Why finasteride stops hair loss forever
Summary
TLDRThe video script discusses the efficacy of finasteride in treating androgenic alopecia, comparing it to other treatments like dutasteride and minoxidil. It emphasizes the importance of starting treatment early and being patient for optimal results. The script refutes fears of finasteride becoming ineffective over time, citing long-term studies that show its benefits are enduring. It also addresses concerns about side effects and the potential for treatment-induced shedding, advocating for trust in scientific evidence over anecdotal claims.
Takeaways
- 💊 Finasteride is an FDA-approved drug for treating androgenic alopecia and has been extensively studied for its efficacy.
- 📉 Finasteride reduces serum DHT levels by about 70%, whereas dutasteride can lower it by over 90%, suggesting different strengths in their 5α-reductase inhibition.
- 📈 A meta-analysis from 2010 showed that finasteride is significantly better than placebo in improving hair growth as self-assessed by patients and through objective measures like phototrichogram.
- 🔬 The effectiveness of finasteride increases over time, with more improvement seen in the long term, highlighting the importance of patience with the treatment.
- 🆚 When compared to topical minoxidil, finasteride has shown to be more effective in treating androgenic alopecia, solidifying its position as a first-line treatment.
- 🌐 Global photographic assessments by dermatologists confirm that finasteride improves the appearance of hair, providing an additional layer of evidence for its efficacy.
- 📊 Another meta-analysis from 2022 compared finasteride to dutasteride and found that while dutasteride is stronger, finasteride still offers significant benefits and is more studied.
- 🌏 Long-term studies, including those from non-Asian populations, confirm that finasteride's benefits are long-lasting, with continued improvement or maintenance of hair over a decade.
- 🚀 Starting finasteride early in the hair loss process is crucial for maximizing its benefits, as it is more effective at preserving existing hair than regrowing lost hair.
- 💡 For those seeking a comprehensive hair loss treatment, the combination of finasteride and minoxidil is recommended due to their synergistic effects.
- 🛡 Despite the availability of stronger alternatives like dutasteride, finasteride remains a preferred choice due to its well-documented safety profile, extensive clinical data, and long-term efficacy.
Q & A
What is the main topic discussed in the video script?
-The main topic discussed in the video script is the efficacy of finasteride in treating androgenic alopecia and whether it is necessary to switch to other treatments like dutasteride or minoxidil.
What is the difference between finasteride and dutasteride in terms of their effect on DHT levels?
-Finasteride lowers serum DHT by about 70%, whereas dutasteride lowers it by over 90%. Additionally, dutasteride at 0.5 milligrams can lower scalp DHT by about 50%, compared to finasteride which lowers it by 40%.
What is the significance of a meta-analysis in scientific research?
-A meta-analysis is significant in scientific research as it combines the results of multiple studies into one large study, providing more valid and reliable results from the combined data.
What does the force plot in a meta-analysis represent?
-A force plot in a meta-analysis represents the likelihood of improvement from a treatment compared to a control. It shows the amount of improvement and whether the treatment is better, worse, or equal to the control.
According to the 2010 meta-analysis, how effective is finasteride in improving hair growth as assessed by patients?
-According to the 2010 meta-analysis, finasteride improves hair growth as assessed by patients, with the overall results showing a significant likelihood of improvement compared to placebo.
How does finasteride compare to minoxidil in treating androgenic alopecia based on the studies mentioned in the script?
-Finasteride is more effective than minoxidil in treating androgenic alopecia. In the studies mentioned, 80% of men on finasteride showed improvement compared to 52% on minoxidil, and finasteride alone was better than minoxidil alone or a combination of finasteride with ketoconazole shampoo.
What is the general consensus on the combination of finasteride and minoxidil for treating hair loss?
-The general consensus is that the combination of finasteride and minoxidil has an additive and potentially synergistic effect, providing additional benefits compared to using either treatment alone, making it the gold standard hair loss stack.
What does the 2022 meta-analysis reveal about the comparison between finasteride and dutasteride?
-The 2022 meta-analysis reveals that while both finasteride and dutasteride are effective, dutasteride is stronger than finasteride in increasing hair counts, with a notable difference of 6.1 hairs per square centimeter after 24 weeks of treatment.
What do the long-term studies on finasteride suggest about its efficacy over time?
-The long-term studies suggest that finasteride's efficacy continues over time, with some studies showing continued improvement in hair growth up to 10 years, and a significant percentage of patients experiencing either maintained or further improvement in their hair.
Why does the video script recommend starting with finasteride instead of dutasteride?
-The script recommends starting with finasteride due to its extensive clinical data, FDA approval for androgenic alopecia, and long-term safety data. It also mentions that finasteride might be a safer drug due to its shorter half-life compared to dutasteride.
What advice does the script give regarding the use of finasteride and concerns about its long-term effectiveness?
-The script advises not to worry about finasteride's long-term effectiveness, as it has been proven to work indefinitely for the majority of users. It emphasizes that finasteride should be taken consistently and that any initial shedding is a normal part of the treatment process.
Outlines
💊 Finasteride's Role in Hair Loss Treatment
This paragraph discusses the efficacy of finasteride for treating androgenic alopecia, addressing concerns about its long-term effectiveness. It compares finasteride to other treatments like dutasteride and topical minoxidil, highlighting that finasteride is an FDA-approved medication with substantial clinical data supporting its use. The speaker aims to alleviate fears that finasteride may not be sufficient in the long run, emphasizing that many users experience improved results over time. The paragraph also introduces meta-analyses that consolidate various studies to provide a comprehensive view of finasteride's effectiveness.
📊 Analyzing Finasteride's Efficacy Through Studies
The speaker presents data from a 2010 meta-analysis comparing finasteride to a placebo, detailing the methodology and results of various studies included in the analysis. The paragraph focuses on different measures of finasteride's effectiveness, such as patient self-assessment, hair count improvements, and dermatologist evaluations. The summary underscores the objective improvements in hair growth and the significance of long-term use, as well as the comparison between finasteride and minoxidil, establishing finasteride as a more potent treatment for androgenic alopecia.
🔬 Finasteride vs. Dutasteride: A Scientific Showdown
This section delves into the comparison between finasteride and dutasteride, discussing the biological processes behind their actions on DHT levels. The paragraph reviews a 2022 meta-analysis that includes studies on finasteride's efficacy against hair loss, both in comparison to placebo and to dutasteride. It presents data on hair count increases and discusses the implications of these findings, suggesting that while dutasteride may be more potent, finasteride remains a strong contender in the treatment of hair loss.
🌐 Long-Term Studies on Finasteride's Sustainability
The speaker reviews long-term studies on finasteride's effectiveness, including data from Asian populations and a 10-year follow-up study from Italy. The paragraph emphasizes the importance of starting treatment early for better results and discusses the plateauing of finasteride's benefits after two years of use. It also addresses the misconception that finasteride's effectiveness diminishes over time, providing evidence to the contrary and highlighting the drug's long-lasting benefits for most patients.
🛡️ Choosing the Right Treatment Protocol for Hair Loss
In this concluding paragraph, the speaker offers recommendations on starting with finasteride due to its extensive clinical data and long-term efficacy. They discuss the possibility of using minoxidil in conjunction with finasteride for added benefits but caution about the commitment required for ongoing use. The paragraph also touches on the option of upgrading to dutasteride if necessary and reinforces the message that finasteride is a reliable, long-term solution for hair loss, urging individuals to trust scientific evidence over anecdotal claims.
Mindmap
Keywords
💡Finasteride
💡Dutasteride
💡Androgenetic Alopecia
💡Minoxidil
💡Meta-Analysis
💡5-alpha Reductase
💡DHT (Dihydrotestosterone)
💡Phototrichogram
💡Long-term Efficacy
💡Hair Loss Stack
💡Norwood Scale
Highlights
Finasteride is often considered overhyped, but it works for some and may not be enough alone for others.
Dutasteride is a stronger 5α-reductase inhibitor that may be considered for those who do not respond well to finasteride.
Finasteride reduces scalp DHT by about 40%, while dutasteride at 0.5 milligrams can lower it by approximately 50%.
A dose of 2.5 milligrams of dutasteride daily can lower scalp DHT by nearly 80%.
The question of whether to start with finasteride or go straight to dutasteride is raised.
Finasteride is an FDA-approved drug with extensive studies on its effectiveness.
Meta-analyses provide a combined view of multiple studies, enhancing the validity of the results.
Finasteride has been shown to improve hair growth as assessed by patients themselves.
Phototrichogram, a tool for measuring hair counts, provides objective evidence of finasteride's effectiveness.
Long-term studies show continued improvement with finasteride, suggesting it works better over time.
Finasteride is more potent than topical minoxidil in treating androgenic alopecia.
Combining finasteride with minoxidil has an additive and possibly synergistic effect.
A recent meta-analysis from 2022 compares the efficacy of finasteride and dutasteride.
Dutasteride is stronger than finasteride in head-to-head comparisons, but the difference is not drastic.
Long-term efficacy data for finasteride is available, showing its effectiveness over a span of 10 years.
The importance of starting treatment early with finasteride is emphasized for better long-term results.
Finasteride is recommended as a first-line treatment due to its extensive clinical data and long-term safety profile.
Dutasteride has a longer half-life than finasteride, which may affect the duration of side effects.
The video discusses the fear-mongering around post-finasteride syndrome and emphasizes the drug's safety.
Finasteride is confirmed to be effective for the vast majority of users, with benefits that are long-lasting.
Transcripts
sup chooms how y'all living hope
everything is no then you're all having
a pream week so a lot of people have
been telling me that I over hyped
finasteride sure it works for some but
come on Kevin for most people it isn't
going to be enough by itself and
eventually all of us are going to have
to use other drugs like topical
minoxidil or a stronger 5ar inhibitor
like dutasteride after all do test ride
lowers serum DHT over 90 percent versus
finasteride which only lowers it by
about 70 percent and more importantly
dutasteride at 0.5 milligrams lower
scalp DHT about 50 versus finasteride
lowering it 40 even better dutasteride
have a dose of 2.5 milligrams per day
can lower scalp DHT by almost 80 percent
so that leads a lot of people to think
that finasteride will only work in the
short term and eventually all of us will
have to switch to detestaride which
really begs the question why even bother
starting with finasteride we might as
well just start with the good stuff and
join the dutasteride master race right
away right but is it really necessary do
we really need to go balls to the wall
with our 5 Air inhibition or is
finasteride by itself good enough in
stopping hair loss from androgenic
alopecia even more important than that
will finasteride be enough to stop hair
loss indefinitely even a lot of people
who are taking finasteride and are
pleased with the results they have
gotten so far still kind of have that
lingering fear that one day finasteride
will not be enough and they'll start to
lose ground again people want assurance
that the finasteride they are using will
still work even when they are much older
this is important to know because I am
seeing more and more people telling me
they are worried that finasteride isn't
going to be enough for them or won't be
enough long term after all a 40
reduction in scalp tht really doesn't
sound like all that much so let's take
another look at finasteride and take our
patented balls deep approach to see if
we're doing it enough to stop our hair
loss by using finasteride both in the
short and the long term so let's take a
look at the efficacy of finasteride we
all know know that it works of course
but does it work well enough that we can
take it not have to worry about hair
loss at all well fortunately this is an
FDA approved drug we're talking about
here so there is no shortage of studies
on the effectiveness of oral finasteride
this data includes the original clinical
studies that resulted in its approval by
the FDA as well as more recent studies
when a lot of studies on the same
subject are available it's often good to
see if someone has done a meta-analysis
of these studies a meta-analysis is a
way to combine the results of many
studies into one big study and it is a
good way to get the most valid results
possible from data as you can see right
here m a meaning meta-analysis is at the
very top of the pyramid when we look at
the hierarchy of scientific evidence so
whenever you are doing research it is
good to know what the quality of the
research is so you know what belongs in
a serious scientific discussion so
someone for instance wants to claim that
dutasteride made their hair loss worse
somehow and they can't provide any
stronger evidence than just their own
anecdote then you can safely dismiss
them as being full of and ignore
them so it's good we're working with
actual meta-analyzes here as opposed to
the testimonies of a bunch of
hypochondriac crayon eating morons on
trustless in fact we actually have two
bed analyzes that examine the efficacy
of finasteride for hair loss the first
one is from 2010 that looks at
finasteride versus placebo and the other
one is from this year of Our Lord in
2022 that compares the efficacy of
finasteride versus dutasteride we also
have some data on the efficacy of
finasteride versus topical minoxidil as
well as data on long-term finasteride
efficacy over at least five years of use
so it's time to massage our scalps and
get that boot flow going to our brains
and let's find out once and for all if
finasteride is still the first line
choice for treating androgenic alopecia
today the first meta-analysis is from
2010 and it is titled quote efficacy and
safety of finasteride therapy for
androgenetic Alopecia a systematic
review unquote in this meta-analysis 12
randomized controlled studies of
finasteride versus placebo were combined
there were
3927 male subjects with 2152 being on
finasteride and
1775 on Placebo so this was a huge study
it has more subjects than all the
subjects in every study ever funded by
the PFS Foundation combined this table
here shows the characteristics of the
studies included in the meta-analysis
most of the studies used a standard dose
of one milligram per day of finasteride
though three studies did use five
milligrams per day which is what is
typically prescribed for an enlarged
prostate most of the studies lasted 12
to 24 months a few were of a shorter
duration and two studies lasted up to 48
and 60 months so this is already much
longer term than most hair loss research
but we have data which is even more
long-term coming up soon so these
studies all looked at different
endpoints including patient
self-assessment of the results hair
counts and Global photographic
assessment by dermatologists who were
blinded to the treatment group let's
take a look at the results of
finasteride assessed by the patients
themselves first
so first let's get oriented to this type
of figure on the left there are a whole
bunch of numbers representing short-term
and long-term results from the
individual studies but instead of
getting bogged down with all that let's
concentrate on the graph on the right
this graph is what's called a force plot
and it's important to understand this
type of graph because they are used all
the time in meta-analyzes basically a
force plot shows the amount of
improvement from a treatment versus a
control so in this case this Force plot
is showing us the likelihood that a
subject on finasteride would see an
improvement in their hair growth versus
a subject on a placebo the vertical line
in the middle represents the number one
and if the result was one then
finasteride would be equally as good as
Placebo which would mean it wasn't doing
anything at all if a point was to the
left of that line meaning less than one
it would mean that finasteride was worse
than Placebo and anything to the right
of the line meaning greater than one
means that finasteride was better than
Placebo anyway the little squares with
the horizontal line show the individual
will study results along with What's
called the confidence limits which is
basically similar to the range of these
results and the Diamonds show the
average results the bottom Diamond shows
the overall result of all the studies
and clearly as you can see finasteride
improves hair growth as assessed by the
patients themselves however
patient self-assessments can be pretty
subjective and it is hard to determine
exactly how effective finasteride is at
determining objective improvements like
increased hair counts fortunately we see
in the next graph here that hair count
as assessed by phototrichogram also
improve a finasteride a photo trigger
Ram is a tool that can measure exact
hair counts so it is better at giving us
objective measurements compared to
researcher or patient self-assessments
in fact in the short term meaning less
than or equal to a year on finasteride
hair counts improved by 9.42 percent
overall in the long term meaning over 12
months the results are even better with
24.3 percent increase in hair counts
this goes along with most of the studies
on finasteride that showed more
Improvement the longer you are on it and
that is important to keep in mind if you
have been on finasteride for less than a
year oftentimes people give up and
assume the treatment isn't effective
when they haven't even given it a year
yet so again it can take over a year for
finance tried to really Flex its muscles
so please don't give up keep using
finasteride and always remember the best
best is yet
finally right here we see the results of
a global photographic assessment and it
is clear that finasteride results in
Improvement in the appearance of the
hair as judged by dermatologists So
based on all this evidence it's clear
that finasteride works but how does it
compare to other treatments well let's
dispense with Minoxidil first minoxidil
is of great hair growth stimulant of
course but it can't compare to
finasteride in treating androgenic
alopecia here's a couple of randomized
controlled studies the first study is
titled quote an open randomized
comparative study of oral finasteride
and 5 topical minoxidil and male
androgenetic alopecia unquote this study
was a direct comparison of one milligram
of finasteride daily to five percent
topical minoxidil applied twice daily 65
men were enrolled and the study lasted
for 12 months overall eighty percent of
the men on finasteride showed
Improvement by clinical assessment
whereas only 52 percent of those on
minoxidil improved this figure shows the
results in detail tale and clearly men
did better on finasteride when comparing
the two treatments here is another study
that compared finasteride at one
milligram daily finasteride plus
minoxidil two percent two percent
minoxidil alone and finasteride plus
Ketoconazole shampoo and 100 men with
androgenic alopecia in this figure group
one is finasteride alone and group three
is two percent minoxidil alone clearly
one milligram finasteride per day is
much better than two percent minoxidil
and it's by a long shot which is no
surprise since we already know that
finasteride even beats out five percent
minoxidil by nearly 30 percent group
four is finasteride plus Ketoconazole
and there was really not any difference
from just plain finasteride which really
begs the question as to whether or not
Ketoconazole shampoos really do anything
at all maybe they do but they're clearly
not even in the same Stratosphere as
finasteride and minoxidil group 2
however did the best and that group used
a combination of finasteride plus two
percent minoxidil so clearly finasteride
plus minoxidil has has an additive and
even a synergistic effect which gives
additional benefits compared to using
either one alone that is why the gold
standard hair loss stack is finasteride
plus five percent topical minoxidil so
none of this is controversial no one
seriously questions that finasteride is
more potent than topical minoxidil after
all unlike minoxidil finasteride works
by actually targeting the root cause of
androgenic alopecia which is the trash
hormone DHT but what happens when it's
brother against brother or finasteride
versus dutasteride which one Reigns
Supreme in the good fight against the
slap head curse well that brings us to
the next meta-analysis this one was just
published this year in 2022 it is titled
quote finasteride for hair loss A reveal
unquote this article is a good review of
finasteride in general and it includes
some helpful figures like this one here
this figure shows how testosterone is
converted by the five air enzyme in the
cells into the trash hormone DHT which
then binds with the angioreceptors in
the cell nuclei that then activates
signaling Pathways and other factors
that end up triggering off the long
chain of events that ends in the
destruction of our hair finasteride of
course stops this destruction dead in
its tracks by inhibiting the five-air
enzyme and thus preserves the alpha Chad
hormone testosterone by preventing the
five air enzyme from wasting it by
turning it into the beta version
hormone DHT so this study was another
meta-analysis and it looked not only at
finasteride versus placebo but also
finasteride versus dutasteride eight
studies were combined and some of them
overlapped with the previous
meta-analysis we already covered but
since the study was published 12 years
after the last one some of the studies
are new anyways the results are
presented much like in the other
meta-analysis using Force plots here the
endpoint is changed in hair counts per
square centimeter with finasteride one
milligram per day versus placebo the top
graph is after 24 weeks and the bottom
one is after 48 weeks the raw numbers
showed an increase in hair counts of
12.4 hairs per square centimeter at 24
weeks and 16.4 hairs per square
centimeter at 48 weeks with finasteride
this is once again an indication that
finasteride not only works but it works
better the longer you take it so if
you're getting good results with
finasteride now then Rejoice because
things are only going to get better and
your hair will age like a fine wine the
top Force plot in the next figure here
shows dutasteride at 0.5 milligrams per
day versus placebo after 24 weeks of
treatment dutasteride increased hair
counts by 18.4 hairs per square
centimeter compared to Placebo the
bottom graph shows two studies that did
a head-to-head comparison between
finasteride right at one milligram daily
versus dutasteride at 0.5 milligrams
daily for 24 weeks do testeride as you
might expect given its stronging 5ar
blocking capabilities outgrew hair
versus finasteride by 6.1 hairs per
square centimeter which isn't a huge
difference but still a notable one so
the data shows that dutasteride is
stronger than finasteride and
finasteride is stronger than minoxidil
but let's look at one more aspect of
finasteride before coming up with some
recommendations about which five air
inhibitor you should use the last
question is does finasteride work
forever I know a lot of people who have
started finasteride as teenagers and
they're now worried that by the time
they're in their 30s the drobe won't be
effective anymore but is it really
something we need to worry about will
finasteride work as long as you keep
using it well I touched on the long-term
efficacy of finasteride before in
another video which I'll link below but
one source of criticism I got from that
video is that the data I cited has the
limitation in that the long-term studies
were done exclusively in Asian
populations so how is this relevant you
may ask well people like to argue that
androgenic alopecia is different in
Asians because it occurs less frequently
in them well even though it is less
frequent there is nothing else to
suggest that the actual disease process
is different even if it is less common
in that population but even if you do
believe that Asians have some genetic
resistance to hair loss compared to
Caucasians it turns out we do have some
long-term data now in non-asian
populations which confirms that Asian
studies are completely valid so before
we get into that let's review the Asian
studies one of the first long-term
studies was this one from Japan titled
quote five-year efficacy of finasteride
an 801 Japanese men with androgenetic
alopecia unquote in the study men were
assessed using Global photographs after
five years of treatment with finasteride
at one milligram daily the results are
difficult to believe though after four
years of treatment there was Improvement
in 99.4 percent of men and prevention of
disease progression and 100 of men I
mean I'm a big believer in finasteride
of course but this seems like an outlier
study to me and I find these results
hard to swallow no drug has a 100
efficacy rate not even lethal injection
drugs fortunately there is more data on
this though in this study from good
Korea 126 patients who had been on
finasteride had one milligram per day
for at least five years were evaluated
using photographs the investigators used
their own made-up alopecia scoring
system so it is hard to translate the
results into something familiar like the
Norwood scale but anyways this graph
used in the good Korean Norwood scale
shows that the effectiveness of
finasteride keeps rising and then Peaks
at two years after that it plateaus with
only a very small falloff and efficacy
overall 85.7 percent of patients showed
Improvement on finasteride after five
years of treatment so this study brings
us back to what I was saying about the
importance of being patient finasteride
can take up to two years to fully Flex
its muscles so people who say they've
been on it for two months and it's not
working should just take a deep breath
and relax it's going to be okay chims
now we're back to the Japanese again
this time with a 10-year follow-up study
in the study there were 532 Japanese men
and the main assessment was based on
global photographs of the hair this
graph here shows the main findings this
graph is especially interesting though
because it breaks down the results by
Norwood class so I guess the Japanese
don't have their own interpretation of
the Norwood scale like the good Koreans
do overall though for most Norwood
classes there was continued Improvement
in hair growth until five years at which
point the Improvement tends to Plateau
however those with the lowest Norwood
scales like one and two at the top of
the graph seem to improve throughout the
whole 10-year period while the North
with sevens at the bottom of the graph
get less Improvement and their gains
tend to drop off a little over time so
to explain it as simply as possible the
sooner you start treatment the better
finasteride works not just in the short
term but also in the long term people
who report unsatisfactory results with
finasteride are usually those who
started when they've already lost
significant ground and now thanks to
this graph we know exactly why that's
the case the longer you wait the less
effective finasteride is going to be so
this really reinforces the idea that it
is important to start treatment as soon
as you possibly can before hair loss has
had any chance to progress at all
although even if you have lost some
ground you're much better off with
finasteride than without it so don't
give up just because you're a Norwood 3
Norwood 4 or Beyond in fact the golden
option is to start finasteride before
you even notice hair loss at all rather
than waiting until you've lost ground
because finasteride is much better at
preserving what you've lost compared to
getting back what you've lost family
history of hair loss is an indicator but
it's not a 100 accurate predictor
meaning you can have a family member
with no evidence of hair loss and still
have the androgenic alopecia genes and
vice versa so don't think family history
is everything it isn't finally
let's look at the non-asian long-term
study that I mentioned before this study
is from Italy and it is titled quote
finasteride one milligram daily
Administration on male androgenetic
alopecia in different age groups 10-year
follow-up unquote in the study 118 men
on finasteride had one milligram per day
were assessed by photographs over a
period of 10 years so like the Japanese
study this is a very long-term study the
results of the study are somewhat
complex though because they divided the
men by different age groups and by
different Norwood classes there were two
main results number one if you are going
to respond to finasteride you will
usually start to see some results within
the first year of treatment number two
if you respond within the first year
there is only a four percent chance your
hair will get worse after 10 years while
there is a 28 chance it will be
maintained and a whopping 68 percent
chance of further Improvement overall in
this study after 10 years only 14
percent of patients had worsening of
their hair loss and 86 percent had
improvement over the 10-year period in
fact 21 of the subjects had better hair
at 10 years than after five years of
treatment so this study absolutely
confirms that the majority of patients
get long-lasting benefits from oral
finasteride and in many cases the hair
continues to improve during all 10 years
of treatment so all this data confirms
that finasteride is an extremely
effective drug for treating androgenic
alopecia and its benefits are long
lasting but there is some data that do
pastoride may even be more effective so
why is it that I recommend starting with
finasteride well I am not
anti-dutasteride and I fully believe
that both finasteride and dutasteride
are outstanding treatments that will
stop hair loss in the vast majority of
people who use them one of the reasons I
prefer finasteride though is that there
is a lot more clinical data on
finasteride than dutasteride which is
one recent finasteride is FDA approved
for androgenic Alopecia and dutasteride
is not there is also as I already showed
a lot of long-term data on finasteride
lasting up to 10 years that dutasteride
doesn't have when it comes to side
effects both drugs are extremely well
tolerated and the side effect profiles
from both drugs are comparable and I've
talked about that in many many videos
you can find on my channel but overall I
think finasteride might be a safer drug
given that dutasteride has such a long
Half-Life lasting five weeks versus six
to eight hours with finasteride thus if
you get side effects from dutasteride it
may take a longer time for them to
subside than with finasteride although I
should note that the side effects do
subside 100 of the time and the idea of
persistent side effects from either drug
are 100
fear-mongering and I've done
many videos where I prove that post
finasteride syndrome is little more than
a pseudoscientific q Anon conspiracy
theory so if you want a treatment
protocol where you can feel confident in
maintaining your hair forever then the
best thing to do is to start with
finasteride if you start early it
probably will be the only thing you will
ever need but just in case you want a
little extra insurance for your hair you
can always keep minoxidil on reserve
although if you want to start with both
minoxidil and finasteride at the same
time that's fine too but just keep in
mind that since the drugs work
differently any additional benefits you
get with Minoxidil on top of finasteride
will need to be maintained with
Minoxidil indefinitely so just be ready
for the long-term Commitment if that's
what you choose if you've given
finasteride a fair shot and it's been
say a couple of years after that time
you can then consider upgrading your 5
AR inhibitor to do test ride at 0.5
milligrams daily so if for some reason
that's not strong enough which is
extremely unlikely keep in mind that
dutasteride can be safely titrated all
the way up to 2.5 milligrams daily which
will suppress 80 percent of scalp DHT
which is twice as much of what as what
one milligrams of finasteride suppresses
and I have a video about that which I'll
link below again though I must reiterate
with as strong of an emphasis as I
possibly can that finasteride will
completely stop and even reverse hair
loss in the vast majority of people who
use it and this has all been validated
through the strongest and highest
quality scientific evidence in existence
so you should trust the science far more
than you trust some random douchebag on
a subreddit who claims without any
photographic documentation whatsoever
that somehow his hair is getting worse
on treatment these people are either
trolling you or more likely they are
just hypochondriacs who are freaking out
about a shed because they are
self-medicating and thus they never
received any proper education about the
drug all the hair loss treatments will
cause an initial shed and likely
repeated sheds will happen as well as it
is impossible to keep a hair follicle in
the ancient growth phase forever
anything lost while on treatment will
grow back and likely grow back stronger
and I have a video which goes over all
this which I'll link below so please
chooms stop worrying about shedding you
should be far more worried about what
happens if you stop treatment and for
the love of God stop worrying that
somehow finasteride is going to just
magically stop working someday it isn't
some drug you build a tolerance for like
alcohol and cigarettes it works
indefinitely and chances are greater it
will work even better in the long term
compared to how it works in the short
term so just take your finasteride like
an aspirin forget about hair loss and go
enjoy your life because you've earned it
God bless
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