Enclomiphene TRT? Enclomiphene vs Clomid? Which is Better? Boost Testosterone. Is it Safe?

Summary

In this informative video, Dr. Downey delves into the topic of clomiphene and its stereoisomers, in-clomiphene and zucchromethane, which together form clomiphene citrate. The study discussed compares the efficacy of these two in treating male infertility, revealing that while both increase testosterone, in-clomiphene is more effective in boosting gonadotropin levels and may have a higher estrogenic effect. The video also touches on the potential side effects and the use of aromatase inhibitors in fertility treatments, inviting viewers to share their experiences and opinions on the subject.

Takeaways

• 🌟 Clomiphene citrate and zucchromethane are two stereoisomers of plomothine citrate, with in clomiphene accounting for 68% and zucchromethane for 38%.
• 🔍 The individual preparations of these stereoisomers were created with the belief that in clomiphene leads to positive antagonistic effects on the estrogen receptor.
• 📊 Inclomiphene has been found to be more antagonistic than zucchromethane, which is a weak agonist to the estrogen receptor.
• 💊 Long-term use of clomiphene citrate as a testosterone replacement therapy can lead to an increase in zucchromethane concentrations, which has been shown to be toxic to testicular tissue in rats.
• 🧪 A study on pure zucchromethane in men with prostate cancer undergoing Androgen deprivation therapy showed no benefits over placebo for hot flashes or testosterone levels.
• 📝 The study comparing in clomiphene to clomiphene citrate for male infertility treatment was a retrospective one, which comes with inherent limitations.
• 👨‍⚕️ The study included men over 18 with primary infertility, abnormal semen parameters, or hypogonadism, treated with either form of clomiphene.
• 📉 Inclomiphene was found to increase total testosterone production and gonadotropin levels (LH and FSH) more effectively than clomiphene citrate.
• 🌡️ Inclomiphene was associated with a significant increase in estradiol levels, which was unexpected given its antagonistic properties.
• 🍇 Both in clomiphene and clomiphene citrate improved sperm motility, but only in clomiphene increased the total motile sperm count.
• 🤔 The study suggests that in clomiphene may be a better option for fertility outcomes due to its effects on gonadotropins and estrogen, but more research is needed to confirm these findings.

Q & A

What is the main topic of the video by Dr. Downey?

The main topic of the video is a discussion on implomevine (in clomiphene) and a comparison study between in clomiphene and clomiphene citrate for male infertility treatment.

What are in clomiphene and zucchromethane?

In clomiphene and zucchromethane are two stereoisomers that make up clomiphene citrate, with in clomiphene accounting for 68% and zucchromethane 38% of the compound.

Why were individual preparations of in clomiphene and zucchromethane created?

Individual preparations were created because it was thought that in clomiphene leads to the positive antagonistic effects on the estrogen receptor, which could result in better outcomes for fertility and testosterone levels in men.

What is the significance of the study comparing in clomiphene to clomiphene citrate?

The study is significant as it is one of the first to compare the two compounds, aiming to understand their efficacy in treating male infertility.

What is the limitation of the retrospective study mentioned in the video?

The limitation is that, being a retrospective study, it relies on past data and cannot intervene or control variables, which may affect the accuracy and reliability of the findings.

What were the inclusion criteria for the study on male infertility treatment?

The inclusion criteria were men over the age of 18 who had received in clomiphene citrate or clomiphene citrate monotherapy and had primary infertility, abnormal semen parameters, or hypogonadism.

What dosages were used for in clomiphene and clomiphene citrate in the study?

In the study, in clomiphene was administered at either 12.5 milligrams daily or 25 milligrams daily, while clomiphene citrate was given at 50 milligrams every other day.

Why might the increase in estrogen levels observed in the in clomiphene group be unexpected?

The increase was unexpected because it was previously thought that the in clomiphene component of clomiphene citrate would not have such strong estrogenic effects.

What is the potential reason for the increase in estrogen levels in the in clomiphene group?

A potential reason could be that in clomiphene might inhibit 3-beta hydroxy dehydrogenase activity, an enzyme important for estrogen production via the adrenal pathway, leading to a buildup of estrogen.

What are the fertility markers that improved with both in clomiphene and clomiphene citrate treatment?

Both in clomiphene and clomiphene citrate improved sperm motility, but only in clomiphene increased the total motile sperm count.

What is the recommendation for users of aromatase inhibitors who are trying to improve fertility?

It is recommended to stop the use of aromatase inhibitors one week before conception due to the negative impact on sperm motility.

What is the conclusion Dr. Downey draws about the use of in clomiphene for increasing testosterone levels?

Dr. Downey concludes that if you're using in clomiphene purely to increase testosterone levels, clomiphene citrate does just as well, and in clomiphene might be preferred only if one experiences side effects from clomiphene.

What is the potential advantage of in clomiphene for fertility outcomes?

In clomiphene might be a better option for fertility outcomes due to its ability to increase gonadotropin levels such as LH and FSH, and possibly due to the necessary role of estrogen in fertility.