Exactly How Much Muscle Does 25mg, 50mg, 125mg, 300mg & 600mg Of Testosterone Build?

Summary

This video discusses the impact of anabolic steroids on muscle gain, highlighting a study examining the effects of various testosterone doses on healthy young men over 20 weeks. The study reveals a dose-dependent increase in muscle mass and strength, with significant gains observed at 125mg, 300mg, and 600mg doses. It emphasizes the importance of understanding the relationship between dosage and outcomes, as well as the potential risks associated with higher doses, providing valuable insights for those interested in pharmacology and muscle building.

Takeaways

• 💪 The video discusses the impact of anabolic steroids, specifically testosterone, on muscle gain and how the dosage affects the results.
• 🧬 The study mentioned in the video investigates the effects of super-physiological doses of testosterone on healthy young men over a 20-week period.
• 📊 The study included weekly administrations of 25, 50, 125, 300, and 600 milligrams of testosterone to compare the outcomes.
• 🏋️‍♂️ The participants were aged 18 to 35, had prior weightlifting experience, normal testosterone levels, and were not involved in competitive sports.
• 📉 A dose of 25 milligrams actually led to a loss in muscle mass, as it was less than the natural production of the participants.
• 🔼 The 50 milligram dose did not result in significant muscle gain, suggesting a threshold effect for noticeable changes.
• 📈 The 125, 300, and 600 milligram groups experienced substantial increases in fat-free mass, with the 600 milligram group gaining the most at 7.9 kilograms.
• 💧 Fat-free mass includes water, which is also retained as testosterone doses increase, contributing to the weight gain.
• 🏋️‍♀️ Strength levels increased in parallel with testosterone concentrations, indicating a positive correlation.
• 🚫 Higher testosterone levels were associated with worse HDL cholesterol levels, indicating potential health risks.
• 🤔 The video emphasizes that while the study provides insight into the effects of testosterone on muscle gain, it does not promote the use of anabolics for performance enhancement.

Q & A

What is the main topic discussed in the video script?

The main topic discussed in the video script is the impact of anabolic steroids, specifically anabolic testosterone, on muscle gain in healthy young men.

Why is the study mentioned in the script considered significant?

The study is significant because it is one of the few that examines the effects of super-physiological doses of testosterone on healthy young men, providing insights into the expected muscle gains from different dosages.

What are the weekly dosages of testosterone examined in the study?

The study looked at weekly dosages of 25 milligrams, 50 milligrams, 125 milligrams, 300 milligrams, and 600 milligrams of testosterone.

What was the duration of the study?

The study lasted for 20 weeks.

What was the age range of the participants in the study?

The participants were between 18 to 35 years old.

What was the outcome for the participants who received the 25 milligram dose?

The participants who received the 25 milligram dose actually lost muscle mass, likely due to the dose being insufficient compared to their natural testosterone levels.

Did the 50 milligram dose result in any significant muscle gain?

No, the 50 milligram dose did not result in a notable increase in lean muscle mass.

How much fat-free mass did the participants gain in the 125 milligram group?

The participants in the 125 milligram group gained 3.4 kilograms of fat-free mass.

What is the relationship between the dosage of testosterone and the amount of muscle gained?

The study showed a dose-dependent change in muscle mass, with higher dosages leading to more significant gains in muscle mass.

What was the correlation between testosterone levels and HDL cholesterol levels in the study?

The study found a negative correlation between testosterone levels and HDL cholesterol levels, meaning higher testosterone levels led to worse HDL cholesterol levels.

What is the name of the study mentioned in the script, and where can it be found?

The study is named 'Testosterone dose-response relationships in healthy young men'. It is recommended to check the video description for a link to the study.

Outlines

00:00

💪 Effects of Anabolic Steroids on Muscle Gain

This paragraph discusses the impact of anabolic steroids, specifically testosterone, on muscle gain. The speaker references a study that administered various doses of testosterone to healthy young men over 20 weeks to observe the effects on muscle mass and strength. The study revealed a dose-dependent increase in muscle mass, with no significant gains at lower doses (25 and 50 milligrams per week), and substantial gains at higher doses (125, 300, and 600 milligrams per week). The 25-milligram dose resulted in muscle loss due to the suppression of natural testosterone production. The speaker emphasizes the importance of this study for understanding the effects of testosterone in a controlled clinical setting, including the correlation between dose, muscle gain, and strength increase, as well as the negative impact on HDL cholesterol levels.

05:02

📊 Testosterone Dosage and Its Impact on Muscle Building

The second paragraph delves deeper into the study's findings on the relationship between testosterone dosage and muscle building. It highlights the significant increase in fat-free mass observed in the higher dosage groups, with the 125-milligram group gaining 3.4 kilograms, the 300-milligram group gaining 5.2 kilograms, and the 600-milligram group gaining 7.9 kilograms. The speaker points out the diminishing returns in terms of muscle gain relative to the increase in dosage, questioning the risk-to-reward ratio of higher dosages. The paragraph also mentions the side effects associated with higher dosages and the importance of understanding the pharmacology of testosterone for those interested in performance enhancement or pharmacology in general. The speaker concludes by recommending the study, titled 'Testosterone Dose-Response Relationships in Healthy Young Men,' for further reading and provides social media handles for follow-up.

Keywords

💡Anabolics

Anabolics refer to substances that promote anabolism, the process of building up body tissues. In the context of the video, anabolics are likely referring to anabolic steroids or similar compounds that are used to enhance muscle growth. The script discusses the effects of anabolics on muscle gain, indicating that the amount of muscle gained from their use is a common question among viewers.

💡Caloric Intake

Caloric intake is the amount of energy in the form of calories that an individual consumes through food and beverages. The script mentions caloric intake as one of the factors influencing the extent of muscle gain from anabolics, emphasizing that muscle growth is not solely dependent on the substance itself but also on the individual's diet.

💡Training Adherence

Training adherence refers to the consistency and commitment with which an individual follows a training regimen. The script points out that adherence to a training program is a critical factor in determining muscle gain from anabolics, suggesting that even with the use of anabolic substances, a disciplined training routine is necessary for optimal results.

💡Testosterone

Testosterone is a hormone that plays a key role in muscle growth, among other functions. The video script discusses a study on the effects of super-physiological doses of testosterone on muscle mass and strength in healthy young men, highlighting the hormone's significance in the context of muscle gain.

💡Dose-Dependent

Dose-dependent refers to the relationship where the effect of a substance is directly proportional to the dose administered. The script describes the study's findings as dose-dependent changes in muscle mass and strength, indicating that the higher the dose of testosterone, the more significant the increase in muscle mass and strength.

💡Fat-Free Mass

Fat-free mass is the portion of body weight that excludes fat, including muscle, bone, water, and connective tissue. The script uses the term to describe the increases in muscle mass observed in the study participants, with different doses of testosterone leading to different amounts of fat-free mass gain.

💡Aromatization

Aromatization is the process by which androgens like testosterone are converted into estrogens. The script mentions that higher doses of testosterone lead to more aromatization, which in turn causes more water retention, affecting the body composition and the perceived gains in muscle mass.

💡HDL Levels

HDL, or high-density lipoprotein, is a type of cholesterol that is considered 'good' for the body as it helps remove other forms of cholesterol from the bloodstream. The script notes that HDL levels were negatively correlated with testosterone levels, implying that higher testosterone levels could lead to worse lipid profiles.

💡Pharmaceutical Grade

Pharmaceutical grade refers to substances that meet the standards and purity levels required for use in the pharmaceutical industry. The script mentions that the testosterone used in the study was pharmaceutical grade, ensuring that the results were due to the hormone itself and not impurities or other factors.

💡Risk to Reward

Risk to reward is a concept that assesses the balance between the potential benefits and the potential risks of an action or substance. The script questions whether the increased muscle gain from higher doses of testosterone is worth the risks and side effects, suggesting that there may be diminishing returns as the dosage increases.

💡CRT

CRT, or Clinically Relevant Thresholds, refers to the dosage levels of a substance that are considered medically significant or relevant. The script suggests that the study and its findings are relevant to those interested in the clinical effects of testosterone, particularly in the context of muscle building.

Highlights

The discussion revolves around the effects of anabolics on muscle gain, a common inquiry among the audience.

The study in focus examines the impact of super physiological doses of testosterone on healthy young men.

The study provides insights into the expected muscle gain from different weekly doses of testosterone.

Participants in the study were aged 18 to 35, with prior weightlifting experience and normal testosterone levels.

The study found a dose-dependent increase in muscle mass and strength.

Lower doses of 25 and 50 milligrams did not improve lean muscle mass and the 25 milligram dose resulted in muscle loss.

The 125 milligram dose led to a significant increase in fat-free mass.

Higher doses of 300 and 600 milligrams resulted in greater gains in fat-free mass.

Strength levels increased in correlation with testosterone concentrations.

Higher testosterone levels were associated with worse HDL levels.

The study emphasizes the importance of understanding the effects of testosterone dosage on muscle gain.

The discussion is not promoting the use of anabolics for performance enhancement but rather providing clinical insights.

The study's results are substantial and warrant consideration for those interested in pharmacology and testosterone.

The study's findings on muscle gain and side effects provide a perspective on the risk-to-reward ratio of high-dose testosterone.

The study's name is 'Testosterone Dose Response Relationships and Healthy Young Men', recommended for further reading.

The video provides links and social media information for further engagement with the content creator.

Transcripts

so guys Derek more plates more dates

talk calm

today we're gonna be talking about

exactly how much muscle somebody can

gain from anabolics because this is

something I get asked all the time Derek

if I take X then how many pounds do I

gain obviously this isn't something you

can just answer flat-out it's based on

caloric intake training adherence you

know a million other factors but this

study in particular I felt like was a

perfect way to exhibit in general what

can be expected and it's one of the only

studies that looks at super

physiological doses of testosterone in

healthy young men to see exactly how

much of a difference a certain dose

actually equates to a lot of times

people want to know how much will 200

equate to how much will 500 milligrams

equate to you this study looked at

weekly administration's of 25 milligrams

50 milligrams 125 milligrams 300

milligrams and 600 milligrams for 20

weeks this is like a very very good

example to show what can be expected

from testosterone itself in a clinical

setting so relating this to real life

application it's pretty I don't think

there's a better example than for what

can somebody gain cause this is

completely controlled nutritional intake

it's controlled exercise regimen is

controlled the doses control its

pharmaceutical grade stuff so you can

see exactly what happens so without

getting into the details of energy and

protein intake and blah blah blah it's

like all the factors are the same the

only thing that differs is the dose so

it's a very good example of exactly what

kind of changes can occur just from the

dose not from some guy who happens to

you know have a better adherence to his

diet than another guy so basically all

of the participants they're 18 to 35

years old prior weightlifting experience

and normal test levels they've not used

any antibiotics before had not

participated in competitive sports

events in the preceding year and are not

planning to compete in any events in the

following year so

what we saw was a dose-dependent change

in muscle mass and strength which I play

obviously logically we're gonna assume

occurs but the exact amount in

particular is interesting if you

actually look at the 25 and 50 milligram

dose weight body composition did not

improve in lean muscle mass at all

really

like there's no notable increase and in

fact at the 25 milligram dose they

actually lost muscle and the reason for

that is if you take a healthy young man

who has like let's just say a 700

nanogram per deciliter natural test

level he's going to negatively progress

because he now is operating with an

exhaustion of source that his body's

relying on but it's less than he was

naturally producing so the consequence

of that is the 25 milligram group

actually lost muscle mass and then the

50 milligram group didn't gain very much

at all the 125 300 and 600 group or the

ones who gained significant amounts of

muscle and the difference between them

is pretty interesting so in the 125

milligrams group per week there was

three point four kilograms of fat free

mass increased now you have to

understand fat free mass also accounts

for water it's not just muscle tissue so

and obviously as you would expect the

hire these testosterone doses get and

there's more aromatization occurring and

therefore more water retention so that's

gonna play a role too so we have the 125

milligrams group gained three point four

kilograms the 300 milligram group gained

five point two kilograms and the 600

milligram group gained seven point nine

kilograms obviously strength levels

increased in parallel to this as well if

they were positively correlated with

testosterone concentrations and HDL

levels were negatively correlated so you

know the higher your test level goes the

worst your lipids are gonna be to your

HDL suppression is gonna be worse and

worse the higher the testosterone level

is so obviously these are expected

logical conclusions to make even if you

were just guessing and a lot of people

would say well what's the point of

looking that but it just goes to show

how much you can really expect

like four people doing this for

performance enhancement purposes this

isn't the point - you know I'm not

trying to promote use in a performance

enhancing context or anything like that

but it's just a really interesting way

to show in a clinical setting exactly

what can be expected in a muscle

building context from the master hormone

testosterone that we all operate with

and depend on for gaining muscle mass at

least endogenously people who are

natural and most people who use

enhancement testosterone as the main

thing honestly

the amount 125 milligrams increased is

pretty substantial like the 7.9 kilogram

it's obviously a double but they had to

increase the dose to get that doubling

was like over four times the dosage of

the 125 milligrams rip so you had to

take 600 divided by 125 you have to take

four point eight times as much

testosterone equates to extra four point

five kilograms which is you know

obviously substantial but I mean the

amount of side effects that occur at

that higher dosage is a you know the

risk to reward is it really worth it it

doesn't even account for the water

weight it's it's just fat free mass

anyways the difference in muscle fat

free mass gain interesting to say the

least and it's a study you should

definitely take a look at if you are on

CRT or you're just interested in the

pharmacology and testosterone in general

and how it impacts our functions and our

performance on a day to day basis a

study name is testosterone dose response

relationships and healthy young men

highly recommend you check it out I'll

put it in the link in the video

description below thank you guys for

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