Enclomiphene TRT? Enclomiphene vs Clomid? Which is Better? Boost Testosterone. Is it Safe?

Summary

In this informative video, Dr. Downey delves into the topic of clomiphene and its stereoisomers, in-clomiphene and zucchromethane, which together form clomiphene citrate. The study discussed compares the efficacy of these two in treating male infertility, revealing that while both increase testosterone, in-clomiphene is more effective in boosting gonadotropin levels and may have a higher estrogenic effect. The video also touches on the potential side effects and the use of aromatase inhibitors in fertility treatments, inviting viewers to share their experiences and opinions on the subject.

Takeaways

• 🌟 Clomiphene citrate and zucchromethane are two stereoisomers of plomothine citrate, with in clomiphene accounting for 68% and zucchromethane for 38%.
• 🔍 The individual preparations of these stereoisomers were created with the belief that in clomiphene leads to positive antagonistic effects on the estrogen receptor.
• 📊 Inclomiphene has been found to be more antagonistic than zucchromethane, which is a weak agonist to the estrogen receptor.
• 💊 Long-term use of clomiphene citrate as a testosterone replacement therapy can lead to an increase in zucchromethane concentrations, which has been shown to be toxic to testicular tissue in rats.
• 🧪 A study on pure zucchromethane in men with prostate cancer undergoing Androgen deprivation therapy showed no benefits over placebo for hot flashes or testosterone levels.
• 📝 The study comparing in clomiphene to clomiphene citrate for male infertility treatment was a retrospective one, which comes with inherent limitations.
• 👨‍⚕️ The study included men over 18 with primary infertility, abnormal semen parameters, or hypogonadism, treated with either form of clomiphene.
• 📉 Inclomiphene was found to increase total testosterone production and gonadotropin levels (LH and FSH) more effectively than clomiphene citrate.
• 🌡️ Inclomiphene was associated with a significant increase in estradiol levels, which was unexpected given its antagonistic properties.
• 🍇 Both in clomiphene and clomiphene citrate improved sperm motility, but only in clomiphene increased the total motile sperm count.
• 🤔 The study suggests that in clomiphene may be a better option for fertility outcomes due to its effects on gonadotropins and estrogen, but more research is needed to confirm these findings.

Q & A

What is the main topic of the video by Dr. Downey?

The main topic of the video is a discussion on implomevine (in clomiphene) and a comparison study between in clomiphene and clomiphene citrate for male infertility treatment.

What are in clomiphene and zucchromethane?

In clomiphene and zucchromethane are two stereoisomers that make up clomiphene citrate, with in clomiphene accounting for 68% and zucchromethane 38% of the compound.

Why were individual preparations of in clomiphene and zucchromethane created?

Individual preparations were created because it was thought that in clomiphene leads to the positive antagonistic effects on the estrogen receptor, which could result in better outcomes for fertility and testosterone levels in men.

What is the significance of the study comparing in clomiphene to clomiphene citrate?

The study is significant as it is one of the first to compare the two compounds, aiming to understand their efficacy in treating male infertility.

What is the limitation of the retrospective study mentioned in the video?

The limitation is that, being a retrospective study, it relies on past data and cannot intervene or control variables, which may affect the accuracy and reliability of the findings.

What were the inclusion criteria for the study on male infertility treatment?

The inclusion criteria were men over the age of 18 who had received in clomiphene citrate or clomiphene citrate monotherapy and had primary infertility, abnormal semen parameters, or hypogonadism.

What dosages were used for in clomiphene and clomiphene citrate in the study?

In the study, in clomiphene was administered at either 12.5 milligrams daily or 25 milligrams daily, while clomiphene citrate was given at 50 milligrams every other day.

Why might the increase in estrogen levels observed in the in clomiphene group be unexpected?

The increase was unexpected because it was previously thought that the in clomiphene component of clomiphene citrate would not have such strong estrogenic effects.

What is the potential reason for the increase in estrogen levels in the in clomiphene group?

A potential reason could be that in clomiphene might inhibit 3-beta hydroxy dehydrogenase activity, an enzyme important for estrogen production via the adrenal pathway, leading to a buildup of estrogen.

What are the fertility markers that improved with both in clomiphene and clomiphene citrate treatment?

Both in clomiphene and clomiphene citrate improved sperm motility, but only in clomiphene increased the total motile sperm count.

What is the recommendation for users of aromatase inhibitors who are trying to improve fertility?

It is recommended to stop the use of aromatase inhibitors one week before conception due to the negative impact on sperm motility.

What is the conclusion Dr. Downey draws about the use of in clomiphene for increasing testosterone levels?

Dr. Downey concludes that if you're using in clomiphene purely to increase testosterone levels, clomiphene citrate does just as well, and in clomiphene might be preferred only if one experiences side effects from clomiphene.

What is the potential advantage of in clomiphene for fertility outcomes?

In clomiphene might be a better option for fertility outcomes due to its ability to increase gonadotropin levels such as LH and FSH, and possibly due to the necessary role of estrogen in fertility.

Outlines

00:00

🔬 Introduction to Clomiphene and Study Overview

Dr. Downey introduces the topic of clomiphene, focusing on its stereoisomers, in clomiphene and zucchromethane, which together constitute clomiphene citrate. The video aims to discuss a new study comparing these two stereoisomers. In clomiphene is thought to have more antagonistic effects on estrogen receptors, leading to its isolation for potential benefits in testosterone and fertility. The study in question is a retrospective analysis of men receiving off-label treatments with these stereoisomers to improve fertility, with a focus on their effects on testosterone levels and fertility outcomes. The video also touches on the potential long-term effects and toxicity associated with zucchromethane.

05:00

📊 Analysis of Study Results on Testosterone and Hormone Levels

This paragraph delves into the study's findings, noting that both in clomiphene and clomiphene citrate increased testosterone levels, with in clomiphene showing a more significant p-value. The study also examined luteinizing hormone (LH) and follicle-stimulating hormone (FSH), with in clomiphene showing a significant increase in LH and FSH levels, which are crucial for testosterone production and fertility. Unexpectedly, in clomiphene led to a significant increase in estradiol levels, possibly due to its effects on the adrenal pathway and receptor antagonism. The paragraph also discusses the implications of these hormonal changes on fertility and the anecdotal use of aromatase inhibitors to manage estrogen levels.

10:00

🤔 Personal Experiences and Opinions on Clomiphene Stereoisomers

In the final paragraph, Dr. Downey shares personal insights and opinions on the use of in clomiphene versus clomiphene citrate. He discusses the potential benefits of in clomiphene for increasing testosterone levels without the side effects associated with clomiphene citrate. The video also suggests that in clomiphene may be a better option for fertility outcomes due to its impact on gonadotropin levels and the necessary role of estrogen in fertility. Dr. Downey invites viewers to share their thoughts and experiences with these treatments, emphasizing the need for further research and understanding of the side effects and long-term implications.

Keywords

💡Implomevine

Implomevine is a stereoisomer of clomiphene citrate, which is a medication used to treat fertility issues. In the video, Dr. Downey discusses the differences between implomevine and its counterpart, zucchromethane, within the context of their effects on the estrogen receptor and their potential benefits and drawbacks in fertility treatments.

💡Clomiphene Citrate

Clomiphene citrate is a selective estrogen receptor modulator (SERM) often used to treat male infertility. It consists of two stereoisomers, implomevine and zucchromethane. The video explains how clomiphene citrate impacts testosterone levels and fertility, and how it compares to isolated implomevine in a study.

💡Stereoisomers

Stereoisomers are molecules that have the same molecular formula and sequence of bonded atoms but differ in the three-dimensional orientations of their atoms in space. In the script, implomevine and zucchromethane are stereoisomers of clomiphene citrate, each with different effects on the body, which is a central theme of the video.

💡Selective Estrogen Receptor Modulators (SERMs)

SERMs are a class of drugs that have tissue-specific effects on estrogen receptors in the body. Clomiphene citrate and its stereoisomers are examples of SERMs. The video discusses how the different stereoisomers of clomiphene citrate act as either antagonists or weak agonists to the estrogen receptor, affecting fertility outcomes.

💡Testosterone Replacement Therapy

Testosterone replacement therapy is a medical treatment for men with low testosterone levels. The script mentions that long-term use of clomiphene citrate as a form of testosterone replacement therapy can lead to changes in the ratio of its stereoisomers, which may have health implications.

💡Androgen Deprivation Therapy

Androgen deprivation therapy is a treatment for prostate cancer that aims to reduce the levels of male hormones to slow or stop cancer growth. The video script discusses a study involving zucchromethane in men undergoing this therapy, highlighting its potential effects on testosterone levels and hot flashes.

💡Retrospective Study

A retrospective study is a type of research that looks back at events that have already occurred. The video refers to a retrospective study comparing the efficacy of clomiphene citrate versus implomevine citrate for male infertility treatment, noting its limitations due to the nature of the study design.

💡Hypogonadism

Hypogonadism is a condition in which the body produces little or no sex hormones. In the context of the video, men with hypogonadism were included in the study to examine the effects of clomiphene citrate and implomevine citrate on fertility.

💡Luteinizing Hormone (LH)

LH is a hormone produced by the pituitary gland that plays a key role in the reproductive system. The video discusses how changes in LH levels in response to treatment with clomiphene citrate or implomevine citrate can indicate improved testosterone production and fertility outcomes.

💡Follicle-Stimulating Hormone (FSH)

FSH is another hormone produced by the pituitary gland that is important for the development of follicles in the ovaries and sperm production in men. The script mentions that changes in FSH levels in response to treatment could affect fertility outcomes.

💡Estradiol

Estradiol is the primary form of estrogen in women and is also present in men. The video describes an unexpected increase in estradiol levels in the implomevine group, suggesting a more complex interaction with estrogen receptors than initially thought.

💡Aromatase Inhibitors

Aromatase inhibitors are a class of drugs that decrease the production of estrogen in the body. The script discusses how the use of aromatase inhibitors in fertility therapy can impact sperm motility, suggesting the importance of estrogen balance for fertility.

Highlights

Introduction to implomevine and clomiphene as stereoisomers of clomiphene citrate.

Explains the creation of individual preparations of in clomiphene and zucchromethane.

In clomiphene is more antagonistic to the estrogen receptor than zucchromethane.

Long-term use of clomiphene citrate leads to increased zucchromethane concentrations.

Zucchromethane's potential toxicity to testicular tissue based on in vivo studies.

Study on pure zucchromethane in men with prostate cancer undergoing Androgen deprivation therapy.

Zucchromethane does not help with hot flashes or improving testosterone levels.

Introduction of the study comparing in clomiphene to clomiphene citrate for male infertility treatment.

Limitations of the retrospective study design.

Inclusion criteria for the study involving men with infertility or hypogonadism.

Dosing differences between in clomiphene and clomiphene citrate groups.

Lack of side effect analysis in the study.

Hypothesis on zucchromethane as a weak estrogen receptor agonist causing side effects.

Statistical significance of testosterone changes in both treatment groups.

Differences in LH and FSH levels and their significance for testosterone production and fertility.

Unexpected increase in estradiol levels in the in clomiphene group.

Fertility markers improvement with both treatments, but total motile sperm count increase only with in clomiphene.

Recommendations on using aromazine with in clomiphene to manage increased estrogen.

Personal experience with in clomiphene and its effects on testosterone and estrogen levels.

Opinion on the efficacy of in clomiphene versus clomiphene for testosterone increase and fertility outcomes.

Call to action for viewer's opinions and experiences with clomiphene and in clomiphene.

Transcripts

hi guys welcome back to the channel my

name is Dr Downey and today we are going

to talk about implomevine in this video

I'm going to give a brief introduction

into what in clomiphene is and then we

are going to look at a new study that

was published comparing in clomiphene to

cloneophene citrate so for those who

don't know in clomiphene and

zucchromethane are two stereoisomers

that make up plomothine citrate in

clomiphene accounts for 68 of clomipene

citrate and zucchromevine is 38 of

clomiphene citrate the reason they

decided to create individual

preparations of these stereoisomers is

that it was thought in clomeophene leads

to the positive antagonistic effects

that clomiphene citrate have on the

estrogen receptor since both of these

are selective estrogen receptor

modulators and in a few studies it was

demonstrated that inclomaphene is more

antagon than zucchromethane which is

actually a weak Agonist to the estrogen

receptor and therefore they isolated it

because they thought that since

clomipene citrate results in quite

pronounced effects on testosterone and

fertility in men they're getting a more

selective component of clomiphine would

result in better outcomes furthermore

when looking at men who take clomiphene

citrate as a form of testosterone

replacement therapy it's found that

long-term use leads to a relative

increase of zucchromophene

concentrations in the serum or blood in

comparison to inclementine and the

reason it is thought that this is

detrimental is because zucchlomophene in

some in Vivo studies in rats has been

demonstrated to be toxic to testicular

tissue some might say that Zoo clomipene

might actually be beneficial and we're

just relying on in vitro studies to

create this opinion that zoclomaphene is

not beneficial in any way pure zoo

clomiphene in men with prostate cancer

undergoing Androgen deprivation therapy

the study hasn't been published yet you

can see the results and you will notice

that zucchromophene doesn't help with

hot flashes nor did it help with

improving testosterone levels Placebo

actually assisted more than the

zucchromethane itself anyway with all

that out of the way let's get into the

study that was published comparing in

clomeophene to clomiphene this is one of

the first studies of its kind comparing

the two so the study is called efficacy

of plymouthene citrate versus include

methane citrate for male infertility

treatment a retrospective study already

there's a limitation in that is that is

his retrospective but essentially in the

study they went back and looked at men

receiving in chlamophine citrate and

clomidine citrate off-label to improve

fertility and I wanted to see what the

outcomes were in comparison to each

other there are a few issues with the

study and that's mostly due to the fact

that it is retrospective and therefore

they couldn't really intervene much but

essentially inclusioned criteria for the

study was any man over the age of 18 who

had received Clementine citrate or

inclementine citrate monotherapy these

men also either had to have primary

infertility

abnormal semen parameters or

hypogonadism there you can already see

an issue since these problems can be

correlated the abnormal semen parameter

limit as that is in hypogonadism that

isn't always the case and they should

have been looked at individually but

anyway so essentially those use it on in

clomiphene either receive 12.5

milligrams daily or 25 milligrams daily

those on clomiphene receive 50

milligrams every other day already

there's another issue there in that they

just lumped the 12.5 milligram group

with the 25 milligram group so we can't

freely make conclusions from which dose

is most effective another issue with the

study is they didn't really look at the

side effects that tend to make people

avoid clomiphene which is visual side

effects as well as emotional side

effects and just well-being while on

clomeophene

as a lot of people say they experience

emotional side effects from clomiphene

and unfortunately this wasn't looked at

but the hypothesis at this point in time

is that Zoo clomiphene the one

stereoisomer of clomiphene is the reason

for this side effect since it is a weak

estrogen receptor Agonist but again

that's just a hypothesis so let's look

at the results if we look at

testosterone changes we can already see

that in the inclonevine group they had

higher Baseline testosterone levels

technically they wouldn't be defined as

hypogonadal and this is perhaps why the

change is not so dramatic but it did

reach statistical significance as

defined by the p-value the clonefine

citrate group also reached statistical

significance when looking at the change

in testosterone and the p-value was even

more significant now if we look at

luteinizing hormone or LH those in the

in clomiphene group had lower LH level

to start off with When comparing it to

those in the cloneophene group only

those in the in clomiphene group

actually reach statistical significance

when looking at the change in

luteinizing hormone and the same goes

for FSH it didn't reach statistical

significance in the clomiphene group so

what would that mean well an improvement

in LH and FSH LH being so intricately

linked to inter-testicular testosterone

would indicate that production of

testosterone would increase with an

increase in luteinizing hormone if if

the testicular latex cells are still

sensitive to LH and an increase in FSH

would mean more follicle production and

thus better fertility outcomes what is

interesting to note however is that the

change in estradiol was drastic in the

enclosaphine group which was not

expected since it was thought that the

inclomaphene component of Clomid would

not have such drastic estrogenic effects

and I tried to come up with the reason

why in clomiphene might have this

drastic effect and it might be due to

the fact that clomidine citrate was

actually shown to inhibit three beta

hydroxy dehydrogenase activity and this

enzyme would be important for the

creation of something like estrogen via

the adrenal pathway furthermore if in

clomiphene is a better receptor

antagonist this would lead to perhaps a

buildup in estrogen as it's not binding

to The receptors that's just

hypothetical and it would have been

interesting if they looked at side

effects such as the emotional side of

ecstasy if this change in estrogen had a

clinical change in the participants if

we look at fertility markers it was

demonstrated that both in clomiphene and

clomiphene improved sperm motility but

only in clomiphene increased the total

motile sperm count and this might be due

to the fact that in clomeophene resulted

in an increase in FSH so what can we

take away from a study well it's a small

retrospective study with multiple

limitations but it would indicate that

that both in clomiphene and clomiphene

result in the same amount of increase in

total testosterone production however in

clomiphene is better at increasing

gonadotropin levels such as LH and FSH

it would also indicate that in

clomiphene increases estrogen more than

clomiphene does and whether or not this

has side effects would be something to

look out for if we look at anecdotes

around in clomeophene a lot of people

commonly recommend using something like

aromazine 6.25 milligrams every other

day or every three days when using in

Clomid and they say it's because of this

increase in estrogen that in clomipene

causes and if I grow on personal

experience I did a personal experiment

with in clomiphene and I'll perhaps post

the results on some somewhere but yes it

did increase my testosterone level

however it also increased my estrogen

level the only side effects I got from

it was tingling feeling in my nipples

and this could be due to the fact that

whilst clomiphene is a selective

estrogen receptor modulator or in

cloneophene is perhaps its effects at

estrogen antagonism are more Central

than peripheral and therefore this

increase in estrogen might bind to

peripheral receptors such as those found

in breast tissue now if we take all of

this data and come to an opinion about

in clomiphene if you're using in

clomiphene purely because you want to

increase testosterone levels clonidine

does it just as well the only reason you

would use inclementine as opposed to

clomiphene as shown by the doctor is if

you have side effects to clomiphene now

a lot of studies haven't elucidated many

side effects from inclomaphene but that

doesn't mean they don't exist since they

weren't really reporting on them in any

of the research papers I've looked at

they were just looking at serum markers

if you're looking for better fertility

outcomes it would seem that inclementine

is about better option this could be due

to the fact that it increases your

gonadotropins but also due to the fact

that estrogen still is quite necessary

in fertility and we know this because of

aromatase inhibitor therapy used to

improve fertility it's been shown that

with aromatase inhibition motility is

negatively impacted and that's why if

you're using aromatase Inhibitors to

improve your fertility it's recommended

to stop the aromatase inhibitor one week

before conception again this might show

that estrogen whilst and two high

amounts might be negative for fertility

but in two low amounts could also be

negative for fertility but at this point

there isn't too much data to come to a

definitive conclusion but I'd like to

know what you guys think about the study

and what your opinions on clomipene

versus inclomaphene are whether you've

experienced the side effects that people

talk about when speaking about

clomiphene and also what your experience

with inclementine is and as always I

will see you guys in the next video I

hope you enjoyed this topic and thank

you for watching

foreign

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