The SHOCKING ROOT CAUSE Of Alzheimer's Disease NOBODY TALKS ABOUT! | Max Lugavere
Summary
TLDRThis video script delves into the link between diet, lifestyle, and Alzheimer's disease, emphasizing the role of inflammation in chronic conditions. It discusses how modern diets and lifestyles, rich in industrial additives and pro-inflammatory elements, contribute to energy surplus and chronic inflammation. The speaker advocates for a Mediterranean diet, highlighting extra virgin olive oil's anti-inflammatory properties. The importance of monitoring blood sugar, CRP levels, and other health markers to prevent Alzheimer's and other diseases is also underscored.
Takeaways
- π§ Alzheimer's and other neurodegenerative diseases are increasingly common and are often linked to lifestyle and diet.
- πΏ The focus should be on non-communicable diseases, which include Alzheimer's, cardiovascular disease, and cancer.
- π₯ Inflammation, driven by modern diets and lifestyles, is a cornerstone of many chronic diseases.
- π½οΈ Diets rich in industrial additives, sugar, salt, and unhealthy fats can lead to overeating and energy toxicity, contributing to inflammation.
- π₯ A Mediterranean diet, which includes whole foods and extra virgin olive oil, is recommended for its anti-inflammatory properties.
- π Industrial seed oils, when heated, can become inflammatory and should be consumed with caution.
- π« Consuming certain fats on an empty stomach can potentially be inflammatory due to their effect on gut bacteria.
- π High blood sugar levels, often due to insulin resistance, are damaging to blood vessels and the brain.
- π½οΈ To reduce inflammation, prioritize a diet of minimally processed foods and avoid unhealthy, rancid oils.
- π Regular health check-ups, including blood work for CRP, fasting glucose, insulin, and homocysteine levels, are crucial for monitoring inflammation and disease risk.
Q & A
What types of diseases are most responsive to diet and lifestyle modifications according to the speaker?
-The speaker mentions that non-communicable diseases, also known as diseases of civilization, are most responsive to diet and lifestyle modifications. These include Alzheimer's disease, cardiovascular disease, cancer, and type 2 diabetes.
What is the speaker's passion in relation to brain health?
-The speaker's passion is helping people better understand how to maintain better brain health to prevent neurodegenerative conditions like Alzheimer's and Parkinson's diseases.
How does the World Health Organization classify the leading causes of death today?
-According to the World Health Organization, the leading causes of death today are non-communicable diseases such as heart disease, cancer, dementia, and type 2 diabetes, which are often linked to modern lifestyles and diets.
What is the role of inflammation in chronic diseases like Alzheimer's and cardiovascular disease?
-Inflammation is a cornerstone of chronic diseases like Alzheimer's and cardiovascular disease. It is a natural immune response that has become chronic due to pro-inflammatory diets, lifestyles, and environmental toxins, contributing to the development of these conditions.
What is meant by 'energy toxicity' in the context of the speaker's discussion?
-Energy toxicity refers to the state where an overconsumption of food leads to an energy surplus, which becomes toxic and pro-inflammatory. This over-fueling of the body's mitochondria can lead to the generation of reactive oxygen species, causing inflammation.
Why are certain types of fats potentially inflammatory when consumed on an empty stomach?
-Certain fats, when consumed on an empty stomach, can potentially be inflammatory because they may help ferry a component of gram-negative bacteria in the gut through circulation, leading to an inflammatory effect.
What dietary pattern is recommended by the speaker to reduce inflammation?
-The speaker recommends a Mediterranean dietary pattern, which includes both animal products and whole plants, with extra virgin olive oil as the primary oil, for its anti-inflammatory properties.
How much extra virgin olive oil should one consume to gain its anti-inflammatory benefits?
-The speaker suggests that a drizzle of extra virgin olive oil on a salad once a day is enough to gain its anti-inflammatory benefits, while also cautioning against overconsumption due to its calorie density.
What are some blood markers that the speaker suggests monitoring to assess inflammation and related risks?
-The speaker suggests monitoring CRP (C-reactive protein), fasting glucose, fasting insulin, homocysteine levels, and hemoglobin A1c as blood markers to assess inflammation and related risks for chronic diseases.
What role do B vitamins play in managing homocysteine levels and why are they important for brain health?
-B vitamins, particularly methylcobalamin and methylfolate, can help lower homocysteine levels, which are a risk factor for cardiovascular disease and Alzheimer's. High homocysteine levels can be managed with B vitamins, which are also shown to slow brain atrophy, especially for those at risk of Alzheimer's disease.
Outlines
π§ Understanding Alzheimer's and Lifestyle
The speaker begins by defining the types of diseases they will discuss, focusing on non-communicable diseases like Alzheimer's, cardiovascular disease, and cancer. They express a passion for helping people understand how diet and lifestyle modifications can prevent neurodegenerative conditions. The World Health Organization's statistics are cited, highlighting the prevalence of these diseases. The speaker then delves into the role of inflammation, which is common in modern times due to pro-inflammatory diets and lifestyles, as well as exposure to industrial toxins. They explain how chronic inflammation is a cornerstone of many chronic diseases and discuss how energy surplus from overeating leads to energy toxicity and inflammation. The paragraph concludes with a discussion on how certain fats, when consumed, can be inflammatory, especially when oils are used at high temperatures or when saturated fats are consumed in isolation.
π½οΈ The Impact of Diet on Inflammation
In this paragraph, the speaker discusses how certain foods can drive inflammation, differentiating between acute and chronic inflammation. They emphasize the importance of a Mediterranean diet, which includes both animal products and whole plants, and the use of extra virgin olive oil as a primary oil due to its anti-inflammatory properties. The speaker also addresses the issue of insulin resistance caused by overconsumption of food and its link to chronically elevated blood sugar, which is particularly damaging to the brain. They suggest checking blood sugar levels and prioritizing minimally processed foods to maintain anti-inflammatory diets. The paragraph ends with a discussion on the importance of avoiding unhealthy, rancid oils and the benefits of grilled foods over fried.
π©Ί Monitoring Health for Chronic Disease Prevention
The speaker advises on the importance of monitoring health indicators such as CRP (C-reactive protein), fasting glucose, fasting insulin, homocysteine levels, and A1C to prevent chronic diseases like Alzheimer's. They mention the role of B vitamins in lowering homocysteine levels and protecting the brain, especially for those at risk of Alzheimer's or with MTHFR mutations. The paragraph also covers the importance of checking lipid levels, thyroid function, and micronutrient levels for overall health. The speaker recommends their book 'Genius Foods' for a deeper dive into chronic disease prevention and mentions the availability of the audiobook for those interested.
Mindmap
Keywords
π‘Alzheimer's Disease
π‘Non-Communicable Diseases
π‘Diet and Lifestyle Modifications
π‘Inflammation
π‘Energy Surplus
π‘Industrial Additives
π‘Extra Virgin Olive Oil
π‘Mediterranean Diet
π‘Homocysteine
π‘B Vitamins
π‘CRP (C-Reactive Protein)
Highlights
Alzheimer's and other diseases like cardiovascular disease and cancer are non-communicable and responsive to diet and lifestyle modifications.
Inflammation is a major driver of chronic conditions and is influenced by modern diets and lifestyles.
Industrial additives in diets and exposure to toxins contribute to chronic inflammation.
Energy surplus from overeating leads to inflammation and is linked to chronic diseases.
Certain fats, when consumed at high temperatures or in isolation, can be inflammatory.
Saturated fats can drive the translocation of endotoxin, causing inflammation.
Insulin resistance from overconsumption of food leads to chronically elevated blood sugar, damaging blood vessels and increasing Alzheimer's risk.
Type 2 diabetes increases the risk of developing Alzheimer's disease by two to four times.
A Mediterranean diet with extra virgin olive oil is recommended for its anti-inflammatory properties.
Extra virgin olive oil is as anti-inflammatory as low-dose ibuprofen.
A daily drizzle of extra virgin olive oil on a salad can provide anti-inflammatory benefits.
Heavy cream in coffee is an example of a calorie-dense food that is less inflammatory than extra virgin olive oil.
Avoiding unhealthy rancid oils, especially in restaurant settings, is important for reducing inflammation.
Checking CRP levels can help monitor inflammation levels.
B vitamins can help lower homocysteine levels, a risk factor for cardiovascular disease and Alzheimer's.
B vitamins can slow brain atrophy, especially for those at risk of Alzheimer's.
Monitoring A1C levels is important for maintaining healthy blood sugar levels and preventing diabetes-related complications.
Lipid levels, including triglycerides, are important for overall health and should be monitored.
The book 'Genius Foods' provides a deep dive into chronic disease prevention and dietary recommendations.
A paper published in Nature in 2006 with fraudulent data derailed Alzheimer's disease research.
Transcripts
this is the root cause of Alzheimer's
and disease that nobody's talking about
but first we have to Define the types of
diseases that we're going to discuss and
the kinds of diseases like Alzheimer's
disease that I think are most responsive
to diet and lifestyle modifications like
what we're going to talk about are the
non-communicable so-called diseases of
civilization and these include
Alzheimer's disease cardiovascular
disease cancer my passion is helping
people better understand what they can
do to procure better brain health so as
to avert neurogenerative conditions
specifically like Alzheimer's disease
and Parkinson's disease and the like
um but there's no doubt today that
people are
um and mass succumbing to these kinds of
conditions that were relatively rare in
human history right now according to the
World Health Organization these
conditions kill 60 of people are
succumbing to conditions like heart
disease cancer
dementia type 2 diabetes and
complications Etc
so I think one of the things that we
have to talk about is inflammation
inflammation is super common these days
uh in in The Chronic sense inflammation
is a natural function of our immune
systems meant to spot clean cuts wounds
scrapes bruises and things like that
um a life-saving actually function of
our immune systems that's become
hijacked today by the fact that our
diets have become pro-inflammatory in
our lifestyles have become
pro-inflammatory not to mention the fact
that we're Exposed on a daily basis to
any number of industrial toxicants
whether we're talking about BPA
phthalates
um
acrolein and other uh carcinogens
that were exposed to Via you know
car exhaust and the burning of garbage
and various fuels you know in our modern
environments so uh so our immune systems
are have become chronically activated
on a chronic basis at a low level but
nonetheless it's a major driver of many
of these kinds of chronic conditions
inflammation is a Cornerstone of
cardiovascular disease Alzheimer's
disease
and
um and I think a lot of that has to do
with as I mentioned our diets our
lifestyles but specifically
um when looking at diet
our diets have become
saturated with industrial additives
um it's the combination of sugar salt
fat that drives hyperphagia or
overeating
so we tend to over consume today our
food so we're in an energy Surplus and
that energy becomes essentially toxic
it's been referred to as energy toxicity
and that's pro-inflammatory
um so energy Surplus is that the same
thing as I mean because energy and
calories so like is it a calorie Surplus
as well yeah same thing okay yeah same
thing okay calories are energy a calorie
is basically a way in which we measure
the uh energetic contribution of a food
right
um so calories is the unit of
measurement that we that we refer to but
when we're in an energy Surplus I mean
that's essentially a pro-inflammatory
state because we're over we're basically
over fueling our mitochondria
leads to the generation of reactive
oxygen species
um so that that can create inflammation
we also consume individual food items
that are that are potentially
inflammatory
um
it's hard to find uh literature showing
that grain and Seed oils are
inflammatory in the acute setting but
um when we ingest these types of fats
from say the fryer at a restaurant where
they've been held at high temperature
for an extended period of time it's very
likely that these oils have an
inflammatory effect they also come
bundled so to speak with uh aldehydes
like acrolein which we also find in
cigarette smoke
um so they can potentially pose a big
problem
um
certain uh fats when ingested
um on an empty stomach can potentially
be inflammatory because they help Ferry
a component of gram-negative bacteria in
our guts in through circulation so for
example yeah what's an example yeah so
certain
um
saturated fats actually when consumed uh
in isolation which is typically not
where you how you ingest a saturated fat
saturated fats are usually found in
Whole Foods right right where they have
antioxidants and other and other
compounds to protect them but they've
done studies where they've fed people
um I believe uh heavy cream although the
heavy cream that was used in these
studies also had emulsifiers in it which
is a sort of a confounding variable
um but nonetheless they've shown that
certain saturated fats can actually
drive this translocation of uh endotoxin
which is a normal component found in the
membrane of these gram negative bacteria
in our microbiomes
um across the gut epithelium and allow
those bacterial fragments to enter
circulation where they pose a very
powerful inflammatory effect so yeah
certain foods actually can drive
inflammation now that's not the same as
uh chronic inflammation like you might
get an acute
you know inflammatory Spike which might
not have any long-term Health outcomes
but the problem is our diets have become
so aberrant we're consuming processed
foods by and large as the majority of
our caloric intake continuously almost
continuously yeah throughout the day
um so that's a big problem the over
consumption of food in general is also
what drives insulin resistance which
causes our blood sugar to stay
chronically elevated that's an
inflammatory process right because blood
sugar
when it's chronically elevated literally
damages your blood vessels
um so that's a big driver of dysfunction
especially with regard to the brain the
brain relies on vascular health and so
this is one of the reasons why
chronically elevated blood sugar is so
damaging to the brain if you have type 2
diabetes for example your risk for
developing Alzheimer's disease increases
between two and four-fold so four times
up to four times the risk of developing
Alzheimer's disease if you have type 2
diabetes because of the chronically
elevated levels of blood sugar which are
slowly wreaking havoc on those Myriad
blood vessels that are that are there to
supply your brain fuel antioxidants
oxygen
Etc so you want to make sure that you
are keeping your blood sugar in a nice
and healthy range super important and
that you're prioritizing foods that are
minimally processed those are the foods
that are going to be the most
anti-inflammatory so to speak okay
um a Mediterranean dietary pattern
that's generally the kind of diet
dietary pattern that you want to
um adhere to and you know we can sort of
unpack that a little bit and I can offer
my Twist on how to uh even optimize your
diet further but in general a
Mediterranean diet is a diet that
contains both animal products and whole
plants and utilizes extra virgin olive
oil as the primary oil
and that's significant because extra
virgin olive oil has been found to be as
anti-inflammatory as low-dose ibuprofen
so there's sort of that like extra
anti-inflammatory component of the
Mediterranean diet
condoned by the the uh utilization of
extra virgin olive oil how much extra
virgin olive oil do you need to consume
to make sure you are
having those benefits of the extra
virgin olive oil so like I mean I
drizzle it on a salad yeah once a day
yeah that's enough that's a great
question I would say that's enough I
think as long as you're getting a little
bit on a on a regular basis okay you
still have to be mindful of the fact
that oil is a very calorie dense food
easily over consumed and that calories
do matter so you want to make you don't
want to overdo it with the oil but um
were you to add any kind of sort of
added fat to your diet it would be I
mean extra virgin olive oil is is
probably the primary one primary fat
that you want to be adding I
occasionally will will put um or
actually most days I put heavy cream in
my coffee
um
I put about a tablespoon of heavy cream
uh in my coffee every day which has half
of the calories of a tablespoon less
than half the calories of a tablespoon
of extra virgin olive oil really yeah a
table interesting a tablespoon of extra
virgin olive oil has about it's either
120 or 140 calories per tablespoon a
tablespoon of heavy cream has about 50
calories
okay so yeah interesting yeah yeah I
mean
very easily have Googled that but like
when I think heavy cream I'm like that's
calorie dense super calorie dense no
it's not you think it olive oil I'm like
that's nothing yeah interesting okay
um so yeah you generally want to make
sure from a dietary standpoint you're
checking your boxes by eating a
minimally processed diet
um prioritizing extra virgin olive oil
is the primary oil you're not eating out
too much and and and they're by exposing
yourself to unhealthy rancid oils right
people like to argue about whether or
not these oils are really rancid but
chances are when you're eating at a
restaurant you don't know how those oils
were kept you don't know what they've
been used for how long they've been
sitting in the fryer right so it's
absolutely reasonable to assume that the
oils that you're exposed to which are
primarily grain and Seed oils in the
restaurant setting are going to be
rancid
um so I'm definitely a fan of when when
eating out opting more for grilled foods
and things like that
um but yeah with regard to
um with these kinds of chronic diseases
Alzheimer's disease in particular you
want to really be mindful of your levels
of inflammation you can get that checked
at a doctor's office they can look at
your levels of CRP you want that to be
as low as possible
um blood sugar is also super important
um you want to make sure that you're
that you're fasting blood sugar and your
fasting insulin are in a nice and
healthy range
so I think this is great because you go
to the doctor's office and you get blood
work done or you work with you know
someone that comes at home
um to do blood work and things like that
what if you want to look at your
inflammation what were the things that
you should look at on your on your blood
work again your Labs your CRP your high
sensitivity C-reactive protein okay
um fasting glucose your fasting glucose
your fasting insulin okay you want to
also look at your um homocysteine levels
which is a risk factor for
cardiovascular disease and Alzheimer's
disease and the lower that is the better
it's not going to be zero it's usually I
mean mine is about I believe six or
seven
um and that can be lowered uh with B
vitamins
um so B complex of methylcobalamin and
methylfolate particularly what's in the
live on
one yeah to make sure he really yell
yeah okay yeah
um because homocysteine is basically
it's part of uh the methylation cycle
and so
um
you when you ingest uh more methyl
donors which you do when you ingest more
folate okay
um you're able to bring your
homocysteine levels down and there are
other things that affect homocysteine as
well but
um
but that's thought to help protect the
brain especially if you have hyper
homocysteinemia or LL levels of
homocysteine level solution and B
vitamins were actually shown
in research by one of the principal
investigators his name was David Smith I
believe
B vitamins can slow brain atrophy
particularly for people that are at risk
for developing Alzheimer's disease so B
vitamins are great especially if you
carry like an MTHFR mutation
um but definitely a solid supplement to
include I wouldn't say necessarily that
it's important for everybody but it can
be useful especially if you have high
levels of homocysteine right so once you
get your Labs checked to look at yeah
what your inflammation yeah panel yeah
looks like that would be something to
figure out if you need to integrate it
yeah you also want to look at your A1C
your hemoglobin A1c which is a measure
of how much your blood cells your red
blood cells have become glycated your
red blood cells have a
a lifespan of about three months on
average
um more if they live longer with lower
levels of blood sugar and they have
shorter lifespans with higher levels of
blood sugar so
um so generally you want to make sure
that your A1C is in a nice and healthy
range as well
um which a physician can help guide you
through uh micronutrient I think
um
uh levels also important to look at
hormone stuff also important to look at
you want to make sure that your thyroid
is
is uh is doing well functioning well
yeah yeah
um but yeah all super all super
important stuff oh lipids lipids are
really important you want to make sure
that you're
triglycerides are just listing the whole
panel now
but no it's right blood work's super
important but I feel like those first
ones you mentioned were great in terms
of
inflammation key factors yeah yeah cool
so all super helpful to to get you
started at least on your journey of
chronic disease prevention and if you
want further information I mean you
could always check out my book genius
foods which uh is a deep dive into
chronic disease prevention this isn't uh
a pitch to sell the book but if it's a
it does a really deep dive and you've
got all the labs sort of laid out for
you I actually really yeah that um the
audiobook of that is really good this is
not also a picture but I listen to the
audiobook Max narrates it himself guys
so it's it's like listening to a podcast
yeah that's detailed if you like this
book and you if this voice and you want
nine hours of it if not more uh check
out the audiobook of Genius Foods hey if
you like that video you need to check
out this one here and I'll see you there
with regard to Alzheimer's disease it
was revealed that 16 that 16 years ago
in 2006 a paper in nature was published
that presented fraudulent data that
essentially derailed Alzheimer's disease
research in many ways
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