Understanding The Role Of Polynucleotides In Aesthetic Medicine #polynucleotides

Summary

This video script delves into the use of polynucleotides in aesthetic treatments, contrasting them with hyaluronic acid for skin quality improvement and volume restoration. It highlights the unique benefits of polynucleotides for treating crepey skin, stretch marks, and hair growth, while emphasizing that for volume loss, fillers or fat transfer are essential. The script also discusses the versatility of polynucleotides, their mechanism of action, and the concept of priming with polynucleotides before other treatments for enhanced results.

Takeaways

• 💉 Fillers or fat transfer are recommended for volume loss, while polynucleotides are for skin quality improvement.
• 🧬 Polynucleotides are polymers made from trout gonads, used as wound healing accelerators and for their lubricating properties.
• 🚫 Not suitable for vegans, vegetarians, or those allergic to fish due to the fish-derived nature of polynucleotides.
• 🔬 Studies suggest polynucleotides may have a greater biostimulatory effect than hyaluronic acid.
• 💧 Hyaluronic acid provides immediate glossiness and plumpness, whereas polynucleotides offer a more dermal effect.
• 👵 Polynucleotides are effective for treating crepey skin texture and stretch marks, but not for providing long-lasting plumping.
• 🔄 They act on different fibroblast receptors compared to hyaluronic acid, leading to distinct clinical outcomes.
• 🌱 Polynucleotides can also stimulate hair growth and improve scar appearance.
• 🛠️ Other treatments for stretch marks include laser, light therapies, micro needling, and carboxytherapy.
• 🧪 Polynucleotides can be used in various concentrations and can be mixed with other products for customized treatments.
• 📈 The concept of 'polynucleotide priming' suggests better results when used before other treatments like dermal fillers or laser resurfacing.

Q & A

What is the primary solution for volume loss according to the transcript?

The primary solution for volume loss is to have fillers or fat transfer.

What is the main topic discussed in the video script?

The main topic discussed is polynucleotides, their use in the clinic, and their effects on skin quality improvement.

What are the common misconceptions about biostimulators mentioned in the script?

The misconception is that people are happy to have biostimulators injections but are reluctant to have fillers, especially cross-linked ones, which doesn't make sense because many biostimulators are indeed cross-linked.

What are polynucleotides and what are they made from?

Polynucleotides are polymers consisting of double-stranded deoxyribonucleotides, essentially the building blocks of DNA, and they are typically made from trout gonads.

Why might someone not be suitable for polynucleotides treatment?

Someone might not be suitable for polynucleotides treatment if they are vegan, vegetarian, or allergic to fish, as polynucleotides are derived from fish.

How do polynucleotides differ from hyaluronic acid biostimulators in their clinical effects?

Polynucleotides give a more dermal effect, suitable for treating crepey skin texture or stretch marks, while hyaluronic acid provides immediate glossiness, plumpness, and hydration to the skin.

What are some alternative treatments for stretch marks mentioned in the script?

Alternative treatments for stretch marks include laser and light therapies, micro needling, radiofrequency microneedling, and carboxytherapy.

How do polynucleotides affect fibroblasts and what receptors do they act on?

Polynucleotides act on fibroblasts by providing them with necessary components like nitrogen bases and nucleotide precursors, increasing their viability. They act on receptors 39 and 40.

What is the concept of 'polynucleotide priming' as discussed in the script?

Polynucleotide priming is the use of polynucleotides prior to performing other treatments to get a larger and faster onset of response from the second treatment type.

What are the side effects of polynucleotides mentioned in the script?

The only side effects mentioned are potential bruising and downtime, with expense also being a consideration.

How can polynucleotides be applied in treatments and what is the recommended treatment frequency?

Polynucleotides are normally injected using a fine needle, either in a few big papules or smaller injections over a larger area. It is suggested to have one treatment every 14 to 21 days, for a total of four treatments.

Outlines

00:00

💉 Addressing Volume Loss and Skin Quality with Fillers and Polynucleotides

The speaker discusses the treatment options for volume loss and skin quality improvement, emphasizing the simplicity of using fillers or fat transfer for volume issues. They introduce polynucleotides as a biostimulator with a focus on their use in the clinic since before COVID-19, noting an increasing number of patients preferring biostimulators over fillers. The speaker clarifies that biostimulators are not a substitute for volume restoration and highlights the difference between polynucleotides and hyaluronic acid, explaining that polynucleotides are derived from trout gonads and act as wound healing accelerators with a dermal effect, suitable for treating crepey skin texture and stretch marks. They also mention the immediate plumping effect of polynucleotides and their action on different fibroblast receptors compared to hyaluronic acid.

05:04

🧬 Exploring Polynucleotides' Benefits and Application in Aesthetic Treatments

This paragraph delves into the benefits and applications of polynucleotides, including their use in skin rejuvenation, hair growth stimulation, and improvement of stretch marks and scars. The speaker discusses the importance of choosing the right concentration of polynucleotides for different skin types and areas of the body, mentioning various product strengths and the possibility of mixing them with other treatments. They introduce the concept of 'polynucleotide priming,' suggesting that pre-treatment with polynucleotides can enhance the effects of subsequent aesthetic procedures. The speaker also references a study showing polynucleotides' effectiveness in healing venous ulcers compared to hyaluronic acid and outlines the various mechanisms by which polynucleotides benefit the skin, such as reducing inflammation, promoting collagen production, and preventing excessive melanin synthesis.

10:09

🐟 Considering Polynucleotides for Skin and Hair Aesthetics: Safety and Suitability

The final paragraph addresses the safety and suitability of polynucleotides for a wide range of individuals, including those already undergoing aesthetic procedures or seeking skin rejuvenation. The speaker asserts that polynucleotides are a natural product derived from fish and have not caused any complications in their experience. They highlight the benefits of polynucleotides for treating volume loss, improving skin texture, treating hyperpigmentation, and aiding in hair regeneration. The speaker concludes by reiterating that while polynucleotides are beneficial for skin quality improvement, they are not a solution for volume loss, which requires fillers or fat transfer. They end with a humorous note, inviting viewers to subscribe for more information.

Keywords

💡Volume Loss

Volume loss refers to the reduction in the fullness or plumpness of the skin, often due to aging or other factors. In the video, it is mentioned as a condition that can be addressed with fillers or fat transfer, emphasizing its importance in aesthetic treatments. The script suggests that while biostimulators can improve skin quality, they are not a substitute for addressing volume loss.

💡Fillers

Fillers are injectable substances used to restore volume and smooth out wrinkles in the skin. They are a direct solution for volume loss, as mentioned in the script. The term is used to illustrate the difference between treatments that address volume versus those that improve skin quality.

💡Fat Transfer

Fat transfer is a cosmetic procedure where fat is removed from one area of the body and injected into another to restore volume. In the script, it is presented as an alternative to fillers for addressing volume loss, highlighting the range of options available for enhancing skin fullness.

💡Polynucleotides

Polynucleotides are polymers consisting of double-stranded deoxyribonucleotides and are used in medical devices for wound healing and other applications. In the video, they are discussed as an alternative to hyaluronic acid for skin rejuvenation, emphasizing their role in improving skin texture and treating conditions like stretch marks.

💡Hyaluronic Acid

Hyaluronic acid is a naturally occurring substance in the body that helps retain moisture and is often used in aesthetic medicine to add volume and hydration to the skin. The script contrasts hyaluronic acid with polynucleotides, noting that they act on different receptors and produce different clinical effects.

💡Biostimulators

Biostimulators are substances that stimulate biological processes, such as the production of collagen. In the context of the video, the term is used to describe treatments like hyaluronic acid and polynucleotides, which aim to improve skin quality by stimulating the skin's natural processes.

💡Fibroblasts

Fibroblasts are cells that produce collagen and elastin, which are essential for maintaining skin's structure and elasticity. The script discusses how both polynucleotides and hyaluronic acid act on fibroblasts, affecting their production of collagen and thus influencing skin quality.

💡Stretch Marks

Stretch marks are a form of scarring on the skin that occurs when it is stretched rapidly, such as during pregnancy or rapid weight gain. The video mentions polynucleotides as a treatment for improving the appearance of stretch marks, indicating their potential for skin rejuvenation.

💡Microneedling

Microneedling is a minimally invasive procedure that involves creating small punctures in the skin to stimulate collagen production. The script lists microneedling as one of the treatments that can be used alongside polynucleotides to improve skin texture and address issues like stretch marks.

💡Radiofrequency

Radiofrequency is a type of energy that can be used in aesthetic treatments to tighten skin and stimulate collagen production. The video mentions radiofrequency in the context of skin quality improvement, suggesting it as another modality that can complement the effects of polynucleotides.

💡Priming

In the context of the video, priming refers to the pre-treatment with polynucleotides before other aesthetic procedures to enhance their effectiveness. The script explains that priming with polynucleotides can lead to a larger and faster onset of response from subsequent treatments like dermal fillers or laser resurfacing.

Highlights

Volume loss can be addressed with fillers or fat transfer, which are simple solutions.

For skin quality improvement, treatments like polynucleotides, nucleotides, hyaluronic acid, radio frequency, microneedling, and laser can be used.

Polynucleotides have been used in clinics since before COVID-19, offering a wealth of experience with their application.

Some patients prefer biostimulators over fillers, despite the fact that many biostimulators are cross-linked.

Polynucleotides are polymers made from trout gonads and are the building blocks of DNA, not suitable for vegans, vegetarians, or those allergic to fish.

Studies suggest polynucleotides may have a greater biostimulatory effect than hyaluronic acid.

Polynucleotides provide a more dermal effect compared to hyaluronic acid, which offers immediate glossiness and plumpness.

Polynucleotides and hyaluronic acid act on different receptors on fibroblasts, leading to different clinical results.

Polynucleotides can be used for various treatments including around the eyes, neck, backs of hands, and even for hair growth and vulva treatments.

Stretch marks can be treated with polynucleotides, addressing both mechanical stretching and endocrine-related causes.

Polynucleotides help replenish fibroblasts with necessary components like nitrogen bases and nucleotide precursors, enhancing viability.

The Global Aesthetic Improvement scale showed better results with polynucleotides, with minimal side effects like bruising.

Polynucleotide priming, or pre-exposure, before other treatments, can lead to a larger and faster response.

A study on venous ulcers showed that polynucleotides sped up healing compared to hyaluronic acid.

Polynucleotides have various applications, including improving skin texture, treating hyperpigmentation, and aiding hair loss.

Polynucleotides are a natural product derived from fish and have shown to be safe with no reported immune cross-reactivity.

Polynucleotides are suitable for anyone, especially those undergoing aesthetic procedures or seeking skin rejuvenation and quality improvement.

For volume loss, fillers or fat transfer are essential, while polynucleotides are for skin quality improvement.

Transcripts

if you've got volume loss you just need to have  fillers or fat transfer like it's just it's simple  

simple as that really if you've got volume loss  fillers if it's skin quality improvement poly  

nucleotides hyaluronic acid radio frequency micro  needling laser something like that but volume  

loss is only fillers guys Hello friends today  I'm going to be talking about polynucleotides  

we've been using polynucleotides in the clinic  since before covid so we do have a decent amount  

of experience in using them before I start one  thing that I will say is I'm seeing an increasing  

number of people that I like to call victims of  biostimulators and what I mean by that is they're  

totally happy to have an injection to have some  kind of Bio stimulator whether it's a hyaluronic  

acid biostimulator or polynucleotide or um Gouri  something like this but they really don't want  

to have any filler like it's okay as long as it's  not cross-linked which doesn't make any sense to  

me because a lot of the bio stimulators actually  are cross linked like for example Belotero revive  

so look if you need volume you need volume and  no amount of Biostimulator is going to help you  

with that and with that let's continue the more  Eagle eyed amongst you may notice that yes I have  

a bruise that's because I've been having 70hyal  which is a hyaluronic acid based bio stimulator  

but look I don't need volume here I literally just  want some skin Improvement okay so first of all  

what is a polynucleotide and how is it different  from a hyaluronic acid biostimulator so these are  

polymers consisting of double stranded deoxy  ribonucleotides and they are a medical device  

which have been in use since about 2004 and they  have been used as wound healing accelerators or  

for intraarticular injections because they have  this lubricating property so these are typically  

made from trout gonads and polynucleotides are  essentially the building blocks of your DNA so  

these are not something to be having if you  are vegan or vegetarian or allergic to fish  

there are a number of studies showing that the  biostimulatory action of polynucleotide might  

be greater than that found in hyaluronic acid but  it's also worth me saying that they do give you a  

slightly different effect clinically so if you're  looking for an immediate kind of glossiness and  

plumpness hydration to the skin you better off  using hyaluronic acid the polynucleotides though  

give you a more dermal effect so I have been super  happy with them for treatment of more crepey skin  

texture um or the treatment of stretch marks  although it is true to say that you do get an  

immediate Plumping also from the polynucleotide  just because you've injected a gel into the skin  

but it's not something which is long lasting  so both polynucleotides and hyaluronic acid  

will act on different receptors on the fibroblast  which is of course a cell that produces collagen  

the polynucleotide acts on receptor 39 and 40  whereas the hyaluronic acid acts on cd44 or cd1  

168 so it kind of makes sense that you would get  a different result from using the polynucleotide  

than hyaluronic acid and it also kind of makes  sense that you would want to switch between the  

two or alternate them look there's no right or  wrong answer when it comes to which biostimulator  

you should use I think sometimes people get some  Choice paralysis and they they're not sure what to  

do so they don't make a decision my advice would  be try both see which one works for you which one  

you prefer okay so where can you use it pretty  much anywhere uh the most common areas at least  

with me would be be around the eye the neck backs  of the hands you know for this crepey skin texture  

here but you can also use it to stimulate hair  growth even for into the vulva and as I mentioned  

you can use it for stretch mark Improvement and  also scar Improvement as well okay so stretch  

marks are either from mechanical stretching like  for example a bodybuilder um or it can be an  

endocrine thing so during pregnancy or um too much  cortisol cortical steroids something like that  

other treatments include laser and light therapies  micro needling radiofrequency Microneedling  

carboxytherapy and most of these treatments the  aim is to produce new collagen reduce redness  

reduce inflammation and increase pigmentation okay  so I've previously said that the polynucleotide  

acts in the fibroblast great but it also has this  effect where it helps to replenish stuff that  

the fibroblast might need need like for example  nitrogen bases nucleotide precursors and by doing  

this it increases the viability of the fibroblast  so in this study where the patients received a  

course of polynucleotides they saw a bettering in  their Global aesthetic Improvement scale with the  

only side effects being perhaps a little bit of  bruising that was it see this is the thing about  

polynucleotides so the only reason why you would  not do them is because you don't want the bruising  

and downtime and I guess of course there's  the expense as well but if you are going to be  

having another treatment for a specific indication  whether it is stretch marks Hair Skin Rejuvenation  

whatever it makes sense to do of course a  polynucleotides prior to that so different  

products have got different concentrations of  polynucleotides so they might range from something  

like 7.5 milligrams per 2 Mls for something like  a nucleophile soft or Plinest i of course you can  

use these around the eye or in anywhere with very  delicate thin skin right the way up to something  

like the nucleofill strong which has got 40 mgm  per two Ms you would typically use the strong in  

patients with average or thicker skin um so for  example on myself if I was treating my face I  

would use nucleofill strong on other patients if  I'm treating a more delicate area for example the  

neck or perhaps the back of the hands I might  go with the medium and most brands will have a  

selection of different strengths of polynucleotide  some such as the Mastelli brand will even have um  

ones that you can dilute quite a lot and you  can mix it in with other different products if  

you're making your own mesotherapy cocktail  there was a recent consensus report written  

by some doctors in Italy who use an awful lot of  polynucleotides and one of the concepts that they  

came up with although I don't think it was new  or unique to them was the idea of polynucleotide  

priming in which is use of polynucleotides prior  to performing other treatments for example dermal  

fillers laser resurfacing anything really so  the idea behind this is that by pre-exposing  

to the polynucleotides you will get a larger and  faster onset of response from doing your second  

treatment type okay this is really interesting  actually so there was a study done of 39 patients  

who had Venous ulcers on the legs okay so far so  good group one one received Surgical debridement  

and topical application of polynucleotides  group two received the debridement but this  

time application of hyaluronic acid complete  healing occurred in 60% of group one that's the  

polynucleotide group and 22% of group two that's  the hyaluronic acid group so the authors concluded  

that the polynucleotides basically sped up the  healing of these venous ulcers according to this  

consensus group they felt that you would get a  better result if you started your polynucleotide  

injection before you have the second treatment  of whatever else it is you're going to have done  

like you know your laser or whatever but it only  had to be a week before that second treatment this  

is their opinion however how do you apply the  product Well normally you would inject it so  

you take a very fine needle and you do either a  few big papules like you would do with Profhilo  

so it's five injections on each side of the  face or you can do smaller injections where you  

are spreading it out over a larger area you can  use a canulla as well um it's not my preference  

to use a canulla actually I find that patients  tolerate it better if they have injection with  

a needle and it's suggested that you have one  treatment every 14 to 21 days and a total of  

four so we've got this effect on the fibroblast  we've got also this giving the fibrpblast what  

it's needs concept but it also has activity on  reactive oxygen species as well poly nucleotides  

also reduce matrixmetaloprotein one expression  and this thing stops you from producing more  

collagen so it has this effect as well it also  has an anti-inflammatory effect by downregulating  

the mechanism by which you have inflammation it  helps to cause new blood vessel growth and of  

course you need new blood vessels if you're going  to bring in more oxygen and nutrients to the skin  

and it also helps to prevent too much melanin  synthesis so might be useful in patients with  

melasma for example although interestingly there  was a paper that showed if you had radio frequency  

Microneedling with or without polynucleotides  actually there wasn't a difference in terms  

of the melasma what does it mean for you okay so  improv skin texture as I mentioned it inhibits the  

release of this Matrixmetaloprotein one and also  elastase which is bad for your skin improves DNA  

synthesis because it gives you more stuf that  you need to make it treat hyperpigmentation by  

suppressing melanin production helps regenerate  hair loss and that's an increasing thickness  

and hair count it's probably worth me saying  as well that it's a natural product so it's  

from fish essentially but I've never heard of  any kind of immune cross reactivity or indeed  

any complications with polynucleotides since I've  started using them which is is pretty good and we  

do a lot of cases with polynucleotides so they're  very safe so who can have polynucleotides I mean  

literally anybody can have them if you're  already having aesthetic procedures done the  

addition of polynucleotides into your treatment  regime will only improve your results and make  

them appear more quickly if you're not having  any aesthetic treatments done and you want to  

look at skin Rejuvenation and skin quality yeah  polynucleotides are definitely a thing you should  

look at if you've got stretch marks scarring  if you have hair thinning or if you want to  

treat an area which is quite difficult to treat  like for example around the eye polynucleotides  

are right for you they however are not right  for you if you can't have something which is  

made from fish but just to reiterate my first  point if you've got volume loss you just need to  

have fillers or fat transfer like it's just it's  simple simple as that really if you've got volume  

loss fillers if it's skin quality improvement  polynucleotides hyaluronicacid radiofrequency  

Microneeding laser something like that but volume  loss is only fillers guys final thought why did  

the vampire go to the clinic because they  had crepey skin don't forget to subscribe