TLDRThis video script delves into the use of polynucleotides in aesthetic treatments, contrasting them with hyaluronic acid for skin quality improvement and volume restoration. It highlights the unique benefits of polynucleotides for treating crepey skin, stretch marks, and hair growth, while emphasizing that for volume loss, fillers or fat transfer are essential. The script also discusses the versatility of polynucleotides, their mechanism of action, and the concept of priming with polynucleotides before other treatments for enhanced results.
Takeaways
- 💉 Fillers or fat transfer are recommended for volume loss, while polynucleotides are for skin quality improvement.
- 🧬 Polynucleotides are polymers made from trout gonads, used as wound healing accelerators and for their lubricating properties.
- 🚫 Not suitable for vegans, vegetarians, or those allergic to fish due to the fish-derived nature of polynucleotides.
- 🔬 Studies suggest polynucleotides may have a greater biostimulatory effect than hyaluronic acid.
- 💧 Hyaluronic acid provides immediate glossiness and plumpness, whereas polynucleotides offer a more dermal effect.
- 👵 Polynucleotides are effective for treating crepey skin texture and stretch marks, but not for providing long-lasting plumping.
- 🔄 They act on different fibroblast receptors compared to hyaluronic acid, leading to distinct clinical outcomes.
- 🌱 Polynucleotides can also stimulate hair growth and improve scar appearance.
- 🛠️ Other treatments for stretch marks include laser, light therapies, micro needling, and carboxytherapy.
- 🧪 Polynucleotides can be used in various concentrations and can be mixed with other products for customized treatments.
- 📈 The concept of 'polynucleotide priming' suggests better results when used before other treatments like dermal fillers or laser resurfacing.
Q & A
What is the primary solution for volume loss according to the transcript?
-The primary solution for volume loss is to have fillers or fat transfer.
What is the main topic discussed in the video script?
-The main topic discussed is polynucleotides, their use in the clinic, and their effects on skin quality improvement.
What are the common misconceptions about biostimulators mentioned in the script?
-The misconception is that people are happy to have biostimulators injections but are reluctant to have fillers, especially cross-linked ones, which doesn't make sense because many biostimulators are indeed cross-linked.
What are polynucleotides and what are they made from?
-Polynucleotides are polymers consisting of double-stranded deoxyribonucleotides, essentially the building blocks of DNA, and they are typically made from trout gonads.
Why might someone not be suitable for polynucleotides treatment?
-Someone might not be suitable for polynucleotides treatment if they are vegan, vegetarian, or allergic to fish, as polynucleotides are derived from fish.
How do polynucleotides differ from hyaluronic acid biostimulators in their clinical effects?
-Polynucleotides give a more dermal effect, suitable for treating crepey skin texture or stretch marks, while hyaluronic acid provides immediate glossiness, plumpness, and hydration to the skin.
What are some alternative treatments for stretch marks mentioned in the script?
-Alternative treatments for stretch marks include laser and light therapies, micro needling, radiofrequency microneedling, and carboxytherapy.
How do polynucleotides affect fibroblasts and what receptors do they act on?
-Polynucleotides act on fibroblasts by providing them with necessary components like nitrogen bases and nucleotide precursors, increasing their viability. They act on receptors 39 and 40.
What is the concept of 'polynucleotide priming' as discussed in the script?
-Polynucleotide priming is the use of polynucleotides prior to performing other treatments to get a larger and faster onset of response from the second treatment type.
What are the side effects of polynucleotides mentioned in the script?
-The only side effects mentioned are potential bruising and downtime, with expense also being a consideration.
How can polynucleotides be applied in treatments and what is the recommended treatment frequency?
-Polynucleotides are normally injected using a fine needle, either in a few big papules or smaller injections over a larger area. It is suggested to have one treatment every 14 to 21 days, for a total of four treatments.
Outlines
💉 Addressing Volume Loss and Skin Quality with Fillers and Polynucleotides
The speaker discusses the treatment options for volume loss and skin quality improvement, emphasizing the simplicity of using fillers or fat transfer for volume issues. They introduce polynucleotides as a biostimulator with a focus on their use in the clinic since before COVID-19, noting an increasing number of patients preferring biostimulators over fillers. The speaker clarifies that biostimulators are not a substitute for volume restoration and highlights the difference between polynucleotides and hyaluronic acid, explaining that polynucleotides are derived from trout gonads and act as wound healing accelerators with a dermal effect, suitable for treating crepey skin texture and stretch marks. They also mention the immediate plumping effect of polynucleotides and their action on different fibroblast receptors compared to hyaluronic acid.
🧬 Exploring Polynucleotides' Benefits and Application in Aesthetic Treatments
This paragraph delves into the benefits and applications of polynucleotides, including their use in skin rejuvenation, hair growth stimulation, and improvement of stretch marks and scars. The speaker discusses the importance of choosing the right concentration of polynucleotides for different skin types and areas of the body, mentioning various product strengths and the possibility of mixing them with other treatments. They introduce the concept of 'polynucleotide priming,' suggesting that pre-treatment with polynucleotides can enhance the effects of subsequent aesthetic procedures. The speaker also references a study showing polynucleotides' effectiveness in healing venous ulcers compared to hyaluronic acid and outlines the various mechanisms by which polynucleotides benefit the skin, such as reducing inflammation, promoting collagen production, and preventing excessive melanin synthesis.
🐟 Considering Polynucleotides for Skin and Hair Aesthetics: Safety and Suitability
The final paragraph addresses the safety and suitability of polynucleotides for a wide range of individuals, including those already undergoing aesthetic procedures or seeking skin rejuvenation. The speaker asserts that polynucleotides are a natural product derived from fish and have not caused any complications in their experience. They highlight the benefits of polynucleotides for treating volume loss, improving skin texture, treating hyperpigmentation, and aiding in hair regeneration. The speaker concludes by reiterating that while polynucleotides are beneficial for skin quality improvement, they are not a solution for volume loss, which requires fillers or fat transfer. They end with a humorous note, inviting viewers to subscribe for more information.
Mindmap
Keywords
💡Volume Loss
💡Fillers
💡Fat Transfer
💡Polynucleotides
💡Hyaluronic Acid
💡Biostimulators
💡Fibroblasts
💡Stretch Marks
💡Microneedling
💡Radiofrequency
💡Priming
Highlights
Volume loss can be addressed with fillers or fat transfer, which are simple solutions.
For skin quality improvement, treatments like polynucleotides, nucleotides, hyaluronic acid, radio frequency, microneedling, and laser can be used.
Polynucleotides have been used in clinics since before COVID-19, offering a wealth of experience with their application.
Some patients prefer biostimulators over fillers, despite the fact that many biostimulators are cross-linked.
Polynucleotides are polymers made from trout gonads and are the building blocks of DNA, not suitable for vegans, vegetarians, or those allergic to fish.
Studies suggest polynucleotides may have a greater biostimulatory effect than hyaluronic acid.
Polynucleotides provide a more dermal effect compared to hyaluronic acid, which offers immediate glossiness and plumpness.
Polynucleotides and hyaluronic acid act on different receptors on fibroblasts, leading to different clinical results.
Polynucleotides can be used for various treatments including around the eyes, neck, backs of hands, and even for hair growth and vulva treatments.
Stretch marks can be treated with polynucleotides, addressing both mechanical stretching and endocrine-related causes.
Polynucleotides help replenish fibroblasts with necessary components like nitrogen bases and nucleotide precursors, enhancing viability.
The Global Aesthetic Improvement scale showed better results with polynucleotides, with minimal side effects like bruising.
Polynucleotide priming, or pre-exposure, before other treatments, can lead to a larger and faster response.
A study on venous ulcers showed that polynucleotides sped up healing compared to hyaluronic acid.
Polynucleotides have various applications, including improving skin texture, treating hyperpigmentation, and aiding hair loss.
Polynucleotides are a natural product derived from fish and have shown to be safe with no reported immune cross-reactivity.
Polynucleotides are suitable for anyone, especially those undergoing aesthetic procedures or seeking skin rejuvenation and quality improvement.
For volume loss, fillers or fat transfer are essential, while polynucleotides are for skin quality improvement.
Transcripts
if you've got volume loss you just need to have fillers or fat transfer like it's just it's simple
simple as that really if you've got volume loss fillers if it's skin quality improvement poly
nucleotides hyaluronic acid radio frequency micro needling laser something like that but volume
loss is only fillers guys Hello friends today I'm going to be talking about polynucleotides
we've been using polynucleotides in the clinic since before covid so we do have a decent amount
of experience in using them before I start one thing that I will say is I'm seeing an increasing
number of people that I like to call victims of biostimulators and what I mean by that is they're
totally happy to have an injection to have some kind of Bio stimulator whether it's a hyaluronic
acid biostimulator or polynucleotide or um Gouri something like this but they really don't want
to have any filler like it's okay as long as it's not cross-linked which doesn't make any sense to
me because a lot of the bio stimulators actually are cross linked like for example Belotero revive
so look if you need volume you need volume and no amount of Biostimulator is going to help you
with that and with that let's continue the more Eagle eyed amongst you may notice that yes I have
a bruise that's because I've been having 70hyal which is a hyaluronic acid based bio stimulator
but look I don't need volume here I literally just want some skin Improvement okay so first of all
what is a polynucleotide and how is it different from a hyaluronic acid biostimulator so these are
polymers consisting of double stranded deoxy ribonucleotides and they are a medical device
which have been in use since about 2004 and they have been used as wound healing accelerators or
for intraarticular injections because they have this lubricating property so these are typically
made from trout gonads and polynucleotides are essentially the building blocks of your DNA so
these are not something to be having if you are vegan or vegetarian or allergic to fish
there are a number of studies showing that the biostimulatory action of polynucleotide might
be greater than that found in hyaluronic acid but it's also worth me saying that they do give you a
slightly different effect clinically so if you're looking for an immediate kind of glossiness and
plumpness hydration to the skin you better off using hyaluronic acid the polynucleotides though
give you a more dermal effect so I have been super happy with them for treatment of more crepey skin
texture um or the treatment of stretch marks although it is true to say that you do get an
immediate Plumping also from the polynucleotide just because you've injected a gel into the skin
but it's not something which is long lasting so both polynucleotides and hyaluronic acid
will act on different receptors on the fibroblast which is of course a cell that produces collagen
the polynucleotide acts on receptor 39 and 40 whereas the hyaluronic acid acts on cd44 or cd1
168 so it kind of makes sense that you would get a different result from using the polynucleotide
than hyaluronic acid and it also kind of makes sense that you would want to switch between the
two or alternate them look there's no right or wrong answer when it comes to which biostimulator
you should use I think sometimes people get some Choice paralysis and they they're not sure what to
do so they don't make a decision my advice would be try both see which one works for you which one
you prefer okay so where can you use it pretty much anywhere uh the most common areas at least
with me would be be around the eye the neck backs of the hands you know for this crepey skin texture
here but you can also use it to stimulate hair growth even for into the vulva and as I mentioned
you can use it for stretch mark Improvement and also scar Improvement as well okay so stretch
marks are either from mechanical stretching like for example a bodybuilder um or it can be an
endocrine thing so during pregnancy or um too much cortisol cortical steroids something like that
other treatments include laser and light therapies micro needling radiofrequency Microneedling
carboxytherapy and most of these treatments the aim is to produce new collagen reduce redness
reduce inflammation and increase pigmentation okay so I've previously said that the polynucleotide
acts in the fibroblast great but it also has this effect where it helps to replenish stuff that
the fibroblast might need need like for example nitrogen bases nucleotide precursors and by doing
this it increases the viability of the fibroblast so in this study where the patients received a
course of polynucleotides they saw a bettering in their Global aesthetic Improvement scale with the
only side effects being perhaps a little bit of bruising that was it see this is the thing about
polynucleotides so the only reason why you would not do them is because you don't want the bruising
and downtime and I guess of course there's the expense as well but if you are going to be
having another treatment for a specific indication whether it is stretch marks Hair Skin Rejuvenation
whatever it makes sense to do of course a polynucleotides prior to that so different
products have got different concentrations of polynucleotides so they might range from something
like 7.5 milligrams per 2 Mls for something like a nucleophile soft or Plinest i of course you can
use these around the eye or in anywhere with very delicate thin skin right the way up to something
like the nucleofill strong which has got 40 mgm per two Ms you would typically use the strong in
patients with average or thicker skin um so for example on myself if I was treating my face I
would use nucleofill strong on other patients if I'm treating a more delicate area for example the
neck or perhaps the back of the hands I might go with the medium and most brands will have a
selection of different strengths of polynucleotide some such as the Mastelli brand will even have um
ones that you can dilute quite a lot and you can mix it in with other different products if
you're making your own mesotherapy cocktail there was a recent consensus report written
by some doctors in Italy who use an awful lot of polynucleotides and one of the concepts that they
came up with although I don't think it was new or unique to them was the idea of polynucleotide
priming in which is use of polynucleotides prior to performing other treatments for example dermal
fillers laser resurfacing anything really so the idea behind this is that by pre-exposing
to the polynucleotides you will get a larger and faster onset of response from doing your second
treatment type okay this is really interesting actually so there was a study done of 39 patients
who had Venous ulcers on the legs okay so far so good group one one received Surgical debridement
and topical application of polynucleotides group two received the debridement but this
time application of hyaluronic acid complete healing occurred in 60% of group one that's the
polynucleotide group and 22% of group two that's the hyaluronic acid group so the authors concluded
that the polynucleotides basically sped up the healing of these venous ulcers according to this
consensus group they felt that you would get a better result if you started your polynucleotide
injection before you have the second treatment of whatever else it is you're going to have done
like you know your laser or whatever but it only had to be a week before that second treatment this
is their opinion however how do you apply the product Well normally you would inject it so
you take a very fine needle and you do either a few big papules like you would do with Profhilo
so it's five injections on each side of the face or you can do smaller injections where you
are spreading it out over a larger area you can use a canulla as well um it's not my preference
to use a canulla actually I find that patients tolerate it better if they have injection with
a needle and it's suggested that you have one treatment every 14 to 21 days and a total of
four so we've got this effect on the fibroblast we've got also this giving the fibrpblast what
it's needs concept but it also has activity on reactive oxygen species as well poly nucleotides
also reduce matrixmetaloprotein one expression and this thing stops you from producing more
collagen so it has this effect as well it also has an anti-inflammatory effect by downregulating
the mechanism by which you have inflammation it helps to cause new blood vessel growth and of
course you need new blood vessels if you're going to bring in more oxygen and nutrients to the skin
and it also helps to prevent too much melanin synthesis so might be useful in patients with
melasma for example although interestingly there was a paper that showed if you had radio frequency
Microneedling with or without polynucleotides actually there wasn't a difference in terms
of the melasma what does it mean for you okay so improv skin texture as I mentioned it inhibits the
release of this Matrixmetaloprotein one and also elastase which is bad for your skin improves DNA
synthesis because it gives you more stuf that you need to make it treat hyperpigmentation by
suppressing melanin production helps regenerate hair loss and that's an increasing thickness
and hair count it's probably worth me saying as well that it's a natural product so it's
from fish essentially but I've never heard of any kind of immune cross reactivity or indeed
any complications with polynucleotides since I've started using them which is is pretty good and we
do a lot of cases with polynucleotides so they're very safe so who can have polynucleotides I mean
literally anybody can have them if you're already having aesthetic procedures done the
addition of polynucleotides into your treatment regime will only improve your results and make
them appear more quickly if you're not having any aesthetic treatments done and you want to
look at skin Rejuvenation and skin quality yeah polynucleotides are definitely a thing you should
look at if you've got stretch marks scarring if you have hair thinning or if you want to
treat an area which is quite difficult to treat like for example around the eye polynucleotides
are right for you they however are not right for you if you can't have something which is
made from fish but just to reiterate my first point if you've got volume loss you just need to
have fillers or fat transfer like it's just it's simple simple as that really if you've got volume
loss fillers if it's skin quality improvement polynucleotides hyaluronicacid radiofrequency
Microneeding laser something like that but volume loss is only fillers guys final thought why did
the vampire go to the clinic because they had crepey skin don't forget to subscribe
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